{"id":"https://openalex.org/W7220455255","doi":"https://doi.org/10.3389/fimmu.2026.1978654","title":"Biological sex and disease architecture in systemic sclerosis: a multilayer translational framework for precision medicine","display_name":"Biological sex and disease architecture in systemic sclerosis: a multilayer translational framework for precision medicine","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220455255","doi":"https://doi.org/10.3389/fimmu.2026.1978654","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678450"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1978654","doi":"https://doi.org/10.3389/fimmu.2026.1978654","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1978654","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1978654/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1978654/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062778473","display_name":"Yian Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097726","display_name":"Huaian First People\u2019s Hospital","ror":"https://ror.org/00xpfw690","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097726"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi\u2019an Tian","raw_affiliation_strings":["Department of Rheumatology and Immunology, The Affiliated Huai\u2019an No.1 People\u2019s Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, The Affiliated Huai\u2019an No.1 People\u2019s Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210097726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157596842","display_name":"Zhaofang Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097726","display_name":"Huaian First People\u2019s Hospital","ror":"https://ror.org/00xpfw690","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097726"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaofang Tian","raw_affiliation_strings":["Department of Neonatology, The Affiliated Huai\u2019an No.1 People\u2019s Hospital of Nanjing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, The Affiliated Huai\u2019an No.1 People\u2019s Hospital of Nanjing Medical University","institution_ids":["https://openalex.org/I4210097726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5157596842"],"corresponding_institution_ids":["https://openalex.org/I4210097726"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5575179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1978654","last_page":"1978654"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9190000295639038},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tissue-organization","display_name":"tissue organization","score":0.734000027179718},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.3630000054836273},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/disease-trajectories","display_name":"disease trajectories","score":0.6029999852180481},{"id":"https://openalex.org/keywords/sex-stratified-analysis","display_name":"sex-stratified analysis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/organ-involvement","display_name":"organ involvement","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.666100025177002},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6071000099182129},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.4481000006198883},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4052000045776367},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.3637000024318695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36329999566078186},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3172000050544739},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.31060001254081726},{"id":"https://openalex.org/C3018877446","wikidata":"https://www.wikidata.org/wiki/Q1421432","display_name":"Disease monitoring","level":3,"score":0.3098999857902527},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.30390000343322754},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2992264114","wikidata":"https://www.wikidata.org/wiki/Q1394551","display_name":"Clinical disease","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C119709500","wikidata":"https://www.wikidata.org/wiki/Q2142347","display_name":"Exposome","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.288100004196167},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28360000252723694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28029999136924744},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2565000057220459},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C14224292","wikidata":"https://www.wikidata.org/wiki/Q13600188","display_name":"Conceptual framework","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C124978682","wikidata":"https://www.wikidata.org/wiki/Q1201019","display_name":"Proof of concept","level":2,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1978654","doi":"https://doi.org/10.3389/fimmu.2026.1978654","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1978654","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1978654/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:42898638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678450","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678450/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f6c9a0d3210a4b919f67f12be367f06c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f6c9a0d3210a4b919f67f12be367f06c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1978654","doi":"https://doi.org/10.3389/fimmu.2026.1978654","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1978654","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1978654/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/10","score":0.5,"display_name":"Reduced inequalities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000843639","display_name":null,"funder_award_id":"YCT202301","funder_id":"https://openalex.org/F4320324291","funder_display_name":"Nanjing Medical University"}],"funders":[{"id":"https://openalex.org/F4320324291","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220455255.pdf","grobid_xml":"https://content.openalex.org/works/W7220455255.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1540350711","https://openalex.org/W1600041372","https://openalex.org/W1981224038","https://openalex.org/W2008423777","https://openalex.org/W2076272449","https://openalex.org/W2115218576","https://openalex.org/W2119143823","https://openalex.org/W2154576801","https://openalex.org/W2169645723","https://openalex.org/W2267799122","https://openalex.org/W2320771212","https://openalex.org/W2561079487","https://openalex.org/W2595252694","https://openalex.org/W2785308950","https://openalex.org/W2792874817","https://openalex.org/W2964141693","https://openalex.org/W3027051073","https://openalex.org/W3092358813","https://openalex.org/W3131952310","https://openalex.org/W3185023903","https://openalex.org/W4211001791","https://openalex.org/W4211149849","https://openalex.org/W4281716326","https://openalex.org/W4295951577","https://openalex.org/W4296577825","https://openalex.org/W4309588848","https://openalex.org/W4378193599","https://openalex.org/W4385802294","https://openalex.org/W4390571167","https://openalex.org/W4392461952","https://openalex.org/W4399236483","https://openalex.org/W4400702488","https://openalex.org/W4402453771","https://openalex.org/W4402453777","https://openalex.org/W4404691211","https://openalex.org/W4405349660","https://openalex.org/W4406323055","https://openalex.org/W4410612888","https://openalex.org/W4410785797","https://openalex.org/W4411382257","https://openalex.org/W4411918049","https://openalex.org/W4415144704","https://openalex.org/W4416910900","https://openalex.org/W4417297248","https://openalex.org/W4417467135","https://openalex.org/W7154450145","https://openalex.org/W7161166844"],"related_works":["https://openalex.org/W4415144704","https://openalex.org/W4410785797","https://openalex.org/W3212443119","https://openalex.org/W7160711581","https://openalex.org/W4399483150","https://openalex.org/W3005592800","https://openalex.org/W4395041580","https://openalex.org/W1978353448","https://openalex.org/W7154489408","https://openalex.org/W3164901552"],"abstract_inverted_index":{"Biological":[0],"sex":[1,209],"is":[2,185],"routinely":[3],"incorporated":[4],"into":[5],"systemic":[6],"sclerosis":[7],"(SSc)":[8],"research":[9],"as":[10,64,79,93,193],"a":[11,27,65,74,84,94,194],"demographic":[12],"or":[13,44,89,113,175],"stratification":[14],"variable.":[15],"Women":[16],"are":[17],"substantially":[18],"more":[19],"likely":[20],"to":[21,177,188,200],"develop":[22],"SSc,":[23,198],"whereas":[24],"men":[25],"experience":[26],"greater":[28],"burden":[29],"of":[30,181,197],"severe":[31],"organ":[32],"involvement":[33],"and":[34,131,149,162,170,216],"adverse":[35],"outcomes.":[36],"Whether":[37],"these":[38],"observations":[39],"represent":[40],"parallel":[41],"sex-associated":[42,96],"differences":[43,46],"reflect":[45],"in":[47,83,98],"the":[48,58,124,133],"relationships":[49,99],"among":[50,100],"disease":[51,101,121,191],"components":[52],"remains":[53],"unresolved.":[54],"Here,":[55],"we":[56],"propose":[57],"Systemic":[59],"Sclerosis-Multilayer":[60],"Architecture":[61],"Framework":[62],"(SSc-MAF)":[63],"hypothesis-generating":[66],"framework":[67,184],"for":[68,137,205],"addressing":[69],"this":[70],"distinction.":[71],"We":[72,140,165],"define":[73],"sex-dependent":[75,190],"architectural":[76],"difference":[77,82,97],"not":[78,187],"an":[80,202],"isolated":[81],"molecule,":[85],"cell":[86],"population,":[87],"pathway,":[88],"clinical":[90,120],"phenotype,":[91],"but":[92,199],"reproducible":[95],"components,":[102],"including":[103],"multicellular":[104],"communication,":[105],"fibrovascular":[106],"coupling,":[107],"spatial":[108],"tissue":[109],"organization,":[110],"molecular":[111],"co-activation,":[112],"longitudinal":[114],"clinical-biological":[115],"trajectories.":[116],"SSc-MAF":[117],"therefore":[118],"distinguishes":[119],"trajectories":[122],"from":[123,132,158],"biological":[125,208],"architecture":[126,192],"that":[127,172],"may":[128],"generate":[129],"them":[130],"methodological":[134],"strategies":[135],"required":[136],"empirical":[138],"validation.":[139],"critically":[141],"evaluate":[142],"current":[143],"evidence":[144,157,161],"across":[145],"immune,":[146],"fibrovascular,":[147],"metabolic,":[148],"regulatory":[150],"domains,":[151],"while":[152],"distinguishing":[153],"direct":[154],"sex-stratified":[155],"SSc":[156],"indirect":[159],"mechanistic":[160],"framework-level":[163],"hypotheses.":[164],"further":[166],"outline":[167],"measurable":[168],"predictions":[169],"conditions":[171],"would":[173],"weaken":[174],"fail":[176],"support":[178],"individual":[179],"propositions":[180],"SSc-MAF.":[182],"This":[183],"intended":[186],"establish":[189],"proven":[195],"feature":[196],"provide":[201],"operational":[203],"strategy":[204],"testing":[206],"whether":[207],"contributes":[210],"information":[211],"beyond":[212],"conventional":[213],"component-level":[214],"comparisons":[215],"additive":[217],"covariate":[218],"adjustment.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}
