{"id":"https://openalex.org/W7220691899","doi":"https://doi.org/10.64898/2026.10.04.756499","title":"Killer meiotic driver prevents chromosome loss and enhances fitness in a fungal pathogen","display_name":"Killer meiotic driver prevents chromosome loss and enhances fitness in a fungal pathogen","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220691899","doi":"https://doi.org/10.64898/2026.10.04.756499"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.04.756499","doi":"https://doi.org/10.64898/2026.10.04.756499","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.756499","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.04.756499.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.04.756499.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095921857","display_name":"Gema Puebla-Planas","orcid":"https://orcid.org/0000-0003-4776-1459","observed_orcids":["https://orcid.org/0000-0003-4776-1459"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gema Puebla Planas","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4776-1459","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048051317","display_name":"Andrea Doddi","orcid":"https://orcid.org/0000-0003-3149-6304","observed_orcids":["https://orcid.org/0000-0003-3149-6304"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andrea Doddi","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3149-6304","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061239485","display_name":"Dilay Hazal Ayhan","orcid":"https://orcid.org/0000-0002-0497-3294","observed_orcids":["https://orcid.org/0000-0002-0497-3294"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]},{"id":"https://openalex.org/I322491407","display_name":"Ac\u0131badem University","ror":"https://ror.org/01rp2a061","country_code":"TR","type":"education","lineage":["https://openalex.org/I322491407"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"Dilay H. Ayhan","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, USA","Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-0497-3294","affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I322491407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032627099","display_name":"Pilar Guti\u00e9rrez-Escribano","orcid":"https://orcid.org/0000-0002-0604-4819","observed_orcids":["https://orcid.org/0000-0002-0604-4819"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Guti\u00e9rrez Escribano","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0604-4819","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073592065","display_name":"Li\u2010Jun Ma","orcid":"https://orcid.org/0000-0002-2733-3708","observed_orcids":["https://orcid.org/0000-0002-2733-3708"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Jun Ma","raw_affiliation_strings":["Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-2733-3708","affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021697703","display_name":"Manuel S. L\u00f3pez\u2010Berges","orcid":"https://orcid.org/0000-0002-5523-1725","observed_orcids":["https://orcid.org/0000-0002-5523-1725"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel S\u00e1nchez L\u00f3pez-Berges","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5523-1725","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049431372","display_name":"Antonio Di Pietro","orcid":"https://orcid.org/0000-0001-5930-5763","observed_orcids":["https://orcid.org/0000-0001-5930-5763"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio Di Pietro","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5930-5763","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049431372"],"corresponding_institution_ids":["https://openalex.org/I53110688"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.3984000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.3984000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.37380000948905945,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosome-loss","display_name":"chromosome loss","score":0.949999988079071},{"id":"https://openalex.org/keywords/fusarium-oxysporum","display_name":"Fusarium oxysporum","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fungal-pathogens","display_name":"fungal pathogens","score":0.7160000205039978},{"id":"https://openalex.org/keywords/fitness","display_name":"fitness","score":0.4490000009536743},{"id":"https://openalex.org/keywords/hyphal-fusion","display_name":"hyphal fusion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mitotic-instability","display_name":"mitotic instability","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8949999809265137},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.6018999814987183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5960999727249146},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5681999921798706},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5496000051498413},{"id":"https://openalex.org/C3019170707","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Fungal pathogen","level":3,"score":0.5424000024795532},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.48919999599456787},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.46209999918937683},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.34459999203681946},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33970001339912415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33160001039505005},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.31619998812675476},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.3147999942302704},{"id":"https://openalex.org/C2993053932","wikidata":"https://www.wikidata.org/wiki/Q879156","display_name":"Chromosome pairing","level":4,"score":0.31380000710487366},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.29330000281333923},{"id":"https://openalex.org/C174618031","wikidata":"https://www.wikidata.org/wiki/Q177332","display_name":"Spore","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C2776315342","wikidata":"https://www.wikidata.org/wiki/Q21105865","display_name":"SAMHD1","level":5,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.04.756499","doi":"https://doi.org/10.64898/2026.10.04.756499","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.756499","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.04.756499.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.04.756499","doi":"https://doi.org/10.64898/2026.10.04.756499","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.04.756499","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.04.756499.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220691899.pdf","grobid_xml":"https://content.openalex.org/works/W7220691899.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1927326046","https://openalex.org/W1991475492","https://openalex.org/W1993264674","https://openalex.org/W2002659896","https://openalex.org/W2025709412","https://openalex.org/W2039722369","https://openalex.org/W2044725216","https://openalex.org/W2061240424","https://openalex.org/W2075518131","https://openalex.org/W2092786524","https://openalex.org/W2108244474","https://openalex.org/W2113073727","https://openalex.org/W2115372032","https://openalex.org/W2116582646","https://openalex.org/W2118751052","https://openalex.org/W2139762933","https://openalex.org/W2150440022","https://openalex.org/W2154459669","https://openalex.org/W2166254487","https://openalex.org/W2171468101","https://openalex.org/W2346052203","https://openalex.org/W2410568297","https://openalex.org/W2609674356","https://openalex.org/W2900236645","https://openalex.org/W2902166467","https://openalex.org/W2925408623","https://openalex.org/W2964631569","https://openalex.org/W3003424148","https://openalex.org/W3044831147","https://openalex.org/W3156210303","https://openalex.org/W3195821421","https://openalex.org/W3214276403","https://openalex.org/W4280649038","https://openalex.org/W4282938787","https://openalex.org/W4287922033","https://openalex.org/W4311827868","https://openalex.org/W4386089031","https://openalex.org/W4388500562","https://openalex.org/W4394840748","https://openalex.org/W4404035341","https://openalex.org/W4411672391","https://openalex.org/W4412754996","https://openalex.org/W4414161615","https://openalex.org/W7167963891","https://openalex.org/W7170156959"],"related_works":["https://openalex.org/W7005136324","https://openalex.org/W4312019060","https://openalex.org/W4206909710","https://openalex.org/W2410568297","https://openalex.org/W2966738628","https://openalex.org/W3014739963","https://openalex.org/W4294970258","https://openalex.org/W1975759063","https://openalex.org/W2055747989","https://openalex.org/W3156093523"],"abstract_inverted_index":{"Abstract":[0],"Fungal":[1],"pathogens":[2],"often":[3],"carry":[4],"dispensable":[5],"chromosomes":[6],"(DCs)":[7],"that":[8,41],"confer":[9],"a":[10,42,54,62,74,81,86,99,112,115,120],"selective":[11],"advantage":[12],"in":[13,32,65],"adverse":[14],"environments":[15],"or":[16,114],"during":[17],"host":[18],"infection":[19],"but":[20,78],"can":[21],"be":[22],"spontaneously":[23],"lost":[24],"under":[25],"non-selective":[26],"conditions.":[27],"How":[28],"DCs":[29],"are":[30],"maintained":[31,101],"evolving":[33],"populations":[34],"remains":[35],"poorly":[36],"understood.":[37],"Here":[38],"we":[39],"show":[40],"meiotic":[43],"driver":[44],"known":[45],"as":[46],"Spore":[47],"Killer":[48],"(":[49],"spok":[50,76,96,117],"),":[51],"located":[52],"on":[53],"giant":[55],"Starship":[56,139],"transposon,":[57],"limits":[58],"spontaneous":[59],"loss":[60,93,104,147],"of":[61,73,80],"conserved":[63],"DC":[64,89,102,146],"the":[66],"cross-kingdom":[67],"pathogen":[68],"Fusarium":[69],"oxysporum":[70],".":[71],"Transfer":[72],"functional":[75,113],"gene,":[77],"not":[79],"killing-deficient":[82,116],"mutant":[83],"allele,":[84],"to":[85],"mitotically":[87],"unstable":[88],"significantly":[90],"reduced":[91],"its":[92],"rate,":[94],"while":[95],"deletion":[97],"from":[98],"stably":[100],"increased":[103],"frequency.":[105],"Competition":[106],"experiments":[107],"between":[108],"isogenic":[109],"strains":[110],"carrying":[111],"allele":[118],"revealed":[119],"dramatic":[121],"fitness":[122],"gain":[123],"conferred":[124],"by":[125,132,144],"Spok":[126],"killing":[127],"activity,":[128],"which":[129],"required":[130],"transmission":[131],"hyphal":[133],"fusion.":[134],"Thus,":[135],"spoks":[136],"and":[137,148,152],"their":[138],"carriers":[140],"benefit":[141],"fungal":[142],"hosts":[143],"preventing":[145],"preserving":[149],"long-term":[150],"metabolic":[151],"pathogenic":[153],"plasticity.":[154]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-07T00:00:00"}