{"id":"https://openalex.org/W7220659366","doi":"https://doi.org/10.4048/jbc.2026.0085","title":"Poly(ADP-ribose) Polymerase Inhibitor Talazoparib Inhibits DNA Damage Repair in Breast Cancer Cell Lines With or Without BRCA1/2 Mutation","display_name":"Poly(ADP-ribose) Polymerase Inhibitor Talazoparib Inhibits DNA Damage Repair in Breast Cancer Cell Lines With or Without BRCA1/2 Mutation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7220659366","doi":"https://doi.org/10.4048/jbc.2026.0085","pmid":"https://pubmed.ncbi.nlm.nih.gov/42834605"},"language":"en","primary_location":{"id":"doi:10.4048/jbc.2026.0085","doi":"https://doi.org/10.4048/jbc.2026.0085","is_oa":true,"landing_page_url":"https://doi.org/10.4048/jbc.2026.0085","pdf_url":null,"source":{"id":"https://openalex.org/S149213541","display_name":"Journal of Breast Cancer","issn_l":"1598-3641","issn":["1598-3641","1738-6756","2092-9900"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","norway-1","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Breast Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4048/jbc.2026.0085","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015454590","display_name":"Miso Lee","orcid":"https://orcid.org/0009-0002-3224-9145","observed_orcids":["https://orcid.org/0009-0002-3224-9145","https://orcid.org/0009-0008-4025-5856","https://orcid.org/0000-0002-3372-705X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Miso Lee","raw_affiliation_strings":["Cancer Research Institute, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0008-4025-5856","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886232","display_name":"Kyung-Hun Lee","orcid":"https://orcid.org/0000-0002-2390-3240","observed_orcids":["https://orcid.org/0000-0002-2390-3240"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Hun Lee","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea","Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2390-3240","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086634668","display_name":"Ahrum Min","orcid":"https://orcid.org/0000-0003-3236-838X","observed_orcids":["https://orcid.org/0000-0003-3236-838X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ahrum Min","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3236-838X","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054479509","display_name":"Sujin Ham","orcid":"https://orcid.org/0009-0002-4000-5239","observed_orcids":["https://orcid.org/0009-0002-4000-5239"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sujin Ham","raw_affiliation_strings":["Cancer Research Institute, Seoul National University, Seoul, Korea","Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0002-4000-5239","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110992029","display_name":"Jihyeon Moon","orcid":"https://orcid.org/0009-0003-3661-8697","observed_orcids":["https://orcid.org/0009-0003-3661-8697"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihyeon Moon","raw_affiliation_strings":["Cancer Research Institute, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0003-3661-8697","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157761774","display_name":"Yu-Jin Kim","orcid":"https://orcid.org/0009-0001-0808-3686","observed_orcids":["https://orcid.org/0009-0001-0808-3686"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu-Jin Kim","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0001-0808-3686","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073856619","display_name":"Hae Min Hwang","orcid":"https://orcid.org/0009-0002-3807-6783","observed_orcids":["https://orcid.org/0009-0002-3807-6783"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hae Min Hwang","raw_affiliation_strings":["Cancer Research Institute, Seoul National University, Seoul, Korea","Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0002-3807-6783","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065370213","display_name":"Youlim Noh","orcid":"https://orcid.org/0009-0002-7993-9397","observed_orcids":["https://orcid.org/0009-0002-7993-9397"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youlim Noh","raw_affiliation_strings":["Cancer Research Institute, Seoul National University, Seoul, Korea","Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0002-7993-9397","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081450991","display_name":"Eunice Yoojin Lee","orcid":"https://orcid.org/0000-0001-9342-423X","observed_orcids":["https://orcid.org/0000-0001-9342-423X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunice Yoojin Lee","raw_affiliation_strings":["Department of Internal Medicine, University of California San Francisco, San Francisco, USA"],"raw_orcid":"https://orcid.org/0000-0001-9342-423X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of California San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152624737","display_name":"Hye Yeon Park","orcid":"https://orcid.org/0009-0001-1712-5585","observed_orcids":["https://orcid.org/0009-0001-1712-5585"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Yeon Park","raw_affiliation_strings":["Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0001-1712-5585","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023831858","display_name":"Jiwon Koh","orcid":"https://orcid.org/0000-0002-7687-6477","observed_orcids":["https://orcid.org/0000-0002-7687-6477"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiwon Koh","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea","Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7687-6477","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061924691","display_name":"Changhee Park","orcid":"https://orcid.org/0000-0002-7125-9795","observed_orcids":["https://orcid.org/0000-0002-7125-9795"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Changhee Park","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea","Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7125-9795","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033149765","display_name":"Dae\u2010Won Lee","orcid":"https://orcid.org/0000-0001-7133-6669","observed_orcids":["https://orcid.org/0000-0001-7133-6669"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Won Lee","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea","Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7133-6669","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069050806","display_name":"Seock\u2010Ah Im","orcid":"https://orcid.org/0000-0002-5396-6533","observed_orcids":["https://orcid.org/0000-0002-5396-6533"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4405258583","display_name":"Seoul National University Hospital Biomedical Research Institute","ror":"https://ror.org/00xx85724","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405258583"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seock-Ah Im","raw_affiliation_strings":["Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","Cancer Research Institute, Seoul National University, Seoul, Korea","Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea","Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5396-6533","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388","https://openalex.org/I4405258583"]},{"raw_affiliation_string":"Cancer Research Institute, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Internal Medicine and Translational Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"5","first_page":"395","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8309999704360962},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/brca2-mutation","display_name":"BRCA2 mutation","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.9020000100135803},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8379999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parp1-trapping","display_name":"PARP1 trapping","score":0.7400000095367432},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7459999918937683},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.6660000085830688},{"id":"https://openalex.org/keywords/rpa-phosphorylation","display_name":"RPA phosphorylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7491000294685364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6212000250816345},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.616599977016449},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5597000122070312},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5561000108718872},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5519999861717224},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5300999879837036},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.5056999921798706},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.47530001401901245},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4503999948501587},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.44029998779296875},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.43650001287460327},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4343999922275543},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3817000091075897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3481000065803528},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3012999892234802},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2881999909877777},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.25589999556541443}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4048/jbc.2026.0085","doi":"https://doi.org/10.4048/jbc.2026.0085","is_oa":true,"landing_page_url":"https://doi.org/10.4048/jbc.2026.0085","pdf_url":null,"source":{"id":"https://openalex.org/S149213541","display_name":"Journal of Breast Cancer","issn_l":"1598-3641","issn":["1598-3641","1738-6756","2092-9900"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","norway-1","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Breast Cancer","raw_type":"journal-article"},{"id":"pmid:42834605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42834605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of breast cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4048/jbc.2026.0085","doi":"https://doi.org/10.4048/jbc.2026.0085","is_oa":true,"landing_page_url":"https://doi.org/10.4048/jbc.2026.0085","pdf_url":null,"source":{"id":"https://openalex.org/S149213541","display_name":"Journal of Breast Cancer","issn_l":"1598-3641","issn":["1598-3641","1738-6756","2092-9900"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","norway-1","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Breast Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1973268287","https://openalex.org/W1982602899","https://openalex.org/W2046406848","https://openalex.org/W2074730941","https://openalex.org/W2083960841","https://openalex.org/W2098737737","https://openalex.org/W2145200068","https://openalex.org/W2187574279","https://openalex.org/W2343685960","https://openalex.org/W2528228811","https://openalex.org/W2531736191","https://openalex.org/W2567140140","https://openalex.org/W2732346161","https://openalex.org/W2735881421","https://openalex.org/W2754327139","https://openalex.org/W2759659372","https://openalex.org/W2806210526","https://openalex.org/W2886477543","https://openalex.org/W2900056609","https://openalex.org/W2975141952","https://openalex.org/W2995641421","https://openalex.org/W3004561516","https://openalex.org/W3134914296","https://openalex.org/W4283012954","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W2594265850","https://openalex.org/W4313368192","https://openalex.org/W4389227568","https://openalex.org/W2399357550","https://openalex.org/W3184156379","https://openalex.org/W4401164999","https://openalex.org/W2741337068","https://openalex.org/W3013350468","https://openalex.org/W2241624846","https://openalex.org/W2601536553"],"abstract_inverted_index":{"PURPOSE:":[0],"/2":[1],"wild-type":[2,9,37],"breast":[3],"cancer":[4],"cells.":[5],"METHODS:":[6],"/2-mutant":[7,35],"and":[8,15,30,36,53,68,77,86,103],"cells,":[10],"were":[11,32,93],"treated":[12],"with":[13],"talazoparib,":[14],"the":[16,19],"effects":[17],"of":[18,51],"treatment":[20],"on":[21,107],"cell":[22,24,61,97],"proliferation,":[23],"cycle":[25],"progression,":[26],"DNA":[27,55],"damage":[28,56],"accumulation,":[29],"apoptosis":[31],"evaluated.":[33],"RESULTS:":[34],"cells":[38],"in":[39,59,95],"a":[40],"long-term":[41],"culture":[42],"system,":[43],"as":[44,63,80],"assessed":[45],"by":[46,65,74,82],"colony":[47],"formation":[48],"assays.":[49],"Accumulation":[50],"single-stranded":[52],"double-stranded":[54],"was":[57,72],"observed":[58,94],"talazoparib-sensitive":[60,96],"lines,":[62,98],"indicated":[64],"phosphorylated":[66],"RPA":[67],"\u03b3-H2AX,":[69],"respectively.":[70],"This":[71],"accompanied":[73],"G2/M":[75],"arrest":[76],"subsequent":[78],"apoptosis,":[79],"evidenced":[81],"cleaved":[83],"caspase-3":[84],"expression":[85],"Annexin":[87],"V":[88],"staining.":[89],"Abnormal":[90],"mitotic":[91],"nuclei":[92],"which":[99],"also":[100],"exhibited":[101],"potent":[102],"sustained":[104],"PARP1":[105],"trapping":[106],"chromatin.":[108],"CONCLUSION:":[109],"-mutant":[110],"tumors.":[111]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-07T00:00:00"}
