{"id":"https://openalex.org/W7220466607","doi":"https://doi.org/10.64898/2026.10.02.755967","title":"A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria","display_name":"A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220466607","doi":"https://doi.org/10.64898/2026.10.02.755967"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.755967","doi":"https://doi.org/10.64898/2026.10.02.755967","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.755967","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.755967.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.755967.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116472657","display_name":"Jaime Fernandez-Macgregor","orcid":"https://orcid.org/0000-0002-2494-6541","observed_orcids":["https://orcid.org/0000-0002-2494-6541"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jaime Fernandez-Macgregor","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-2494-6541","affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120779873","display_name":"Laura Ilari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laura Ilari","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026704745","display_name":"Fabien Durbesson","orcid":"https://orcid.org/0000-0001-7972-2054","observed_orcids":["https://orcid.org/0000-0001-7972-2054"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Durbesson","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-7972-2054","affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002637615","display_name":"St\u00e9phane Audebert","orcid":"https://orcid.org/0000-0002-9409-2588","observed_orcids":["https://orcid.org/0000-0002-9409-2588"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Audebert","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Marseille Proteomics, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-9409-2588","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Marseille Proteomics, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021912565","display_name":"Luc Camoin","orcid":"https://orcid.org/0000-0002-1230-4787","observed_orcids":["https://orcid.org/0000-0002-1230-4787"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Luc Camoin","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Marseille Proteomics, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-1230-4787","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Marseille Proteomics, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012331147","display_name":"Bastien Morlet","orcid":"https://orcid.org/0000-0001-6058-7366","observed_orcids":["https://orcid.org/0000-0001-6058-7366"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bastien Morlet","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire IGBMC, Universit\u00e9 de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, F-67404 Illkirch, France"],"raw_orcid":"https://orcid.org/0000-0001-6058-7366","affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire IGBMC, Universit\u00e9 de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, F-67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007677700","display_name":"Virginie Millet","orcid":"https://orcid.org/0000-0001-6014-3001","observed_orcids":["https://orcid.org/0000-0001-6014-3001"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Millet","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy, CIML, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-6014-3001","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy, CIML, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077180700","display_name":"Jean Michel Dela Vedova-Costa","orcid":"https://orcid.org/0000-0002-5656-7239","observed_orcids":["https://orcid.org/0000-0002-5656-7239"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jean Michel Dela Vedova-Costa","raw_affiliation_strings":["Molecular Biology Laboratory, Federal University of Parana, Curitiba, Parana 81531-990, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Laboratory, Federal University of Parana, Curitiba, Parana 81531-990, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157596206","display_name":"Charlene Gaedke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charlene Gaedke","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157471955","display_name":"Vincent Kourilsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Kourilsky","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123859570","display_name":"Lou Bergogne","orcid":"https://orcid.org/0009-0004-9409-0154","observed_orcids":["https://orcid.org/0009-0004-9409-0154"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lou Bergogne","raw_affiliation_strings":["Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024105275","display_name":"Eric Mart\u00ednez","orcid":"https://orcid.org/0000-0001-8568-3725","observed_orcids":["https://orcid.org/0000-0001-8568-3725"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Martinez","raw_affiliation_strings":["Institut de Recherche en Infectiologie de Montpelier (IRIM), CNRS UMR 9004, Universit\u00e9 de Montpelier, Montpelier, France"],"raw_orcid":"https://orcid.org/0000-0001-8568-3725","affiliations":[{"raw_affiliation_string":"Institut de Recherche en Infectiologie de Montpelier (IRIM), CNRS UMR 9004, Universit\u00e9 de Montpelier, Montpelier, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020571619","display_name":"Achille Broggi","orcid":"https://orcid.org/0000-0002-7244-2401","observed_orcids":["https://orcid.org/0000-0002-7244-2401"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Achille Broggi","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy, CIML, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy, CIML, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007070901","display_name":"Jean\u2010Paul Borg","orcid":"https://orcid.org/0000-0001-8418-3382","observed_orcids":["https://orcid.org/0000-0001-8418-3382"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I185839726","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266","country_code":"FR","type":"education","lineage":["https://openalex.org/I185839726"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Paul Borg","raw_affiliation_strings":["Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Marseille Proteomics, Marseille, France","Institut Universitaire de France, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-8418-3382","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Marseille Proteomics, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"raw_affiliation_string":"Institut Universitaire de France, Paris, France","institution_ids":["https://openalex.org/I185839726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026921239","display_name":"S\u00f8ren \u00d8stergaard","orcid":"https://orcid.org/0000-0002-9415-3352","observed_orcids":["https://orcid.org/0000-0002-9415-3352"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren \u00d8stergaard","raw_affiliation_strings":["Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Research Park, 2760, Maaloev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Research Park, 2760, Maaloev, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031768698","display_name":"Gilles Trav\u00e9","orcid":"https://orcid.org/0000-0002-4160-4121","observed_orcids":["https://orcid.org/0000-0002-4160-4121"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Trave","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire IGBMC, Universit\u00e9 de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, F-67404 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire IGBMC, Universit\u00e9 de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, F-67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016373272","display_name":"\u00c9lodie Monsellier","orcid":"https://orcid.org/0000-0001-7944-7531","observed_orcids":["https://orcid.org/0000-0001-7944-7531"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Monsellier","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire IGBMC, Universit\u00e9 de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, F-67404 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire IGBMC, Universit\u00e9 de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, F-67404 Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060161630","display_name":"Christine Brun","orcid":"https://orcid.org/0000-0002-5563-6765","observed_orcids":["https://orcid.org/0000-0002-5563-6765"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Brun","raw_affiliation_strings":["Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France","CNRS, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"CNRS, Marseille, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088248109","display_name":"Andreas Zanzoni","orcid":"https://orcid.org/0000-0002-4818-6161","observed_orcids":["https://orcid.org/0000-0002-4818-6161"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andreas Zanzoni","raw_affiliation_strings":["Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-4818-6161","affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, INSERM, TAGC, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053486944","display_name":"Renaud Vincentelli","orcid":"https://orcid.org/0000-0001-9667-0196","observed_orcids":["https://orcid.org/0000-0001-9667-0196"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Renaud Vincentelli","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-9667-0196","affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Architecture et Fonction des Macromol\u00e9cules Biologiques, AFMB, UMR CNRS 7257, Turing Center for Living Systems, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5053486944"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.6439999938011169},{"id":"https://openalex.org/keywords/molecular-mimicry","display_name":"molecular mimicry","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pdz-binding-motif","display_name":"PDZ-binding motif","score":0.9729999899864197},{"id":"https://openalex.org/keywords/protein-protein-binding-affinity","display_name":"protein-protein binding affinity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bacterial-effectors","display_name":"bacterial effector proteins","score":0.656000018119812},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pathogenic-bacteria","display_name":"pathogenic bacteria","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intracellular-transport","display_name":"intracellular transport","score":0.8040000200271606},{"id":"https://openalex.org/keywords/membrane-organization","display_name":"membrane organization","score":0.925000011920929},{"id":"https://openalex.org/keywords/glycocalyx","display_name":"glycocalyx","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8586999773979187},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.8410999774932861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7245000004768372},{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.7197999954223633},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5031999945640564},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.47870001196861267},{"id":"https://openalex.org/C2777119779","wikidata":"https://www.wikidata.org/wiki/Q963278","display_name":"Molecular mimicry","level":3,"score":0.46459999680519104},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.46239998936653137},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43689998984336853},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.37950000166893005},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.3508000075817108},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2815999984741211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27090001106262207},{"id":"https://openalex.org/C25824698","wikidata":"https://www.wikidata.org/wiki/Q6840012","display_name":"Microscale thermophoresis","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.25459998846054077},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.10.02.755967","doi":"https://doi.org/10.64898/2026.10.02.755967","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.755967","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.755967.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:HAL:hal-05796678v1","doi":null,"is_oa":true,"landing_page_url":"https://amu.hal.science/hal-05796678","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2026","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.755967","doi":"https://doi.org/10.64898/2026.10.02.755967","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.755967","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.755967.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1052072530","display_name":null,"funder_award_id":"ANR-10-INSB-05-01.","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1275603294","display_name":"CenTuri : Centre Turing des Syst\u00e8mes vivants","funder_award_id":"ANR-16-CONV-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1669488153","display_name":null,"funder_award_id":"10-INSB-05-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2247417377","display_name":null,"funder_award_id":"ANR- 10-INSB-05","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2519618546","display_name":"Full affinity mapping of the Human PDZ-PBM interactome and interactome-phenotype relationship of the viral HPV oncoprotein E6.","funder_award_id":"ANR-22-CE44-0018","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G502948375","display_name":null,"funder_award_id":"ANR-10- INSB-05","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G654663749","display_name":null,"funder_award_id":"ANR-10-INSB-0501","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G6887564038","display_name":null,"funder_award_id":"AMX-21-PEP-043","funder_id":"https://openalex.org/F4320314159","funder_display_name":"Joint Programming Initiative A healthy diet for a healthy life"},{"id":"https://openalex.org/G7011901419","display_name":null,"funder_award_id":"ANR-16-CONV-0001","funder_id":"https://openalex.org/F4320309911","funder_display_name":"Aix-Marseille Universit\u00e9"},{"id":"https://openalex.org/G7237471465","display_name":null,"funder_award_id":"INSB-05","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G8095343203","display_name":"The role of diet-dependent human microbiome encoded T3SS-dependent effectors in modulating health","funder_award_id":"ANR-17-HDIM-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320309911","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20"},{"id":"https://openalex.org/F4320314159","display_name":"Joint Programming Initiative A healthy diet for a healthy life","ror":"https://ror.org/015zqm698"},{"id":"https://openalex.org/F4320315862","display_name":"Infrastructures en Biologie Sant\u00e9 et Agronomie","ror":"https://ror.org/054q97b08"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320327185","display_name":"French Infrastructure for Integrated Structural Biology","ror":"https://ror.org/045sst074"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220466607.pdf","grobid_xml":"https://content.openalex.org/works/W7220466607.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1577019338","https://openalex.org/W1647551795","https://openalex.org/W1964533331","https://openalex.org/W1968578345","https://openalex.org/W1968693703","https://openalex.org/W1969353942","https://openalex.org/W1973582015","https://openalex.org/W1987148584","https://openalex.org/W1988541981","https://openalex.org/W1990408005","https://openalex.org/W1992439215","https://openalex.org/W1993548347","https://openalex.org/W1996076856","https://openalex.org/W1998408165","https://openalex.org/W2000632630","https://openalex.org/W2005027841","https://openalex.org/W2009680241","https://openalex.org/W2010297881","https://openalex.org/W2019152307","https://openalex.org/W2021071631","https://openalex.org/W2022113253","https://openalex.org/W2023857290","https://openalex.org/W2032243072","https://openalex.org/W2043764521","https://openalex.org/W2043790670","https://openalex.org/W2048698900","https://openalex.org/W2054360688","https://openalex.org/W2055509168","https://openalex.org/W2073426323","https://openalex.org/W2074570440","https://openalex.org/W2079635715","https://openalex.org/W2086734383","https://openalex.org/W2092627831","https://openalex.org/W2095744711","https://openalex.org/W2115389814","https://openalex.org/W2117876140","https://openalex.org/W2130410032","https://openalex.org/W2130599662","https://openalex.org/W2131363025","https://openalex.org/W2148059118","https://openalex.org/W2156801648","https://openalex.org/W2156999424","https://openalex.org/W2158352115","https://openalex.org/W2163416367","https://openalex.org/W2169382766","https://openalex.org/W2208025102","https://openalex.org/W2261598201","https://openalex.org/W2280733329","https://openalex.org/W2463195069","https://openalex.org/W2568632606","https://openalex.org/W2606365851","https://openalex.org/W2735799356","https://openalex.org/W2751016974","https://openalex.org/W2766971704","https://openalex.org/W2767113588","https://openalex.org/W2777934057","https://openalex.org/W2793799230","https://openalex.org/W2797104734","https://openalex.org/W2800998762","https://openalex.org/W2805254230","https://openalex.org/W2806512480","https://openalex.org/W2939584033","https://openalex.org/W2952244535","https://openalex.org/W2955662457","https://openalex.org/W2969550528","https://openalex.org/W2973966495","https://openalex.org/W2991106430","https://openalex.org/W3013169983","https://openalex.org/W3085022707","https://openalex.org/W3093740009","https://openalex.org/W3095583226","https://openalex.org/W3120408653","https://openalex.org/W3212342036","https://openalex.org/W4206082317","https://openalex.org/W4282919886","https://openalex.org/W4284882692","https://openalex.org/W4296139765","https://openalex.org/W4301594919","https://openalex.org/W4304080474","https://openalex.org/W4304084152","https://openalex.org/W4307493887","https://openalex.org/W4307630923","https://openalex.org/W4309944312","https://openalex.org/W4312178418","https://openalex.org/W4372332501","https://openalex.org/W4383723507","https://openalex.org/W4387058195","https://openalex.org/W4388249232","https://openalex.org/W4388668618","https://openalex.org/W4389738213","https://openalex.org/W4391012430","https://openalex.org/W4391447409","https://openalex.org/W4399889823","https://openalex.org/W4405287722","https://openalex.org/W7125704828"],"related_works":["https://openalex.org/W3107141572","https://openalex.org/W3158665167","https://openalex.org/W2005027841","https://openalex.org/W1990408005","https://openalex.org/W4386648995","https://openalex.org/W3009392844","https://openalex.org/W377510480","https://openalex.org/W2061553335","https://openalex.org/W7143351039","https://openalex.org/W2911019675"],"abstract_inverted_index":{"Abstract":[0],"Bacteria":[1],"employ":[2],"molecular":[3,183],"mimicry":[4],"to":[5,46,62,91,104,155,180],"hijack":[6,105],"host":[7,153],"cellular":[8,108],"functions":[9],"for":[10,128,139],"their":[11,48,106],"own":[12],"benefit.":[13],"Despite":[14],"the":[15,58,65,114,121,152,181],"wealth":[16],"of":[17,25,67,113,178],"data":[18],"mapping":[19],"human-bacteria":[20],"interactions,":[21],"a":[22,111],"comprehensive":[23],"view":[24],"how":[26],"these":[27],"networks":[28],"are":[29],"fine-tuned":[30],"remains":[31],"elusive.":[32],"In":[33],"particular,":[34],"there":[35],"have":[36],"been":[37],"no":[38],"large-scale":[39],"screenings":[40],"measuring":[41],"human-bacterial":[42],"protein-protein":[43],"binding":[44,99],"affinities":[45,100],"explore":[47],"role":[49],"in":[50,76,144],"functional":[51],"and":[52,71,80,125,147],"pathological":[53],"outcomes.":[54],"Here,":[55],"we":[56,116,159],"report":[57],"largest":[59],"quantitative":[60],"interactome":[61],"date":[63],"between":[64],"family":[66],"human":[68,102],"PDZ":[69,93,172],"domains":[70,94],"C-terminal":[72,135],"PDZ-binding":[73],"motifs":[74,162],"(PBMs)":[75],"effectors":[77],"from":[78],"pathogenic":[79,129],"resident":[81],"gut":[82],"bacteria.":[83],"We":[84],"show":[85,126,160],"that":[86,127,161],"bacteria":[87],"tailor":[88],"effector":[89,132,165],"sequences":[90],"bind":[92],"with":[95,120,141,164],"similar":[96],"or":[97],"higher":[98],"than":[101,171],"PBMs":[103,166],"associated":[107],"functions.":[109],"For":[110],"subset":[112],"dataset,":[115],"validate":[117],"PDZ-PBM":[118],"interactions":[119,140],"corresponding":[122],"full-length":[123],"proteins":[124,142],"E.":[130],"coli":[131],"NleA,":[133],"its":[134],"PBM":[136],"is":[137],"necessary":[138],"involved":[143],"intracellular":[145],"transport":[146],"membrane":[148],"organization,":[149],"probably":[150],"impacting":[151],"glycocalyx":[154],"favor":[156],"infection.":[157],"Finally,":[158],"overlapping":[163],"target":[167],"interaction":[168],"modules":[169],"other":[170],"domains,":[173],"adding":[174],"an":[175],"additional":[176],"layer":[177],"complexity":[179],"host-microbe":[182],"dialogue.":[184]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}