{"id":"https://openalex.org/W7220466908","doi":"https://doi.org/10.1002/ctd2.70214","title":"Stability\u2010guided transition modelling reveals an Active\u2010to\u2010Evasive immune ecosystem continuum in cervical cancer","display_name":"Stability\u2010guided transition modelling reveals an Active\u2010to\u2010Evasive immune ecosystem continuum in cervical cancer","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220466908","doi":"https://doi.org/10.1002/ctd2.70214"},"language":"en","primary_location":{"id":"doi:10.1002/ctd2.70214","doi":"https://doi.org/10.1002/ctd2.70214","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.70214","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70214","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70214","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157479978","display_name":"Chia\u2010Hung Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia\u2010Hung Chen","raw_affiliation_strings":["Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077544447","display_name":"Tzu\u2010Hsiang Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu\u2010Hsiang Weng","raw_affiliation_strings":["Department of Obstetrics and Gynecology MacKay Memorial Hospital  Taipei Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology MacKay Memorial Hospital  Taipei Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048626778","display_name":"Hui-Ju Kao","orcid":"https://orcid.org/0000-0001-6109-0319","observed_orcids":["https://orcid.org/0000-0001-6109-0319"]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui\u2010Ju Kao","raw_affiliation_strings":["Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159677320","display_name":"Chen\u2010Lin Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen\u2010Lin Yu","raw_affiliation_strings":["Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157416092","display_name":"Cheng\u2010Yi Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng\u2010Yi Pan","raw_affiliation_strings":["Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157445081","display_name":"Chen\u2010Chen Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen\u2010Chen Huang","raw_affiliation_strings":["Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157615171","display_name":"Kai\u2010Yao Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I35926432","display_name":"Mackay Medical University","ror":"https://ror.org/00t89kj24","country_code":"TW","type":"education","lineage":["https://openalex.org/I35926432"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kai\u2010Yao Huang","raw_affiliation_strings":["Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","Department of Medicine MacKay Medical University  New Taipei Taiwan Republic of China","Institute of Biomedical Sciences MacKay Medical University  New Taipei Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medical Research Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Medicine MacKay Medical University  New Taipei Taiwan Republic of China","institution_ids":["https://openalex.org/I35926432"]},{"raw_affiliation_string":"Institute of Biomedical Sciences MacKay Medical University  New Taipei Taiwan Republic of China","institution_ids":["https://openalex.org/I35926432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157534873","display_name":"Shun\u2010Long Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I35926432","display_name":"Mackay Medical University","ror":"https://ror.org/00t89kj24","country_code":"TW","type":"education","lineage":["https://openalex.org/I35926432"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shun\u2010Long Weng","raw_affiliation_strings":["Department of Biological Science and Technology College of Engineering Bioscience National Yang Ming Chiao Tung University  Hsinchu Taiwan Republic of China","Department of Medicine MacKay Medical University  New Taipei Taiwan Republic of China","Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","Department of Obstetrics and Gynecology Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology College of Engineering Bioscience National Yang Ming Chiao Tung University  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Medicine MacKay Medical University  New Taipei Taiwan Republic of China","institution_ids":["https://openalex.org/I35926432"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology Hsinchu Municipal MacKay Children's Hospital  Hsinchu Taiwan Republic of China","institution_ids":["https://openalex.org/I2802753785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5157534873","https://openalex.org/A5157615171"],"corresponding_institution_ids":["https://openalex.org/I148366613","https://openalex.org/I2802753785","https://openalex.org/I35926432"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72230992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.902999997138977},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7749999761581421},{"id":"https://openalex.org/keywords/immune-checkpoint-genes","display_name":"immune checkpoint genes","score":0.4230000078678131},{"id":"https://openalex.org/keywords/tigit","display_name":"TIGIT","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cd96","display_name":"CD96","score":0.8270000219345093},{"id":"https://openalex.org/keywords/prf1","display_name":"PRF1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nkg7","display_name":"NKG7","score":0.9750000238418579},{"id":"https://openalex.org/keywords/trac","display_name":"TRAC","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.734000027179718},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7820000052452087},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8222000002861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6449999809265137},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6323999762535095},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4185999929904938},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.40470001101493835},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4025000035762787},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3919999897480011},{"id":"https://openalex.org/C110872660","wikidata":"https://www.wikidata.org/wiki/Q37813","display_name":"Ecosystem","level":2,"score":0.3698999881744385},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3643999993801117},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3537999987602234},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3452000021934509},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3450999855995178},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.3343999981880188},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C2779118045","wikidata":"https://www.wikidata.org/wiki/Q21114021","display_name":"TIGIT","level":4,"score":0.3012999892234802},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.25600001215934753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ctd2.70214","doi":"https://doi.org/10.1002/ctd2.70214","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.70214","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70214","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:9522126ef42c48d5a53bc93b5aefbc00","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9522126ef42c48d5a53bc93b5aefbc00","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Discovery, Vol 6, Iss 5, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ctd2.70214","doi":"https://doi.org/10.1002/ctd2.70214","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.70214","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70214","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220466908.pdf","grobid_xml":"https://content.openalex.org/works/W7220466908.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1806981800","https://openalex.org/W1967954493","https://openalex.org/W1984883254","https://openalex.org/W2060469376","https://openalex.org/W2114586150","https://openalex.org/W2146512944","https://openalex.org/W2562162676","https://openalex.org/W2569856193","https://openalex.org/W2771542157","https://openalex.org/W2796207838","https://openalex.org/W2801309958","https://openalex.org/W2898830231","https://openalex.org/W2899145148","https://openalex.org/W2907783748","https://openalex.org/W2927507212","https://openalex.org/W2942610007","https://openalex.org/W3147368647","https://openalex.org/W3159772108","https://openalex.org/W3162215872","https://openalex.org/W3168566183","https://openalex.org/W4211233744","https://openalex.org/W4220893907","https://openalex.org/W4294541781","https://openalex.org/W4309467080","https://openalex.org/W4321167021","https://openalex.org/W4378212544","https://openalex.org/W4403245544","https://openalex.org/W4405983094","https://openalex.org/W7155445430"],"related_works":["https://openalex.org/W4380987109","https://openalex.org/W3112373113","https://openalex.org/W3160118848","https://openalex.org/W3134580165","https://openalex.org/W4323844336","https://openalex.org/W4383710320","https://openalex.org/W3205430003","https://openalex.org/W2811221708","https://openalex.org/W4283395766","https://openalex.org/W4388824136"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,86,261,319],"transcriptomic":[3,54,115,255,280],"organization":[4],"of":[5,100,107,163,195,219,286,328,353],"tumour":[6,225],"immune":[7,36,49,60,70,77,170,177,246,252,313,340],"ecosystems":[8],"in":[9,39,236,316],"cervical":[10,238,317],"cancer":[11,239],"remains":[12],"poorly":[13],"defined":[14],"beyond":[15],"conventional":[16],"static":[17],"immunophenotyping":[18],"frameworks.":[19],"Methods":[20],"In":[21],"the":[22,95,101,181,202,210,278,287,329,354],"present":[23],"study,":[24],"we":[25],"developed":[26],"a":[27,45,90,231,266,273,283,295,323],"stability\u2010guided":[28,308],"and":[29,58,68,82,97,113,136,153,187,197,222,257,291,334],"transition\u2010aware":[30],"systems":[31,233],"immuno\u2010oncology":[32,234],"framework":[33,43,309],"to":[34],"characterise":[35],"ecosystem":[37,50,61,247,263,314,343],"organisation":[38],"TCGA\u2010CESC.":[40],"Results":[41],"This":[42],"identified":[44,120],"biologically":[46,91,150,267,296,324,346],"coherent":[47],"Active\u2010to\u2010Evasive":[48,245,312],"continuum":[51,212,248,289,315,356],"through":[52],"continuous":[53],"modelling,":[55],"stability":[56,145],"analysis,":[57],"complementary":[59,154,335],"characterisation.":[62],"Active":[63,96],"tumours":[64,74,240],"demonstrated":[65,160,208],"preserved":[66],"interferon\u2010associated":[67],"cytotoxic":[69,169],"programs,":[71,109],"whereas":[72,172,277],"Evasive":[73,98,203],"exhibited":[75],"coordinated":[76,339],"attenuation":[78,106],"accompanied":[79],"by":[80,104,250],"hypoxia\u2010associated":[81],"adaptive":[83,254],"ecosystem\u2010remodelling":[84],"programs.":[85],"Intermediate":[87,262,320],"subgroup":[88],"occupied":[89],"structured":[92,268],"region":[93,270,327],"between":[94],"ends":[99],"continuum,":[102,182],"characterised":[103,249],"graded":[105,176,251],"immune\u2010active":[108],"altered":[110],"immune\u2010gene":[111],"coordination,":[112],"transition\u2010associated":[114,122,269,326],"remodelling.":[116],"Bootstrap\u2010guided":[117],"repeated\u2010convergence":[118],"analyses":[119,159,206,337],"reproducible":[121],"sentinel":[123,165],"genes,":[124,221],"including":[125,183],"SIRPG":[126],",":[127,129,131,133,135,138],"TIGIT":[128],"CD96":[130],"PRF1":[132],"NKG7":[134],"TRAC":[137],"which":[139,237],"consistently":[140],"converged":[141],"across":[142,180,342],"trajectory\u2010associated":[143],"analyses,":[144],"profiling,":[146],"Evidence":[147],"Matrix":[148],"prioritisation,":[149],"anchored":[151,297,347],"compression,":[152],"analytical":[155],"layers.":[156],"Single\u2010cell":[157],"localisation":[158],"preferential":[161],"enrichment":[162,194],"these":[164],"genes":[166,333],"within":[167],"activated":[168],"compartments,":[171],"LM22\u2010based":[173],"deconvolution":[174],"supported":[175],"compositional":[178],"remodelling":[179,341],"reduced":[184],"CD8":[185],"T\u2010cell":[186],"M1":[188],"macrophage\u2010associated":[189],"components":[190],"together":[191],"with":[192],"relative":[193],"neutrophil\u2010":[196],"macrophage":[198],"M0\u2010associated":[199],"fractions":[200],"towards":[201],"end.":[204],"Sensitivity":[205],"further":[207],"that":[209],"underlying":[211],"was":[213,292],"retained":[214],"after":[215],"outcome\u2010independent":[216],"reconstruction,":[217],"exclusion":[218],"immune\u2010definition":[220],"adjustment":[223],"for":[224],"purity.":[226],"Conclusions":[227],"These":[228],"findings":[229],"support":[230,338],"cross\u2010sectional":[232],"model":[235],"are":[241],"organised":[242],"along":[243],"an":[244,301,311],"attenuation,":[253],"remodelling,":[256],"increasing":[258],"immune\u2013tumour":[259],"uncoupling.":[260],"state":[264,321],"represents":[265,322],"rather":[271,299],"than":[272,300],"simple":[274],"residual":[275],"category,":[276],"compressed":[279],"representation":[281],"captured":[282],"parsimonious":[284],"component":[285],"broader":[288,355],"architecture":[290],"interpreted":[293],"as":[294],"projection":[298],"independently":[302],"validated":[303],"prognostic":[304],"signature.":[305],"Highlights":[306],"A":[307,345],"characterises":[310],"cancer.":[318],"structured,":[325],"inferred":[330],"continuum.":[331],"Sentinel":[332],"cellular":[336],"states.":[344],"7\u2010gene":[348],"compression":[349],"preserves":[350],"core":[351],"features":[352],"architecture.":[357]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-06T00:00:00"}