{"id":"https://openalex.org/W7220451859","doi":"https://doi.org/10.64898/2026.10.05.756390","title":"Conserved mycobacteriophage protein uses structural mimicry to displace host initiation factors","display_name":"Conserved mycobacteriophage protein uses structural mimicry to displace host initiation factors","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220451859","doi":"https://doi.org/10.64898/2026.10.05.756390"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.05.756390","doi":"https://doi.org/10.64898/2026.10.05.756390","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756390","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.05.756390.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.05.756390.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040164861","display_name":"David Parker","orcid":"https://orcid.org/0000-0002-0025-3919","observed_orcids":["https://orcid.org/0000-0002-0025-3919"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"David R. Parker","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101701641","display_name":"Shrestha Ghosh","orcid":"https://orcid.org/0000-0002-0237-7827","observed_orcids":["https://orcid.org/0000-0002-0237-7827"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Shrestha Ghosh","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157621774","display_name":"Adela Dujiskova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adela Dujiskova","raw_affiliation_strings":["Laboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031284852","display_name":"Paul Dominic B. Olinares","orcid":"https://orcid.org/0000-0002-3429-6618","observed_orcids":["https://orcid.org/0000-0002-3429-6618"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Dominic B. Olinares","raw_affiliation_strings":["Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137499556","display_name":"Sarah Narrowe Danielsson","orcid":"https://orcid.org/0000-0003-0087-8756","observed_orcids":["https://orcid.org/0000-0003-0087-8756"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sarah Narrowe Danielsson","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059905905","display_name":"Grisna Isabel Prensa","orcid":"https://orcid.org/0009-0002-7101-7224","observed_orcids":["https://orcid.org/0009-0002-7101-7224"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Grisna Isabel Prensa","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157563141","display_name":"Doyeon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Doyeon Kim","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024887620","display_name":"Florian A. Rosenberger","orcid":"https://orcid.org/0000-0003-4604-6170","observed_orcids":["https://orcid.org/0000-0003-4604-6170"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Florian Andreas Rosenberger","raw_affiliation_strings":["Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany","Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072903725","display_name":"Arne Elofsson","orcid":"https://orcid.org/0000-0002-7115-9751","observed_orcids":["https://orcid.org/0000-0002-7115-9751"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Arne Elofsson","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7115-9751","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090940750","display_name":"Matthias Mann","orcid":"https://orcid.org/0000-0003-1292-4799","observed_orcids":["https://orcid.org/0000-0003-1292-4799","https://orcid.org/0000-0002-7122-6379"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Matthias Mann","raw_affiliation_strings":["Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany","NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2200, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2200, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101042040","display_name":"Elizabeth Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Campbell","raw_affiliation_strings":["Laboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011766022","display_name":"Andrea Fossati","orcid":"https://orcid.org/0000-0001-5170-4903","observed_orcids":["https://orcid.org/0000-0001-5170-4903"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Andrea Fossati","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum C9, Solnav\u00e4gen 9, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Science for Life Laboratory, Karolinska Institutet, Tomtebodav\u00e4gen 23A, Solna, 17165, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5011766022"],"corresponding_institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacteriophage-d29","display_name":"mycobacteriophage D29","score":0.9800000190734863},{"id":"https://openalex.org/keywords/host-rna-polymerase","display_name":"host RNA polymerase","score":0.7820000052452087},{"id":"https://openalex.org/keywords/structural-mimicry","display_name":"structural mimicry","score":0.7379999756813049},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.742900013923645},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.603600025177002},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5878000259399414},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5870000123977661},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.5737000107765198},{"id":"https://openalex.org/C2777119779","wikidata":"https://www.wikidata.org/wiki/Q963278","display_name":"Molecular mimicry","level":3,"score":0.5648000240325928},{"id":"https://openalex.org/C7863114","wikidata":"https://www.wikidata.org/wiki/Q192627","display_name":"Mimicry","level":2,"score":0.5449000000953674},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5412999987602234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5264999866485596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4417000114917755},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.3612000048160553},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.35740000009536743},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.35370001196861267},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.32519999146461487},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.32409998774528503},{"id":"https://openalex.org/C47319516","wikidata":"https://www.wikidata.org/wiki/Q306436","display_name":"Sigma factor","level":5,"score":0.31949999928474426},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.3181999921798706},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.30799999833106995},{"id":"https://openalex.org/C2777627835","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factor","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2989000082015991},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.29109999537467957},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C192772702","wikidata":"https://www.wikidata.org/wiki/Q2583975","display_name":"Structural genomics","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.27880001068115234},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.26010000705718994},{"id":"https://openalex.org/C2994092193","wikidata":"https://www.wikidata.org/wiki/Q16769446","display_name":"Coat protein","level":4,"score":0.25940001010894775},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.25099998712539673},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.05.756390","doi":"https://doi.org/10.64898/2026.10.05.756390","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756390","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.05.756390.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.05.756390","doi":"https://doi.org/10.64898/2026.10.05.756390","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.05.756390","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.10.05.756390.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3225332876","display_name":"Predictions of protein-protein interactions by PconsDock, a fold-and-dock algorithm.","funder_award_id":"2021-03979","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G326506993","display_name":null,"funder_award_id":"KAW 2020.0239","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G3467366347","display_name":null,"funder_award_id":"SNIC 2021/5-297","funder_id":"https://openalex.org/F4320322225","funder_display_name":"Link\u00f6pings Universitet"},{"id":"https://openalex.org/G5106711973","display_name":null,"funder_award_id":"Berzelius-2021-29.","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G8511050629","display_name":null,"funder_award_id":"2020.0239","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G8709696155","display_name":null,"funder_award_id":"KAW 2020.0239","funder_id":"https://openalex.org/F4320325677","funder_display_name":"Science for Life Laboratory"},{"id":"https://openalex.org/G8736901730","display_name":"Identifying novel vulnerabilities in M. tuberculosis using proteomics and genomic approaches","funder_award_id":"2023-01970","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320317161","display_name":"Swedish e-Science Research Centre","ror":"https://ror.org/01e59yk92"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322225","display_name":"Link\u00f6pings Universitet","ror":"https://ror.org/05ynxx418"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220451859.pdf","grobid_xml":"https://content.openalex.org/works/W7220451859.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220743183","https://openalex.org/W1997676049","https://openalex.org/W7106232004","https://openalex.org/W4412487646","https://openalex.org/W4412522508","https://openalex.org/W112639499","https://openalex.org/W2291802992","https://openalex.org/W4322201503","https://openalex.org/W2094262591","https://openalex.org/W7097818745"],"abstract_inverted_index":{"Abstract":[0],"Compact":[1],"viral":[2,126],"genomes":[3],"encode":[4],"sophisticated":[5],"strategies":[6],"to":[7],"reprogram":[8],"host":[9,47,69,132],"gene":[10],"expression,":[11],"often":[12],"by":[13],"co-opting":[14],"rather":[15],"than":[16],"replacing":[17],"RNA":[18,48,81],"polymerase.":[19,49],"How":[20],"bacteriophages":[21],"achieve":[22],"such":[23],"control":[24],"in":[25,100,117],"Mycobacteria":[26],"remains":[27],"largely":[28],"unknown.":[29],"Here,":[30],"time-resolved":[31],"interaction":[32],"proteomics":[33],"of":[34,54,80,87,114,119],"mycobacteriophage":[35],"D29":[36],"infection":[37],"identifies":[38],"a":[39,112,124],"conserved":[40,93],"two-protein":[41],"module,":[42],"gp53-gp52,":[43],"that":[44,65],"binds":[45],"the":[46,58,68,77],"Affinity":[50],"purification":[51],"confirmed":[52],"association":[53],"both":[55],"proteins":[56],"with":[57,84],"polymerase,":[59,82],"while":[60],"native":[61],"mass":[62],"spectrometry":[63],"demonstrated":[64],"gp53":[66,75],"displaces":[67],"sigma":[70],"factor.":[71],"Structural":[72],"modelling":[73],"places":[74],"at":[76],"sigma-binding":[78],"surface":[79],"consistent":[83],"molecular":[85,133],"mimicry":[86],"sigma-factor":[88,109],"engagement.":[89],"The":[90],"module":[91,127],"is":[92],"throughout":[94],"Cluster":[95],"A":[96],"mycobacteriophages":[97],"and":[98,121],"occurs":[99],"fused":[101],"or":[102],"split":[103],"genomic":[104],"architectures.":[105],"These":[106],"findings":[107],"suggest":[108],"displacement":[110],"as":[111],"mechanism":[113],"transcriptional":[115],"takeover":[116],"viruses":[118],"mycobacteria":[120],"show":[122],"how":[123],"compact":[125],"can":[128],"repurpose":[129],"an":[130],"essential":[131],"machine.":[134]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}