{"id":"https://openalex.org/W7220730685","doi":"https://doi.org/10.64898/2026.10.05.26364743","title":"A Reduced Digital Motor Assessment using Multimodal Biomarkers in Parkinson\u2019s Disease","display_name":"A Reduced Digital Motor Assessment using Multimodal Biomarkers in Parkinson\u2019s Disease","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220730685","doi":"https://doi.org/10.64898/2026.10.05.26364743"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.26364743","doi":"https://doi.org/10.64898/2026.10.05.26364743","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.26364743","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.05.26364743.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.05.26364743.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117618911","display_name":"J\u00falia Rey Vilches","orcid":"https://orcid.org/0009-0005-5338-1198","observed_orcids":["https://orcid.org/0009-0005-5338-1198"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"J\u00falia Rey Vilches","raw_affiliation_strings":["Department of Electrical and Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0009-0005-5338-1198","affiliations":[{"raw_affiliation_string":"Department of Electrical and Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045351207","display_name":"Trine H\u00f8rmann Thomsen","orcid":"https://orcid.org/0000-0001-9441-1000","observed_orcids":["https://orcid.org/0000-0001-9441-1000","https://orcid.org/0000-0001-9414-0722"]},"institutions":[{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Trine H\u00f8rmann Thomsen","raw_affiliation_strings":["Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark","Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9441-1000","affiliations":[{"raw_affiliation_string":"Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087762842","display_name":"Bo Biering\u2010S\u00f8rensen","orcid":"https://orcid.org/0000-0002-7682-1353","observed_orcids":["https://orcid.org/0000-0002-7682-1353"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2800929696","display_name":"Amager Hospital","ror":"https://ror.org/02g2pz956","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2800929696","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bo Biering-S\u00f8rensen","raw_affiliation_strings":["Department of Neurology, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark","Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7682-1353","affiliations":[{"raw_affiliation_string":"Department of Neurology, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2800929696","https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072860842","display_name":"Sadasivan K Puthusserypady","orcid":"https://orcid.org/0000-0001-7564-2612","observed_orcids":["https://orcid.org/0000-0001-7564-2612"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sadasivan Puthusserypady","raw_affiliation_strings":["Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-7564-2612","affiliations":[{"raw_affiliation_string":"Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048001312","display_name":"Silvia Tolu","orcid":"https://orcid.org/0000-0003-1825-8440","observed_orcids":["https://orcid.org/0000-0003-1825-8440"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Silvia Tolu","raw_affiliation_strings":["Department of Electrical and Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-1825-8440","affiliations":[{"raw_affiliation_string":"Department of Electrical and Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5117618911"],"corresponding_institution_ids":["https://openalex.org/I96673099"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10444","display_name":"Context-Aware Activity Recognition Systems","score":0.2824999988079071,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10444","display_name":"Context-Aware Activity Recognition Systems","score":0.2824999988079071,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.14669999480247498,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.06930000334978104,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/digital-biomarkers","display_name":"digital biomarkers","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mds-updrs-part-iii","display_name":"MDS-UPDRS III","score":0.8820000290870667},{"id":"https://openalex.org/keywords/motor-function-assessment","display_name":"motor function assessment","score":0.671999990940094},{"id":"https://openalex.org/keywords/multimodal-fusion","display_name":"multimodal fusion","score":0.5680000185966492},{"id":"https://openalex.org/keywords/surface-electromyography","display_name":"surface electromyography","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inertial-motion-capture","display_name":"inertial motion capture","score":0.9850000143051147},{"id":"https://openalex.org/keywords/musculoskeletal-modeling","display_name":"musculoskeletal modeling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pronation-and-supination","display_name":"pronation and supination","score":0.8479999899864197},{"id":"https://openalex.org/keywords/postural-tremor","display_name":"postural tremor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/finger-tapping","display_name":"finger tapping","score":0.796999990940094},{"id":"https://openalex.org/keywords/wearable-sensing","display_name":"wearable sensing","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.661899983882904},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.5709999799728394},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5691999793052673},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5263000130653381},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49480000138282776},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.48030000925064087},{"id":"https://openalex.org/C150594956","wikidata":"https://www.wikidata.org/wiki/Q1334829","display_name":"Wearable computer","level":2,"score":0.4749000072479248},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.44920000433921814},{"id":"https://openalex.org/C89805583","wikidata":"https://www.wikidata.org/wiki/Q192940","display_name":"Accelerometer","level":2,"score":0.4140999913215637},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3937999904155731},{"id":"https://openalex.org/C2777515770","wikidata":"https://www.wikidata.org/wiki/Q507369","display_name":"Electromyography","level":2,"score":0.3693000078201294},{"id":"https://openalex.org/C2992114214","wikidata":"https://www.wikidata.org/wiki/Q7684805","display_name":"Finger tapping","level":2,"score":0.33399999141693115},{"id":"https://openalex.org/C79061980","wikidata":"https://www.wikidata.org/wiki/Q941680","display_name":"Inertial measurement unit","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C104114177","wikidata":"https://www.wikidata.org/wiki/Q79782","display_name":"Motion (physics)","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30820000171661377},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C48007421","wikidata":"https://www.wikidata.org/wiki/Q676252","display_name":"Motion capture","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C197947376","wikidata":"https://www.wikidata.org/wiki/Q5155608","display_name":"Comparability","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.2705000042915344},{"id":"https://openalex.org/C173906292","wikidata":"https://www.wikidata.org/wiki/Q1493441","display_name":"Gait analysis","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C54290928","wikidata":"https://www.wikidata.org/wiki/Q4845080","display_name":"Wearable technology","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C169976356","wikidata":"https://www.wikidata.org/wiki/Q13208902","display_name":"Motor skill","level":2,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.05.26364743","doi":"https://doi.org/10.64898/2026.10.05.26364743","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.26364743","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.05.26364743.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.26364743","doi":"https://doi.org/10.64898/2026.10.05.26364743","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.26364743","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.05.26364743.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323124","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220730685.pdf","grobid_xml":"https://content.openalex.org/works/W7220730685.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4295093260","https://openalex.org/W7167365690","https://openalex.org/W7134107737","https://openalex.org/W7161629827","https://openalex.org/W7204866996","https://openalex.org/W4205387009","https://openalex.org/W4404089787","https://openalex.org/W4393309798","https://openalex.org/W4415349239","https://openalex.org/W2316832005"],"abstract_inverted_index":{"A":[0,132],"bstract":[1],"Background":[2],"Wearable":[3],"sensing":[4],"and":[5,23,25,46,52,76,81,94,98,101,120,147,154,199,217,232],"machine":[6],"learning":[7],"can":[8],"support":[9,241],"objective":[10],"assessment":[11,34,231],"of":[12],"Parkinson\u2019s":[13,62],"disease":[14],"(PD),":[15],"but":[16],"performance":[17],"depends":[18],"on":[19,227],"sensor":[20],"placement,":[21],"modality,":[22,148],"analysis,":[24],"studies":[26],"often":[27],"target":[28],"selected":[29],"motor":[30,246],"tasks,":[31,165],"whereas":[32],"clinical":[33,250],"integrates":[35],"multiple":[36],"standardized":[37,57],"movements.":[38],"How":[39],"discriminative":[40,224],"information":[41,225],"is":[42],"distributed":[43],"across":[44,71],"tasks":[45,70,109],"modalities":[47],"remains":[48],"unclear,":[49],"limiting":[50],"comparability":[51],"translation.":[53],"Objectives":[54],"To":[55],"quantify":[56],"Movement":[58],"Disorder":[59],"Society":[60],"Unified":[61],"Disease":[63],"Rating":[64],"Scale":[65],"Part":[66],"III":[67,108],"(MDS-UPDRS":[68],"III)":[69],"complementary":[72,208],"modalities,":[73],"determine":[74],"task-":[75],"modality-specific":[77],"contributions":[78],"to":[79],"discrimination,":[80],"identify":[82],"complementary,":[83],"stable":[84,204],"candidate":[85,205],"digital":[86,245],"biomarkers.":[87],"Methods":[88],"Thirty-one":[89],"participants":[90],"with":[91,166],"PD":[92],"(Hoehn":[93],"Yahr":[95],"stages":[96],"I\u2013III)":[97],"30":[99],"age-":[100],"sex-matched":[102],"healthy":[103],"controls":[104],"performed":[105],"seven":[106],"MDS-UPDRS":[107],"(items":[110],"3.4\u20133.8,":[111],"3.10,":[112],"3.15).":[113],"Unilateral":[114],"surface":[115],"electromyography":[116],"from":[117],"task-specific":[118],"muscles":[119],"full-body":[121],"inertial":[122],"motion":[123],"capture":[124],"were":[125],"acquired,":[126],"which":[127],"drove":[128],"subject-specific":[129],"musculoskeletal":[130],"simulations.":[131],"leakage-free":[133],"classification":[134],"pipeline":[135],"(in-fold":[136],"feature":[137],"selection,":[138],"repeated":[139],"cross-validation,":[140],"permutation":[141],"testing)":[142],"was":[143,160],"applied":[144],"by":[145,150],"task":[146,152],"followed":[149],"sparse":[151],"fusion":[153,178],"stability-based":[155],"biomarker":[156,237],"selection.":[157],"Results":[158],"Discrimination":[159],"concentrated":[161],"in":[162,210],"four":[163],"upper-limb":[164,230],"pronation\u2013supination":[167,197],"(3.6)":[168],"performing":[169],"best":[170],"(ROC-AUC":[171,181],"0.94;":[172],"balanced":[173,183],"accuracy":[174,184],"0.92).":[175],"Multitask":[176],"multimodal":[177,236],"maintained":[179],"discrimination":[180],"0.93;":[182],"0.92;":[185],"sensitivity":[186],"0.87;":[187],"specificity":[188],"0.97),":[189],"retaining":[190],"finger":[191],"tapping":[192],"(3.4),":[193],"hand":[194],"movements":[195],"(3.5),":[196],"(3.6),":[198],"postural":[200],"tremor":[201],"(3.15).":[202],"Eighteen":[203],"biomarkers":[206],"captured":[207],"alterations":[209],"movement":[211],"execution,":[212],"muscle":[213],"activation,":[214],"coordination,":[215],"tremor,":[216],"proximal":[218],"stabilization.":[219],"Conclusions":[220],"In":[221],"this":[222],"cohort,":[223],"converged":[226],"a":[228,233],"four-task":[229],"physiologically":[234],"interpretable":[235],"profile.":[238],"These":[239],"findings":[240],"shorter,":[242],"clinically":[243],"anchored":[244],"assessment,":[247],"pending":[248],"independent":[249],"validation.":[251]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-07T00:00:00"}