{"id":"https://openalex.org/W7220701065","doi":"https://doi.org/10.3389/fimmu.2026.1816598","title":"GPR183-mediated immune cell positioning and function: an integrative perspective across ligand gradients, tissue environments, and disease stages","display_name":"GPR183-mediated immune cell positioning and function: an integrative perspective across ligand gradients, tissue environments, and disease stages","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220701065","doi":"https://doi.org/10.3389/fimmu.2026.1816598","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903344","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13681182"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1816598","doi":"https://doi.org/10.3389/fimmu.2026.1816598","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1816598","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1816598/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1816598/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125524999","display_name":"Xinrui Lin","orcid":"https://orcid.org/0009-0003-1032-2054","observed_orcids":["https://orcid.org/0009-0003-1032-2054"]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinrui Lin","raw_affiliation_strings":["School of Public Health, Guilin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Guilin Medical University","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123378741","display_name":"Xinyu Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Dong","raw_affiliation_strings":["School of Public Health, Guilin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Guilin Medical University","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028110539","display_name":"Zhe Jiang","orcid":"https://orcid.org/0000-0002-7684-4977","observed_orcids":["https://orcid.org/0000-0002-7684-4977"]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Jiang","raw_affiliation_strings":["School of Public Health, Guilin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Guilin Medical University","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157712051","display_name":"Xuekun Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuekun Xing","raw_affiliation_strings":["Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health, Guilin Medical University","School of Public Health, Guilin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health, Guilin Medical University","institution_ids":["https://openalex.org/I176134282"]},{"raw_affiliation_string":"School of Public Health, Guilin Medical University","institution_ids":["https://openalex.org/I176134282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5157712051"],"corresponding_institution_ids":["https://openalex.org/I176134282"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52850998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1816598","last_page":"1816598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr183","display_name":"GPR183","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ebi2","display_name":"EBI2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/7alpha-25-dihydroxycholesterol","display_name":"7\u03b1,25-dihydroxycholesterol","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chemoattractant-receptors","display_name":"chemoattractant receptors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chemokine-gradients","display_name":"chemokine gradients","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tissue-microenvironment","display_name":"tissue microenvironment","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.9449999928474426},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.718999981880188},{"id":"https://openalex.org/keywords/receptor-agonism","display_name":"receptor agonism","score":0.7580000162124634},{"id":"https://openalex.org/keywords/pharmacological-inhibition","display_name":"pharmacological inhibition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immune-cell-engineering","display_name":"immune cell engineering","score":0.9670000076293945},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6840000152587891},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6272000074386597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5824999809265137},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5738999843597412},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5184000134468079},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5016000270843506},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47110000252723694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4311000108718872},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3882000148296356},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3871999979019165},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34779998660087585},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.34619998931884766},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33390000462532043},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3034999966621399},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26820001006126404},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006888","descriptor_name":"Hydroxycholesterols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060833","descriptor_name":"Cellular Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1816598","doi":"https://doi.org/10.3389/fimmu.2026.1816598","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1816598","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1816598/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13681182","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681182/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681182/pdf/fimmu-17-1816598.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42903344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bd3751f4465445999d91782a0783e6bf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bd3751f4465445999d91782a0783e6bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1816598","doi":"https://doi.org/10.3389/fimmu.2026.1816598","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1816598","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1816598/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1933722076","display_name":null,"funder_award_id":"82260802","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220701065.pdf","grobid_xml":"https://content.openalex.org/works/W7220701065.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1963635975","https://openalex.org/W1972407010","https://openalex.org/W1980587656","https://openalex.org/W2049447424","https://openalex.org/W2051822277","https://openalex.org/W2053483416","https://openalex.org/W2062188732","https://openalex.org/W2068045033","https://openalex.org/W2071074768","https://openalex.org/W2073546439","https://openalex.org/W2093418362","https://openalex.org/W2104067212","https://openalex.org/W2113398790","https://openalex.org/W2127117918","https://openalex.org/W2130164640","https://openalex.org/W2132407668","https://openalex.org/W2218761264","https://openalex.org/W2312541568","https://openalex.org/W2346100156","https://openalex.org/W2520951886","https://openalex.org/W2564906081","https://openalex.org/W2583259744","https://openalex.org/W2585928134","https://openalex.org/W2604445430","https://openalex.org/W2773391987","https://openalex.org/W2782743094","https://openalex.org/W2810050131","https://openalex.org/W2942768502","https://openalex.org/W2951514370","https://openalex.org/W3016606515","https://openalex.org/W3019631820","https://openalex.org/W3097643358","https://openalex.org/W3183079035","https://openalex.org/W3186513334","https://openalex.org/W4205674563","https://openalex.org/W4210510588","https://openalex.org/W4211150370","https://openalex.org/W4221113286","https://openalex.org/W4229374808","https://openalex.org/W4281612104","https://openalex.org/W4287147398","https://openalex.org/W4288096999","https://openalex.org/W4307464940","https://openalex.org/W4309366583","https://openalex.org/W4317501567","https://openalex.org/W4322011852","https://openalex.org/W4362549001","https://openalex.org/W4362602280","https://openalex.org/W4366773288","https://openalex.org/W4383197156","https://openalex.org/W4384819693","https://openalex.org/W4385805223","https://openalex.org/W4388408655","https://openalex.org/W4389305175","https://openalex.org/W4392243261","https://openalex.org/W4401821934","https://openalex.org/W4402428804","https://openalex.org/W4403489468","https://openalex.org/W4403620095","https://openalex.org/W4403853576","https://openalex.org/W4403996565","https://openalex.org/W4405638508","https://openalex.org/W4406432863","https://openalex.org/W4407940562","https://openalex.org/W4408040639","https://openalex.org/W4411473410","https://openalex.org/W4411667175","https://openalex.org/W4412936104","https://openalex.org/W4415660397","https://openalex.org/W7130350089","https://openalex.org/W7133354031","https://openalex.org/W7137893039","https://openalex.org/W7140099210","https://openalex.org/W7152465574","https://openalex.org/W7160617569","https://openalex.org/W7162879079","https://openalex.org/W7168257697","https://openalex.org/W7169604491","https://openalex.org/W7202073104"],"related_works":["https://openalex.org/W7221099086","https://openalex.org/W7029081447","https://openalex.org/W7162879079","https://openalex.org/W4403180130","https://openalex.org/W7164167765","https://openalex.org/W3012292036","https://openalex.org/W7220946309","https://openalex.org/W4387341555","https://openalex.org/W4385188829","https://openalex.org/W2766066839"],"abstract_inverted_index":{"G":[0],"protein-coupled":[1],"receptor":[2,12,52,139],"183":[3],"(GPR183),":[4],"also":[5],"known":[6],"as":[7,83],"EBI2,":[8],"is":[9,17],"a":[10,84],"chemoattractant":[11],"whose":[13],"principal":[14],"endogenous":[15],"ligand":[16,54,165],"7\u03b1,25-dihydroxycholesterol":[18],"(7\u03b1,25-OHC).":[19],"Its":[20],"expression":[21],"varies":[22],"dynamically":[23],"across":[24,178],"immune-cell":[25,45,144,182],"subsets":[26],"and":[27,49,56,61,77,93,111,118,132,143,169,189,193,200,213],"activation":[28],"states.":[29],"By":[30],"sensing":[31],"local":[32],"7\u03b1,25-OHC":[33,185],"gradients,":[34],"GPR183":[35,100,199],"converts":[36],"tissue":[37,47,63,109,167,187,209],"metabolic":[38],"cues":[39],"into":[40],"spatial":[41],"information,":[42],"thereby":[43],"regulating":[44],"migration,":[46],"distribution,":[48],"function.":[50],"Dynamic":[51],"expression,":[53],"synthesis":[55],"degradation,":[57],"responding":[58],"cell":[59],"type,":[60,183],"the":[62,67,184,195],"microenvironment":[64],"collectively":[65],"shape":[66],"direction":[68],"of":[69,115,158,198],"pathway":[70],"activity,":[71,129],"whereas":[72,155],"intervention":[73,135],"studies":[74,95],"in":[75],"animals":[76],"longitudinal":[78],"observations":[79],"establish":[80],"disease":[81,128,190],"stage":[82,191],"temporal":[85],"coordinate":[86],"for":[87],"interpreting":[88],"divergent":[89],"effects.":[90],"Genetic,":[91],"pharmacological,":[92],"cell-engineering":[94],"provide":[96],"functional":[97],"evidence":[98,177],"that":[99],"contributes":[101],"to":[102,125],"lymphoid-tissue":[103],"compartmentalization,":[104],"host":[105],"defense,":[106],"inflammatory":[107],"responses,":[108],"repair,":[110,210],"tumor-immune":[112,211],"remodeling.":[113],"Analyses":[114],"patient":[116],"tissues":[117],"clinical":[119,153],"cohorts":[120],"extend":[121],"this":[122],"mechanistic":[123],"framework":[124],"associations":[126],"with":[127],"treatment":[130],"response,":[131],"prognosis.":[133],"Three":[134],"strategies":[136,161],"have":[137],"emerged:":[138],"agonism,":[140],"pharmacological":[141],"inhibition,":[142],"engineering.":[145],"The":[146],"oral":[147],"antagonist":[148],"IPG11406":[149],"has":[150,162],"entered":[151],"early":[152],"evaluation,":[154],"preclinical":[156],"assessment":[157],"other":[159],"candidate":[160],"focused":[163],"on":[164],"stability,":[166],"selectivity,":[168],"long-term":[170],"immune":[171],"safety.":[172],"This":[173],"review":[174],"integrates":[175],"current":[176],"four":[179],"dimensions":[180],"-":[181,192],"gradient,":[186],"microenvironment,":[188],"organizes":[194],"disease-related":[196],"actions":[197],"potential":[201],"stratified":[202],"interventions":[203],"around":[204],"pathogenic":[205],"recruitment,":[206,208],"protective":[207],"remodeling,":[212],"biomarker":[214],"applications.":[215]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-07T00:00:00"}
