{"id":"https://openalex.org/W7220697173","doi":"https://doi.org/10.64898/2026.10.05.755959","title":"Prime editing enables high-throughput identification and characterization of selective MutS\u03b2 inhibitors","display_name":"Prime editing enables high-throughput identification and characterization of selective MutS\u03b2 inhibitors","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220697173","doi":"https://doi.org/10.64898/2026.10.05.755959","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692117"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.755959","doi":"https://doi.org/10.64898/2026.10.05.755959","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.755959","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.755959.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.755959.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009365985","display_name":"Yangwode Jing","orcid":"https://orcid.org/0000-0002-1692-6567","observed_orcids":["https://orcid.org/0000-0002-1692-6567"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yangwode Jing","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065512327","display_name":"Jun Yan","orcid":"https://orcid.org/0000-0002-5641-5710","observed_orcids":["https://orcid.org/0000-0002-5641-5710"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Yan","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I1321430492","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062122307","display_name":"Denny Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Denny Yang","raw_affiliation_strings":["UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157745505","display_name":"Yanjin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanjin Chen","raw_affiliation_strings":["Department of Computer Science, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100282898","display_name":"Issam Senoussi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I4405254385","display_name":"Institute of Biochemistry","ror":"https://ror.org/01rd8n845","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254385"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Issam Senoussi","raw_affiliation_strings":["Department of Biology, Institute of Biochemistry, Eidgen\u00f6ssische Technische Hochschule (ETH), Z\u00fcrich 8093, Switzerland","Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana (USI), Bellinzona 6500, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Institute of Biochemistry, Eidgen\u00f6ssische Technische Hochschule (ETH), Z\u00fcrich 8093, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254385"]},{"raw_affiliation_string":"Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana (USI), Bellinzona 6500, Switzerland","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157772438","display_name":"James Woodward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Woodward","raw_affiliation_strings":["UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456888","display_name":"Katya Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katya Williams","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hahn Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hahn Kim","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, NJ 08544, USA","Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA","Princeton University Small Molecule Screening Center, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843","https://openalex.org/I4210150094"]},{"raw_affiliation_string":"Princeton University Small Molecule Screening Center, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143933223","display_name":"Kangning He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kangning He","raw_affiliation_strings":["UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053335478","display_name":"Herwin Daub","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herwin Daub","raw_affiliation_strings":["Proteros biostructures GmbH, Bunsenstr 7a, Martinsried 82152, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteros biostructures GmbH, Bunsenstr 7a, Martinsried 82152, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056532113","display_name":"Vinay Dahiya","orcid":"https://orcid.org/0000-0003-1900-0468","observed_orcids":["https://orcid.org/0000-0003-1900-0468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinay Dahiya","raw_affiliation_strings":["Proteros biostructures GmbH, Bunsenstr 7a, Martinsried 82152, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteros biostructures GmbH, Bunsenstr 7a, Martinsried 82152, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033914169","display_name":"Maren Thomsen","orcid":"https://orcid.org/0000-0003-2561-7595","observed_orcids":["https://orcid.org/0000-0003-2561-7595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maren Thomsen","raw_affiliation_strings":["Proteros biostructures GmbH, Bunsenstr 7a, Martinsried 82152, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteros biostructures GmbH, Bunsenstr 7a, Martinsried 82152, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075453045","display_name":"Jia Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Ling","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054266950","display_name":"Purnima Ravisankar","orcid":"https://orcid.org/0000-0001-7799-4558","observed_orcids":["https://orcid.org/0000-0001-7799-4558"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Purnima Ravisankar","raw_affiliation_strings":["Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065602641","display_name":"Yuri Pritykin","orcid":"https://orcid.org/0000-0001-6589-981X","observed_orcids":["https://orcid.org/0000-0001-6589-981X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Pritykin","raw_affiliation_strings":["Department of Computer Science, Princeton University, Princeton, NJ 08544, USA","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":"https://orcid.org/0000-0001-6589-981X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006103615","display_name":"Gabriel Balmus","orcid":"https://orcid.org/0000-0003-2872-4468","observed_orcids":["https://orcid.org/0000-0003-2872-4468"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405276525","display_name":"Transylvanian Institute of Neuroscience","ror":"https://ror.org/05mkatf28","country_code":"RO","type":"nonprofit","lineage":["https://openalex.org/I4405276525"]}],"countries":["GB","RO"],"is_corresponding":false,"raw_author_name":"Gabriel Balmus","raw_affiliation_strings":["Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca 400191, Romania","UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca 400191, Romania","institution_ids":["https://openalex.org/I4405276525"]},{"raw_affiliation_string":"UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056096904","display_name":"Petr \u0106ejka","orcid":"https://orcid.org/0000-0002-9087-032X","observed_orcids":["https://orcid.org/0000-0002-9087-032X"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Petr Cejka","raw_affiliation_strings":["Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana (USI), Bellinzona 6500, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9087-032X","affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana (USI), Bellinzona 6500, Switzerland","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029112174","display_name":"Jeffrey A. Hussmann","orcid":"https://orcid.org/0000-0002-7778-9893","observed_orcids":["https://orcid.org/0000-0002-7778-9893"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Hussmann","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157784291","display_name":"Longbin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802085568","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802085568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Longbin Liu","raw_affiliation_strings":["CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I2802085568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101525387","display_name":"Thomas Vogt","orcid":"https://orcid.org/0000-0001-6155-3360","observed_orcids":["https://orcid.org/0000-0001-6155-3360","https://orcid.org/0009-0003-6041-0116","https://orcid.org/0000-0002-4731-2787"]},"institutions":[{"id":"https://openalex.org/I2802085568","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802085568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas F. Vogt","raw_affiliation_strings":["CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I2802085568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088054300","display_name":"Michael Finley","orcid":"https://orcid.org/0000-0002-5547-5519","observed_orcids":["https://orcid.org/0000-0002-5547-5519"]},"institutions":[{"id":"https://openalex.org/I2802085568","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802085568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Finley","raw_affiliation_strings":["CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I2802085568"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089203415","display_name":"Britt Adamson","orcid":"https://orcid.org/0000-0002-9451-5819","observed_orcids":["https://orcid.org/0000-0002-9451-5819"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Britt Adamson","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5089203415"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prime-editing","display_name":"prime editing","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mutsbeta","display_name":"MutS\u03b2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/trinucleotide-repeat-disorders","display_name":"trinucleotide repeat disorders","score":0.8360000252723694},{"id":"https://openalex.org/keywords/repeat-instability","display_name":"repeat instability","score":0.671999990940094},{"id":"https://openalex.org/keywords/cag-repeat-expansion","display_name":"CAG repeat expansion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/small-molecule-screening","display_name":"small molecule screening","score":0.7730000019073486},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6538000106811523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4799000024795532},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4410000145435333},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39239999651908875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38609999418258667},{"id":"https://openalex.org/C166252455","wikidata":"https://www.wikidata.org/wiki/Q6736610","display_name":"Trinucleotide repeat expansion","level":4,"score":0.36239999532699585},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3517000079154968},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.32910001277923584},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.31130000948905945},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.2996000051498413},{"id":"https://openalex.org/C184992742","wikidata":"https://www.wikidata.org/wiki/Q7243229","display_name":"Prime (order theory)","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.2522999942302704}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.05.755959","doi":"https://doi.org/10.64898/2026.10.05.755959","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.755959","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.755959.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42926609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692117","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926609/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.755959","doi":"https://doi.org/10.64898/2026.10.05.755959","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.755959","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.755959.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2104897622","display_name":null,"funder_award_id":"NCI-CCSG P30CA072720-5921","funder_id":"https://openalex.org/F4320309886","funder_display_name":"Rutgers Cancer Institute of New Jersey"},{"id":"https://openalex.org/G2131311388","display_name":null,"funder_award_id":"P30-CA072720-5921","funder_id":"https://openalex.org/F4320309886","funder_display_name":"Rutgers Cancer Institute of New Jersey"},{"id":"https://openalex.org/G3664767099","display_name":null,"funder_award_id":"NCI-CCSG P30CA072720-5921","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3670273158","display_name":null,"funder_award_id":"P30 CA072720","funder_id":"https://openalex.org/F4320309886","funder_display_name":"Rutgers Cancer Institute of New Jersey"},{"id":"https://openalex.org/G6309704273","display_name":null,"funder_award_id":"NCI-CCSG P30CA072720-5921","funder_id":"https://openalex.org/F4320309292","funder_display_name":"Princeton University"},{"id":"https://openalex.org/G6613711565","display_name":"Mapping the DNA damage response in human cells with high-resolution functional genomics","funder_award_id":"R35GM138167","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000033417","display_name":null,"funder_award_id":"NCI-CCSG P30CA072720-5921","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862921","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA072720","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000912514","display_name":"Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease","funder_award_id":"RM1HG009490","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000953542","display_name":"Flow Cytometry and Cell Sorting","funder_award_id":"p30ca072720:5921","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308687","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80"},{"id":"https://openalex.org/F4320309292","display_name":"Princeton University","ror":"https://ror.org/00hx57361"},{"id":"https://openalex.org/F4320309886","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/05vt9qd57"},{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220697173.pdf","grobid_xml":"https://content.openalex.org/works/W7220697173.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W1159439052","https://openalex.org/W1491727284","https://openalex.org/W1895398290","https://openalex.org/W1977909744","https://openalex.org/W1982276380","https://openalex.org/W1991001144","https://openalex.org/W2003056152","https://openalex.org/W2010752599","https://openalex.org/W2012046786","https://openalex.org/W2024908018","https://openalex.org/W2026802661","https://openalex.org/W2036176224","https://openalex.org/W2036897871","https://openalex.org/W2037898576","https://openalex.org/W2044884266","https://openalex.org/W2065301294","https://openalex.org/W2065305397","https://openalex.org/W2065398669","https://openalex.org/W2070918875","https://openalex.org/W2073315036","https://openalex.org/W2075637141","https://openalex.org/W2081023620","https://openalex.org/W2088522869","https://openalex.org/W2089509232","https://openalex.org/W2090737357","https://openalex.org/W2112331024","https://openalex.org/W2121642311","https://openalex.org/W2124295966","https://openalex.org/W2126892015","https://openalex.org/W2141323033","https://openalex.org/W2142096492","https://openalex.org/W2147555368","https://openalex.org/W2149843002","https://openalex.org/W2163906048","https://openalex.org/W2169735361","https://openalex.org/W2271163371","https://openalex.org/W2409293519","https://openalex.org/W2482458164","https://openalex.org/W2597646117","https://openalex.org/W2601016637","https://openalex.org/W2614103706","https://openalex.org/W2722517739","https://openalex.org/W2737125117","https://openalex.org/W2786119759","https://openalex.org/W2793124477","https://openalex.org/W2883377762","https://openalex.org/W2887571739","https://openalex.org/W2915459742","https://openalex.org/W2969081693","https://openalex.org/W2981137429","https://openalex.org/W3000358775","https://openalex.org/W3005152669","https://openalex.org/W3087701445","https://openalex.org/W3128380777","https://openalex.org/W3129436612","https://openalex.org/W3165152327","https://openalex.org/W3174895520","https://openalex.org/W3198419829","https://openalex.org/W3206354438","https://openalex.org/W4221037461","https://openalex.org/W4221083162","https://openalex.org/W4225009797","https://openalex.org/W4282979939","https://openalex.org/W4308612173","https://openalex.org/W4317885821","https://openalex.org/W4321076925","https://openalex.org/W4376598552","https://openalex.org/W4377024399","https://openalex.org/W4383066375","https://openalex.org/W4386580828","https://openalex.org/W4387799158","https://openalex.org/W4389704361","https://openalex.org/W4391350860","https://openalex.org/W4391575341","https://openalex.org/W4392022465","https://openalex.org/W4392251200","https://openalex.org/W4393902863","https://openalex.org/W4394727560","https://openalex.org/W4394765884","https://openalex.org/W4396890472","https://openalex.org/W4399671583","https://openalex.org/W4399893117","https://openalex.org/W4404497408","https://openalex.org/W4406284854","https://openalex.org/W4406464838","https://openalex.org/W4406706759","https://openalex.org/W4407369212","https://openalex.org/W4407394582","https://openalex.org/W4410283879","https://openalex.org/W4411157720","https://openalex.org/W4412034252","https://openalex.org/W4412993096","https://openalex.org/W4414922733","https://openalex.org/W4415585007","https://openalex.org/W7155079589","https://openalex.org/W7155191794","https://openalex.org/W7163644681"],"related_works":["https://openalex.org/W4392251200","https://openalex.org/W4213457786","https://openalex.org/W4377024399","https://openalex.org/W3206354438","https://openalex.org/W4402373717","https://openalex.org/W2766032240","https://openalex.org/W7167616871","https://openalex.org/W1982276380","https://openalex.org/W2409293519","https://openalex.org/W4230496978"],"abstract_inverted_index":{"ABSTRACT":[0],"DNA":[1,69],"mismatch":[2],"repair":[3],"(MMR)":[4],"maintains":[5],"genome":[6],"stability":[7],"but":[8],"paradoxically":[9],"drives":[10],"expansion":[11,124],"of":[12,26,33,42,54,61,67,91,97,117,145],"pathogenic":[13],"repeats":[14],"responsible":[15],"for":[16,45,106,135],"trinucleotide":[17],"repeat":[18,21],"disorders.":[19],"Attenuating":[20],"instability":[22],"through":[23],"targeted":[24],"inhibition":[25],"MMR":[27,49,63,76,99],"is":[28,37],"therefore":[29],"a":[30,40,79,89,114,126],"therapeutic":[31,146],"strategy":[32],"interest;":[34],"however,":[35],"progress":[36],"constrained":[38],"by":[39,84],"lack":[41],"robust":[43],"methods":[44,134],"defining":[46],"and":[47,73,101],"isolating":[48],"subpathways.":[50],"We":[51],"exploited":[52],"features":[53],"prime":[55],"editing":[56],"to":[57,142],"profile":[58],"the":[59],"effects":[60],"core":[62],"genes":[64],"on":[65],"thousands":[66],"programmed":[68],"mispairs":[70],"in":[71,125],"cells":[72],"resolved":[74],"distinct":[75],"processes,":[77],"including":[78],"noncanonical":[80],"\u201cloop-directed\u201d":[81],"mechanism.":[82],"Guided":[83],"these":[85],"results,":[86],"we":[87],"built":[88],"set":[90],"scalable":[92],"reporters":[93],"that":[94,120],"detect":[95],"loss":[96],"separable":[98],"processes":[100],"screened":[102],"\u223c72,000":[103],"small":[104],"molecules":[105],"activity":[107],"against":[108],"MutS\u03b2-directed":[109],"MMR.":[110],"This":[111],"effort":[112],"identified":[113],"novel":[115],"series":[116],"MutS\u03b2":[118],"inhibitors":[119,144],"reduced":[121],"(CAG)":[122],"n":[123],"cell":[127],"model.":[128],"Altogether,":[129],"this":[130],"study":[131],"establishes":[132],"several":[133],"systematically":[136],"interrogating":[137],"MMR,":[138],"with":[139],"demonstrated":[140],"capacity":[141],"identify":[143],"value.":[147]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-07T00:00:00"}
