{"id":"https://openalex.org/W7220724561","doi":"https://doi.org/10.64898/2026.09.29.755486","title":"Axonal dysfunction precedes axonal degeneration in a mouse model of progressive parkinsonism","display_name":"Axonal dysfunction precedes axonal degeneration in a mouse model of progressive parkinsonism","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220724561","doi":"https://doi.org/10.64898/2026.09.29.755486","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926411","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13691961"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.29.755486","doi":"https://doi.org/10.64898/2026.09.29.755486","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755486","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.09.29.755486.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.09.29.755486.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030607005","display_name":"Anna M. Lipkin","orcid":"https://orcid.org/0000-0001-5887-9044","observed_orcids":["https://orcid.org/0000-0001-5887-9044"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna M Lipkin","raw_affiliation_strings":["Cellular Neurophysiology Section, National Institute of Neurological Disorder, National Institutes of Health, Bethesda, MD 20892, USA;"],"raw_orcid":"https://orcid.org/0000-0001-5887-9044","affiliations":[{"raw_affiliation_string":"Cellular Neurophysiology Section, National Institute of Neurological Disorder, National Institutes of Health, Bethesda, MD 20892, USA;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083939094","display_name":"Alejandra Boronat-Garc\u00eda","orcid":"https://orcid.org/0009-0001-9171-0934","observed_orcids":["https://orcid.org/0009-0001-9171-0934"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Boronat-Garcia","raw_affiliation_strings":["Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0009-0001-9171-0934","affiliations":[{"raw_affiliation_string":"Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157696760","display_name":"Nora L O'Prey","orcid":"https://orcid.org/0000-0003-2263-0428","observed_orcids":["https://orcid.org/0000-0003-2263-0428"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora L O'Prey","raw_affiliation_strings":["Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0000-0003-2263-0428","affiliations":[{"raw_affiliation_string":"Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020448323","display_name":"Renshu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renshu Zhang","raw_affiliation_strings":["Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050910385","display_name":"Zayd M. Khaliq","orcid":"https://orcid.org/0000-0002-1445-1457","observed_orcids":["https://orcid.org/0000-0002-1445-1457"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zayd M Khaliq","raw_affiliation_strings":["Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0000-0002-1445-1457","affiliations":[{"raw_affiliation_string":"Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050910385"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9039999842643738},{"id":"https://openalex.org/keywords/axonal-dysfunction","display_name":"axonal dysfunction","score":0.746999979019165},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dopaminergic-axons","display_name":"dopaminergic axons","score":0.8389999866485596},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9539999961853027},{"id":"https://openalex.org/keywords/action-potential-propagation","display_name":"action potential propagation","score":0.847000002861023},{"id":"https://openalex.org/keywords/dieback","display_name":"dieback","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8590999841690063},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7789999842643738},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6905999779701233},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6729999780654907},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6427000164985657},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.516700029373169},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4657000005245209},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.4603999853134155},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.44429999589920044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43700000643730164},{"id":"https://openalex.org/C54407271","wikidata":"https://www.wikidata.org/wiki/Q194277","display_name":"Action potential","level":3,"score":0.41760000586509705},{"id":"https://openalex.org/C2909516373","wikidata":"https://www.wikidata.org/wiki/Q1753825","display_name":"Axonal degeneration","level":2,"score":0.3833000063896179},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C2776355744","wikidata":"https://www.wikidata.org/wiki/Q4318555","display_name":"Nigrostriatal pathway","level":5,"score":0.3666999936103821},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.3637000024318695},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2782999873161316},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2531000077724457},{"id":"https://openalex.org/C2992208609","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neuronal degeneration","level":3,"score":0.25189998745918274}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.29.755486","doi":"https://doi.org/10.64898/2026.09.29.755486","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755486","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.09.29.755486.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13691961","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926411/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13691961/pdf/nihpp-2026.09.29.755486v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42926411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.29.755486","doi":"https://doi.org/10.64898/2026.09.29.755486","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755486","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.09.29.755486.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000910165","display_name":"Synaptic integration and intrinsic firing properties of basal ganglia neurons","funder_award_id":"ZIANS003135","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220724561.pdf","grobid_xml":"https://content.openalex.org/works/W7220724561.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2165128853","https://openalex.org/W4385543838","https://openalex.org/W4405711489","https://openalex.org/W4408607772"],"related_works":["https://openalex.org/W2351308073","https://openalex.org/W2368142746","https://openalex.org/W2313304154","https://openalex.org/W2901266087","https://openalex.org/W2040838030","https://openalex.org/W7162691743","https://openalex.org/W2978366729","https://openalex.org/W3207096532","https://openalex.org/W2106056374","https://openalex.org/W1996194036"],"abstract_inverted_index":{"Axons":[0],"of":[1,34,43,53,64,71,97,132],"substantia":[2],"nigra":[3],"dopaminergic":[4,44,65,98],"neurons":[5],"\"die":[6],"back\"":[7],"in":[8,24,67,82,88,114,120],"Parkinson's":[9],"disease":[10],"(PD),":[11],"exhibiting":[12],"early":[13,51],"degeneration":[14],"relative":[15],"to":[16,38],"cell":[17],"bodies,":[18],"a":[19,79],"key":[20],"feature":[21],"also":[22],"observed":[23],"PD":[25,72],"models.":[26],"A":[27],"critical":[28],"step":[29],"towards":[30],"understanding":[31],"the":[32,40,50,59,68,95,121,130,144],"process":[33],"axonal":[35,122,148],"neurodegeneration":[36],"is":[37],"determine":[39],"physiological":[41,134],"properties":[42],"axons":[45,66,90],"that":[46,91,136,146],"are":[47],"altered":[48],"during":[49],"stages":[52],"cellular":[54],"dysfunction.":[55],"Here,":[56],"we":[57],"compared":[58],"electrophysiology":[60],"and":[61,101,108],"calcium":[62,86,106],"dynamics":[63],"MitoPark":[69,89],"model":[70],"with":[73],"age-matched":[74],"controls.":[75],"Our":[76],"experiments":[77],"show":[78],"pronounced":[80],"reduction":[81],"action":[83],"potential":[84],"(AP)-evoked":[85],"signals":[87],"emerges":[92],"well":[93],"before":[94,139],"onset":[96],"fiber":[99],"loss":[100],"motor":[102],"deficits.":[103],"In":[104],"addition,":[105],"imaging":[107],"direct":[109],"axon":[110],"recording":[111],"revealed":[112],"deficits":[113,135],"AP":[115,123],"propagation":[116],"accompanied":[117],"by":[118],"alterations":[119],"waveform.":[124],"Therefore,":[125],"our":[126],"experimental":[127],"findings":[128],"identify":[129],"progression":[131],"axon-specific":[133],"occur":[137],"long":[138],"neurodegeneration,":[140],"more":[141],"precisely":[142],"defining":[143],"period":[145],"precedes":[147],"loss.":[149]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-07T00:00:00"}
