{"id":"https://openalex.org/W7220726244","doi":"https://doi.org/10.64898/2026.10.04.756569","title":"Thalamic Dysconnectivity and Negative Symptoms in Schizophrenia Spectrum Disorder","display_name":"Thalamic Dysconnectivity and Negative Symptoms in Schizophrenia Spectrum Disorder","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220726244","doi":"https://doi.org/10.64898/2026.10.04.756569"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.04.756569","doi":"https://doi.org/10.64898/2026.10.04.756569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.756569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.04.756569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.04.756569.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050885697","display_name":"Keiko Kunitoki","orcid":"https://orcid.org/0000-0002-7641-5427","observed_orcids":["https://orcid.org/0000-0002-7641-5427"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keiko Kunitoki","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069137051","display_name":"Bhim Mani Adhikari","orcid":"https://orcid.org/0009-0008-1047-4206","observed_orcids":["https://orcid.org/0009-0008-1047-4206","https://orcid.org/0000-0003-1164-0989"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhim M. Adhikari","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157666990","display_name":"AL Ankeeta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Ankeeta","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137003676","display_name":"Si Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Si Gao","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123617483","display_name":"Yizhou Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yizhou Ma","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039932234","display_name":"Kelsey T. Straub","orcid":"https://orcid.org/0000-0002-1480-6000","observed_orcids":["https://orcid.org/0000-0002-1480-6000"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey Straub","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042990872","display_name":"Gustavo dos Santos Alves Maria","orcid":"https://orcid.org/0000-0002-7143-1743","observed_orcids":["https://orcid.org/0000-0002-7143-1743"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Dos Santos Alves Maria","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086070617","display_name":"Antonio F. Pag\u00e1n","orcid":"https://orcid.org/0000-0002-4724-768X","observed_orcids":["https://orcid.org/0000-0002-4724-768X","https://orcid.org/0009-0003-2015-1906"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio F. Pag\u00e1n","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-4724-768X","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091553660","display_name":"Alia R. Warner","orcid":"https://orcid.org/0000-0003-0818-6367","observed_orcids":["https://orcid.org/0000-0003-0818-6367"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alia Warner","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134568817","display_name":"Xiaoming Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoming Du","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022342401","display_name":"Peter Kochunov","orcid":"https://orcid.org/0000-0003-3656-4281","observed_orcids":["https://orcid.org/0000-0003-3656-4281","https://orcid.org/0000-0002-6496-5325"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kochunov","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101415368","display_name":"L. Elliot Hong","orcid":"https://orcid.org/0000-0002-2705-2076","observed_orcids":["https://orcid.org/0000-0002-2705-2076"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Elliot Hong","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050885697"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.4765999913215637,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia-spectrum-disorders","display_name":"schizophrenia spectrum disorders","score":0.890999972820282},{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/blunted-affect","display_name":"blunted affect","score":0.8029999732971191},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"default mode network","score":0.7829999923706055},{"id":"https://openalex.org/keywords/dorsal-attention-network","display_name":"dorsal attention network","score":0.828000009059906},{"id":"https://openalex.org/keywords/somatosensory-network","display_name":"somatosensory network","score":0.8519999980926514},{"id":"https://openalex.org/keywords/temporoparietal-junction","display_name":"temporoparietal junction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/superior-temporal-sulcus","display_name":"superior temporal sulcus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.8339999914169312},{"id":"https://openalex.org/keywords/subcortical-volume","display_name":"subcortical volume","score":0.878000020980835},{"id":"https://openalex.org/keywords/brief-negative-symptom-scale","display_name":"Brief Negative Symptom Scale","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.8141999840736389},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.705299973487854},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6549000144004822},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6208999752998352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5231999754905701},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4471000134944916},{"id":"https://openalex.org/C2777132076","wikidata":"https://www.wikidata.org/wiki/Q2560248","display_name":"Sulcus","level":2,"score":0.44359999895095825},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.415800005197525},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.40459999442100525},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3776000142097473},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.35600000619888306},{"id":"https://openalex.org/C3018432486","wikidata":"https://www.wikidata.org/wiki/Q7575316","display_name":"Schizophrenia spectrum","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C2778355574","wikidata":"https://www.wikidata.org/wiki/Q732362","display_name":"Superior temporal sulcus","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.04.756569","doi":"https://doi.org/10.64898/2026.10.04.756569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.756569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.04.756569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.04.756569","doi":"https://doi.org/10.64898/2026.10.04.756569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.756569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.04.756569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220726244.pdf","grobid_xml":"https://content.openalex.org/works/W7220726244.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W801138929","https://openalex.org/W1876943069","https://openalex.org/W1970520385","https://openalex.org/W1988652567","https://openalex.org/W2000428226","https://openalex.org/W2001390449","https://openalex.org/W2004293194","https://openalex.org/W2008062633","https://openalex.org/W2028639251","https://openalex.org/W2033552074","https://openalex.org/W2035887588","https://openalex.org/W2062274361","https://openalex.org/W2078445556","https://openalex.org/W2079590167","https://openalex.org/W2084331056","https://openalex.org/W2096192353","https://openalex.org/W2100471394","https://openalex.org/W2101135654","https://openalex.org/W2102108192","https://openalex.org/W2104255009","https://openalex.org/W2111447016","https://openalex.org/W2111858999","https://openalex.org/W2117140276","https://openalex.org/W2121313171","https://openalex.org/W2165988750","https://openalex.org/W2206163921","https://openalex.org/W2220546658","https://openalex.org/W2262263514","https://openalex.org/W2419119392","https://openalex.org/W2488998741","https://openalex.org/W2509157657","https://openalex.org/W2535250402","https://openalex.org/W2570330660","https://openalex.org/W2580975499","https://openalex.org/W2587606972","https://openalex.org/W2593371527","https://openalex.org/W2617903284","https://openalex.org/W2767687421","https://openalex.org/W2788086150","https://openalex.org/W2792942691","https://openalex.org/W2796866427","https://openalex.org/W2796902804","https://openalex.org/W2800604227","https://openalex.org/W2804287612","https://openalex.org/W2811386582","https://openalex.org/W2891144030","https://openalex.org/W2900898094","https://openalex.org/W2904035371","https://openalex.org/W2906423463","https://openalex.org/W2911248665","https://openalex.org/W2911452443","https://openalex.org/W2913822739","https://openalex.org/W2914932952","https://openalex.org/W2923061357","https://openalex.org/W2944939511","https://openalex.org/W2950086191","https://openalex.org/W2950845927","https://openalex.org/W2951846486","https://openalex.org/W2955501090","https://openalex.org/W2965743895","https://openalex.org/W2965878065","https://openalex.org/W2990915417","https://openalex.org/W2995276946","https://openalex.org/W3005845319","https://openalex.org/W3007830452","https://openalex.org/W3040443323","https://openalex.org/W3041908961","https://openalex.org/W3083094732","https://openalex.org/W3096020263","https://openalex.org/W3096823185","https://openalex.org/W3107476337","https://openalex.org/W3133235347","https://openalex.org/W3135020997","https://openalex.org/W3139296667","https://openalex.org/W3160510691","https://openalex.org/W3165182260","https://openalex.org/W3175677715","https://openalex.org/W3177972781","https://openalex.org/W3196277650","https://openalex.org/W3203028609","https://openalex.org/W4213436721","https://openalex.org/W4220735620","https://openalex.org/W4220846567","https://openalex.org/W4221003426","https://openalex.org/W4224212725","https://openalex.org/W4225959093","https://openalex.org/W4241074797","https://openalex.org/W4281658837","https://openalex.org/W4281852522","https://openalex.org/W4287218996","https://openalex.org/W4294752934","https://openalex.org/W4297369593","https://openalex.org/W4304757278","https://openalex.org/W4306352973","https://openalex.org/W4313828188","https://openalex.org/W4367400032","https://openalex.org/W4377020091","https://openalex.org/W4379768549","https://openalex.org/W4386046825","https://openalex.org/W4386254660","https://openalex.org/W4387375952","https://openalex.org/W4387660936","https://openalex.org/W4387957076","https://openalex.org/W4389752902","https://openalex.org/W4396494538","https://openalex.org/W4396801755","https://openalex.org/W4400322125","https://openalex.org/W4400646781","https://openalex.org/W4402922998","https://openalex.org/W4403044712","https://openalex.org/W4405802028","https://openalex.org/W4406290566","https://openalex.org/W4408096510","https://openalex.org/W4411234068","https://openalex.org/W4411431932","https://openalex.org/W4411753898","https://openalex.org/W4411989626","https://openalex.org/W4413324079","https://openalex.org/W4414436098","https://openalex.org/W4414499409","https://openalex.org/W4416999818","https://openalex.org/W6911697505","https://openalex.org/W7131680705","https://openalex.org/W7140110854","https://openalex.org/W7153008335","https://openalex.org/W7161959558"],"related_works":["https://openalex.org/W2792942691","https://openalex.org/W4414997617","https://openalex.org/W4281658837","https://openalex.org/W4414436098","https://openalex.org/W2167682271","https://openalex.org/W4390951054","https://openalex.org/W2608541548","https://openalex.org/W4292616001","https://openalex.org/W4280493191","https://openalex.org/W4393409614"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,17,61,98,105,141,159,194,215,233,251],"Hypothesis":[3],"Negative":[4,114,264],"symptoms":[5,60,109,140,232],"in":[6,47,131,157,249],"schizophrenia":[7],"spectrum":[8],"disorder":[9],"(SSD)":[10],"are":[11,68],"associated":[12,185,228],"with":[13,107,138,162,179,186,224,229],"poor":[14],"functional":[15,128],"outcomes":[16],"reduced":[18],"quality":[19],"of":[20,30,58,245],"life;":[21],"however,":[22],"effective":[23],"treatments":[24],"remain":[25,52],"limited.":[26],"A":[27],"better":[28,39],"understanding":[29],"the":[31,56,72,112,149,187,205,212,239],"underlying":[32,75],"brain":[33,45,62],"mechanisms":[34],"is":[35],"needed":[36],"to":[37,70,94,135],"develop":[38],"treatments.":[40],"Neuroimaging":[41],"studies":[42],"implicate":[43],"multiple":[44],"networks":[46,197],"negative":[48,76,108,139,180,231,246],"symptoms,":[49,181],"though":[50],"findings":[51],"heterogeneous,":[53],"potentially":[54],"reflecting":[55],"multidimensionality":[57],"both":[59,102,120,156],"networks.":[63],"Larger,":[64],"more":[65],"systematic":[66],"dissections":[67],"required":[69],"identify":[71,95],"key":[73],"hub(s)":[74],"symptoms.":[77],"Study":[78,144],"Design":[79],"Structural":[80,266],"MRI":[81],"data":[82],"from":[83],"394":[84],"participants":[85],"(210":[86],"SSD,":[87],"184":[88],"healthy":[89],"controls":[90],"[HC])":[91],"were":[92,122,170,176],"analyzed":[93],"cortical":[96,188],"thickness":[97],"subcortical":[99],"volume":[100],"demonstrating":[101,152],"SSD-HC":[103],"differences":[104],"associations":[106],"measured":[110],"by":[111],"Brief":[113],"Symptom":[115],"Scale":[116],"(BNSS).":[117],"Regions":[118],"meeting":[119],"criteria":[121],"selected":[123],"as":[124,241,256],"seeds":[125],"for":[126,259],"resting-state":[127],"connectivity":[129,209],"analyses":[130],"143":[132],"SSD":[133,158,250],"patients":[134],"examine":[136],"association":[137,161],"their":[142],"subdomains.":[143],"Results":[145],"The":[146],"thalamus":[147,240],"was":[148,226],"only":[150],"region":[151],"significant":[153],"structural":[154],"abnormalities":[155],"an":[160],"BNSS":[163],"total":[164],"score":[165],"(p-FDR<0.05).":[166],"Functional-network-defined":[167],"thalamic":[168,174,183,208,254],"subregions":[169,184],"subsequently":[171],"examined.":[172],"Several":[173],"hypoconnectivities":[175],"significantly":[177],"corresponded":[178],"involving":[182,211],"default":[189],"mode,":[190],"somatosensory,":[191],"medial":[192],"temporal,":[193],"dorsal":[195],"attention":[196],"(p=0.001,":[198],"a":[199,242],"corrected":[200],"<0.05).":[201],"Blunted":[202],"affect":[203],"showed":[204],"most":[206],"extensive":[207],"alterations,":[210],"striatum,":[213],"cerebellum,":[214],"temporoparietal":[216],"junction/superior":[217],"temporal":[218],"sulcus":[219],"(TPJ-":[220],"STS).":[221],"Thalamic":[222],"hypoconnectivity":[223],"TPJ-STS":[225],"also":[227],"overall":[230],"anhedonia.":[234],"Conclusions":[235],"This":[236],"study":[237],"identifies":[238],"central":[243],"hub":[244],"symptom-related":[247],"dysfunction":[248],"highlights":[252],"specific":[253],"subnetworks":[255],"potential":[257],"targets":[258],"circuit-based":[260],"interventions.":[261],"Keyword:":[262],"Schizophrenia,":[263],"Symptoms,":[265],"MRI,":[267],"Functional":[268],"Connectivity,":[269],"Thalamus":[270]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-07T00:00:00"}
