{"id":"https://openalex.org/W7220469870","doi":"https://doi.org/10.1152/ajpheart.00475.2026","title":"A Newly Curated Single Cell Sequencing Atlas Predicts Efferocytic-dependent Crosstalk in Hearts","display_name":"A Newly Curated Single Cell Sequencing Atlas Predicts Efferocytic-dependent Crosstalk in Hearts","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7220469870","doi":"https://doi.org/10.1152/ajpheart.00475.2026","pmid":"https://pubmed.ncbi.nlm.nih.gov/42932980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13734699"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00475.2026","doi":"https://doi.org/10.1152/ajpheart.00475.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpheart.00475.2026","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1152/ajpheart.00475.2026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122857235","display_name":"Isaac Meite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Isaac Meite","raw_affiliation_strings":["Northwestern University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115516119","display_name":"Lorenzo Pesce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Pesce","raw_affiliation_strings":["Northwestern University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039826847","display_name":"Matthew J. Feinstein","orcid":"https://orcid.org/0000-0002-8958-7666","observed_orcids":["https://orcid.org/0000-0002-8958-7666"]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Feinstein","raw_affiliation_strings":["Indiana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027947816","display_name":"Edward Benjamin Thorp","orcid":"https://orcid.org/0000-0003-1387-7058","observed_orcids":["https://orcid.org/0000-0003-1387-7058"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward B. Thorp","raw_affiliation_strings":["Heart Center","Northwestern University"],"raw_orcid":"https://orcid.org/0000-0003-1387-7058","affiliations":[{"raw_affiliation_string":"Heart Center","institution_ids":[]},{"raw_affiliation_string":"Northwestern University","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012755429","display_name":"Connor W. Lantz","orcid":"https://orcid.org/0000-0003-3317-6486","observed_orcids":["https://orcid.org/0000-0003-3317-6486"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Connor W. Lantz","raw_affiliation_strings":["Northwestern University","Northwestern University Feinberg School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012755429","https://openalex.org/A5027947816","https://openalex.org/A5122857235"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74825587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mertk","display_name":"MERTK","score":0.9710000157356262},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cardiac-repair","display_name":"cardiac repair","score":0.7710000276565552},{"id":"https://openalex.org/keywords/macrophage-heterogeneity","display_name":"macrophage heterogeneity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7419999837875366},{"id":"https://openalex.org/keywords/efferocytosis","display_name":"efferocytosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ccr2-macrophages","display_name":"CCR2+ macrophages","score":0.800000011920929},{"id":"https://openalex.org/keywords/b-cell-expansion","display_name":"B cell expansion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/macrophage-identity","display_name":"macrophage identity","score":0.5339999794960022},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.7523999810218811},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5867000222206116},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5778999924659729},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5250999927520752},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.3626999855041504},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3497999906539917},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C141674004","wikidata":"https://www.wikidata.org/wiki/Q1344256","display_name":"Ensembl","level":5,"score":0.32089999318122864},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C52001869","wikidata":"https://www.wikidata.org/wiki/Q812530","display_name":"Naive Bayes classifier","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26429998874664307},{"id":"https://openalex.org/C2982933515","wikidata":"https://www.wikidata.org/wiki/Q104381823","display_name":"Public access","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25029999017715454}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1152/ajpheart.00475.2026","doi":"https://doi.org/10.1152/ajpheart.00475.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpheart.00475.2026","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13734699","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734699/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734699/pdf/nihms-2219283.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Heart Circ Physiol","raw_type":"Text"},{"id":"pmid:42932980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42932980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"},{"id":"doi:10.5281/zenodo.23132607","doi":"https://doi.org/10.5281/zenodo.23132607","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23132607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.23132608","doi":"https://doi.org/10.5281/zenodo.23132608","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23132608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1152/ajpheart.00475.2026","doi":"https://doi.org/10.1152/ajpheart.00475.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpheart.00475.2026","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000893708","display_name":"Phagocyte Crosstalk in the Balance of Inflammation & Cardiac Disease","funder_award_id":"R35HL177401","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308271","display_name":"American Society of Transplantation","ror":"https://ror.org/05cqqj259"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220469870.pdf","grobid_xml":"https://content.openalex.org/works/W7220469870.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387615205","https://openalex.org/W4404797296","https://openalex.org/W4296564754","https://openalex.org/W4389088620","https://openalex.org/W4388600160","https://openalex.org/W4385507215","https://openalex.org/W7062094131","https://openalex.org/W4417340517","https://openalex.org/W4404359653","https://openalex.org/W7166068889"],"abstract_inverted_index":{"Cardiac":[0],"repair":[1],"after":[2],"myocardial":[3],"infarction":[4],"(MI)":[5],"requires":[6],"coordinated":[7],"immune":[8,53,63,156],"cell":[9,64,79,131],"communication,":[10],"yet":[11],"the":[12,201,217,230,236],"signaling":[13,173],"networks":[14],"mediating":[15],"this":[16,97],"process":[17],"and":[18,39,85,137,228],"how":[19,49],"they":[20],"are":[21,144],"disrupted":[22],"in":[23,163,167,183,206,224],"disease":[24],"remain":[25],"incompletely":[26],"defined.":[27],"MERTK,":[28],"a":[29,60,90,147,161,191],"receptor":[30],"tyrosine":[31],"kinase":[32],"expressed":[33],"on":[34,96],"macrophages,":[35,136],"promotes":[36],"inflammation":[37],"resolution,":[38,57],"its":[40],"loss":[41],"leads":[42],"to":[43,113],"inefficient":[44],"cardiac":[45,52,62,72],"repair.":[46],"To":[47],"investigate":[48],"MERTK":[50,223],"shapes":[51],"communication":[54,233],"at":[55,121],"single-cell":[56],"we":[58],"constructed":[59],"curated":[61],"atlas":[65,98],"integrating":[66],"36,932":[67],"cells/nuclei":[68],"from":[69,149],"8":[70],"murine":[71],"RNA":[73],"sequencing":[74],"datasets,":[75],"yielding":[76],"22":[77],"annotated":[78],"populations":[80],"spanning":[81],"myeloid,":[82],"lymphoid,":[83],"endothelial,":[84],"stromal":[86,188,202],"compartments.":[87],"We":[88],"developed":[89],"cardiac-specific":[91],"k-nearest":[92],"neighbor":[93],"classifier":[94,112],"trained":[95],"that":[99,209],"achieved":[100],"an":[101],"enhanced":[102],"weighted":[103],"F1":[104],"versus":[105,117,153],"other":[106],"widely":[107],"used":[108],"platforms.":[109],"Applying":[110],"our":[111],"Mertk":[114],"knockout":[115],"(KO)":[116],"control":[118],"adult":[119],"mice":[120],"7":[122],"days":[123],"post-MI":[124,237],"revealed":[125,160],"striking":[126],"compositional":[127],"differences":[128],"including":[129],"B":[130],"expansion,":[132],"reduction":[133,162],"of":[134,139,171,235],"CCR2+":[135],"enrichment":[138],"MHCII":[140,210],"macrophages.":[141],"The":[142],"data":[143],"consistent":[145],"with":[146],"shift":[148],"monocyte-derived":[150],"macrophage-coordinated":[151],"activation":[152],"sustained":[154],"adaptive":[155],"activation.":[157],"CellChat":[158],"analysis":[159],"total":[164],"predicted":[165,218,231],"interactions":[166],"KOs":[168,184,207],"alongside":[169],"near-doubling":[170],"per-interaction":[172],"strength.":[174],"ARG1+":[175],"macrophages":[176,199,211],"selectively":[177],"lost":[178],"SPP1":[179],"autocrine":[180],"self-renewal":[181],"signatures":[182],"while":[185],"preserving":[186],"outgoing":[187],"signals.":[189],"Moreover,":[190],"multi-sender":[192],"Cyclophilin":[193],"A-CD147":[194],"program":[195],"deployed":[196],"by":[197],"mature":[198,213],"across":[200],"compartment":[203],"was":[204],"reprogrammed":[205],"so":[208],"replaced":[212],"macrophage":[214,226],"subtypes":[215],"as":[216],"sender.":[219],"These":[220],"findings":[221],"implicate":[222],"shaping":[225],"identity":[227],"influencing":[229],"intercellular":[232],"architecture":[234],"heart.":[238]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-06T00:00:00"}
