{"id":"https://openalex.org/W7220695946","doi":"https://doi.org/10.64898/2026.10.02.26364598","title":"Vascular Aging and Bladder Health: Associations Between Peripheral Arterial Disease and Lower Urinary Tract Symptoms in Mid-Life Women from CARDIA-PLUS","display_name":"Vascular Aging and Bladder Health: Associations Between Peripheral Arterial Disease and Lower Urinary Tract Symptoms in Mid-Life Women from CARDIA-PLUS","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220695946","doi":"https://doi.org/10.64898/2026.10.02.26364598","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692376"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.26364598","doi":"https://doi.org/10.64898/2026.10.02.26364598","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.26364598","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.02.26364598.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.02.26364598.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017120928","display_name":"Alayne D. Markland","orcid":"https://orcid.org/0000-0002-6567-6744","observed_orcids":["https://orcid.org/0000-0002-6567-6744"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alayne D. Markland","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040025075","display_name":"Whitney K. Hendrickson","orcid":"https://orcid.org/0000-0003-4603-2879","observed_orcids":["https://orcid.org/0000-0003-4603-2879"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Whitney K. Hendrickson","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":"https://orcid.org/0000-0003-4603-2879","affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018114939","display_name":"Andr\u00e9s Arguedas","orcid":"https://orcid.org/0000-0001-6299-052X","observed_orcids":["https://orcid.org/0000-0001-6299-052X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres Arguedas","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157659651","display_name":"Simon De","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simion De","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140150735","display_name":"Katelyn Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Adams","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069988352","display_name":"Cora Elizabeth Lewis","orcid":"https://orcid.org/0000-0002-2301-5796","observed_orcids":["https://orcid.org/0000-0002-2301-5796"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Elizabeth Lewis","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010368679","display_name":"Gerhard Hellemann","orcid":"https://orcid.org/0000-0003-2449-7704","observed_orcids":["https://orcid.org/0000-0003-2449-7704"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerhard Hellemann","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024612180","display_name":"Cynthia S. Fok","orcid":"https://orcid.org/0000-0003-1197-0099","observed_orcids":["https://orcid.org/0000-0003-1197-0099"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia S. Fok","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016634129","display_name":"Sonya S. Brady","orcid":"https://orcid.org/0000-0001-8660-9308","observed_orcids":["https://orcid.org/0000-0001-8660-9308"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonya S. Brady","raw_affiliation_strings":["From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Utah, Department of Internal Medicine and the Department of Obstetrics and Gynecology, Salt Lake City, UT; the University of Alabama at Birmingham, Department of Medicine, Birmingham, AL; the University of Alabama at Birmingham School of Public Health, Departments of Epidemiology and Biostatistics, Birmingham, AL; and the University of Minnesota Medical School, Department of Family Medicine and Community Health, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017120928"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I223532165","https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bladder-health","display_name":"bladder health","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vascular-aging","display_name":"vascular aging","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ankle-brachial-index","display_name":"ankle-brachial index","score":0.8939999938011169},{"id":"https://openalex.org/keywords/middle-aged-women","display_name":"middle-aged women","score":0.8389999866485596},{"id":"https://openalex.org/keywords/urinary-incontinence","display_name":"urinary incontinence","score":0.6980000138282776},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.6549999713897705},{"id":"https://openalex.org/keywords/bladder-symptoms","display_name":"bladder symptoms","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9192000031471252},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6852999925613403},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.6769999861717224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5406000018119812},{"id":"https://openalex.org/C3018348675","wikidata":"https://www.wikidata.org/wiki/Q4797557","display_name":"Arterial disease","level":3,"score":0.5396000146865845},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.4851999878883362},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4690000116825104},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4514999985694885},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.424699991941452},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.3864000141620636},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35100001096725464},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C2778640784","wikidata":"https://www.wikidata.org/wiki/Q168002","display_name":"Ankle","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.30399999022483826},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.2547000050544739}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.02.26364598","doi":"https://doi.org/10.64898/2026.10.02.26364598","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.26364598","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.02.26364598.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42926852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692376","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692376/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.26364598","doi":"https://doi.org/10.64898/2026.10.02.26364598","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.26364598","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/06/2026.10.02.26364598.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1000644980","display_name":null,"funder_award_id":"75N92023D00005","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G1586844134","display_name":null,"funder_award_id":"75N92023D00004","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1732223801","display_name":null,"funder_award_id":"75N92023D00006","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1879745488","display_name":null,"funder_award_id":"75N92023D00004","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G2125316032","display_name":null,"funder_award_id":"DK084997/115-9107-01-M1","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G3017670077","display_name":null,"funder_award_id":"75N92023D00006","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G30286026","display_name":null,"funder_award_id":"DK084997/115-9107-01-M1","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3114895611","display_name":null,"funder_award_id":"75N92023D00005","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3931708253","display_name":null,"funder_award_id":"75N92023D00003)","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G5240659570","display_name":null,"funder_award_id":"75N92023D00003","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G5348427392","display_name":null,"funder_award_id":"75N92023D00002","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5435011327","display_name":null,"funder_award_id":"75N92023D00002","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G5499422579","display_name":"CARDIA-PLUS: A Life Course Investigation of Biopsychosocial Pathways to Bladder Health and Lower Urinary Tract Symptoms","funder_award_id":"R01DK125274","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5654020273","display_name":null,"funder_award_id":"DK084997/115-9107-01","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G5671222836","display_name":null,"funder_award_id":"75N92023D00002","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G662645278","display_name":null,"funder_award_id":"75N92023D00002","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G674475515","display_name":null,"funder_award_id":"75N92023D00003","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7295477853","display_name":null,"funder_award_id":"75N92023D00004","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G7328697105","display_name":null,"funder_award_id":"75N92023D00003","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G7379922140","display_name":null,"funder_award_id":"75N92023D00004","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G7422092500","display_name":null,"funder_award_id":"75N92023D00005","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G7842515143","display_name":null,"funder_award_id":"75N92023D00006","funder_id":"https://openalex.org/F4320332509","funder_display_name":"Kaiser Foundation Research Institute"},{"id":"https://openalex.org/G7974859583","display_name":null,"funder_award_id":"75N92023D00006","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G8478215588","display_name":null,"funder_award_id":"75N92023D00005","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G9000877486","display_name":"Research and Mentoring Program in Improving Access to Incontinence Care for Older Adults","funder_award_id":"K24AG073586","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332509","display_name":"Kaiser Foundation Research Institute","ror":"https://ror.org/00t60zh31"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220695946.pdf","grobid_xml":"https://content.openalex.org/works/W7220695946.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1959563429","https://openalex.org/W1968946707","https://openalex.org/W1970755029","https://openalex.org/W1983437405","https://openalex.org/W1983955609","https://openalex.org/W1987772033","https://openalex.org/W2014124110","https://openalex.org/W2048859899","https://openalex.org/W2055774080","https://openalex.org/W2087613565","https://openalex.org/W2087917879","https://openalex.org/W2115881642","https://openalex.org/W2118835581","https://openalex.org/W2123394487","https://openalex.org/W2140442117","https://openalex.org/W2149534928","https://openalex.org/W2161125648","https://openalex.org/W2484519907","https://openalex.org/W2769801153","https://openalex.org/W2951869240","https://openalex.org/W2952434611","https://openalex.org/W2965029066","https://openalex.org/W3006707280","https://openalex.org/W3007173654","https://openalex.org/W3045782101","https://openalex.org/W3165267785","https://openalex.org/W3181487300","https://openalex.org/W4220947622","https://openalex.org/W4253207321","https://openalex.org/W4309647992","https://openalex.org/W4313436815","https://openalex.org/W4315753060","https://openalex.org/W4317479973","https://openalex.org/W4362737887","https://openalex.org/W4382364442","https://openalex.org/W4387823578","https://openalex.org/W4396644432","https://openalex.org/W4396907535","https://openalex.org/W4398246937","https://openalex.org/W4399330953","https://openalex.org/W4401794357","https://openalex.org/W4404135789","https://openalex.org/W4408311943"],"related_works":["https://openalex.org/W2597354653","https://openalex.org/W7099791137","https://openalex.org/W2807213497","https://openalex.org/W1975681027","https://openalex.org/W2949384116","https://openalex.org/W2090191958","https://openalex.org/W4210469132","https://openalex.org/W3165267785","https://openalex.org/W1970755029","https://openalex.org/W2927360291"],"abstract_inverted_index":{"Objectives:":[0],"To":[1],"describe":[2],"associations":[3],"between":[4],"peripheral":[5],"arterial":[6],"disease":[7],"(PAD)":[8],"and":[9,13,42,72,77,107,115,129,140,150,156,167,189,241,247],"bladder":[10,53],"health":[11],"(BH)":[12],"lower":[14,203],"urinary":[15],"tract":[16],"symptoms":[17,54],"(LUTS)":[18],"among":[19],"a":[20,50],"subset":[21,82],"of":[22,111],"women":[23,135,174,214],"in":[24,55],"the":[25,65,73,78,89,141,144],"Coronary":[26],"Artery":[27],"Risk":[28],"Development":[29],"In":[30,230],"Young":[31],"Adults":[32],"(CARDIA)":[33],"study.":[34],"Methods:":[35],"Women":[36],"from":[37],"CARDIA":[38],"at":[39],"Birmingham,":[40],"AL":[41],"Minneapolis,":[43],"MN":[44],"were":[45,98,118,161],"eligible":[46],"if":[47],"they":[48],"completed":[49,84,137],"questionnaire":[51],"about":[52],"2022-23,":[56],"an":[57,85],"ancillary":[58],"study":[59],"post-year":[60],"35":[61],"called":[62],"CARDIA-PLUS,":[63],"including":[64,88],"global":[66],"BH":[67,114,204,226],"scale":[68],"(possible":[69],"range,":[70],"0-100)":[71],"LURN-SI":[74,181],"10":[75],"(0-38)":[76],"AUASI":[79,194],"(0-35).":[80],"A":[81],"(n=216)":[83],"inperson":[86],"examination,":[87],"ankle":[90],"brachial":[91],"index":[92],"(ABI)":[93],"procedure":[94],"(n=194).":[95],"ABI":[96,121,142,159,177,217,221],"scores":[97,178,182,195,205],"clinically":[99],"categorized":[100],"as":[101],"normal":[102,162,216],"(1.00-1.40),":[103],"borderline":[104,164],"abnormal":[105,108,165,168,176,220],"(0.91-0.99),":[106],"(\u22640.90;":[109],"evidence":[110],"PAD).":[112],"Continuous":[113],"LUTS":[116,238,242],"variables":[117],"regressed":[119],"on":[120],"category,":[122],"adjusting":[123,171],"for":[124,172],"sociodemographics,":[125],"obstetric/gynecologic":[126],"variables,":[127],"co-morbidities,":[128],"physical":[130],"activity.":[131],"Key":[132],"Results:":[133],"Among":[134],"who":[136],"BH/LUTS":[138],"questionnaires":[139],"(n=192),":[143],"mean":[145],"age":[146],"was":[147,153,222,234],"63\u00b14":[148],"years":[149],"racial":[151],"composition":[152],"47%":[154],"Black":[155],"53%":[157],"White.":[158],"results":[160],"(74%),":[163],"(20%),":[166],"(6%).":[169],"After":[170],"covariates,":[173],"with":[175,215,225,236],"had":[179],"higher":[180,193],"(4.1":[183],"points,":[184,197,207],"95%":[185,198,208],"CI":[186,199,209],"0.7,":[187],"7.5)":[188],"did":[190],"not":[191,223],"have":[192],"(1.4":[196],"-3.1,":[200],"5.7)":[201],"or":[202,227],"(-9.6":[206],"-24.0,":[210],"4.9)":[211],"compared":[212],"to":[213],"scores.":[218],"Borderline":[219],"associated":[224,235],"LUTS.":[228],"Discussion/Conclusion:":[229],"this":[231],"cohort,":[232],"PAD":[233,240],"greater":[237],"severity.":[239],"may":[243],"share":[244],"common":[245],"etiologies":[246],"risk":[248],"factors":[249],"that":[250],"need":[251],"additional":[252],"research.":[253]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-07T00:00:00"}