{"id":"https://openalex.org/W7220655197","doi":"https://doi.org/10.64898/2026.10.05.756662","title":"Thioesterase modulates antibacterial Type VI secretion system via alteration in oxidative stress responses in Burkholderia","display_name":"Thioesterase modulates antibacterial Type VI secretion system via alteration in oxidative stress responses in Burkholderia","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220655197","doi":"https://doi.org/10.64898/2026.10.05.756662"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.756662","doi":"https://doi.org/10.64898/2026.10.05.756662","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756662.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124014432","display_name":"Rajni Yadav","orcid":"https://orcid.org/0009-0003-7349-5964","observed_orcids":["https://orcid.org/0009-0003-7349-5964"]},"institutions":[{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajni Yadav","raw_affiliation_strings":["BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India"],"raw_orcid":"https://orcid.org/0009-0003-7349-5964","affiliations":[{"raw_affiliation_string":"BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India","institution_ids":["https://openalex.org/I4210153536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051668345","display_name":"Kristi Kabyashree","orcid":"https://orcid.org/0000-0002-0408-3160","observed_orcids":["https://orcid.org/0000-0002-0408-3160"]},"institutions":[{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]},{"id":"https://openalex.org/I4405253771","display_name":"Atria University","ror":"https://ror.org/012avmg86","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405253771"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kristi Kabyashree","raw_affiliation_strings":["BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India","COE-Life Sciences, Atria University, Bengaluru, Karnataka-560024, India"],"raw_orcid":"https://orcid.org/0000-0002-0408-3160","affiliations":[{"raw_affiliation_string":"BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India","institution_ids":["https://openalex.org/I4210153536"]},{"raw_affiliation_string":"COE-Life Sciences, Atria University, Bengaluru, Karnataka-560024, India","institution_ids":["https://openalex.org/I4405253771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100749674","display_name":"Rahul Kumar","orcid":"https://orcid.org/0000-0001-7781-0309","observed_orcids":["https://orcid.org/0000-0001-7781-0309"]},"institutions":[{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rahul Kumar","raw_affiliation_strings":["BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India"],"raw_orcid":"https://orcid.org/0000-0001-7781-0309","affiliations":[{"raw_affiliation_string":"BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India","institution_ids":["https://openalex.org/I4210153536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102898392","display_name":"Meenakshi Roy","orcid":"https://orcid.org/0009-0009-2036-6521","observed_orcids":["https://orcid.org/0009-0009-2036-6521"]},"institutions":[{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mandira Roy","raw_affiliation_strings":["BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India"],"raw_orcid":"https://orcid.org/0009-0009-2036-6521","affiliations":[{"raw_affiliation_string":"BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India","institution_ids":["https://openalex.org/I4210153536"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051900247","display_name":"Gopaljee Jha","orcid":"https://orcid.org/0000-0002-3965-3135","observed_orcids":["https://orcid.org/0000-0002-3965-3135"]},"institutions":[{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gopaljee Jha","raw_affiliation_strings":["BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India"],"raw_orcid":"https://orcid.org/0000-0002-3965-3135","affiliations":[{"raw_affiliation_string":"BRIC-National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi-110067, India","institution_ids":["https://openalex.org/I4210153536"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051900247"],"corresponding_institution_ids":["https://openalex.org/I4210153536"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioesterase","display_name":"thioesterase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/type-vi-secretion-system","display_name":"type VI secretion system","score":0.9900000095367432},{"id":"https://openalex.org/keywords/burkholderia-gladioli","display_name":"Burkholderia gladioli","score":0.9629999995231628},{"id":"https://openalex.org/keywords/siderophore-biosynthesis","display_name":"siderophore biosynthesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.7770000100135803},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/reactive-oxygen-species-homeostasis","display_name":"reactive oxygen species homeostasis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interbacterial-competition","display_name":"bacterial competition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/plant-colonization","display_name":"plant colonization","score":0.7390000224113464},{"id":"https://openalex.org/keywords/contact-dependent-killing","display_name":"contact-dependent killing","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2780622759","wikidata":"https://www.wikidata.org/wiki/Q76818446","display_name":"Thioesterase","level":4,"score":0.8166999816894531},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7287999987602234},{"id":"https://openalex.org/C2780855054","wikidata":"https://www.wikidata.org/wiki/Q135239","display_name":"Burkholderia","level":3,"score":0.6105999946594238},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5769000053405762},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5767999887466431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5026999711990356},{"id":"https://openalex.org/C2778827730","wikidata":"https://www.wikidata.org/wiki/Q24944355","display_name":"Type VI secretion system","level":4,"score":0.4848000109195709},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4781999886035919},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.4733000099658966},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.46070000529289246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45210000872612},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.439300000667572},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42179998755455017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4124000072479248},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.4027999937534332},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3734999895095825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3695000112056732},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29499998688697815},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C130211564","wikidata":"https://www.wikidata.org/wiki/Q21199165","display_name":"Type three secretion system","level":4,"score":0.26440000534057617},{"id":"https://openalex.org/C191678065","wikidata":"https://www.wikidata.org/wiki/Q7905656","display_name":"V-ATPase","level":4,"score":0.2583000063896179}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.05.756662","doi":"https://doi.org/10.64898/2026.10.05.756662","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.756662","doi":"https://doi.org/10.64898/2026.10.05.756662","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/06/2026.10.05.756662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306227","display_name":"Arthritis National Research Foundation","ror":"https://ror.org/03abbex33"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220655197.pdf","grobid_xml":"https://content.openalex.org/works/W7220655197.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1529038629","https://openalex.org/W1568956298","https://openalex.org/W1603707660","https://openalex.org/W2014937949","https://openalex.org/W2015093385","https://openalex.org/W2044734067","https://openalex.org/W2060635096","https://openalex.org/W2062134783","https://openalex.org/W2087126790","https://openalex.org/W2094643746","https://openalex.org/W2107277218","https://openalex.org/W2127438500","https://openalex.org/W2136943949","https://openalex.org/W2147722966","https://openalex.org/W2154300730","https://openalex.org/W2165573752","https://openalex.org/W2170758673","https://openalex.org/W2260987152","https://openalex.org/W2511722628","https://openalex.org/W2535017472","https://openalex.org/W2561508218","https://openalex.org/W2563256976","https://openalex.org/W2581865612","https://openalex.org/W2593090067","https://openalex.org/W2597760097","https://openalex.org/W2619139233","https://openalex.org/W2731958902","https://openalex.org/W2750038298","https://openalex.org/W2783189103","https://openalex.org/W2800713905","https://openalex.org/W2803815369","https://openalex.org/W2888636777","https://openalex.org/W2899044262","https://openalex.org/W2998020331","https://openalex.org/W3012018132","https://openalex.org/W3035939071","https://openalex.org/W3045315172","https://openalex.org/W3092436616","https://openalex.org/W3107629351","https://openalex.org/W3152401000","https://openalex.org/W3175149249","https://openalex.org/W3214357955","https://openalex.org/W4200597810","https://openalex.org/W4206401475","https://openalex.org/W4220696355","https://openalex.org/W4220766074","https://openalex.org/W4224883251","https://openalex.org/W4237385302","https://openalex.org/W4287377372","https://openalex.org/W4288038966","https://openalex.org/W4297143350","https://openalex.org/W4312076858","https://openalex.org/W4312213835","https://openalex.org/W4362521449","https://openalex.org/W4366603308","https://openalex.org/W4388523533","https://openalex.org/W4390671370","https://openalex.org/W4391969077","https://openalex.org/W4399923661","https://openalex.org/W4400542375","https://openalex.org/W4403233279","https://openalex.org/W4406736918","https://openalex.org/W4416794423","https://openalex.org/W4417153366","https://openalex.org/W7154596257"],"related_works":["https://openalex.org/W3152401000","https://openalex.org/W3210339660","https://openalex.org/W4403116751","https://openalex.org/W1970786682","https://openalex.org/W7126211513","https://openalex.org/W7204995818","https://openalex.org/W4391969077","https://openalex.org/W2987448451","https://openalex.org/W3040897417","https://openalex.org/W4390671370"],"abstract_inverted_index":{"Abstract":[0],"Bacteria":[1],"utilize":[2],"specialized":[3],"protein":[4],"secretion":[5,11],"systems,":[6],"particularly":[7],"the":[8,20,33,38,47,50,57,75,78,100,172],"type":[9],"VI":[10],"system":[12],"(T6SS),":[13],"to":[14,92,122],"dominate":[15],"interbacterial":[16,147],"competitions":[17],"and":[18,71,125,140,165,185],"kill":[19],"prey":[21],"bacteria":[22,184],"in":[23,37,49,56,127,138,178,183],"a":[24,108],"contact-dependent":[25],"manner.":[26],"Here,":[27],"we":[28],"report":[29],"that":[30,99,118,158],"disruption":[31],"of":[32,59,74,106,132,176],"thioesterase":[34,62,86,160],"gene":[35,44,76],"encoded":[36],"gramibactin":[39],"(a":[40],"bacterial":[41],"siderophore)":[42],"biosynthetic":[43],"cluster":[45],"activates":[46,141,166],"T6SS":[48,114,128],"Burkholderia":[51],"gladioli":[52],"strain":[53],"NGJ1,":[54],"even":[55],"absence":[58],"prey.":[60],"The":[61,95],"mutant":[63,82,102],"(":[64],"\u0394thio":[65,81,101],")":[66],"exhibits":[67],"enhanced":[68,90],"antibacterial":[69,187],"activity,":[70],"ectopic":[72],"expression":[73,105],"complements":[77],"phenotype.":[79],"Notably,":[80],"as":[83,85],"well":[84],"-complement":[87],"strains":[88],"show":[89],"sensitivity":[91],"oxidative":[93,123,135],"stress.":[94],"qRT-PCR":[96],"analysis":[97],"showed":[98],"had":[103],"upregulated":[104],"RpoN1,":[107],"sigma":[109],"factor,":[110],"which":[111],"positively":[112],"regulates":[113],"functions.":[115],"We":[116,143],"demonstrate":[117],"\u0394rpoN1":[119],"is":[120],"hypersensitive":[121],"stress":[124,136],"defective":[126],"activation,":[129],"whereas":[130],"overexpression":[131],"RpoN1":[133,163],"enhances":[134],"tolerance":[137],"NGJ1":[139,153],"T6SS.":[142,167],"propose":[144],"that,":[145],"during":[146,150],"conflicts":[148],"encountered":[149],"plant":[151],"colonization,":[152],"faces":[154],"an":[155],"oxidative-stress-enriched":[156],"environment":[157],"modulates":[159],"expression,":[161],"induces":[162],",":[164],"Overall,":[168],"our":[169],"study":[170],"exemplifies":[171],"broader":[173],"physiological":[174],"role":[175],"Thioesterase":[177],"maintaining":[179],"intracellular":[180],"ROS":[181],"homeostasis":[182],"stimulating":[186],"activity.":[188]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-07T00:00:00"}
