{"id":"https://openalex.org/W7220443256","doi":"https://doi.org/10.3390/biom16101443","title":"A Long-Acting Farnesoid X Receptor (FXR) Agonist Prevents Fibrosis","display_name":"A Long-Acting Farnesoid X Receptor (FXR) Agonist Prevents Fibrosis","publication_year":2026,"publication_date":"2026-10-03","ids":{"openalex":"https://openalex.org/W7220443256","doi":"https://doi.org/10.3390/biom16101443","pmid":"https://pubmed.ncbi.nlm.nih.gov/42939697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13702190"},"language":"en","primary_location":{"id":"doi:10.3390/biom16101443","doi":"https://doi.org/10.3390/biom16101443","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101443","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biom16101443","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020451537","display_name":"Ashrafi Sultana","orcid":"https://orcid.org/0000-0003-2653-6834","observed_orcids":["https://orcid.org/0000-0003-2653-6834"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashrafi Sultana","raw_affiliation_strings":["Medical Sciences Interdepartmental Area Program, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sciences Interdepartmental Area Program, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031795709","display_name":"Grace A Bybee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Bybee","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087616711","display_name":"Anup Singh Pathania","orcid":"https://orcid.org/0000-0002-1517-2919","observed_orcids":["https://orcid.org/0000-0002-1517-2919"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anup S. Pathania","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0000-0002-1517-2919","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147198256","display_name":"Weimin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weimin Wang","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107280064","display_name":"Nam Thai Hoang Le","orcid":"https://orcid.org/0009-0001-0492-1275","observed_orcids":["https://orcid.org/0009-0001-0492-1275"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nam Thai Hoang Le","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0009-0001-0492-1275","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011794164","display_name":"Brandon W. Hanson","orcid":"https://orcid.org/0009-0007-0740-1201","observed_orcids":["https://orcid.org/0009-0007-0740-1201"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon W. Hanson","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002750814","display_name":"Christopher D. Bauer","orcid":"https://orcid.org/0000-0002-5652-9582","observed_orcids":["https://orcid.org/0000-0002-5652-9582"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Bauer","raw_affiliation_strings":["Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070664867","display_name":"Deanna D. Mosley","orcid":"https://orcid.org/0009-0006-8783-7576","observed_orcids":["https://orcid.org/0009-0006-8783-7576"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanna D. Mosley","raw_affiliation_strings":["Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0009-0006-8783-7576","affiliations":[{"raw_affiliation_string":"Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058974129","display_name":"Howard Eliot Gendelman","orcid":"https://orcid.org/0000-0002-7831-0370","observed_orcids":["https://orcid.org/0000-0002-7831-0370"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard E. Gendelman","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0000-0002-7831-0370","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029395581","display_name":"Samuel M. Cohen","orcid":"https://orcid.org/0000-0002-5047-0962","observed_orcids":["https://orcid.org/0000-0002-5047-0962"]},"institutions":[{"id":"https://openalex.org/I4390039344","display_name":"Fred and Pamela Buffett Cancer Center","ror":"https://ror.org/03n63wv08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695","https://openalex.org/I4390039344"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel M. Cohen","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, and Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0000-0002-5047-0962","affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, and Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I4390039344","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030545609","display_name":"Todd A. Wyatt","orcid":"https://orcid.org/0000-0002-9273-6730","observed_orcids":["https://orcid.org/0000-0002-9273-6730"]},"institutions":[{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd A. Wyatt","raw_affiliation_strings":["Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA","Department of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine Division, University of Nebraska Medical Center, Omaha, NE 68198, USA","Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, 4101 Woolworth Avenue, Omaha, NE 68105, USA"],"raw_orcid":"https://orcid.org/0000-0002-9273-6730","affiliations":[{"raw_affiliation_string":"Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine Division, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, 4101 Woolworth Avenue, Omaha, NE 68105, USA","institution_ids":["https://openalex.org/I4210155874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026111070","display_name":"Larisa Y. Poluektova","orcid":"https://orcid.org/0000-0001-7339-8732","observed_orcids":["https://orcid.org/0000-0001-7339-8732"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larisa Y. Poluektova","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0000-0001-7339-8732","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029066855","display_name":"Benson Edagwa","orcid":"https://orcid.org/0000-0003-1484-9331","observed_orcids":["https://orcid.org/0000-0003-1484-9331"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Benson J. Edagwa","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0000-0003-1484-9331","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051120536","display_name":"Natalia A. Osna","orcid":"https://orcid.org/0000-0001-7498-0556","observed_orcids":["https://orcid.org/0000-0001-7498-0556"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natalia A. Osna","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":"https://orcid.org/0000-0001-7498-0556","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029066855","https://openalex.org/A5051120536"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7054967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"1443","last_page":"1443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesoid-x-receptor-agonist","display_name":"farnesoid X receptor agonist","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.871999979019165},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/long-acting-drug-delivery","display_name":"long-acting drug delivery","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hbv-cccdna","display_name":"HBV cccDNA","score":0.8370000123977661},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antiviral-therapy-adherence","display_name":"antiviral therapy adherence","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.8547999858856201},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8299000263214111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6431999802589417},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5501999855041504},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5429999828338623},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5073000192642212},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.46970000863075256},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.387800008058548},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3546000123023987},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30570000410079956},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.26170000433921814},{"id":"https://openalex.org/C189490182","wikidata":"https://www.wikidata.org/wiki/Q1052153","display_name":"cccDNA","level":5,"score":0.2533999979496002},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.25119999051094055},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2502000033855438}],"mesh":[{"descriptor_ui":"D000099150","descriptor_name":"Receptor, Farnesoid X-Activated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/biom16101443","doi":"https://doi.org/10.3390/biom16101443","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101443","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13702190","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702190/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702190/pdf/biomolecules-16-01443.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:42939697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42939697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.unmc.edu:coph_env_articles-1028","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/coph_env_articles/29","pdf_url":"https://digitalcommons.unmc.edu/context/coph_env_articles/article/1028/viewcontent/2026_Wyatt_Biomolecules.pdf","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Articles: Environmental, Agricultural & Occupational Health","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bbc26cf4a9cf4e21816eeca7eb819d56","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bbc26cf4a9cf4e21816eeca7eb819d56","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 16, Iss 10, p 1443 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom16101443","doi":"https://doi.org/10.3390/biom16101443","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101443","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G154207969","display_name":null,"funder_award_id":"BX005886","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G1600607514","display_name":null,"funder_award_id":"IK6-BX005962","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5447225426","display_name":"Thymic selection of Foxp3+ regulatory T cells","funder_award_id":"R56AI088553","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6131138226","display_name":null,"funder_award_id":"P50 AA030407","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G6487643833","display_name":null,"funder_award_id":"BX005962","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000315985","display_name":"Alcohol Center Of Research -- Nebraska (ACORN)","funder_award_id":"P50AA030407","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000856944","display_name":"LASER ART for PreP","funder_award_id":"R01AI158160","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000877012","display_name":"Prodrug Formulations Create Sustained-Release Antiretrovirals","funder_award_id":"R01AI145542","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000889944","display_name":"New generation of long acting nucleos(t)ides and immune stimulant for treatment of chronic hepatitis B","funder_award_id":"R01AI163042","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309137","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220443256.pdf","grobid_xml":"https://content.openalex.org/works/W7220443256.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1969253768","https://openalex.org/W2014233890","https://openalex.org/W2042198595","https://openalex.org/W2074673128","https://openalex.org/W2075400164","https://openalex.org/W2084404396","https://openalex.org/W2087389370","https://openalex.org/W2090930344","https://openalex.org/W2094975370","https://openalex.org/W2111199541","https://openalex.org/W2128635872","https://openalex.org/W2134164289","https://openalex.org/W2168986165","https://openalex.org/W2289874599","https://openalex.org/W2326276715","https://openalex.org/W2519114186","https://openalex.org/W2587903612","https://openalex.org/W2897916903","https://openalex.org/W2981031910","https://openalex.org/W3000320209","https://openalex.org/W3009494891","https://openalex.org/W3010480204","https://openalex.org/W3018289581","https://openalex.org/W3107197960","https://openalex.org/W3136229646","https://openalex.org/W3157916043","https://openalex.org/W3166762075","https://openalex.org/W3197061720","https://openalex.org/W3201379478","https://openalex.org/W4281706677","https://openalex.org/W4285596741","https://openalex.org/W4308294171","https://openalex.org/W4320490029","https://openalex.org/W4384023277","https://openalex.org/W4385648809","https://openalex.org/W4394827792","https://openalex.org/W4409409430","https://openalex.org/W4410042937","https://openalex.org/W4415760641","https://openalex.org/W7125175182"],"related_works":["https://openalex.org/W3197061720","https://openalex.org/W2039861850","https://openalex.org/W6891730024","https://openalex.org/W7212289094","https://openalex.org/W7203471736","https://openalex.org/W7143872889","https://openalex.org/W2133775721","https://openalex.org/W4408997536","https://openalex.org/W2611970905","https://openalex.org/W4395677649"],"abstract_inverted_index":{"Despite":[0],"effective":[1],"vaccines":[2],"and":[3,20,41,83,99,102,129],"antiviral":[4],"therapies,":[5],"patients":[6],"with":[7],"chronic":[8,61,109],"hepatitis":[9],"B":[10],"(CHB)":[11],"remain":[12],"at":[13],"risk":[14],"of":[15,60,120],"developing":[16],"progressive":[17],"liver":[18,39,101,110,128],"fibrosis":[19,40],"cirrhosis.":[21],"Vonafexor":[22],"(VON),":[23],"a":[24,71,106],"second-generation":[25],"synthetic":[26],"non-steroidal,":[27],"non-bile":[28],"acid":[29],"farnesoid":[30],"X":[31],"receptor":[32],"agonist,":[33],"has":[34],"been":[35],"shown":[36],"to":[37,49,57],"prevent":[38],"target":[42],"the":[43,88],"HBV":[44],"cccDNA":[45],"reservoir.":[46],"However,":[47],"adherence":[48],"daily":[50],"oral":[51],"therapy":[52],"is":[53],"an":[54],"established":[55],"barrier":[56],"successful":[58],"treatment":[59],"infections.":[62],"To":[63],"overcome":[64],"this":[65],"barrier,":[66],"VON":[67,122],"was":[68,96],"transformed":[69],"into":[70],"long-acting":[72],"(LA)":[73],"prodrug":[74,78],"nanosuspension.":[75],"The":[76,94,113],"LA":[77,121],"formulation":[79,95],"suppressed":[80],"\u03b1SMA,":[81],"TGF\u03b2,":[82],"Col1A1":[84],"gene":[85],"expression":[86],"in":[87,105],"LX2":[89],"hepatic":[90],"stellate":[91],"cell":[92],"line.":[93],"well":[97],"tolerated":[98],"prevented":[100],"lung":[103,130],"damage":[104],"carbon":[107],"tetrachloride-induced":[108],"injury":[111],"model.":[112],"promising":[114],"preclinical":[115],"data":[116],"support":[117],"further":[118],"development":[119],"prodrugs":[123],"as":[124],"potential":[125],"treatments":[126],"for":[127],"fibrosis.":[131]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}
