{"id":"https://openalex.org/W7220668951","doi":"https://doi.org/10.3389/fped.2026.1897364","title":"Pathogenesis and molecular mechanisms of steroid-induced femoral head necrosis in children: a narrative review","display_name":"Pathogenesis and molecular mechanisms of steroid-induced femoral head necrosis in children: a narrative review","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220668951","doi":"https://doi.org/10.3389/fped.2026.1897364","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903505","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13680962"},"language":"en","primary_location":{"id":"doi:10.3389/fped.2026.1897364","doi":"https://doi.org/10.3389/fped.2026.1897364","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2026.1897364","pdf_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1897364/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1897364/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157712145","display_name":"Fadong Gou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092839","display_name":"Gansu University of Traditional Chinese Medicine","ror":"https://ror.org/00g741v42","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092839"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fadong Gou","raw_affiliation_strings":["Gansu University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu University of Chinese Medicine","institution_ids":["https://openalex.org/I4210092839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112721530","display_name":"Lu Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092839","display_name":"Gansu University of Traditional Chinese Medicine","ror":"https://ror.org/00g741v42","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092839"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wu","raw_affiliation_strings":["Gansu University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu University of Chinese Medicine","institution_ids":["https://openalex.org/I4210092839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157781576","display_name":"Xingwen Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092839","display_name":"Gansu University of Traditional Chinese Medicine","ror":"https://ror.org/00g741v42","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092839"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingwen Bao","raw_affiliation_strings":["Gansu University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu University of Chinese Medicine","institution_ids":["https://openalex.org/I4210092839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157760263","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092839","display_name":"Gansu University of Traditional Chinese Medicine","ror":"https://ror.org/00g741v42","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092839"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Gansu University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu University of Chinese Medicine","institution_ids":["https://openalex.org/I4210092839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157684723","display_name":"Chen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092839","display_name":"Gansu University of Traditional Chinese Medicine","ror":"https://ror.org/00g741v42","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092839"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["Gansu University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gansu University of Chinese Medicine","institution_ids":["https://openalex.org/I4210092839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133980741","display_name":"Mingxuan Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingxuan Gao","raw_affiliation_strings":["Joint Surgery, Gansu Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Surgery, Gansu Provincial Hospital","institution_ids":["https://openalex.org/I4210114785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5133980741"],"corresponding_institution_ids":["https://openalex.org/I4210114785"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59704641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"1897364","last_page":"1897364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steroid-induced-osteonecrosis-of-the-femoral-head","display_name":"steroid-induced osteonecrosis of the femoral head","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteonecrosis","display_name":"glucocorticoid-induced osteonecrosis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.8429999947547913},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9210000038146973},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.7009999752044678},{"id":"https://openalex.org/keywords/vascular-structure","display_name":"vascular architecture","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intraosseous-pressure","display_name":"intraosseous pressure","score":0.9350000023841858},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8248000144958496},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.6557000279426575},{"id":"https://openalex.org/C2779100257","wikidata":"https://www.wikidata.org/wiki/Q582849","display_name":"Femoral head","level":2,"score":0.618399977684021},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5126000046730042},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5120999813079834},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.46959999203681946},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4474000036716461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44609999656677246},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.3995000123977661},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.35910001397132874},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.3513000011444092},{"id":"https://openalex.org/C2777560053","wikidata":"https://www.wikidata.org/wiki/Q503629","display_name":"Avascular necrosis","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2808000147342682},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.25699999928474426},{"id":"https://openalex.org/C2778826181","wikidata":"https://www.wikidata.org/wiki/Q3310538","display_name":"Culprit","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fped.2026.1897364","doi":"https://doi.org/10.3389/fped.2026.1897364","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2026.1897364","pdf_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1897364/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13680962","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13680962/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13680962/pdf/fped-14-1897364.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pediatr","raw_type":"Text"},{"id":"pmid:42903505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9903e69a8b734feeb7fe1b6a1bea1d63","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9903e69a8b734feeb7fe1b6a1bea1d63","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pediatrics, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fped.2026.1897364","doi":"https://doi.org/10.3389/fped.2026.1897364","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2026.1897364","pdf_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1897364/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220668951.pdf","grobid_xml":"https://content.openalex.org/works/W7220668951.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1591023406","https://openalex.org/W1887804558","https://openalex.org/W1891689427","https://openalex.org/W1971446340","https://openalex.org/W1980085087","https://openalex.org/W2016554055","https://openalex.org/W2017267523","https://openalex.org/W2024849265","https://openalex.org/W2029391324","https://openalex.org/W2030243235","https://openalex.org/W2036644772","https://openalex.org/W2037981313","https://openalex.org/W2038254116","https://openalex.org/W2042188398","https://openalex.org/W2046074704","https://openalex.org/W2047210194","https://openalex.org/W2049330472","https://openalex.org/W2060587883","https://openalex.org/W2064865884","https://openalex.org/W2065395436","https://openalex.org/W2071654708","https://openalex.org/W2073204534","https://openalex.org/W2089185791","https://openalex.org/W2095821285","https://openalex.org/W2095862736","https://openalex.org/W2123582341","https://openalex.org/W2135473007","https://openalex.org/W2136293320","https://openalex.org/W2165802019","https://openalex.org/W2175165928","https://openalex.org/W2316172400","https://openalex.org/W2316296632","https://openalex.org/W2321687835","https://openalex.org/W2464248320","https://openalex.org/W2531367662","https://openalex.org/W2564765929","https://openalex.org/W2598774403","https://openalex.org/W2738651303","https://openalex.org/W2765091883","https://openalex.org/W2770938935","https://openalex.org/W2776888942","https://openalex.org/W2777012430","https://openalex.org/W2806443711","https://openalex.org/W2886933813","https://openalex.org/W2909950596","https://openalex.org/W2912663500","https://openalex.org/W2939729138","https://openalex.org/W2949446482","https://openalex.org/W2951274404","https://openalex.org/W2985634921","https://openalex.org/W2989576036","https://openalex.org/W2991181198","https://openalex.org/W3020933549","https://openalex.org/W3093525250","https://openalex.org/W3118667212","https://openalex.org/W3134763901","https://openalex.org/W4286007399","https://openalex.org/W4323348042","https://openalex.org/W4362458390","https://openalex.org/W4377291377","https://openalex.org/W4391539888","https://openalex.org/W4399258347","https://openalex.org/W4406380317","https://openalex.org/W4412653397","https://openalex.org/W4414874765","https://openalex.org/W7128587845","https://openalex.org/W7165573689"],"related_works":["https://openalex.org/W7161945275","https://openalex.org/W173825413","https://openalex.org/W2806443711","https://openalex.org/W7128687280","https://openalex.org/W4404287251","https://openalex.org/W2248793453","https://openalex.org/W2800837436","https://openalex.org/W3157293950","https://openalex.org/W4404164475","https://openalex.org/W3028975468"],"abstract_inverted_index":{"In":[0,192],"recent":[1,47],"years,":[2],"significant":[3],"progress":[4],"has":[5,196],"been":[6],"made":[7],"in":[8,25,38,54,75,100],"the":[9,12,21,30,51,76,96,115,149,164,173,189],"study":[10],"of":[11,17,20,36,93,167,175,239],"pathological":[13],"mechanisms":[14,32,88],"and":[15,33,49,59,79,85,110,134,170,172,184,219,237],"pathology":[16],"steroid-induced":[18,240],"osteonecrosis":[19],"femoral":[22,242],"head":[23,243],"(SONFH)":[24],"adults.":[26,94,139],"However,":[27,140],"research":[28],"on":[29,66,181,215],"molecular":[31,60,199],"clinical":[34],"translation":[35],"SONFH":[37,158,195],"children":[39,101],"remains":[40],"relatively":[41],"limited.":[42],"This":[43],"narrative":[44],"review":[45],"synthesizes":[46],"studies":[48],"reviews":[50],"latest":[52],"advances":[53],"etiology,":[55],"pathogenesis,":[56],"genetic":[57,176,216],"susceptibility,":[58],"mechanisms,":[61],"with":[62,107,145],"a":[63,103,120,160,197,223],"particular":[64],"focus":[65],"pediatric-specific":[67],"features.":[68],"Unlike":[69],"adults,":[70],"children's":[71],"skeletons":[72],"are":[73],"still":[74],"developmental":[77],"stage,":[78],"their":[80],"vascular":[81,105],"architecture,":[82],"metabolic":[83],"characteristics,":[84],"injury":[86],"repair":[87],"differ":[89],"significantly":[90],"from":[91,205,227],"those":[92],"Specifically,":[95],"open":[97],"growth":[98,116,150],"plate":[99,151],"creates":[102],"unique":[104,198],"architecture":[106],"distinct":[108,204],"epiphyseal":[109],"metaphyseal":[111],"blood":[112],"supplies,":[113],"while":[114],"plate's":[117],"elasticity":[118],"provides":[119],"biomechanical":[121],"buffering":[122],"effect":[123],"against":[124],"increased":[125],"intraosseous":[126],"pressure.":[127],"Children's":[128],"bones":[129],"also":[130],"exhibit":[131],"superior":[132],"remodeling":[133],"regenerative":[135],"capacity":[136],"compared":[137],"to":[138,221,230],"these":[141],"advantages":[142],"gradually":[143],"diminish":[144],"age,":[146],"particularly":[147],"as":[148],"approaches":[152],"closure":[153],"during":[154],"puberty.":[155],"Furthermore,":[156],"pediatric":[157,194,241],"is":[159,203],"complex":[161],"disease":[162],"involving":[163],"combined":[165],"effects":[166],"multiple":[168],"genes":[169],"pathways,":[171],"impact":[174],"variations":[177],"may":[178],"vary":[179],"depending":[180],"treatment":[182,224,238],"regimens":[183],"ethnic":[185],"backgrounds,":[186],"further":[187],"increasing":[188],"disease's":[190],"complexity.":[191],"summary,":[193],"biological":[200],"basis":[201],"that":[202],"adult":[206],"SONFH.":[207],"Future":[208],"efforts":[209],"should":[210],"incorporate":[211],"assessment":[212],"methods":[213],"based":[214],"susceptibility":[217],"loci":[218],"biomarkers":[220],"establish":[222],"model":[225],"ranging":[226],"early":[228],"warning":[229],"personalized":[231],"intervention,":[232],"thereby":[233],"achieving":[234],"precise":[235],"prevention":[236],"necrosis.":[244]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-07T00:00:00"}