{"id":"https://openalex.org/W7220654222","doi":"https://doi.org/10.3389/fcvm.2026.1952434","title":"Ubiquitination regulation in coronary microcirculation dysfunction: focus on the endothelial cells","display_name":"Ubiquitination regulation in coronary microcirculation dysfunction: focus on the endothelial cells","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220654222","doi":"https://doi.org/10.3389/fcvm.2026.1952434","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903409","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13680752"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1952434","doi":"https://doi.org/10.3389/fcvm.2026.1952434","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1952434","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1952434/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1952434/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157677277","display_name":"Qingying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingying Zhang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151391242","display_name":"Tingting Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Wang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157747815","display_name":"Siyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Wang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004583279","display_name":"\u9648\u7389\u5584","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yushan Chen","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157664385","display_name":"Yiwen Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Sheng","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157736943","display_name":"Haodi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haodi Zhang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157687093","display_name":"Yunhao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunhao Wang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120396735","display_name":"Jin BoYuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boyuan Jin","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120396736","display_name":"Hua ChengJun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengjun Hua","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157687842","display_name":"Xinyi Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Han","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","The First Clinical Medical College, Henan University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210144860"]},{"raw_affiliation_string":"The First Clinical Medical College, Henan University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004583279"],"corresponding_institution_ids":["https://openalex.org/I4210144860"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43137803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1952434","last_page":"1952434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9649999737739563},{"id":"https://openalex.org/keywords/coronary-microvascular-dysfunction","display_name":"coronary microvascular dysfunction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/coronary-microcirculation","display_name":"coronary microcirculation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9210000038146973},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.9620000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":1.0},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.859000027179718},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6317999958992004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6225000023841858},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5320000052452087},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.47540000081062317},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.46790000796318054},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4171999990940094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4133000075817108},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.353300005197525},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.34709998965263367},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3253999948501587},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31619998812675476},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25920000672340393},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2026.1952434","doi":"https://doi.org/10.3389/fcvm.2026.1952434","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1952434","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1952434/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13680752","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13680752/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13680752/pdf/fcvm-13-1952434.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:42903409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:00a3bb4c26db4130a1a41785522e3b3c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/00a3bb4c26db4130a1a41785522e3b3c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1952434","doi":"https://doi.org/10.3389/fcvm.2026.1952434","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1952434","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1952434/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329926","display_name":"National Health Commission of the People's Republic of China","ror":"https://ror.org/04bdenw41"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220654222.pdf","grobid_xml":"https://content.openalex.org/works/W7220654222.grobid-xml"},"referenced_works_count":150,"referenced_works":["https://openalex.org/W170281222","https://openalex.org/W187359130","https://openalex.org/W1600472471","https://openalex.org/W1832030339","https://openalex.org/W1993429855","https://openalex.org/W1995747121","https://openalex.org/W2039778682","https://openalex.org/W2070068309","https://openalex.org/W2071374729","https://openalex.org/W2088504425","https://openalex.org/W2128345996","https://openalex.org/W2136781613","https://openalex.org/W2137949264","https://openalex.org/W2148707962","https://openalex.org/W2166987747","https://openalex.org/W2171783221","https://openalex.org/W2289887068","https://openalex.org/W2418215637","https://openalex.org/W2549913707","https://openalex.org/W2553689505","https://openalex.org/W2584949986","https://openalex.org/W2600455045","https://openalex.org/W2612329843","https://openalex.org/W2732350501","https://openalex.org/W2750793803","https://openalex.org/W2765506069","https://openalex.org/W2803941007","https://openalex.org/W2889640115","https://openalex.org/W2939317173","https://openalex.org/W2947524951","https://openalex.org/W2965306804","https://openalex.org/W2965419534","https://openalex.org/W2969472398","https://openalex.org/W2982176822","https://openalex.org/W2988480211","https://openalex.org/W2997129745","https://openalex.org/W3002503982","https://openalex.org/W3044688449","https://openalex.org/W3055867783","https://openalex.org/W3082530693","https://openalex.org/W3083851647","https://openalex.org/W3087617819","https://openalex.org/W3096728664","https://openalex.org/W3112674048","https://openalex.org/W3133605163","https://openalex.org/W3192264994","https://openalex.org/W3196588895","https://openalex.org/W3213199654","https://openalex.org/W4200244578","https://openalex.org/W4200562358","https://openalex.org/W4205544024","https://openalex.org/W4221083268","https://openalex.org/W4223538125","https://openalex.org/W4229032225","https://openalex.org/W4283031293","https://openalex.org/W4283727954","https://openalex.org/W4302424765","https://openalex.org/W4313829875","https://openalex.org/W4315702564","https://openalex.org/W4318198444","https://openalex.org/W4323074900","https://openalex.org/W4323538339","https://openalex.org/W4367186182","https://openalex.org/W4376121536","https://openalex.org/W4377103532","https://openalex.org/W4380523383","https://openalex.org/W4380576423","https://openalex.org/W4380793651","https://openalex.org/W4382181640","https://openalex.org/W4382632016","https://openalex.org/W4384820117","https://openalex.org/W4385406218","https://openalex.org/W4386101484","https://openalex.org/W4386162782","https://openalex.org/W4386198060","https://openalex.org/W4386386625","https://openalex.org/W4386568250","https://openalex.org/W4386725727","https://openalex.org/W4387078012","https://openalex.org/W4387497697","https://openalex.org/W4387739252","https://openalex.org/W4387842100","https://openalex.org/W4387966831","https://openalex.org/W4388570169","https://openalex.org/W4388625747","https://openalex.org/W4389410268","https://openalex.org/W4389505727","https://openalex.org/W4390240070","https://openalex.org/W4390745089","https://openalex.org/W4390748663","https://openalex.org/W4391721179","https://openalex.org/W4391723879","https://openalex.org/W4391780612","https://openalex.org/W4392034896","https://openalex.org/W4392197161","https://openalex.org/W4392376649","https://openalex.org/W4392796288","https://openalex.org/W4393087662","https://openalex.org/W4394689701","https://openalex.org/W4394785758","https://openalex.org/W4394823910","https://openalex.org/W4394869704","https://openalex.org/W4395049333","https://openalex.org/W4396779865","https://openalex.org/W4397032105","https://openalex.org/W4399471968","https://openalex.org/W4399534802","https://openalex.org/W4399867153","https://openalex.org/W4400621015","https://openalex.org/W4400951634","https://openalex.org/W4401026736","https://openalex.org/W4401395051","https://openalex.org/W4402313775","https://openalex.org/W4402520183","https://openalex.org/W4402689723","https://openalex.org/W4402884250","https://openalex.org/W4403024588","https://openalex.org/W4403044933","https://openalex.org/W4403417425","https://openalex.org/W4403703780","https://openalex.org/W4404054585","https://openalex.org/W4404105387","https://openalex.org/W4405294566","https://openalex.org/W4406235869","https://openalex.org/W4406942828","https://openalex.org/W4407563827","https://openalex.org/W4407722201","https://openalex.org/W4407761353","https://openalex.org/W4407776404","https://openalex.org/W4407858834","https://openalex.org/W4407879628","https://openalex.org/W4408893588","https://openalex.org/W4409541014","https://openalex.org/W4410014075","https://openalex.org/W4410177683","https://openalex.org/W4410591560","https://openalex.org/W4411184165","https://openalex.org/W4411297589","https://openalex.org/W4412599724","https://openalex.org/W4412710016","https://openalex.org/W4413293191","https://openalex.org/W4414487033","https://openalex.org/W4415249077","https://openalex.org/W4415566161","https://openalex.org/W4416566767","https://openalex.org/W7118015674","https://openalex.org/W7119122982","https://openalex.org/W7124418681","https://openalex.org/W7127953435","https://openalex.org/W7166684490"],"related_works":["https://openalex.org/W7118015674","https://openalex.org/W7165894555","https://openalex.org/W4318198444","https://openalex.org/W3200114168","https://openalex.org/W339506736","https://openalex.org/W3002577956","https://openalex.org/W4401645775","https://openalex.org/W2003504771","https://openalex.org/W4220848299","https://openalex.org/W4388007324"],"abstract_inverted_index":{"Basic":[0],"and":[1,48,56,81,104,112,122,140],"clinical":[2],"research":[3],"on":[4],"coronary":[5,20,85,102],"microvascular":[6,86],"disease":[7],"(CMD)":[8],"has":[9,23],"spanned":[10],"half":[11],"a":[12,15,25,32,50],"century.":[13],"As":[14],"pathogenesis":[16],"independent":[17],"of":[18,72,125],"epicardial":[19],"stenosis,":[21],"CMD":[22,73],"become":[24],"major":[26],"hotspot":[27],"in":[28,36,53,69,84,94,100,109],"cardiovascular":[29,54],"medicine.":[30],"Ubiquitination,":[31],"vital":[33],"post-translational":[34],"modification":[35],"eukaryotic":[37],"cells,":[38],"precisely":[39],"regulates":[40],"target":[41],"proteins":[42],"via":[43],"the":[44,62,70,127],"E1-E2-E3":[45],"enzymatic":[46],"cascade":[47],"plays":[49],"critical":[51],"role":[52],"homeostasis":[55],"pathophysiology.":[57],"Recent":[58],"evidence":[59],"indicates":[60],"that":[61],"ubiquitin-proteasome":[63],"system":[64],"(UPS)":[65],"is":[66],"deeply":[67],"involved":[68],"development":[71],"by":[74],"modulating":[75],"nitric":[76],"oxide":[77],"production,":[78],"barrier":[79],"function,":[80],"inflammatory":[82],"signaling":[83],"endothelial":[87],"cells.":[88],"This":[89],"review":[90],"summarizes":[91],"recent":[92],"advances":[93],"ubiquitination,":[95],"elaborates":[96],"its":[97,106],"molecular":[98],"mechanisms":[99],"regulating":[101],"microcirculation,":[103],"dissects":[105],"pathogenic":[107],"roles":[108],"diabetes,":[110],"hypertension,":[111],"myocardial":[113],"ischemia/reperfusion":[114],"injury":[115],"(MIRI).We":[116],"further":[117],"discuss":[118],"potential":[119],"therapeutic":[120],"strategies":[121],"translational":[123],"challenges":[124],"targeting":[126],"ubiquitination":[128],"pathway":[129],"for":[130,147],"CMD,":[131],"including":[132],"proteasome":[133],"inhibitors,":[134],"E3":[135],"ligase":[136],"modulators,":[137],"deubiquitinase":[138],"agonists,":[139],"PROTACs,":[141],"aiming":[142],"to":[143],"provide":[144],"new":[145],"insights":[146],"future":[148],"research.":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-07T00:00:00"}