{"id":"https://openalex.org/W7220718772","doi":"https://doi.org/10.1016/j.jpi.2026.100747","title":"MyoPath: A deep learning pipeline for objective morphometric assessment of skeletal muscle biopsies","display_name":"MyoPath: A deep learning pipeline for objective morphometric assessment of skeletal muscle biopsies","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220718772","doi":"https://doi.org/10.1016/j.jpi.2026.100747","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13742344"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpi.2026.100747","doi":"https://doi.org/10.1016/j.jpi.2026.100747","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpi.2026.100747","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2153353926002099/pdf","source":{"id":"https://openalex.org/S4210177785","display_name":"Journal of Pathology Informatics","issn_l":"2153-3539","issn":["2153-3539","2229-5089"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pathology Informatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2153353926002099/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157697522","display_name":"Huahua Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huahua Zhong","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153503462","display_name":"Mingshi Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingshi Gao","raw_affiliation_strings":["Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136594530","display_name":"Shang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shang Ma","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157784049","display_name":"Wenhan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhan Zhang","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075265334","display_name":"Nachuan Cheng","orcid":"https://orcid.org/0000-0002-4045-9946","observed_orcids":["https://orcid.org/0000-0002-4045-9946"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nachuan Cheng","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153431230","display_name":"Kexin Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kexin Jiao","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124743224","display_name":"Bochen Zhu","orcid":"https://orcid.org/0009-0000-7249-6955","observed_orcids":["https://orcid.org/0009-0000-7249-6955"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bochen Zhu","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157741522","display_name":"Jie Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Song","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157722078","display_name":"Chong Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong Yan","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023969067","display_name":"Dongyue Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyue Yue","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074071169","display_name":"Jianying Xi","orcid":"https://orcid.org/0000-0003-1028-3801","observed_orcids":["https://orcid.org/0000-0003-1028-3801"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianying Xi","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153497949","display_name":"Zunguo Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zunguo Du","raw_affiliation_strings":["Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157665992","display_name":"Wenhua Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhua Zhu","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128259412","display_name":"Chongbo Zhao","orcid":"https://orcid.org/0000-0001-9481-1418","observed_orcids":["https://orcid.org/0000-0001-9481-1418"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chongbo Zhao","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128272548","display_name":"Sushan Luo","orcid":"https://orcid.org/0000-0002-9033-7568","observed_orcids":["https://orcid.org/0000-0002-9033-7568"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sushan Luo","raw_affiliation_strings":["Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huashan Rare Disease Centre, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5128259412","https://openalex.org/A5128272548"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":{"value":2070,"currency":"USD","value_usd":2070},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66877905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":null,"first_page":"100747","last_page":"100747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.21799999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.1014999970793724,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-biopsy","display_name":"muscle biopsy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/muscle-morphometry","display_name":"muscle morphometry","score":0.5540000200271606},{"id":"https://openalex.org/keywords/myopathy","display_name":"myopathy","score":0.5479999780654907},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/transfer-learning","display_name":"transfer learning","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gtex","display_name":"GTEx","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6854000091552734},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.6783999800682068},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6389999985694885},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6028000116348267},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5774999856948853},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.44040000438690186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4171999990940094},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C2992644362","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle disease","level":3,"score":0.28209999203681946},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27079999446868896},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.2705000042915344},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2515000104904175}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jpi.2026.100747","doi":"https://doi.org/10.1016/j.jpi.2026.100747","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpi.2026.100747","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2153353926002099/pdf","source":{"id":"https://openalex.org/S4210177785","display_name":"Journal of Pathology Informatics","issn_l":"2153-3539","issn":["2153-3539","2229-5089"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pathology Informatics","raw_type":"journal-article"},{"id":"pmid:42997577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pathology informatics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ed6f1d3277f94d9e86a32408ca8d01a3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ed6f1d3277f94d9e86a32408ca8d01a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pathology Informatics, Vol 23, Iss , Pp 100747- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jpi.2026.100747","doi":"https://doi.org/10.1016/j.jpi.2026.100747","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpi.2026.100747","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2153353926002099/pdf","source":{"id":"https://openalex.org/S4210177785","display_name":"Journal of Pathology Informatics","issn_l":"2153-3539","issn":["2153-3539","2229-5089"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pathology Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2028554005","display_name":null,"funder_award_id":"82571592","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3058788532","display_name":null,"funder_award_id":"82471426","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220718772.pdf","grobid_xml":"https://content.openalex.org/works/W7220718772.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W2007995332","https://openalex.org/W2027126364","https://openalex.org/W2066125032","https://openalex.org/W2068064099","https://openalex.org/W2076284651","https://openalex.org/W2089858031","https://openalex.org/W2110065044","https://openalex.org/W2119910794","https://openalex.org/W2127460024","https://openalex.org/W2169295440","https://openalex.org/W2328069846","https://openalex.org/W2763424450","https://openalex.org/W2790090635","https://openalex.org/W2803489227","https://openalex.org/W2883699559","https://openalex.org/W2885080211","https://openalex.org/W2899636858","https://openalex.org/W2901219010","https://openalex.org/W2910310212","https://openalex.org/W2921179102","https://openalex.org/W2946352801","https://openalex.org/W2952481429","https://openalex.org/W2964756323","https://openalex.org/W3089090082","https://openalex.org/W3090822216","https://openalex.org/W3111521801","https://openalex.org/W3133859624","https://openalex.org/W3199925708","https://openalex.org/W3203852240","https://openalex.org/W4212919282","https://openalex.org/W4284965703","https://openalex.org/W4304893180","https://openalex.org/W4366985444","https://openalex.org/W4385798347","https://openalex.org/W4392561320","https://openalex.org/W4394689656","https://openalex.org/W4408198708"],"related_works":["https://openalex.org/W4244412163","https://openalex.org/W4309551081","https://openalex.org/W2025710021","https://openalex.org/W4312067676","https://openalex.org/W4366985444","https://openalex.org/W2994713976","https://openalex.org/W4391217521","https://openalex.org/W4415978749","https://openalex.org/W4408808951","https://openalex.org/W2947371893"],"abstract_inverted_index":{"Aims:":[0],"Muscle":[1],"biopsy":[2],"assessment":[3],"relies":[4],"on":[5,82,103],"descriptive":[6],"features":[7,21,71],"that":[8],"are":[9],"difficult":[10],"to":[11,18,43,90,101],"compare":[12],"across":[13],"samples.":[14],"We":[15,51],"developed":[16],"MyoPath":[17,34,196],"quantify":[19],"these":[20],"and":[22,29,37,48,55,63,85,110,126,128,136,145,158,182,205],"examined":[23],"their":[24],"usefulness":[25],"in":[26,122,133,156,161,191],"clinical":[27,202],"biopsies":[28],"population-based":[30],"autopsy":[31,68],"material.":[32],"Methods:":[33],"combines":[35],"Cellpose-SAM":[36],"conventional":[38],"image":[39],"analysis":[40],"within":[41],"QuPath":[42],"segment":[44],"myofibers,":[45],"fat,":[46],"nuclei,":[47],"connective":[49],"tissue.":[50],"analyzed":[52],"478":[53],"hematoxylin":[54],"eosin":[56],"images":[57],"from":[58,99,120,130],"HuashanMuscle":[59,91,123],"(79":[60],"snap-frozen":[61],"biopsies)":[62],"GTEx":[64,83,134,139,157],"(399":[65],"formalin-fixed,":[66],"paraffin-embedded":[67],"samples).":[69],"Thirty-seven":[70],"were":[72],"summarized":[73],"by":[74],"seven":[75],"pathology":[76,190],"indicators.":[77],"A":[78],"composite":[79,149],"model":[80],"trained":[81],"healthy":[84,131],"wasting":[86,129],"strata":[87],"was":[88,170],"transferred":[89],"without":[92],"retraining.":[93],"Results:":[94],"Segmentation":[95],"Dice":[96],"coefficients":[97],"ranged":[98],"0.87":[100],"0.95":[102],"annotated":[104],"cryosections.":[105],"Nuclear":[106],"centralization":[107],"index":[108],"(NCI)":[109],"fiber":[111,183],"size":[112],"coefficient":[113],"of":[114,178,188,207],"variation":[115],"(fiber":[116],"CV)":[117],"discriminated":[118],"myopathy":[119,176],"controls":[121],"(AUC":[124],"0.85":[125],"0.79)":[127],"donors":[132],"(0.74":[135],"0.74).":[137],"Their":[138],"associations":[140],"changed":[141],"little":[142],"after":[143],"age":[144],"sex":[146],"adjustment.":[147],"The":[148],"achieved":[150],"AUC":[151],"0.788":[152],"(95%":[153],"CI":[154],"0.71-0.85)":[155],"0.873":[159],"(0.78-0.94)":[160],"HuashanMuscle.":[162],"In":[163],"the":[164],"latter":[165],"cohort,":[166],"mean":[167],"predicted":[168],"probability":[169],"0.49":[171],"compared":[172],"with":[173],"an":[174],"observed":[175],"proportion":[177],"0.79.":[179],"Conclusions:":[180],"NCI":[181],"CV":[184],"provide":[185],"interpretable":[186],"measures":[187],"muscle":[189],"two":[192],"distinct":[193],"tissue":[194],"settings.":[195],"supports":[197],"quantitative":[198],"comparison":[199],"between":[200],"groups;":[201],"severity":[203],"grading":[204],"interpretation":[206],"absolute":[208],"scores":[209],"require":[210],"further":[211],"validation.":[212]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-07T00:00:00"}
