{"id":"https://openalex.org/W7220463259","doi":"https://doi.org/10.3390/ijms27198838","title":"Biopsy-Based Molecular Signatures Predicting Therapeutic Response in Ulcerative Colitis","display_name":"Biopsy-Based Molecular Signatures Predicting Therapeutic Response in Ulcerative Colitis","publication_year":2026,"publication_date":"2026-10-03","ids":{"openalex":"https://openalex.org/W7220463259","doi":"https://doi.org/10.3390/ijms27198838","pmid":"https://pubmed.ncbi.nlm.nih.gov/42884080","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13664742"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27198838","doi":"https://doi.org/10.3390/ijms27198838","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198838","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27198838","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035448176","display_name":"Ilaria Grassi","orcid":"https://orcid.org/0000-0002-9566-7670","observed_orcids":["https://orcid.org/0000-0002-9566-7670","https://orcid.org/0009-0001-7940-4977"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Grassi","raw_affiliation_strings":["Histopathology Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":"https://orcid.org/0009-0001-7940-4977","affiliations":[{"raw_affiliation_string":"Histopathology Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021825117","display_name":"Marina Liso","orcid":"https://orcid.org/0000-0002-8766-1869","observed_orcids":["https://orcid.org/0000-0002-8766-1869"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Liso","raw_affiliation_strings":["IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8766-1869","affiliations":[{"raw_affiliation_string":"IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088074320","display_name":"Mauro Mastronardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Mastronardi","raw_affiliation_strings":["IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042297380","display_name":"Anna Maria Valentini","orcid":"https://orcid.org/0000-0002-6798-808X","observed_orcids":["https://orcid.org/0000-0002-6798-808X"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Maria Valentini","raw_affiliation_strings":["Histopathology Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6798-808X","affiliations":[{"raw_affiliation_string":"Histopathology Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006949363","display_name":"Margherita Curlo","orcid":"https://orcid.org/0000-0001-7235-3495","observed_orcids":["https://orcid.org/0000-0001-7235-3495"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Curlo","raw_affiliation_strings":["IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103204305","display_name":"Raffaele Armentano","orcid":"https://orcid.org/0000-0003-1661-5504","observed_orcids":["https://orcid.org/0000-0003-1661-5504"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Armentano","raw_affiliation_strings":["Histopathology Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1661-5504","affiliations":[{"raw_affiliation_string":"Histopathology Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047049372","display_name":"Elisabetta Cavalcanti","orcid":"https://orcid.org/0000-0003-2952-0053","observed_orcids":["https://orcid.org/0000-0003-2952-0053"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Elisabetta Cavalcanti","raw_affiliation_strings":["IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2952-0053","affiliations":[{"raw_affiliation_string":"IBD Unit, National Institute of Gastroenterology\u2014IRCCS \u201cSaverio de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047049372"],"corresponding_institution_ids":["https://openalex.org/I4210155710"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76373347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"19","first_page":"8838","last_page":"8838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.6899999976158142},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/sparc","display_name":"SPARC","score":0.9829999804496765},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7089999914169312},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.5799999833106995},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8600000143051147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8123999834060669},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.6536999940872192},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5881999731063843},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4697999954223633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46140000224113464},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4099999964237213},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.39899998903274536},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.38370001316070557},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33090001344680786},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3176000118255615},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.3095000088214874},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30329999327659607},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26750001311302185},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.25}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015676","descriptor_name":"Osteonectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015676","descriptor_name":"Osteonectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27198838","doi":"https://doi.org/10.3390/ijms27198838","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198838","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13664742","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664742/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664742/pdf/ijms-27-08838.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42884080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42884080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27198838","doi":"https://doi.org/10.3390/ijms27198838","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198838","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1864982059","display_name":null,"funder_award_id":"PNCE3-2022-23683266","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G7039972366","display_name":null,"funder_award_id":"E3-2022-23683266","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220463259.pdf","grobid_xml":"https://content.openalex.org/works/W7220463259.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W2102013054","https://openalex.org/W2154813174","https://openalex.org/W2171297959","https://openalex.org/W2201859789","https://openalex.org/W2313203176","https://openalex.org/W2888061430","https://openalex.org/W2916794721","https://openalex.org/W2971645292","https://openalex.org/W2977287116","https://openalex.org/W2985209166","https://openalex.org/W3011813642","https://openalex.org/W3115410759","https://openalex.org/W3201347050","https://openalex.org/W3203449030","https://openalex.org/W4211138554","https://openalex.org/W4281289938","https://openalex.org/W4281760529","https://openalex.org/W4282965418","https://openalex.org/W4323661972","https://openalex.org/W4386760095","https://openalex.org/W4387230606","https://openalex.org/W4392883211","https://openalex.org/W4399039988","https://openalex.org/W4399781479","https://openalex.org/W4402412196","https://openalex.org/W4406116252","https://openalex.org/W4406986529","https://openalex.org/W4408671401","https://openalex.org/W4409502717","https://openalex.org/W4410331693","https://openalex.org/W4411456970","https://openalex.org/W4412780968","https://openalex.org/W7128518246","https://openalex.org/W7138405835"],"related_works":["https://openalex.org/W3125706186","https://openalex.org/W2330655337","https://openalex.org/W4376615402","https://openalex.org/W3158265593","https://openalex.org/W2145245891","https://openalex.org/W2077064565","https://openalex.org/W2133288043","https://openalex.org/W3126653297","https://openalex.org/W4220674678","https://openalex.org/W2057907374"],"abstract_inverted_index":{"Ulcerative":[0],"colitis":[1],"(UC)":[2],"is":[3,40,139],"a":[4,66,89,142],"chronic":[5,129],"inflammatory":[6,104],"bowel":[7],"disease":[8],"with":[9,115,128,141],"marked":[10,93],"molecular":[11,91],"heterogeneity,":[12],"resulting":[13],"in":[14,46,122,178],"highly":[15],"variable":[16],"responses":[17],"to":[18,30,78,137,174],"biologic":[19],"therapies.":[20],"Despite":[21],"the":[22,111,168],"efficacy":[23],"of":[24,37,51],"Infliximab":[25],"(IFX),":[26],"many":[27],"patients":[28],"fail":[29],"achieve":[31],"sustained":[32],"remission.":[33],"Identifying":[34],"biomarkers":[35],"predictive":[36],"treatment":[38],"response":[39],"essential":[41],"for":[42,164,170,182],"advancing":[43],"precision":[44],"medicine":[45],"UC.":[47],"Gene":[48],"expression":[49,82,121],"profiling":[50],"colonic":[52],"mucosal":[53],"biopsies":[54],"from":[55],"IFX":[56,58,86,138],"responders,":[57],"non-responders,":[59],"and":[60,75,83,102,107,119,132,149],"healthy":[61],"controls":[62],"was":[63],"performed":[64],"using":[65],"multiplex":[67],"array,":[68],"followed":[69],"by":[70,73,94,147],"technical":[71],"confirmation":[72],"RT-qPCR":[74],"immunohistochemical":[76],"assessment":[77],"further":[79],"characterize":[80],"tissue":[81,130],"biological":[84],"relevance.":[85],"non-responders":[87],"displayed":[88],"stromal\u2013immune":[90,144],"signature":[92],"extracellular":[95],"matrix":[96],"remodeling,":[97,99],"stromal":[98],"integrin-mediated":[100],"signaling,":[101],"persistent":[103],"pathways.":[105],"SPARC":[106,148],"SPP1":[108,150],"emerged":[109],"as":[110,160],"most":[112],"prominent":[113],"biomarkers,":[114],"significantly":[116],"increased":[117],"gene":[118],"protein":[120],"non-responder":[123],"patients,":[124],"highlighting":[125,167],"their":[126,176],"association":[127],"remodeling":[131],"therapeutic":[133],"resistance.":[134],"Mucosal":[135],"resistance":[136],"associated":[140],"specific":[143],"profile":[145],"characterized":[146],"upregulation.":[151],"These":[152],"findings":[153],"suggest":[154],"that":[155],"both":[156],"molecules":[157],"may":[158],"serve":[159],"promising":[161],"candidate":[162],"markers":[163],"patient":[165],"stratification,":[166],"need":[169],"future":[171],"prospective":[172],"studies":[173],"explore":[175],"role":[177],"personalized":[179],"management":[180],"strategies":[181],"ulcerative":[183],"colitis.":[184]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}