{"id":"https://openalex.org/W7220566147","doi":null,"title":"Studies On 3/7 Caspase Activity And Apoptosis Induction By Diarylheptaniods Isolated From Garuga Pinnata Roxb","display_name":"Studies On 3/7 Caspase Activity And Apoptosis Induction By Diarylheptaniods Isolated From Garuga Pinnata Roxb","publication_year":2023,"publication_date":"2023-12-31","ids":{"openalex":"https://openalex.org/W7220566147"},"language":"en","primary_location":{"id":"pmh:oai:jazindia.com:article/3145","doi":null,"is_oa":true,"landing_page_url":"https://jazindia.com/index.php/jaz/article/view/3145","pdf_url":"https://jazindia.com/index.php/jaz/article/download/3145/2938","source":{"id":"https://openalex.org/S39943216","display_name":"Journal Of Advanced Zoology","issn_l":"0253-7214","issn":["0253-7214"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-7214","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jazindia.com/index.php/jaz/article/download/3145/2938","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087387897","display_name":"Srilekha Konakanchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srilekha Konakanchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113986221","display_name":"Kireety Sharma Anumula","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kireety Sharma Anumula","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157470177","display_name":"Narashimulu K","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121750182","display_name":"National Institute of Technology Warangal","ror":"https://ror.org/017ebfz38","country_code":"IN","type":"education","lineage":["https://openalex.org/I121750182"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narashimulu K","raw_affiliation_strings":["Department of Biotechnology , National Institute of Technology , Warangal Urban 506001 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology , National Institute of Technology , Warangal Urban 506001 , India","institution_ids":["https://openalex.org/I121750182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064733047","display_name":"Thupurani Murali Krishna","orcid":"https://orcid.org/0000-0002-6117-8609","observed_orcids":["https://orcid.org/0000-0002-6117-8609"]},"institutions":[{"id":"https://openalex.org/I4405266258","display_name":"Chaitanya","ror":"https://ror.org/01m1bpg27","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405266258"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Thupurani Murali Krishna","raw_affiliation_strings":["Department of Biotechnology , Chaitanya (Deemed to be University) , Warangal Urban 506001 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology , Chaitanya (Deemed to be University) , Warangal Urban 506001 , India","institution_ids":["https://openalex.org/I4405266258"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.3330000042915344,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.3330000042915344,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.2467000037431717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.09730000048875809,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/garuga-pinnata","display_name":"Garuga pinnata","score":0.953000009059906},{"id":"https://openalex.org/keywords/diarylheptanoids","display_name":"diarylheptanoids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/caspase-3-7-activation","display_name":"caspase-3/7 activation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8899999856948853},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9760000109672546},{"id":"https://openalex.org/keywords/apoptosis-induction","display_name":"apoptosis induction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hct-15-cells","display_name":"HCT-15 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/stem-bark","display_name":"stem bark","score":0.7170000076293945},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.7562000155448914},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7476000189781189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49889999628067017},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4763000011444092},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4481000006198883},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4415999948978424},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4293999969959259},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.39500001072883606},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.38089999556541443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3718999922275543},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.36500000953674316},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.35659998655319214},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3181000053882599},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3174999952316284},{"id":"https://openalex.org/C2909889879","wikidata":"https://www.wikidata.org/wiki/Q13612179","display_name":"Diarylheptanoids","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C2775998712","wikidata":"https://www.wikidata.org/wiki/Q14907714","display_name":"Caspase-9","level":5,"score":0.30880001187324524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30869999527931213},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.3043000102043152},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2985999882221222},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.29840001463890076},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C3020810314","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptotic cell death","level":4,"score":0.26499998569488525},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:jazindia.com:article/3145","doi":null,"is_oa":true,"landing_page_url":"https://jazindia.com/index.php/jaz/article/view/3145","pdf_url":"https://jazindia.com/index.php/jaz/article/download/3145/2938","source":{"id":"https://openalex.org/S39943216","display_name":"Journal Of Advanced Zoology","issn_l":"0253-7214","issn":["0253-7214"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-7214","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:jazindia.com:article/3145","doi":null,"is_oa":true,"landing_page_url":"https://jazindia.com/index.php/jaz/article/view/3145","pdf_url":"https://jazindia.com/index.php/jaz/article/download/3145/2938","source":{"id":"https://openalex.org/S39943216","display_name":"Journal Of Advanced Zoology","issn_l":"0253-7214","issn":["0253-7214"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-7214","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317507","display_name":"National Institute of Technology Warangal","ror":"https://ror.org/017ebfz38"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220566147.pdf","grobid_xml":"https://content.openalex.org/works/W7220566147.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3153899304","https://openalex.org/W3144204191","https://openalex.org/W2039403143","https://openalex.org/W2769060182","https://openalex.org/W2058608085","https://openalex.org/W2031841948","https://openalex.org/W1986642213","https://openalex.org/W1675655239","https://openalex.org/W3146863502","https://openalex.org/W2104791703"],"abstract_inverted_index":{"This":[0],"study":[1],"aims":[2],"to":[3],"evaluate":[4],"the":[5,19,63,79],"stimulation":[6],"of":[7,16,82,87,97,103],"caspase":[8,49],"3/7,":[9,89],"8":[10],"and":[11,14,32,51,56,71,91],"9":[12,92],"activity":[13],"induction":[15,53],"apoptosis":[17,52],"by":[18,47,105],"diarylheptanoids":[20],"isolated":[21],"from":[22,78],"Garuga":[23],"pinnata":[24],"(G.":[25],"pinnata)":[26],"RoxB.":[27],"Garuganin":[28,69],"1,":[29],"3,":[30],"4":[31],"5":[33,72],"which":[34],"were":[35,73],"previously":[36],"reported":[37],"for":[38,43,75],"their":[39,44],"isolation":[40],"have":[41],"tested":[42],"anticancer":[45],"potencies":[46],"different":[48,106],"activation":[50,86,102],"in":[54],"MCF-7":[55],"HCT-15":[57],"cell":[58,99],"lines.":[59],"However,":[60],"based":[61],"on":[62],"MTT":[64],"assay":[65],"results":[66],"(Previously":[67],"reported)":[68],"3":[70],"selected":[74],"this":[76],"study.":[77],"stem":[80],"bark":[81],"G.":[83],"pinnata.":[84],"The":[85],"caspases":[88,104],"8,":[90],"is":[93],"a":[94],"conformational":[95],"process":[96],"cancer":[98],"death.":[100],"Such":[101],"concentrations":[107],"(05,":[108],"10,":[109],"15,":[110],"20":[111]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-06T00:00:00"}