{"id":"https://openalex.org/W7220716918","doi":"https://doi.org/10.64898/2026.10.04.26364695","title":"Contribution of maternal and fetal genetics to fetal weight throughout pregnancy and at birth","display_name":"Contribution of maternal and fetal genetics to fetal weight throughout pregnancy and at birth","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220716918","doi":"https://doi.org/10.64898/2026.10.04.26364695"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.04.26364695","doi":"https://doi.org/10.64898/2026.10.04.26364695","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.26364695","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.04.26364695.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.04.26364695.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092592606","display_name":"Frances Elizabeth Cates","orcid":"https://orcid.org/0009-0005-0423-3332","observed_orcids":["https://orcid.org/0009-0005-0423-3332"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frances E Cates","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0005-0423-3332","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072409716","display_name":"Olivia Wootton","orcid":"https://orcid.org/0000-0002-2433-4975","observed_orcids":["https://orcid.org/0000-0002-2433-4975"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olivia Wootton","raw_affiliation_strings":["Wellcome Sanger Institute, Hinxton, UK"],"raw_orcid":"https://orcid.org/0000-0002-2433-4975","affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001244159","display_name":"Jasmine X Kiley","orcid":"https://orcid.org/0009-0000-2980-5054","observed_orcids":["https://orcid.org/0009-0000-2980-5054"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jasmine X Kiley","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0000-2980-5054","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088158095","display_name":"Tabitha Wishlade","orcid":"https://orcid.org/0009-0008-0640-5929","observed_orcids":["https://orcid.org/0009-0008-0640-5929"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tabitha Wishlade","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0008-0640-5929","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034333560","display_name":"Ulla Sovio","orcid":"https://orcid.org/0000-0002-0799-1105","observed_orcids":["https://orcid.org/0000-0002-0799-1105"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ulla Sovio","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0799-1105","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083345783","display_name":"Gordon C. S. Smith","orcid":"https://orcid.org/0000-0003-2124-0997","observed_orcids":["https://orcid.org/0000-0003-2124-0997"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gordon C S Smith","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2124-0997","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027119462","display_name":"Jasmine A. Mack","orcid":"https://orcid.org/0000-0001-7343-0579","observed_orcids":["https://orcid.org/0000-0001-7343-0579"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jasmine A Mack","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7343-0579","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023386562","display_name":"David S. Jones","orcid":"https://orcid.org/0000-0002-2936-4890","observed_orcids":["https://orcid.org/0000-0002-2936-4890"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]},{"id":"https://openalex.org/I4405263101","display_name":"The Loke Centre for Trophoblast Research","ror":"https://ror.org/02hmmse52","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749","https://openalex.org/I4405263101"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Stephen Charnock-Jones","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-2936-4890","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4405263101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113695742","display_name":"Hilary C. Martin","orcid":"https://orcid.org/0000-0002-4454-9084","observed_orcids":["https://orcid.org/0000-0002-4454-9084"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hilary C Martin","raw_affiliation_strings":["Wellcome Sanger Institute, Hinxton, UK"],"raw_orcid":"https://orcid.org/0000-0002-4454-9084","affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086595936","display_name":"Catherine Aiken","orcid":"https://orcid.org/0000-0002-6510-5626","observed_orcids":["https://orcid.org/0000-0002-6510-5626"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801065305","display_name":"Rosie Hospital","ror":"https://ror.org/01ncx3917","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801065305","https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Catherine E Aiken","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6510-5626","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0SW, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086595936"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801065305","https://openalex.org/I4389425352"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.36250001192092896,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.7639999985694885},{"id":"https://openalex.org/keywords/fetal-growth","display_name":"fetal growth","score":0.6309999823570251},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.8529999852180481},{"id":"https://openalex.org/keywords/estimated-fetal-weight","display_name":"estimated fetal weight","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9509999752044678},{"id":"https://openalex.org/keywords/small-for-gestational-age","display_name":"small for gestational age","score":0.9700000286102295},{"id":"https://openalex.org/keywords/maternal-fetal-interaction","display_name":"maternal-fetal interaction","score":0.5690000057220459},{"id":"https://openalex.org/keywords/genetic-principal-components","display_name":"genetic principal components","score":0.6110000014305115},{"id":"https://openalex.org/keywords/ancestry-differences","display_name":"ancestry differences","score":0.3700000047683716},{"id":"https://openalex.org/keywords/south-asian-ancestry","display_name":"South Asian ancestry","score":0.6890000104904175},{"id":"https://openalex.org/keywords/genetic-risk-stratification","display_name":"genetic risk stratification","score":0.5260000228881836},{"id":"https://openalex.org/keywords/pregnancy-outcome-prediction","display_name":"pregnancy outcome prediction","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7113000154495239},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6830000281333923},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6341000199317932},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5929999947547913},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.5914999842643738},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.5217000246047974},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.47909998893737793},{"id":"https://openalex.org/C2993726049","wikidata":"https://www.wikidata.org/wiki/Q2297155","display_name":"Fetal growth","level":4,"score":0.3801000118255615},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.36719998717308044},{"id":"https://openalex.org/C2780938740","wikidata":"https://www.wikidata.org/wiki/Q1298973","display_name":"Small for gestational age","level":4,"score":0.33169999718666077},{"id":"https://openalex.org/C2993934573","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Fetal weight","level":4,"score":0.3061999976634979},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C117354338","wikidata":"https://www.wikidata.org/wiki/Q1165112","display_name":"Singleton","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C2781291890","wikidata":"https://www.wikidata.org/wiki/Q1886514","display_name":"Fetal macrosomia","level":5,"score":0.26980000734329224},{"id":"https://openalex.org/C166976648","wikidata":"https://www.wikidata.org/wiki/Q7229824","display_name":"Population stratification","level":5,"score":0.2648000121116638},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.25870001316070557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.04.26364695","doi":"https://doi.org/10.64898/2026.10.04.26364695","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.26364695","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.04.26364695.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.04.26364695","doi":"https://doi.org/10.64898/2026.10.04.26364695","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.26364695","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.04.26364695.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1706879627","display_name":"PhD Programme for Health Professionals at Universities of Cambridge and East Anglia","funder_award_id":"223497/Z/21/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1779174361","display_name":null,"funder_award_id":"MR/N024391/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1859760469","display_name":null,"funder_award_id":"NIHR200166","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2493601830","display_name":null,"funder_award_id":"NIHR 203312","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G2493824435","display_name":null,"funder_award_id":"MR/N024391/1","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G2537968379","display_name":null,"funder_award_id":"(NIHR203312","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G274508231","display_name":"PhD Programme for Health Professionals at Universities of Cambridge and East Anglia","funder_award_id":"223497","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2745558375","display_name":null,"funder_award_id":"WT101597MA","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2947762186","display_name":null,"funder_award_id":"WT101597MA","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3106167994","display_name":null,"funder_award_id":"WT101597MA","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3304916181","display_name":"Wellcome Sanger Institute Quinquennial Review 2021-2026","funder_award_id":"220540/Z/20/A","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3405197100","display_name":"Primary Annotated Resources to Advance Discovery In Genomic Medicine (PARADIGM)","funder_award_id":"226083/Z/22/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3766617297","display_name":null,"funder_award_id":"WT101597MA","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G4062506641","display_name":null,"funder_award_id":"CS/16/4/32482","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4753630297","display_name":null,"funder_award_id":"NIHR203312","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5218641380","display_name":"Wellcome Sanger Institute Quinquennial Review 2021-2026","funder_award_id":"220540","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5640424767","display_name":null,"funder_award_id":"NIHR200166","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6468905072","display_name":null,"funder_award_id":"MR/N024391/1","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G6614988770","display_name":null,"funder_award_id":"MR/N024391/1","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6664751172","display_name":null,"funder_award_id":"2021-2026","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7115303499","display_name":null,"funder_award_id":"CS/16/4/32482","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8053612168","display_name":null,"funder_award_id":"2021-2026","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8561118823","display_name":"Primary Annotated Resources to Advance Discovery In Genomic Medicine (PARADIGM)","funder_award_id":"226083","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8782893465","display_name":null,"funder_award_id":"MR/N024391/1","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G9000285489","display_name":null,"funder_award_id":"220540/Z/20","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220716918.pdf","grobid_xml":"https://content.openalex.org/works/W7220716918.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1968532354","https://openalex.org/W2014048005","https://openalex.org/W2025707121","https://openalex.org/W2033228110","https://openalex.org/W2093397599","https://openalex.org/W2127537121","https://openalex.org/W2151439119","https://openalex.org/W2167921663","https://openalex.org/W2178653331","https://openalex.org/W2461397702","https://openalex.org/W2463560934","https://openalex.org/W2510387549","https://openalex.org/W2519262228","https://openalex.org/W2539366050","https://openalex.org/W2604986744","https://openalex.org/W2769869181","https://openalex.org/W2789413961","https://openalex.org/W2789949467","https://openalex.org/W2806758731","https://openalex.org/W2884886729","https://openalex.org/W2896958236","https://openalex.org/W2913735792","https://openalex.org/W2941155685","https://openalex.org/W2953169830","https://openalex.org/W2963160524","https://openalex.org/W2974488063","https://openalex.org/W2982357989","https://openalex.org/W2990334975","https://openalex.org/W3002570165","https://openalex.org/W3007520099","https://openalex.org/W3038613768","https://openalex.org/W3094110148","https://openalex.org/W3111018742","https://openalex.org/W3111933828","https://openalex.org/W3113256024","https://openalex.org/W3122829705","https://openalex.org/W3161481275","https://openalex.org/W3165183252","https://openalex.org/W3183211243","https://openalex.org/W4206023530","https://openalex.org/W4226343892","https://openalex.org/W4313590075","https://openalex.org/W4366817530","https://openalex.org/W4375851907","https://openalex.org/W4388217991","https://openalex.org/W4388500383","https://openalex.org/W4390278195","https://openalex.org/W4393301864","https://openalex.org/W4395453799","https://openalex.org/W4396903059","https://openalex.org/W4399164399","https://openalex.org/W4405815302","https://openalex.org/W4412567092","https://openalex.org/W4416603129","https://openalex.org/W4417321304","https://openalex.org/W7165539645"],"related_works":["https://openalex.org/W4390968993","https://openalex.org/W4200077152","https://openalex.org/W3128695214","https://openalex.org/W7165539645","https://openalex.org/W7221558495","https://openalex.org/W7128635024","https://openalex.org/W3183211243","https://openalex.org/W4412775185","https://openalex.org/W3111933828","https://openalex.org/W2790552383"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Both":[2,241],"fetal":[3,46,50,78,138,175,197,288,307,367,433,463,474,502,532,559,565,679,695],"and":[4,13,51,67,83,123,137,156,174,181,198,216,247,289,301,308,319,323,334,344,350,366,409,432,497,514,527,560,568,572,583,593,658,680,688,719],"maternal":[5,52,136,199,290,309,471,498,528,561,616,681,691],"genomes":[6],"contribute":[7],"to":[8,41,45,72,128,314,379,419,486,518,554,647,662,670,707,721,741],"birthweight,":[9,614],"but":[10,279,446],"the":[11,34,61,101,133,242,272,384,402,405,415,456,556,579,603,634,639,678,705,730],"timing":[12],"relative":[14],"magnitude":[15,403],"of":[16,37,97,196,244,261,274,295,317,331,352,373,404,439,458,558,611,733],"their":[17,74,512,656],"effects":[18,152,369,530,557,683,693],"during":[19],"gestation":[20,270,535],"remain":[21],"unclear.":[22],"Polygenic":[23],"risk":[24,95,292,549,725],"scores":[25],"(PRSs),":[26],"constructed":[27,49],"from":[28,113,193,478,490,735,745],"genome-wide":[29],"association":[30],"studies":[31,716],"(GWAS),":[32],"capture":[33],"cumulative":[35],"influence":[36,501],"common":[38],"birthweight-associated":[39,459],"variants":[40],"quantify":[42],"genetic":[43,203,368,475,529,682,692,715],"predisposition":[44],"growth.":[47],"We":[48,88,142,158,177,545,575,703],"PRSs":[53,92,130,148,163,200,310,434],"for":[54,140,171,186,212,348,437,470,473,552,609,619],"birthweight":[55,85,160,168,355,374,400,411,440,480,553,569,585,635,720,737],"in":[56,69,154,277,285,297,299,303,354,363,376,391,414,442,449,613,621,713],"two":[57,622],"UK":[58],"birth":[59],"cohorts,":[60,236],"Pregnancy":[62],"Outcome":[63],"Prediction":[64],"Study":[65],"(POPS)":[66],"Born":[68],"Bradford":[70],"(BiB),":[71],"evaluate":[73,555],"associations":[75,146,161,330],"with":[76,84,107,147,162,228,250,257,337,625],"estimated":[77,178,192,462,564],"weight":[79,464,566],"(EFW)":[80,567],"throughout":[81],"pregnancy":[82,469,571,718],"at":[86,230,381,393,537,573,700],"delivery.":[87],"also":[89,576],"investigated":[90],"whether":[91],"could":[93],"improve":[94],"stratification":[96],"infants":[98],"born":[99,398],"below":[100],"10th":[102],"centile":[103],"by":[104,389,638],"distinguishing":[105],"those":[106,114,519],"pathological":[108],"intrauterine":[109,597],"growth":[110,503,533,598,696],"restriction":[111,599],"(IUGR)":[112,744],"who":[115,520,595],"are":[116,521,602,697],"constitutionally":[117,491,522,746],"small-for-gestational-age":[118,590],"(SGA).":[119],"Methods":[120],"In":[121,305,340,454,628],"POPS":[122,155,300,396],"BiB,":[124],"we":[125],"used":[126,546],"LDpred2-auto":[127],"estimate":[129],"based":[131],"on":[132,264,461,531,563,684,694],"largest":[134],"available":[135],"GWAS":[139],"birthweight.":[141,339],"longitudinally":[143],"assessed":[144,577],"EFW":[145,229,265,298,315,685],"using":[149,164],"linear":[150,165,325],"mixed":[151],"models":[153,195,326],"BiB.":[157,286],"evaluated":[159],"models,":[166],"where":[167],"was":[169,225,239,282,361,387,412,541,643],"adjusted":[170],"gestational":[172,251],"age":[173,252],"sex.":[176],"R":[179],"2":[180],"conducted":[182,210],"variance":[183,296,316,353,375,385,441,612,636],"decomposition":[184],"analyses":[185,208],"all":[187],"models.":[188],"Genetically-predicted":[189],"birthweights":[190,516,660],"were":[191,209,254],"joint":[194,640],"plus":[201],"ten":[202],"principal":[204],"components":[205],"(PCs).":[206],"BiB":[207],"separately":[211],"genetically-inferred":[213],"European":[214,443,626,648],"(EUR)":[215],"South":[217,451,630],"Asian":[218,452,631],"(SAS)":[219],"ancestry.":[220,627],"Results":[221],"While":[222],"PRS":[223,237,245,248,262,275,332,335,342,345,607,617,642],"fetus":[224,246,276,333,343],"significantly":[226,255],"associated":[227,256],"baseline":[231],"(\u223c22":[232],"weeks":[233],"gestation)":[234],"across":[235,269,468,504,534,570,686],"mother":[238,249,263,336,346],"not.":[240],"interaction":[243],"(GA)":[253],"EFW.":[258],"The":[259],"effect":[260,273,457],"increased":[266],"more":[267,466,698,709,723],"quickly":[268],"than":[271,472],"POPS,":[278,306,341,377,455],"this":[280,542,667],"finding":[281],"not":[283],"replicated":[284,362],"Jointly,":[287],"polygenic":[291,548],"explained":[293,371,386,637],"4%":[294],"1%":[302],"BiB-EUR.":[304,364],"showed":[311,327],"independent":[312],"contributions":[313],"3%":[318],"0.5%,":[320],"respectively.":[321],"Joint":[322],"univariable":[324],"significant":[328],"positive":[329],"observed":[338,408,515,584,659],"accounted":[347],"\u223c10%":[349],"\u223c4%":[351],"over":[356],"covariates":[357],"alone,":[358],"respectively,":[359],"which":[360],"Maternal":[365,431],"jointly":[370,435],"11%":[372],"similar":[378],"BiB-EUR,":[380],"12%;":[382],"however,":[383],"reduced":[388],"half":[390],"BiB-SAS,":[392],"6%.":[394],"Among":[395],"babies":[397,507,592,594,651],"<10th":[399],"centile,":[401],"difference":[406,580],"between":[407,511,581,589,655],"genetically-predicted":[410,479,513,582,736],"greater":[413,509],"group":[416],"judged":[417],"clinically":[418],"be":[420,482],"IUGR":[421,663],"vs.":[422],"SGA":[423,650],"(p=0.008;":[424],"point":[425],"estimate=0.29,":[426],"95%CI:":[427],"0.12,":[428],"0.47).":[429],"Conclusions":[430],"account":[436],"\u223c11-12%":[438,610],"ancestry":[444,632,711],"groups,":[445],"much":[447],"less":[448],"a":[450,483,538,547,629,739],"cohort.":[453],"SNPs":[460],"increases":[465],"rapidly":[467],"effects.":[476],"Deviation":[477],"may":[481],"useful":[484],"metric":[485,740],"help":[487,587],"distinguish":[488,588],"growth-restricted":[489,743],"small":[492,747],"babies.":[493,664,749],"Tweetable":[494],"statement:":[495],"Fetal":[496,526,606],"genetics":[499,562],"both":[500],"gestation.":[505],"Growth-restricted":[506],"have":[508],"differences":[510,654],"compared":[517,646,661],"small.":[523],"Short":[524],"title:":[525],"AJOG":[536],"Glance:":[539],"Why":[540],"study":[543,668,676],"conducted?":[544],"score":[550],"(PRS)":[551],"birth.":[574],"how":[578],"can":[586],"(SGA)":[591,748],"experience":[596],"(IUGR).":[600],"What":[601,665],"key":[604],"findings?":[605],"accounts":[608,618],"while":[615],"\u223c6%":[620],"mother-child":[623],"cohorts":[624,649],"cohort,":[633],"fetal-maternal":[641],"approximately":[644],"halved":[645],"show":[652],"smaller":[653],"predicted":[657],"does":[666],"add":[669],"what":[671],"is":[672],"already":[673],"known?":[674],"This":[675],"separates":[677],"gestation,":[687],"demonstrates":[689],"that":[690],"impactful":[699],"later":[701],"gestations":[702],"demonstrate":[704],"need":[706],"include":[708],"diverse":[710],"groups":[712],"large-scale":[714],"around":[717],"create":[722],"representative":[724],"scores.":[726],"Our":[727],"findings":[728],"suggest":[729],"potential":[731],"use":[732],"deviation":[734],"as":[738],"differentiate":[742]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-07T00:00:00"}