{"id":"https://openalex.org/W7220686872","doi":"https://doi.org/10.3892/ijo.2026.5943","title":"Regulatory T cells in lung adenocarcinoma: Mechanisms of immune escape, prognostic significance and therapeutic opportunities (Review)","display_name":"Regulatory T cells in lung adenocarcinoma: Mechanisms of immune escape, prognostic significance and therapeutic opportunities (Review)","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220686872","doi":"https://doi.org/10.3892/ijo.2026.5943","pmid":"https://pubmed.ncbi.nlm.nih.gov/42852619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713051"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2026.5943","doi":"https://doi.org/10.3892/ijo.2026.5943","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5943","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3892/ijo.2026.5943","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039291260","display_name":"Lijuan Wang","orcid":"https://orcid.org/0000-0001-5076-6088","observed_orcids":["https://orcid.org/0000-0001-5076-6088"]},"institutions":[{"id":"https://openalex.org/I4210132841","display_name":"Taizhou Central Hospital","ror":"https://ror.org/040884w51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132841"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Wang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, P.R. China","institution_ids":["https://openalex.org/I4210132841","https://openalex.org/I82760581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025874814","display_name":"Chenjin Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132841","display_name":"Taizhou Central Hospital","ror":"https://ror.org/040884w51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132841"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenjin Ruan","raw_affiliation_strings":["Department of Thoracic Surgery, Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, P.R. China","institution_ids":["https://openalex.org/I4210132841","https://openalex.org/I82760581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025874814"],"corresponding_institution_ids":["https://openalex.org/I4210132841","https://openalex.org/I82760581"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45816838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"5","first_page":"1","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.20739999413490295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":1.0},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.871999979019165},{"id":"https://openalex.org/keywords/treg-depletion","display_name":"Treg depletion","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.6349999904632568},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7537000179290771},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5830000042915344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5809999704360962},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5171999931335449},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.512499988079071},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4993000030517578},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.41200000047683716},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4058000147342682},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3626999855041504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31450000405311584},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.311599999666214},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.289000004529953},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.25769999623298645},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.2574999928474426},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25270000100135803}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.2026.5943","doi":"https://doi.org/10.3892/ijo.2026.5943","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5943","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713051","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713051/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713051/pdf/ijo-69-05-05943.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"},{"id":"pmid:42852619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42852619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2026.5943","doi":"https://doi.org/10.3892/ijo.2026.5943","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5943","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320336614","display_name":"Science and Technology Plan Project of Taizhou","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220686872.pdf","grobid_xml":"https://content.openalex.org/works/W7220686872.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W137722765","https://openalex.org/W1982488143","https://openalex.org/W1994160001","https://openalex.org/W2019236122","https://openalex.org/W2020293242","https://openalex.org/W2021603971","https://openalex.org/W2029464069","https://openalex.org/W2043503111","https://openalex.org/W2043731481","https://openalex.org/W2049193229","https://openalex.org/W2072853625","https://openalex.org/W2104347254","https://openalex.org/W2106728539","https://openalex.org/W2115818681","https://openalex.org/W2132532093","https://openalex.org/W2141649011","https://openalex.org/W2148226248","https://openalex.org/W2168038014","https://openalex.org/W2344037260","https://openalex.org/W2419439766","https://openalex.org/W2420987345","https://openalex.org/W2482806302","https://openalex.org/W2527905628","https://openalex.org/W2559382297","https://openalex.org/W2561926137","https://openalex.org/W2567564314","https://openalex.org/W2617691667","https://openalex.org/W2753065806","https://openalex.org/W2796582438","https://openalex.org/W2801309958","https://openalex.org/W2801478434","https://openalex.org/W2810097927","https://openalex.org/W2892640821","https://openalex.org/W2895357007","https://openalex.org/W2899783716","https://openalex.org/W2906126011","https://openalex.org/W2913337434","https://openalex.org/W2914396734","https://openalex.org/W2938078995","https://openalex.org/W2944207752","https://openalex.org/W2955949220","https://openalex.org/W2965183847","https://openalex.org/W2966942044","https://openalex.org/W2995065325","https://openalex.org/W2999532564","https://openalex.org/W3000274143","https://openalex.org/W3001029227","https://openalex.org/W3015525801","https://openalex.org/W3015697300","https://openalex.org/W3019755975","https://openalex.org/W3021598078","https://openalex.org/W3042467660","https://openalex.org/W3045078212","https://openalex.org/W3049509522","https://openalex.org/W3082731516","https://openalex.org/W3084241168","https://openalex.org/W3109273351","https://openalex.org/W3111942073","https://openalex.org/W3112933409","https://openalex.org/W3121334342","https://openalex.org/W3121898747","https://openalex.org/W3125196099","https://openalex.org/W3125826904","https://openalex.org/W3128629537","https://openalex.org/W3134912163","https://openalex.org/W3160163145","https://openalex.org/W3160588558","https://openalex.org/W3162226089","https://openalex.org/W3171344244","https://openalex.org/W3194807048","https://openalex.org/W3199241644","https://openalex.org/W3205574513","https://openalex.org/W3211533946","https://openalex.org/W4200187391","https://openalex.org/W4205108565","https://openalex.org/W4205432652","https://openalex.org/W4210367090","https://openalex.org/W4220745713","https://openalex.org/W4220905571","https://openalex.org/W4221126421","https://openalex.org/W4224313240","https://openalex.org/W4225422100","https://openalex.org/W4245879305","https://openalex.org/W4290997336","https://openalex.org/W4294845083","https://openalex.org/W4306155545","https://openalex.org/W4311665401","https://openalex.org/W4315646071","https://openalex.org/W4317780547","https://openalex.org/W4318069738","https://openalex.org/W4323067210","https://openalex.org/W4323567056","https://openalex.org/W4324046205","https://openalex.org/W4361011640","https://openalex.org/W4361251405","https://openalex.org/W4364356532","https://openalex.org/W4377087159","https://openalex.org/W4381598135","https://openalex.org/W4383875934","https://openalex.org/W4384925954","https://openalex.org/W4386027941","https://openalex.org/W4386955436","https://openalex.org/W4387099064","https://openalex.org/W4388974118","https://openalex.org/W4389546222","https://openalex.org/W4390347658","https://openalex.org/W4391850069","https://openalex.org/W4391893425","https://openalex.org/W4392002566","https://openalex.org/W4393197121","https://openalex.org/W4394721567","https://openalex.org/W4395008692","https://openalex.org/W4396907525","https://openalex.org/W4399853992","https://openalex.org/W4401174820","https://openalex.org/W4403729233","https://openalex.org/W4405695496","https://openalex.org/W4406085296","https://openalex.org/W4407443224","https://openalex.org/W4408417574","https://openalex.org/W4410525809","https://openalex.org/W4414619537","https://openalex.org/W4415884601","https://openalex.org/W4416100772","https://openalex.org/W7131370804","https://openalex.org/W7135077960","https://openalex.org/W7154397569","https://openalex.org/W7164476662","https://openalex.org/W7166802473"],"related_works":["https://openalex.org/W4386027941","https://openalex.org/W287183566","https://openalex.org/W7154397569","https://openalex.org/W4412383237","https://openalex.org/W4389070649","https://openalex.org/W3125196099","https://openalex.org/W4224226141","https://openalex.org/W4416100772","https://openalex.org/W4309933632","https://openalex.org/W3030017936"],"abstract_inverted_index":{"T":[0],"cell":[1,61],"subtype":[2],"with":[3,38],"immunosuppressive":[4],"functions,":[5],"play":[6],"a":[7],"pivotal":[8],"role":[9,154],"in":[10,23,56,63,81,120,157],"maintaining":[11],"self\u2011tolerance":[12],"under":[13],"physiological":[14],"conditions.":[15],"Recent":[16],"evidence":[17],"has":[18,65],"increasingly":[19],"highlighted":[20],"their":[21],"involvement":[22,171],"various":[24],"cancers.":[25],"In":[26],"LUAD,":[27],"Treg":[28,60,170],"infiltration":[29],"into":[30],"tissues":[31],"undermines":[32],"the":[33,106,129,152,166],"immune":[34,49,54,160],"anticancer":[35,95],"response,":[36],"correlating":[37],"disease":[39],"stage,":[40],"treatment":[41],"efficacy":[42,96],"and":[43,140,162,172],"prognosis.":[44],"By":[45],"inhibiting":[46],"robust":[47],"anti\u2011tumor":[48],"mechanisms,":[50],"Tregs":[51,73,92,111,134,156],"facilitate":[52],"tumor":[53],"escape":[55,161],"LUAD.":[57,146],"Furthermore,":[58],"elevated":[59],"accumulation":[62],"LUAD":[64,79,158],"been":[66],"linked":[67],"to":[68,93],"reduced":[69],"overall":[70],"survival":[71],"rates.":[72],"serve":[74],"as":[75],"independent":[76],"predictors":[77],"for":[78,114,128,137,145],"diagnosis":[80],"patients":[82],"at":[83],"high":[84],"risk":[85],"of":[86,90,99,109,117,132,155,169],"recurrence.":[87],"Systematic":[88],"depletion":[89],"all":[91],"enhance":[94],"poses":[97],"risks":[98],"inducing":[100],"severe":[101],"autoimmune":[102],"pathologies.":[103],"Consequently,":[104],"understanding":[105],"precise":[107],"structure":[108],"tumor\u2011infiltrating":[110,133],"is":[112,135],"essential":[113],"effective":[115],"targeting":[116],"these":[118],"cells":[119],"tumors.":[121],"Additionally,":[122],"identifying":[123],"candidate":[124],"targets":[125],"or":[126],"methods":[127],"specific":[130],"elimination":[131],"necessary":[136],"developing":[138],"efficient":[139],"safe":[141],"combination":[142],"immunotherapy":[143],"strategies":[144],"The":[147],"present":[148],"study":[149],"focuses":[150],"on":[151],"regulatory":[153],"prognosis,":[159],"targeted":[163],"therapies,":[164],"elucidating":[165],"molecular":[167],"mechanisms":[168],"presenting":[173],"associated":[174],"therapeutic":[175],"targets.":[176]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-07T00:00:00"}
