{"id":"https://openalex.org/W7220704227","doi":"https://doi.org/10.3389/fimmu.2026.1929816","title":"TSPO in systemic-ocular immunometabolic crosstalk: mechanisms and therapeutic implications","display_name":"TSPO in systemic-ocular immunometabolic crosstalk: mechanisms and therapeutic implications","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220704227","doi":"https://doi.org/10.3389/fimmu.2026.1929816","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13681183"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1929816","doi":"https://doi.org/10.3389/fimmu.2026.1929816","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1929816","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1929816/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1929816/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050382831","display_name":"Zuyi Yang","orcid":"https://orcid.org/0000-0002-6471-6783","observed_orcids":["https://orcid.org/0000-0002-6471-6783"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuyi Yang","raw_affiliation_strings":["Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051765810","display_name":"Xinyi Zhang","orcid":"https://orcid.org/0000-0002-4708-3435","observed_orcids":["https://orcid.org/0000-0002-4708-3435"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Zhang","raw_affiliation_strings":["Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013137539","display_name":"Dianzhe Tian","orcid":"https://orcid.org/0009-0006-3618-9054","observed_orcids":["https://orcid.org/0009-0006-3618-9054"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dianzhe Tian","raw_affiliation_strings":["Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157768948","display_name":"Xinshi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinshi Li","raw_affiliation_strings":["Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101680596","display_name":"Xinyu Zhao","orcid":"https://orcid.org/0000-0002-2811-8735","observed_orcids":["https://orcid.org/0000-0002-2811-8735"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhao","raw_affiliation_strings":["Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057449153","display_name":"Erqian Wang","orcid":"https://orcid.org/0000-0003-0096-2050","observed_orcids":["https://orcid.org/0000-0003-0096-2050"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Erqian Wang","raw_affiliation_strings":["Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157766743","display_name":"Youxin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Youxin Chen","raw_affiliation_strings":["Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Key Laboratory of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057449153","https://openalex.org/A5157766743"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57880943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1929816","last_page":"1929816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.20059999823570251,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translocator-protein-tspo","display_name":"translocator protein (TSPO)","score":0.9829999804496765},{"id":"https://openalex.org/keywords/blood-retinal-barrier","display_name":"blood-retinal barrier","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.6959999799728394},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mitochondrial-homeostasis","display_name":"mitochondrial homeostasis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/immune-polarization","display_name":"immune polarization","score":0.9610000252723694},{"id":"https://openalex.org/keywords/autoimmune-ocular-disease","display_name":"autoimmune ocular disease","score":0.7179999947547913},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2776791281","wikidata":"https://www.wikidata.org/wiki/Q2385013","display_name":"Translocator protein","level":4,"score":0.8385999798774719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.595300018787384},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5891000032424927},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4359999895095825},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4277999997138977},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42649999260902405},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3635999858379364},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.33809998631477356},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3151000142097473},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.30160000920295715},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005128","descriptor_name":"Eye Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005128","descriptor_name":"Eye Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018079","descriptor_name":"Receptors, GABA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018079","descriptor_name":"Receptors, GABA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1929816","doi":"https://doi.org/10.3389/fimmu.2026.1929816","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1929816","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1929816/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13681183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681183/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681183/pdf/fimmu-17-1929816.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42903340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f63bd970f933474fa5e7ceda02117ac5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f63bd970f933474fa5e7ceda02117ac5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1929816","doi":"https://doi.org/10.3389/fimmu.2026.1929816","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1929816","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1929816/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220704227.pdf","grobid_xml":"https://content.openalex.org/works/W7220704227.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1604272930","https://openalex.org/W1944096616","https://openalex.org/W1967030806","https://openalex.org/W1985538633","https://openalex.org/W1987834950","https://openalex.org/W1989747234","https://openalex.org/W2012812017","https://openalex.org/W2014343444","https://openalex.org/W2031094958","https://openalex.org/W2031792305","https://openalex.org/W2034742711","https://openalex.org/W2045347306","https://openalex.org/W2069121275","https://openalex.org/W2091536187","https://openalex.org/W2094242581","https://openalex.org/W2097170864","https://openalex.org/W2112901522","https://openalex.org/W2193621263","https://openalex.org/W2233221674","https://openalex.org/W2463788006","https://openalex.org/W2480749475","https://openalex.org/W2516139637","https://openalex.org/W2543745172","https://openalex.org/W2749263509","https://openalex.org/W2755106885","https://openalex.org/W2761467979","https://openalex.org/W2767529516","https://openalex.org/W2792364172","https://openalex.org/W2794677028","https://openalex.org/W2795137969","https://openalex.org/W2809362553","https://openalex.org/W2903189528","https://openalex.org/W2922732728","https://openalex.org/W2924793698","https://openalex.org/W2959618850","https://openalex.org/W2969006138","https://openalex.org/W2977137028","https://openalex.org/W2998295725","https://openalex.org/W3001072828","https://openalex.org/W3030804042","https://openalex.org/W3032010165","https://openalex.org/W3039026718","https://openalex.org/W3039542184","https://openalex.org/W3102634847","https://openalex.org/W3108493784","https://openalex.org/W3112807738","https://openalex.org/W3121608322","https://openalex.org/W3157272299","https://openalex.org/W3165287033","https://openalex.org/W3214298193","https://openalex.org/W4205806163","https://openalex.org/W4211199473","https://openalex.org/W4220874822","https://openalex.org/W4281670501","https://openalex.org/W4283211365","https://openalex.org/W4301603177","https://openalex.org/W4307367111","https://openalex.org/W4318823722","https://openalex.org/W4321003424","https://openalex.org/W4321605965","https://openalex.org/W4322503993","https://openalex.org/W4366824711","https://openalex.org/W4381716215","https://openalex.org/W4386759801","https://openalex.org/W4390398881","https://openalex.org/W4390664563","https://openalex.org/W4392345031","https://openalex.org/W4392458384","https://openalex.org/W4400115805","https://openalex.org/W4404033671","https://openalex.org/W4406080963","https://openalex.org/W4416234133","https://openalex.org/W7124917362"],"related_works":["https://openalex.org/W4390664563","https://openalex.org/W4392352074","https://openalex.org/W3008227023","https://openalex.org/W7128220095","https://openalex.org/W2012812017","https://openalex.org/W846730123","https://openalex.org/W2193509215","https://openalex.org/W2555505034","https://openalex.org/W7095512806","https://openalex.org/W4416028768"],"abstract_inverted_index":{"The":[0],"eye":[1],"is":[2,120],"increasingly":[3],"recognized":[4],"as":[5,104,111],"a":[6,61,112,121],"tissue":[7],"shaped":[8],"by":[9],"systemic":[10,79,95],"immune":[11,44],"and":[12,33,43,57,71,90,110,125,138],"metabolic":[13,85],"states":[14],"rather":[15],"than":[16],"an":[17,24,105],"isolated":[18],"immune-privileged":[19],"organ.":[20],"Translocator":[21],"protein":[22,29],"(TSPO),":[23],"18-kDa":[25],"outer":[26],"mitochondrial":[27,37],"membrane":[28],"enriched":[30],"in":[31,53],"myeloid":[32],"glial":[34,73],"cells,":[35],"links":[36],"homeostasis,":[38],"redox":[39],"signaling,":[40],"lipid":[41],"metabolism,":[42],"polarization.":[45],"This":[46],"review":[47,76],"synthesizes":[48],"evidence":[49,77,116],"for":[50,129],"TSPO":[51,103,119,134],"involvement":[52],"systemic-ocular":[54],"immunometabolic":[55,66,123],"crosstalk":[56],"organizes":[58],"it":[59],"into":[60],"three-stage":[62],"working":[63],"model:":[64],"peripheral":[65],"priming,":[67],"blood-retinal":[68],"barrier":[69],"vulnerability,":[70],"intraocular":[72],"amplification.":[74],"We":[75,97],"from":[78],"autoimmune":[80],"diseases":[81,86,93],"with":[82,87,94],"ocular":[83,88,92,140],"manifestations,":[84],"complications,":[89],"primary":[91],"contributions.":[96],"then":[98],"assess":[99],"the":[100,127],"potential":[101],"of":[102],"imaging":[106],"or":[107],"fluid":[108],"biomarker":[109],"therapeutic":[113],"target.":[114],"Current":[115],"suggests":[117],"that":[118],"promising":[122],"node":[124],"underscores":[126],"need":[128],"cross-organ":[130],"disease":[131],"models,":[132],"cell-specific":[133],"manipulation,":[135],"spatial":[136],"multi-omics,":[137],"local":[139],"delivery":[141],"strategies.":[142]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-07T00:00:00"}
