{"id":"https://openalex.org/W7220454076","doi":"https://doi.org/10.64898/2026.10.02.756302","title":"SETD3 ACTIN HISTIDINE METHYLTRANSFERASE REGULATES INTESTINAL EPITHELIAL BARRIER INTEGRITY AND MUCOSAL INFLAMMATION","display_name":"SETD3 ACTIN HISTIDINE METHYLTRANSFERASE REGULATES INTESTINAL EPITHELIAL BARRIER INTEGRITY AND MUCOSAL INFLAMMATION","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220454076","doi":"https://doi.org/10.64898/2026.10.02.756302","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692052"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.756302","doi":"https://doi.org/10.64898/2026.10.02.756302","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756302","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.756302.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.756302.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031083020","display_name":"Prasath Manogaran","orcid":"https://orcid.org/0000-0001-6105-7818","observed_orcids":["https://orcid.org/0000-0001-6105-7818"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasath Manogaran","raw_affiliation_strings":["Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090314180","display_name":"Nayden G. Naydenov","orcid":"https://orcid.org/0000-0001-8037-6232","observed_orcids":["https://orcid.org/0000-0001-8037-6232"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nayden G. Naydenov","raw_affiliation_strings":["Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;"],"raw_orcid":"https://orcid.org/0000-0001-8037-6232","affiliations":[{"raw_affiliation_string":"Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040857890","display_name":"Susana Lechuga","orcid":"https://orcid.org/0000-0003-0614-1990","observed_orcids":["https://orcid.org/0000-0003-0614-1990"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susana Lechuga","raw_affiliation_strings":["Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089136921","display_name":"Naseer Sangwan","orcid":"https://orcid.org/0000-0002-2407-769X","observed_orcids":["https://orcid.org/0000-0002-2407-769X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naseer Sangwan","raw_affiliation_strings":["Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland, OH 44195;","Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195;","Shared Laboratory Resourses, Cleveland Clinic Research, Cleveland, OH 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Heart, Blood and Kidney Research, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Department of Microbial Sciences in Health, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Shared Laboratory Resourses, Cleveland Clinic Research, Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157483171","display_name":"Andrew Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Deng","raw_affiliation_strings":["Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002892099","display_name":"Ajay H. Zalavadia","orcid":"https://orcid.org/0000-0002-4468-3865","observed_orcids":["https://orcid.org/0000-0002-4468-3865"]},"institutions":[{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay Zalavadia","raw_affiliation_strings":["Imaging Core, Cleveland Clinic Research, Cleveland, OH 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Core, Cleveland Clinic Research, Cleveland, OH 44195","institution_ids":["https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042846824","display_name":"Andrei I. Ivanov","orcid":"https://orcid.org/0000-0003-4823-209X","observed_orcids":["https://orcid.org/0000-0003-4823-209X","https://orcid.org/0000-0002-7226-4078"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrei I. Ivanov","raw_affiliation_strings":["Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, OH 44195;","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042846824"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.260699987411499,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.20730000734329224,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setd3","display_name":"SETD3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9480000138282776},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.9929999709129333},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9279999732971191},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.8924000263214111},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.7914000153541565},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7182000279426575},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.6183000206947327},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5289999842643738},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.526199996471405},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.5146999955177307},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.4837999939918518},{"id":"https://openalex.org/C2776601116","wikidata":"https://www.wikidata.org/wiki/Q24786722","display_name":"Cofilin","level":5,"score":0.4584999978542328},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.4221000075340271},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.3682999908924103},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.33000001311302185},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.3271999955177307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32659998536109924},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.32409998774528503},{"id":"https://openalex.org/C51872919","wikidata":"https://www.wikidata.org/wiki/Q420863","display_name":"Claudin","level":3,"score":0.31839999556541443},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.2921999990940094},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.2791999876499176},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C2781456731","wikidata":"https://www.wikidata.org/wiki/Q868506","display_name":"Intestinal villus","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.2711000144481659},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2524000108242035}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.02.756302","doi":"https://doi.org/10.64898/2026.10.02.756302","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756302","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.756302.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42926441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692052","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692052/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.756302","doi":"https://doi.org/10.64898/2026.10.02.756302","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756302","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.02.756302.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000865459","display_name":"Actin methylation as a novel mechanism that regulates gut barrier integrity and repair","funder_award_id":"R01DK137822","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220454076.pdf","grobid_xml":"https://content.openalex.org/works/W7220454076.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W59935261","https://openalex.org/W191402491","https://openalex.org/W303113995","https://openalex.org/W1970261587","https://openalex.org/W1972076214","https://openalex.org/W1972728921","https://openalex.org/W1992152055","https://openalex.org/W1992299767","https://openalex.org/W1997114475","https://openalex.org/W2000221061","https://openalex.org/W2002167899","https://openalex.org/W2014385625","https://openalex.org/W2018917950","https://openalex.org/W2024689558","https://openalex.org/W2029427335","https://openalex.org/W2042344707","https://openalex.org/W2046835938","https://openalex.org/W2047756972","https://openalex.org/W2049849013","https://openalex.org/W2060861138","https://openalex.org/W2089505716","https://openalex.org/W2094441795","https://openalex.org/W2098080617","https://openalex.org/W2107903378","https://openalex.org/W2108875521","https://openalex.org/W2110905563","https://openalex.org/W2119608842","https://openalex.org/W2122341732","https://openalex.org/W2131271579","https://openalex.org/W2131906927","https://openalex.org/W2145189896","https://openalex.org/W2146548337","https://openalex.org/W2160195427","https://openalex.org/W2169456326","https://openalex.org/W2178450581","https://openalex.org/W2179438025","https://openalex.org/W2267395091","https://openalex.org/W2293656227","https://openalex.org/W2319760762","https://openalex.org/W2328192806","https://openalex.org/W2345356016","https://openalex.org/W2549277677","https://openalex.org/W2581566333","https://openalex.org/W2596770143","https://openalex.org/W2608524463","https://openalex.org/W2800679771","https://openalex.org/W2808917129","https://openalex.org/W2904188188","https://openalex.org/W2907985308","https://openalex.org/W2915103810","https://openalex.org/W2948009614","https://openalex.org/W2950506568","https://openalex.org/W2958154915","https://openalex.org/W2979382144","https://openalex.org/W2985045444","https://openalex.org/W2986910545","https://openalex.org/W3005522568","https://openalex.org/W3011388847","https://openalex.org/W3030459861","https://openalex.org/W3035756243","https://openalex.org/W3094527567","https://openalex.org/W3096013042","https://openalex.org/W3178756715","https://openalex.org/W3179357816","https://openalex.org/W3196578943","https://openalex.org/W3203845059","https://openalex.org/W4225311944","https://openalex.org/W4285388821","https://openalex.org/W4296177767","https://openalex.org/W4308515111","https://openalex.org/W4318044547","https://openalex.org/W4391683730","https://openalex.org/W4396696709","https://openalex.org/W4399807324","https://openalex.org/W4401845085","https://openalex.org/W4408223636","https://openalex.org/W4414163509","https://openalex.org/W4414789222","https://openalex.org/W4414896761","https://openalex.org/W4416308796","https://openalex.org/W4416498819","https://openalex.org/W7140275404","https://openalex.org/W7163418477"],"related_works":["https://openalex.org/W3094527567","https://openalex.org/W7125598717","https://openalex.org/W1986532926","https://openalex.org/W4389026196","https://openalex.org/W1233976893","https://openalex.org/W4400430422","https://openalex.org/W2596770143","https://openalex.org/W3132216207","https://openalex.org/W4414896761","https://openalex.org/W2166024429"],"abstract_inverted_index":{"Intestinal":[0],"epithelial":[1,26,59,93,117,245],"barrier":[2,15,27,101,246],"is":[3,16,28],"a":[4,17,238,249],"key":[5],"feature":[6],"of":[7,13,19,23,46,83,90,109,132,138,166,242],"the":[8,24,40,49,68,81,133,139,243],"healthy":[9],"gut,":[10],"and":[11,34,52,76,88,113,124,146,162,182,192,219,224,247,256],"disruption":[12,102],"this":[14],"driver":[18],"mucosal":[20,104,217,254],"inflammation.":[21,105,257],"Integrity":[22],"intestinal":[25,92,116,160,244,253],"controlled":[29],"by":[30,215],"tight":[31],"junctions":[32,36],"(TJs)":[33],"adherens":[35],"(AJs)":[37],"associated":[38],"with":[39],"underlying":[41],"actin":[42],"cytoskeleton.":[43],"Posttranslational":[44],"modifications":[45,57],"actins":[47,66],"affect":[48],"cytoskeletal":[50],"assembly":[51,137,191],"dynamics,":[53],"however":[54],"whether":[55],"such":[56],"regulate":[58],"barriers":[60],"remains":[61],"unknown.":[62],"SETD3":[63,84,110,154,175,198,235],"methyltransferase":[64],"methylates":[65],"at":[67],"His73":[69],"residue,":[70],"thereby":[71],"enhancing":[72],"filamentous":[73],"(F)-actin":[74],"polymerization":[75],"turnover.":[77],"This":[78],"study":[79],"examines":[80],"role":[82,251],"in":[85,100,111,121,184,189],"regulating":[86],"structure":[87],"function":[89],"normal":[91],"barrier,":[94,135],"as":[95,97,169,237],"well":[96],"its":[98],"involvement":[99],"during":[103,150,206,252],"siRNA":[106],"mediated":[107],"knockdown":[108],"DLD-1":[112],"HCA-7":[114],"human":[115],"cells":[118],"(IEC)":[119],"resulted":[120],"several":[122],"functional":[123],"morphological":[125],"cell":[126,144,180,194,223],"abnormalities.":[127],"These":[128],"include":[129],"increased":[130,143,159,179,220],"permeability":[131,161],"IEC":[134],"diminished":[136],"perijunctional":[140],"F-actin":[141],"belt,":[142],"size,":[145],"delayed":[147],"TJ":[148],"reassembly":[149],"calcium":[151],"switch.":[152],"Consistently,":[153],"knockout":[155],"(KO)":[156],"mice":[157,177,200],"displayed":[158],"decreased":[163],"labeling":[164],"intensity":[165],"apical":[167],"\u03b2-actin":[168],"compared":[170],"to":[171],"wildtype":[172],"controls.":[173],"Furthermore,":[174],"KO":[176,199],"showed":[178],"stemness":[181],"proliferation":[183],"colonic":[185,228],"epithelium":[186],"without":[187],"defects":[188],"AJ/TJ":[190],"secretory":[193],"differentiation.":[195],"In":[196],"addition,":[197],"developed":[201],"more":[202],"severe":[203],"disease":[204],"symptoms":[205],"dextran":[207],"sodium":[208],"sulfate":[209],"(DSS)-induced":[210],"colitis,":[211],"which":[212],"were":[213],"accompanied":[214],"accelerated":[216],"erosion":[218],"macrophage,":[221],"T":[222],"neutrophil":[225],"infiltration":[226],"into":[227],"tissue.":[229],"Overall,":[230],"our":[231],"data":[232],"suggests":[233],"that":[234],"acts":[236],"novel":[239],"positive":[240],"regulator":[241],"plays":[248],"protective":[250],"damage":[255]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-06T00:00:00"}