{"id":"https://openalex.org/W7220654564","doi":"https://doi.org/10.3389/fimmu.2026.1961903","title":"Targeting lysine acetyltransferase 6A/B in cancer: a conceptual and translational review of epigenetic regulation, immune microenvironment remodeling, and the dual-compartment hypothesis","display_name":"Targeting lysine acetyltransferase 6A/B in cancer: a conceptual and translational review of epigenetic regulation, immune microenvironment remodeling, and the dual-compartment hypothesis","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220654564","doi":"https://doi.org/10.3389/fimmu.2026.1961903","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13681363"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1961903","doi":"https://doi.org/10.3389/fimmu.2026.1961903","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1961903","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1961903/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1961903/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037299835","display_name":"Cong Ma","orcid":"https://orcid.org/0000-0002-7912-1424","observed_orcids":["https://orcid.org/0000-0002-7912-1424"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Ma","raw_affiliation_strings":["Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023331712","display_name":"Jingru Wang","orcid":"https://orcid.org/0009-0007-7599-3771","observed_orcids":["https://orcid.org/0009-0007-7599-3771"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingru Wang","raw_affiliation_strings":["Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157730609","display_name":"Guanhua Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanhua Qiao","raw_affiliation_strings":["Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136155910","display_name":"Xinhong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinhong Wu","raw_affiliation_strings":["Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122281206","display_name":"Hongmei Zheng","orcid":"https://orcid.org/0000-0001-8955-4218","observed_orcids":["https://orcid.org/0000-0001-8955-4218"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongmei Zheng","raw_affiliation_strings":["Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5122281206","https://openalex.org/A5136155910"],"corresponding_institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I47720641"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43144795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1961903","last_page":"1961903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.5410000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.5410000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.10480000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.765999972820282},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9419999718666077},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.8330000042915344},{"id":"https://openalex.org/keywords/protac-degraders","display_name":"PROTAC degraders","score":0.9340000152587891},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.7900000214576721},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6935999989509583},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6682000160217285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6075000166893005},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5710999965667725},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.505299985408783},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41670000553131104},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.37549999356269836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3571000099182129},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3495999872684479},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.26759999990463257},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.2547000050544739}],"mesh":[{"descriptor_ui":"D000070837","descriptor_name":"Lysine Acetyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000070837","descriptor_name":"Lysine Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000070837","descriptor_name":"Lysine Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000094243","descriptor_name":"Proteolysis Targeting Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1961903","doi":"https://doi.org/10.3389/fimmu.2026.1961903","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1961903","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1961903/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13681363","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681363/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681363/pdf/fimmu-17-1961903.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42903410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ba7b54334e6448ce866839f68a54ee7d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ba7b54334e6448ce866839f68a54ee7d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1961903","doi":"https://doi.org/10.3389/fimmu.2026.1961903","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1961903","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1961903/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7033261041","display_name":null,"funder_award_id":"WJ2025Q058","funder_id":"https://openalex.org/F4320317798","funder_display_name":"Health Commission of Hubei Province"}],"funders":[{"id":"https://openalex.org/F4320317798","display_name":"Health Commission of Hubei Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220654564.pdf","grobid_xml":"https://content.openalex.org/works/W7220654564.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W1907661270","https://openalex.org/W1910012553","https://openalex.org/W1953890763","https://openalex.org/W1967214802","https://openalex.org/W1971590084","https://openalex.org/W1972274031","https://openalex.org/W1985991629","https://openalex.org/W1986598783","https://openalex.org/W1998162919","https://openalex.org/W2016305287","https://openalex.org/W2016661249","https://openalex.org/W2036397325","https://openalex.org/W2036701253","https://openalex.org/W2038590884","https://openalex.org/W2066671159","https://openalex.org/W2095617425","https://openalex.org/W2096083625","https://openalex.org/W2107556275","https://openalex.org/W2117138389","https://openalex.org/W2138659224","https://openalex.org/W2143277424","https://openalex.org/W2144914032","https://openalex.org/W2147516356","https://openalex.org/W2148862424","https://openalex.org/W2295526061","https://openalex.org/W2337959725","https://openalex.org/W2411937682","https://openalex.org/W2521615871","https://openalex.org/W2521913238","https://openalex.org/W2534222932","https://openalex.org/W2536322725","https://openalex.org/W2541574334","https://openalex.org/W2549188196","https://openalex.org/W2560129407","https://openalex.org/W2581279204","https://openalex.org/W2592133876","https://openalex.org/W2605076107","https://openalex.org/W2738136165","https://openalex.org/W2785803176","https://openalex.org/W2809237949","https://openalex.org/W2884937981","https://openalex.org/W2887443702","https://openalex.org/W2907564726","https://openalex.org/W2909165540","https://openalex.org/W2913744515","https://openalex.org/W2943793201","https://openalex.org/W2954445592","https://openalex.org/W2956018511","https://openalex.org/W2970843395","https://openalex.org/W2982017357","https://openalex.org/W3009779122","https://openalex.org/W3081970986","https://openalex.org/W3122102409","https://openalex.org/W3150482938","https://openalex.org/W3150736119","https://openalex.org/W3173222845","https://openalex.org/W3176618876","https://openalex.org/W3194486794","https://openalex.org/W3204518392","https://openalex.org/W3215621251","https://openalex.org/W4212858046","https://openalex.org/W4214566297","https://openalex.org/W4221091893","https://openalex.org/W4225984600","https://openalex.org/W4291298171","https://openalex.org/W4293157076","https://openalex.org/W4297976316","https://openalex.org/W4327921948","https://openalex.org/W4365483183","https://openalex.org/W4367599184","https://openalex.org/W4379285941","https://openalex.org/W4382181400","https://openalex.org/W4385295851","https://openalex.org/W4385650419","https://openalex.org/W4386187743","https://openalex.org/W4387591891","https://openalex.org/W4387783860","https://openalex.org/W4387798596","https://openalex.org/W4390956299","https://openalex.org/W4391956909","https://openalex.org/W4394844082","https://openalex.org/W4394847328","https://openalex.org/W4396591151","https://openalex.org/W4399255326","https://openalex.org/W4399737534","https://openalex.org/W4399775730","https://openalex.org/W4400427359","https://openalex.org/W4402271792","https://openalex.org/W4402863609","https://openalex.org/W4403141262","https://openalex.org/W4404111439","https://openalex.org/W4404195411","https://openalex.org/W4405042267","https://openalex.org/W4405565294","https://openalex.org/W4406094079","https://openalex.org/W4406501988","https://openalex.org/W4406833317","https://openalex.org/W4407230173","https://openalex.org/W4408693566","https://openalex.org/W4409690151","https://openalex.org/W4409691101","https://openalex.org/W4409821531","https://openalex.org/W4409865056","https://openalex.org/W4411274976","https://openalex.org/W4411452293","https://openalex.org/W4411754653","https://openalex.org/W4411942191","https://openalex.org/W4412137786","https://openalex.org/W4412459617","https://openalex.org/W4412548902","https://openalex.org/W4413311287","https://openalex.org/W4414153329","https://openalex.org/W4414889715","https://openalex.org/W4415104866","https://openalex.org/W4416869935","https://openalex.org/W4417026620","https://openalex.org/W4417027510","https://openalex.org/W4417183457","https://openalex.org/W4417484362","https://openalex.org/W7116113704","https://openalex.org/W7117357431","https://openalex.org/W7126059792","https://openalex.org/W7128596470","https://openalex.org/W7129551847","https://openalex.org/W7140043872","https://openalex.org/W7140098225","https://openalex.org/W7148733668","https://openalex.org/W7148895505","https://openalex.org/W7154741501","https://openalex.org/W7214209210"],"related_works":["https://openalex.org/W4417026620","https://openalex.org/W3022640766","https://openalex.org/W2899175470","https://openalex.org/W4415444373","https://openalex.org/W4409689574","https://openalex.org/W2518453524","https://openalex.org/W4393095664","https://openalex.org/W2887443702","https://openalex.org/W4409628051","https://openalex.org/W4396591047"],"abstract_inverted_index":{"While":[0],"lysine":[1],"acetyltransferase":[2],"6A":[3],"(KAT6A;":[4],"MOZ/MYST3)":[5],"and":[6,31,43,62,110,134,144,217,225,246],"6B":[7],"(KAT6B;":[8],"MORF/MYST4)":[9],"function":[10],"as":[11,25,53,213],"context-dependent":[12],"oncogenic":[13],"drivers-with":[14],"KAT6B":[15,203],"also":[16,155],"displaying":[17],"tissue-specific":[18],"tumor-suppressive":[19],"roles-their":[20],"pharmacological":[21,40,180],"targeting":[22],"holds":[23],"promise":[24],"a":[26,54,138],"therapeutic":[27,244],"avenue.":[28],"This":[29],"conceptual":[30,55],"translational":[32,210],"review":[33],"synthesizes":[34],"evidence":[35,61,193],"from":[36,179,195],"genetic":[37,176,196],"depletion":[38],"models,":[39,197],"catalytic":[41],"inhibitors,":[42],"emerging":[44],"proteolysis-targeting":[45],"chimera":[46],"(PROTAC)":[47],"degraders,":[48],"introducing":[49],"the":[50,71,82,127,151,191],"\"Dual-Compartment":[51],"Hypothesis\"":[52],"interpretive":[56],"framework":[57],"to":[58,88,166,221,252],"organize":[59],"current":[60,231],"generate":[63],"testable":[64,209],"hypotheses":[65],"regarding":[66],"their":[67],"putative":[68,115],"impacts":[69],"on":[70,118],"tumor":[72,84,99,152],"immune":[73,119,142,148],"microenvironment":[74,153],"(TIME).":[75],"Under":[76],"this":[77],"framework,":[78],"KAT6A/B":[79,160],"blockade":[80],"within":[81,150],"primary":[83],"compartment":[85,129],"is":[86,186],"proposed":[87],"indirectly":[89],"foster":[90],"regional":[91],"antitumor":[92],"immunity":[93],"via":[94],"preclinically":[95],"implicated":[96],"pathways,":[97],"including":[98],"cell":[100],"ferroptosis,":[101],"cyclic":[102],"GMP-AMP":[103],"synthase-stimulator":[104],"of":[105,190],"interferon":[106],"genes":[107],"(cGAS-STING)":[108],"activation,":[109],"interleukin-6":[111],"(IL-6)":[112],"suppression,":[113],"alongside":[114],"downstream":[116],"influences":[117],"checkpoints.":[120],"In":[121],"contrast,":[122],"systemic":[123,145],"drug":[124],"exposure":[125],"in":[126],"secondary":[128],"may":[130,154],"directly":[131,157],"alter":[132],"hematopoiesis":[133],"lymphocyte":[135],"development,":[136],"creating":[137],"tension":[139],"between":[140],"local":[141],"activation":[143],"constraints.":[146],"Importantly,":[147],"cells":[149],"be":[156,167],"suppressed":[158],"by":[159],"inhibition-an":[161],"alternative":[162],"outcome":[163],"that":[164,185,230],"remains":[165],"systematically":[168],"investigated.":[169],"Resolving":[170],"these":[171],"divergent":[172],"outcomes":[173],"necessitates":[174],"distinguishing":[175],"knockout/knockdown":[177],"(KO/KD)":[178],"inhibition":[181],"or":[182],"degradation-a":[183],"distinction":[184],"critical":[187],"because":[188],"much":[189],"mechanistic":[192],"derives":[194],"while":[198,228],"accounting":[199],"for":[200],"KAT6A":[201],"versus":[202],"isoform":[204],"selectivity.":[205],"Finally,":[206],"we":[207],"outline":[208],"frameworks,":[211],"such":[212],"intermittent":[214],"dosing":[215],"schedules":[216],"rational":[218],"immunotherapeutic":[219],"combinations,":[220],"direct":[222],"subsequent":[223],"experimental":[224],"clinical":[226,233],"validation,":[227],"acknowledging":[229],"early-phase":[232],"observations":[234],"(objective":[235],"response":[236],"rate":[237,240],"[ORR]/clinical":[238],"benefit":[239],"[CBR])":[241],"reflect":[242],"composite":[243],"responses":[245],"require":[247],"further":[248],"paired":[249],"biomarker":[250],"validation":[251],"definitively":[253],"isolate":[254],"immune-mediated":[255],"effects.":[256]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-07T00:00:00"}