{"id":"https://openalex.org/W7220653772","doi":"https://doi.org/10.3389/fimmu.2026.1932718","title":"Towards epigenetically informed and biobank-driven precision immunotherapy in melanoma","display_name":"Towards epigenetically informed and biobank-driven precision immunotherapy in melanoma","publication_year":2026,"publication_date":"2026-10-06","ids":{"openalex":"https://openalex.org/W7220653772","doi":"https://doi.org/10.3389/fimmu.2026.1932718","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13681299"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1932718","doi":"https://doi.org/10.3389/fimmu.2026.1932718","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932718","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932718/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932718/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019167350","display_name":"Ludovica Ciuffreda","orcid":"https://orcid.org/0000-0002-7964-7119","observed_orcids":["https://orcid.org/0000-0002-7964-7119"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ludovica Ciuffreda","raw_affiliation_strings":["Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065468093","display_name":"Italia Falcone","orcid":"https://orcid.org/0000-0003-2796-0792","observed_orcids":["https://orcid.org/0000-0003-2796-0792"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Italia Falcone","raw_affiliation_strings":["Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063749499","display_name":"Cristina Sorino","orcid":"https://orcid.org/0000-0002-6100-289X","observed_orcids":["https://orcid.org/0000-0002-6100-289X"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Sorino","raw_affiliation_strings":["Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111240971","display_name":"Alessandro Valenti","orcid":"https://orcid.org/0009-0001-1327-9296","observed_orcids":["https://orcid.org/0009-0001-1327-9296"]},"institutions":[{"id":"https://openalex.org/I4210141574","display_name":"San Gallicano Hospital","ror":"https://ror.org/03zhmy467","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210137471","https://openalex.org/I4210141574","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Valenti","raw_affiliation_strings":["Radiology and Diagnostic Imaging Unit, Department of Clinical and Dermatological Research, San Gallicano Dermatological Institute IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology and Diagnostic Imaging Unit, Department of Clinical and Dermatological Research, San Gallicano Dermatological Institute IRCCS","institution_ids":["https://openalex.org/I4210141574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093796848","display_name":"Celeste Accetta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Celeste Accetta","raw_affiliation_strings":["Department of Pathology Unit, Tissue Biobank, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Unit, Tissue Biobank, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063051267","display_name":"Francesca De Nicola","orcid":"https://orcid.org/0000-0002-2187-7544","observed_orcids":["https://orcid.org/0000-0002-2187-7544"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca De Nicola","raw_affiliation_strings":["Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047482498","display_name":"Valentina Roglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Roglia","raw_affiliation_strings":["Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057548226","display_name":"Maurizio Fanciulli","orcid":"https://orcid.org/0000-0002-5281-4191","observed_orcids":["https://orcid.org/0000-0002-5281-4191"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Fanciulli","raw_affiliation_strings":["Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene expression and Cancer Model Unit, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047759445","display_name":"Giovanni Blandino","orcid":"https://orcid.org/0000-0002-6970-2241","observed_orcids":["https://orcid.org/0000-0002-6970-2241"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Blandino","raw_affiliation_strings":["Scientific Direction, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Direction, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091117889","display_name":"Edoardo O. Pescarmona","orcid":"https://orcid.org/0009-0007-8743-8951","observed_orcids":["https://orcid.org/0009-0007-8743-8951","https://orcid.org/0000-0002-0443-9331"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Pescarmona","raw_affiliation_strings":["Department of Pathology Unit, Tissue Biobank, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Unit, Tissue Biobank, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136169181","display_name":"Simona Di Martino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Di Martino","raw_affiliation_strings":["Department of Pathology Unit, Tissue Biobank, IRCCS Regina Elena National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Unit, Tissue Biobank, IRCCS Regina Elena National Cancer Institute","institution_ids":["https://openalex.org/I4387152244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019167350"],"corresponding_institution_ids":["https://openalex.org/I4387152244"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52542186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1932718","last_page":"1932718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8119999766349792},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6800000071525574},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cold-tumors","display_name":"cold tumors","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7269999980926514},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.6610000133514404},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.621999979019165},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.9259999990463257},{"id":"https://openalex.org/keywords/biobanking","display_name":"biobanking","score":0.7089999914169312},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/spatial-profiling","display_name":"spatial profiling","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.675599992275238},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6536999940872192},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6499000191688538},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6358000040054321},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4657999873161316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46399998664855957},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.45809999108314514},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.4408999979496002},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.44029998779296875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4287000000476837},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4106000065803528},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3774000108242035},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.37560001015663147},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3668999969959259},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3499000072479248},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3452000021934509},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.34310001134872437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33079999685287476},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.295199990272522},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.29440000653266907},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.25}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018070","descriptor_name":"Biological Specimen Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1932718","doi":"https://doi.org/10.3389/fimmu.2026.1932718","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932718","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932718/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13681299","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681299/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681299/pdf/fimmu-17-1932718.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42903663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9fa85315a7d941bebef71560b7280921","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9fa85315a7d941bebef71560b7280921","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1932718","doi":"https://doi.org/10.3389/fimmu.2026.1932718","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932718","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932718/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G304590355","display_name":"Providing cutting edge cancer research services across Europe","funder_award_id":"101058620","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G9000924140","display_name":null,"funder_award_id":"CANSERV GA N. 101058620","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220653772.pdf","grobid_xml":"https://content.openalex.org/works/W7220653772.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1492293982","https://openalex.org/W1953890763","https://openalex.org/W1985594917","https://openalex.org/W2008322756","https://openalex.org/W2011458181","https://openalex.org/W2018433132","https://openalex.org/W2028994134","https://openalex.org/W2055246997","https://openalex.org/W2102448788","https://openalex.org/W2118263932","https://openalex.org/W2127956110","https://openalex.org/W2133701572","https://openalex.org/W2153162429","https://openalex.org/W2157681026","https://openalex.org/W2165263439","https://openalex.org/W2186855780","https://openalex.org/W2271028635","https://openalex.org/W2326014866","https://openalex.org/W2491982852","https://openalex.org/W2569601970","https://openalex.org/W2587048937","https://openalex.org/W2592983486","https://openalex.org/W2594897444","https://openalex.org/W2606495925","https://openalex.org/W2655262992","https://openalex.org/W2737220388","https://openalex.org/W2797906965","https://openalex.org/W2801309958","https://openalex.org/W2807611908","https://openalex.org/W2809237949","https://openalex.org/W2865458437","https://openalex.org/W2884607428","https://openalex.org/W2912870841","https://openalex.org/W2913558101","https://openalex.org/W2913744515","https://openalex.org/W2955958085","https://openalex.org/W2973246174","https://openalex.org/W2974304113","https://openalex.org/W3004480399","https://openalex.org/W3093166440","https://openalex.org/W3100080748","https://openalex.org/W3134746059","https://openalex.org/W3152326806","https://openalex.org/W3177829085","https://openalex.org/W3183988223","https://openalex.org/W3202943405","https://openalex.org/W4200168827","https://openalex.org/W4210612530","https://openalex.org/W4220666345","https://openalex.org/W4221010007","https://openalex.org/W4238041119","https://openalex.org/W4307927142","https://openalex.org/W4309665401","https://openalex.org/W4311156429","https://openalex.org/W4377104854","https://openalex.org/W4386958475","https://openalex.org/W4391067309","https://openalex.org/W4391098890","https://openalex.org/W4391423461","https://openalex.org/W4392194573","https://openalex.org/W4394579481","https://openalex.org/W4400135507","https://openalex.org/W4400162392","https://openalex.org/W4400493920","https://openalex.org/W4402552559","https://openalex.org/W4402552706","https://openalex.org/W4403299725","https://openalex.org/W4404460040","https://openalex.org/W4405481199","https://openalex.org/W4409484001","https://openalex.org/W4409967449","https://openalex.org/W4410019298","https://openalex.org/W4410027175","https://openalex.org/W4410784603","https://openalex.org/W4414015057","https://openalex.org/W4416088670","https://openalex.org/W7119978530","https://openalex.org/W7123654696","https://openalex.org/W7128741093","https://openalex.org/W7130426324","https://openalex.org/W7133996110","https://openalex.org/W7142458164"],"related_works":["https://openalex.org/W7162297135","https://openalex.org/W4281488890","https://openalex.org/W2071383348","https://openalex.org/W2997289071","https://openalex.org/W7140057502","https://openalex.org/W4411545855","https://openalex.org/W3197627168","https://openalex.org/W2096925818","https://openalex.org/W2057243929","https://openalex.org/W3188062518"],"abstract_inverted_index":{"Cutaneous":[0],"melanoma":[1,32,86,101,121],"(CM)":[2],"is":[3,161,232],"a":[4,123,235],"highly":[5],"immunogenic":[6],"and":[7,17,78,103,129,166,194,208,226],"therapeutically":[8,131],"intricate":[9],"solid":[10],"tumor,":[11],"exemplifying":[12],"the":[13,18,22,54,90,104,107,138,146,180,203],"interactions":[14],"between":[15],"tumors":[16],"immune":[19,35,49,96,108,133,173,224],"system.":[20],"Despite":[21],"significant":[23,65],"enhancement":[24],"in":[25,84,111,245],"survival":[26],"rates":[27],"for":[28,238],"patients":[29,40],"with":[30,186],"advanced":[31],"due":[33],"to":[34,44,57,113,171,197],"checkpoint":[36],"inhibitors":[37],"(ICIs),":[38],"numerous":[39],"either":[41],"exhibit":[42],"resistance":[43],"these":[45,116],"agents":[46],"or":[47,151],"develop":[48],"evasion":[50],"mechanisms.":[51],"This":[52,88,135,160,230],"underscores":[53],"pressing":[55],"necessity":[56,181],"identify":[58],"biological":[59],"determinants":[60],"of":[61,67,92,106,126,149,182,190,205],"drug":[62],"responses.":[63],"A":[64],"body":[66],"research":[68,236],"indicates":[69],"that":[70,141],"epigenetic":[71,142,222],"alterations,":[72],"including":[73],"DNA":[74],"methylation,":[75],"histone":[76],"modifications,":[77],"ATP-dependent":[79],"chromatin":[80],"remodeling,":[81],"are":[82,118],"essential":[83],"modulating":[85],"immunogenicity.":[87],"encompasses":[89],"modulation":[91],"antigen":[93],"presentation,":[94],"innate":[95],"detection,":[97],"interferon":[98],"(IFN)":[99],"signaling,":[100],"plasticity,":[102],"reconfiguration":[105],"microenvironment.":[109],"Furthermore,":[110],"contrast":[112],"genetic":[114],"mutations,":[115],"mechanisms":[117],"reversible,":[119],"positioning":[120],"as":[122,234],"prime":[124],"example":[125],"epigenetically":[127],"regulated":[128],"potentially":[130],"targeted":[132],"resistance.":[134],"review":[136],"examines":[137],"novel":[139],"insight":[140],"therapies":[143],"can":[144],"enhance":[145],"immunological":[147],"activity":[148],"\"cold\"":[150],"immune-excluded":[152],"melanomas,":[153],"transforming":[154],"them":[155],"into":[156],"inflamed,":[157],"drug-responsive":[158],"tumors.":[159],"achievable":[162],"by":[163],"restoring":[164],"antigenicity":[165],"reactivating":[167],"IFN-related":[168],"pathways,":[169],"leading":[170],"enhanced":[172],"cell":[174],"infiltration.":[175],"The":[176],"paper":[177],"also":[178],"addresses":[179],"longitudinal":[183],"biobanking":[184],"combined":[185],"integrated":[187],"multi-omics":[188],"analyses":[189],"epigenomics,":[191],"transcriptomics,":[192],"proteomics,":[193],"spatial":[195],"profiling":[196],"investigate":[198],"dynamic":[199],"tumor-immune":[200],"configurations,":[201],"support":[202],"validation":[204],"candidate":[206],"biomarkers,":[207],"explore":[209],"biologically":[210],"informed":[211,242],"patient":[212],"stratification.":[213],"In":[214],"conclusion,":[215],"we":[216],"propose":[217],"an":[218],"integrative":[219],"model":[220,231],"connecting":[221],"vulnerability,":[223],"reconfiguration,":[225],"biobank-driven":[227],"systems":[228],"biology.":[229],"proposed":[233],"framework":[237],"investigating":[239],"future":[240],"biomarker":[241],"immunotherapy":[243],"strategies":[244],"melanoma.":[246]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-07T00:00:00"}
