{"id":"https://openalex.org/W7220678694","doi":"https://doi.org/10.64898/2026.10.05.756744","title":"HIV-1 Assembly is Assisted by IRSp53 Through an Interaction that Extends Gag Conformation","display_name":"HIV-1 Assembly is Assisted by IRSp53 Through an Interaction that Extends Gag Conformation","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220678694","doi":"https://doi.org/10.64898/2026.10.05.756744","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692132"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.756744","doi":"https://doi.org/10.64898/2026.10.05.756744","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756744","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756744.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756744.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053042001","display_name":"Curt Waltmann","orcid":"https://orcid.org/0000-0001-7029-214X","observed_orcids":["https://orcid.org/0000-0001-7029-214X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt Waltmann","raw_affiliation_strings":["Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637"],"raw_orcid":"https://orcid.org/0000-0001-7029-214X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020045711","display_name":"Peggy M\u00e9rida","orcid":"https://orcid.org/0009-0001-5613-2745","observed_orcids":["https://orcid.org/0009-0001-5613-2745"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Peggy Merida","raw_affiliation_strings":["Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France"],"raw_orcid":"https://orcid.org/0009-0001-5613-2745","affiliations":[{"raw_affiliation_string":"Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082655875","display_name":"Puja Banerjee","orcid":"https://orcid.org/0000-0002-8905-558X","observed_orcids":["https://orcid.org/0000-0002-8905-558X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puja Banjeree","raw_affiliation_strings":["Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637"],"raw_orcid":"https://orcid.org/0000-0002-8905-558X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121236640","display_name":"Karolina Buresova","orcid":"https://orcid.org/0009-0005-6432-0745","observed_orcids":["https://orcid.org/0009-0005-6432-0745"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karolina Buresova","raw_affiliation_strings":["Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029682704","display_name":"Chlo\u00e9 Poussineau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chlo\u00e9 Poussineau","raw_affiliation_strings":["Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081394185","display_name":"Julien Burlaud\u2010Gaillard","orcid":"https://orcid.org/0000-0001-5171-9873","observed_orcids":["https://orcid.org/0000-0001-5171-9873"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Burlaud-Gaillard","raw_affiliation_strings":["UAR Microscopy core facility, University of Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UAR Microscopy core facility, University of Tours, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106882997","display_name":"Raviteja Gurram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raviteja Gurram","raw_affiliation_strings":["Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055436633","display_name":"Jeriann R. Beiter","orcid":"https://orcid.org/0009-0002-0434-1112","observed_orcids":["https://orcid.org/0009-0002-0434-1112"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeriann Beiter","raw_affiliation_strings":["Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637"],"raw_orcid":"https://orcid.org/0009-0002-0434-1112","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075832876","display_name":"Cyril Favard","orcid":"https://orcid.org/0000-0002-8304-2980","observed_orcids":["https://orcid.org/0000-0002-8304-2980"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyril Favard","raw_affiliation_strings":["Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France"],"raw_orcid":"https://orcid.org/0000-0002-8304-2980","affiliations":[{"raw_affiliation_string":"Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052705256","display_name":"Delphine M. Muriaux","orcid":"https://orcid.org/0000-0001-8517-9342","observed_orcids":["https://orcid.org/0000-0001-8517-9342"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140640","display_name":"Institut de Recherche en Infectiologie de Montpellier","ror":"https://ror.org/036eg1q44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210137371","https://openalex.org/I4210139971","https://openalex.org/I4210140640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Muriaux","raw_affiliation_strings":["Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious disease Research Institute of Montpellier (IRIM), CNRS UMR 9004, University of Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210140640"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088327041","display_name":"Gregory A. Voth","orcid":"https://orcid.org/0000-0002-3267-6748","observed_orcids":["https://orcid.org/0000-0002-3267-6748"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory A. Voth","raw_affiliation_strings":["Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637"],"raw_orcid":"https://orcid.org/0000-0002-3267-6748","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088327041"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-assembly","display_name":"HIV-1 assembly","score":0.9200000166893005},{"id":"https://openalex.org/keywords/irsp53","display_name":"IRSp53","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.9369999766349792},{"id":"https://openalex.org/keywords/virus-budding","display_name":"viral budding","score":0.824999988079071},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.5149999856948853},{"id":"https://openalex.org/keywords/rna-binding","display_name":"RNA binding","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C198410946","wikidata":"https://www.wikidata.org/wiki/Q845312","display_name":"Budding","level":2,"score":0.7095000147819519},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.671500027179718},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5443999767303467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5242000222206116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5220999717712402},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5026999711990356},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.48820000886917114},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.44440001249313354},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4302999973297119},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4189999997615814},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.37950000166893005},{"id":"https://openalex.org/C6881719","wikidata":"https://www.wikidata.org/wiki/Q5611048","display_name":"Group-specific antigen","level":3,"score":0.35429999232292175},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.35249999165534973},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.3352999985218048},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.33180001378059387},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3244999945163727},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.30709999799728394},{"id":"https://openalex.org/C2992884146","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Budding yeast","level":4,"score":0.3059999942779541},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.257999986410141},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.2549999952316284}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.05.756744","doi":"https://doi.org/10.64898/2026.10.05.756744","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756744","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756744.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692132","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926599/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692132/pdf/nihpp-2026.10.05.756744v2.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42926599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.756744","doi":"https://doi.org/10.64898/2026.10.05.756744","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756744","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756744.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G168860532","display_name":null,"funder_award_id":"F32 AI186429","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000120034","display_name":"Behavior of HIV in Viral Environments (B-HIVE)","funder_award_id":"U54AI170855","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000920001","display_name":"Multiscale Simulation of HIV-1 Virion Release and Maturation","funder_award_id":"R01AI178850","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320324510","display_name":"Universit\u00e9 Fran\u00e7ois-Rabelais","ror":"https://ror.org/02wwzvj46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220678694.pdf","grobid_xml":"https://content.openalex.org/works/W7220678694.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7130542318"],"related_works":["https://openalex.org/W3167860353","https://openalex.org/W4230297001","https://openalex.org/W4398793557","https://openalex.org/W3135299726","https://openalex.org/W2734451627","https://openalex.org/W2800509900","https://openalex.org/W4377227108","https://openalex.org/W2023015083","https://openalex.org/W4285393087","https://openalex.org/W2115382947"],"abstract_inverted_index":{"Budding":[0],"of":[1,9,45,57,107,115,129,202,227],"the":[2,10,31,36,42,51,55,65,76,81,104,112,127,130,140,206,217,222],"immature":[3],"virion":[4],"is":[5,38,152],"an":[6],"essential":[7],"part":[8],"HIV-1":[11,85,162,228],"life":[12],"cycle.":[13],"However,":[14],"understanding":[15],"and":[16,26,87,117,187,230],"inhibiting":[17,235],"this":[18,121],"process":[19],"has":[20],"been":[21],"challenging,":[22],"as":[23,166],"both":[24],"simulations":[25,124],"theoretical":[27],"studies":[28],"suggest":[29,63,231],"that":[30,64,103,126],"energy":[32],"required":[33],"to":[34,101,138,148,154,189],"bend":[35],"membrane":[37,53,208],"too":[39],"high":[40],"for":[41,195,234],"complete":[43],"assembly":[44,86,237],"a":[46,145],"spherical":[47],"viral":[48,236],"particle":[49],"at":[50,205],"plasma":[52,207],"without":[54],"assistance":[56],"cellular":[58],"host":[59,73],"factors.":[60],"Recent":[61],"results":[62,215],"I-BAR":[66],"protein":[67],"IRSp53":[68,108,133],"may":[69],"be":[70],"one":[71],"such":[72],"factor,":[74],"but":[75,209],"molecular":[77,94],"mechanism":[78,219],"by":[79,168,220],"which":[80,151,221],"Gag-IRSp53":[82,223],"interaction":[83,131,176,224],"promotes":[84,225],"budding":[88,212,229],"remains":[89],"poorly":[90],"understood.":[91],"We":[92,158],"employ":[93],"dynamics":[95],"simulations,":[96,169],"starting":[97],"from":[98,135],"AlphaFold":[99],"models,":[100],"show":[102,125],"SH3":[105,179],"domain":[106,114],"interacts":[109],"directly":[110],"with":[111,132,177],"MACANTD":[113,141],"Gag":[116,142,156,163,183,203],"we":[118,198],"experimentally":[119],"validate":[120,216],"interaction.":[122],"Our":[123],"specificity":[128],"arises":[134],"its":[136],"ability":[137],"extend":[139],"conformation":[143],"in":[144,191],"manner":[146],"similar":[147],"RNA":[149],"binding,":[150],"known":[153],"activate":[155],"assembly.":[157],"then":[159],"computationally":[160],"design":[161],"mutants":[164,184,197],"that,":[165],"confirmed":[167],"do":[170],"not":[171],"undergo":[172],"conformational":[173],"changes":[174],"upon":[175],"theIRSp53":[178],"domain.":[180],"Experimentally,":[181],"these":[182,196],"are":[185],"tested":[186],"shown":[188],"accumulate":[190],"cells.":[192],"In":[193],"addition,":[194],"observe":[199],"large":[200,211],"quantities":[201],"assembling":[204],"exhibiting":[210],"defects.":[213],"These":[214],"proposed":[218],"completion":[226],"new":[232],"routes":[233],"or":[238],"budding.":[239]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-07T00:00:00"}
