{"id":"https://openalex.org/W7220465007","doi":"https://doi.org/10.3389/fimmu.2026.1839925","title":"Machine learning-derived R-loop-related diagnostic signature for psoriasis: a multi-cohort and single-cell validation study","display_name":"Machine learning-derived R-loop-related diagnostic signature for psoriasis: a multi-cohort and single-cell validation study","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220465007","doi":"https://doi.org/10.3389/fimmu.2026.1839925","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677910"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1839925","doi":"https://doi.org/10.3389/fimmu.2026.1839925","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1839925","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1839925/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1839925/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029083191","display_name":"Yeqi Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yeqi Feng","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099287670","display_name":"Song Lebin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lebin Song","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022737882","display_name":"Xiaozheng Jiang","orcid":"https://orcid.org/0009-0005-8406-5913","observed_orcids":["https://orcid.org/0009-0005-8406-5913"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaozheng Jiang","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157459077","display_name":"Hongyu Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Ruan","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135609550","display_name":"Jiayi Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayi Zhao","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157583371","display_name":"Yan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Lu","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210152119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5157583371"],"corresponding_institution_ids":["https://openalex.org/I4210152119"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67179988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1839925","last_page":"1839925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.9950000047683716},{"id":"https://openalex.org/keywords/diagnostic-signature","display_name":"diagnostic signature","score":0.7020000219345093},{"id":"https://openalex.org/keywords/srpk1","display_name":"SRPK1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/keratinocyte-hyperproliferation","display_name":"keratinocyte hyperproliferation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.625},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9480000138282776},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6019999980926514},{"id":"https://openalex.org/keywords/shap-analysis","display_name":"SHAP analysis","score":0.5389999747276306},{"id":"https://openalex.org/keywords/elastic-net","display_name":"elastic net","score":0.5690000057220459},{"id":"https://openalex.org/keywords/non-lesional-skin","display_name":"non-lesional skin","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.9387999773025513},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.6621000170707703},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.65420001745224},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5442000031471252},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4065999984741211},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4043999910354614},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4041999876499176},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3849000036716461},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.3650999963283539},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34470000863075256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33399999141693115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32409998774528503},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3019999861717224},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.29260000586509705},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.27790001034736633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27630001306533813},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.26109999418258667},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.25850000977516174}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1839925","doi":"https://doi.org/10.3389/fimmu.2026.1839925","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1839925","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1839925/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677910","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677910/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677910/pdf/fimmu-17-1839925.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42898510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:38b2c76b7adb4cf197593f614615b719","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/38b2c76b7adb4cf197593f614615b719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1839925","doi":"https://doi.org/10.3389/fimmu.2026.1839925","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1839925","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1839925/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324291","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220465007.pdf","grobid_xml":"https://content.openalex.org/works/W7220465007.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1987784314","https://openalex.org/W2789815934","https://openalex.org/W3040273200","https://openalex.org/W3121652298","https://openalex.org/W3134981746","https://openalex.org/W3135844375","https://openalex.org/W3172429018","https://openalex.org/W3175712893","https://openalex.org/W3182162115","https://openalex.org/W3184907113","https://openalex.org/W3199336556","https://openalex.org/W3213066457","https://openalex.org/W4221109087","https://openalex.org/W4225143850","https://openalex.org/W4225163971","https://openalex.org/W4281937473","https://openalex.org/W4283315285","https://openalex.org/W4283645631","https://openalex.org/W4304758045","https://openalex.org/W4304943536","https://openalex.org/W4308916009","https://openalex.org/W4312095753","https://openalex.org/W4323046362","https://openalex.org/W4362696725","https://openalex.org/W4384626889","https://openalex.org/W4388615901","https://openalex.org/W4389030365","https://openalex.org/W4390697528","https://openalex.org/W4394622592","https://openalex.org/W4402996934","https://openalex.org/W4403109714","https://openalex.org/W4403971570","https://openalex.org/W4409311870","https://openalex.org/W4409653741","https://openalex.org/W4411343380","https://openalex.org/W4411398777","https://openalex.org/W4412100393","https://openalex.org/W4413025886","https://openalex.org/W4413052151","https://openalex.org/W4413220209","https://openalex.org/W4417508092","https://openalex.org/W7117360240"],"related_works":["https://openalex.org/W4396868109","https://openalex.org/W7125503616","https://openalex.org/W7168188015","https://openalex.org/W4388330683","https://openalex.org/W4416098982","https://openalex.org/W7163148326","https://openalex.org/W7201991340","https://openalex.org/W6964616173","https://openalex.org/W4403109925","https://openalex.org/W4413869488"],"abstract_inverted_index":{"Background:":[0],"Psoriasis":[1],"is":[2],"a":[3,239,244,292,297],"chronic":[4],"inflammatory":[5,40],"skin":[6,107],"disease":[7,73],"characterized":[8],"by":[9,180,259,275],"dysregulated":[10],"immune":[11],"responses":[12],"and":[13,39,67,89,91,105,115,140,187,208,261,296],"keratinocyte":[14,248,268],"(KC)":[15],"hyperproliferation.":[16],"Although":[17],"therapeutic":[18,299],"strategies":[19],"have":[20],"advanced":[21],"considerably,":[22],"achieving":[23],"durable":[24],"long-term":[25],"remission":[26],"remains":[27,50],"challenging.":[28],"R-loops":[29,59],"are":[30],"three-stranded":[31],"nucleic":[32],"acid":[33],"structures":[34],"involved":[35],"in":[36,42,48,60,177,199,229,252,301],"genomic":[37],"stability":[38],"regulation":[41],"multiple":[43],"diseases;":[44],"however,":[45],"their":[46],"role":[47],"psoriasis":[49],"poorly":[51],"understood.":[52],"Objective:":[53],"To":[54],"investigate":[55],"the":[56,125,150,162,165,170,225,230],"involvement":[57],"of":[58,72,103,152,173,247],"psoriasis,":[61],"develop":[62],"an":[63,119,210],"R-loop-related":[64,109,120],"diagnostic":[65,121,231,294],"signature,":[66],"identify":[68],"key":[69],"molecular":[70],"drivers":[71],"pathogenesis.":[74],"Methods:":[75],"Transcriptomic":[76],"data":[77,156],"from":[78,217],"five":[79],"public":[80],"bulk":[81],"RNA":[82,94],"expression":[83],"cohorts":[84],"(GSE30999,":[85],"GSE41664,":[86],"GSE13355,":[87],"GSE6710,":[88],"GSE14905)":[90],"one":[92],"single-cell":[93],"sequencing":[95],"(scRNA-seq)":[96],"dataset":[97],"(GSE173706)":[98],"were":[99,113,157],"integrated":[100],"for":[101],"analysis":[102,145,221,234],"psoriatic":[104,200,216],"non-lesional":[106,204],"samples.":[108],"differentially":[110],"expressed":[111],"genes":[112],"identified":[114,222],"used":[116],"to":[117,148,160,238],"construct":[118],"signature":[122],"(RRDS)":[123],"using":[124,135],"Elastic":[126],"Net":[127],"machine":[128],"learning":[129],"algorithm.":[130],"Model":[131],"performance":[132],"was":[133,146,175,196],"evaluated":[134],"three":[136],"complementary":[137],"analytical":[138],"approaches,":[139],"SHapley":[141],"Additive":[142],"exPlanations":[143],"(SHAP)":[144],"performed":[147],"quantify":[149],"contribution":[151],"individual":[153],"genes.":[154],"scRNA-seq":[155],"further":[158,235],"analyzed":[159],"validate":[161],"findings":[163],"at":[164,243],"cellular":[166],"level.":[167],"In":[168],"addition,":[169],"biological":[171],"function":[172],"SRPK1":[174,223,237,257,264,287],"examined":[176],"HaCaT":[178,253],"cells":[179,254],"siRNA-mediated":[181],"knockdown,":[182],"quantitative":[183],"real-time":[184],"PCR":[185],"(qRT-PCR),":[186],"Cell":[188],"Counting":[189],"Kit-8":[190],"(CCK-8)":[191],"assays.":[192],"Results:":[193],"R-loop":[194],"activity":[195],"significantly":[197,266],"elevated":[198],"lesions":[201],"compared":[202],"with":[203],"skin.":[205,219],"We":[206],"established":[207],"validated":[209],"eight-gene":[211],"RRDS":[212],"that":[213,263,286],"accurately":[214],"distinguished":[215],"healthy":[218],"SHAP":[220],"as":[224,273,290],"most":[226],"influential":[227],"feature":[228],"model.":[232],"Single-cell":[233],"localized":[236],"pathogenic":[240],"KC_4":[241],"subpopulation":[242],"critical":[245],"stage":[246],"differentiation.":[249],"Functional":[250],"validation":[251],"confirmed":[255],"efficient":[256],"knockdown":[258],"qRT-PCR":[260],"demonstrated":[262],"silencing":[265],"suppressed":[267],"proliferation":[269],"over":[270],"96":[271],"hours,":[272],"determined":[274],"CCK-8":[276],"assays":[277],"(P":[278],"<":[279],"0.001).":[280],"Conclusion:":[281],"findings,":[282],"these":[283],"results":[284],"suggest":[285],"may":[288],"serve":[289],"both":[291],"promising":[293],"biomarker":[295],"potential":[298],"target":[300],"psoriasis.":[302]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}