{"id":"https://openalex.org/W7220442272","doi":"https://doi.org/10.1016/j.crmeth.2026.101617","title":"Mycobacterium tuberculosis gene expression dynamics in host environments with single-cell resolution","display_name":"Mycobacterium tuberculosis gene expression dynamics in host environments with single-cell resolution","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220442272","doi":"https://doi.org/10.1016/j.crmeth.2026.101617","pmid":"https://pubmed.ncbi.nlm.nih.gov/42833215"},"language":"en","primary_location":{"id":"doi:10.1016/j.crmeth.2026.101617","doi":"https://doi.org/10.1016/j.crmeth.2026.101617","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101617","pdf_url":null,"source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.crmeth.2026.101617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047775249","display_name":"Beren Aylan","orcid":"https://orcid.org/0009-0008-7741-2712","observed_orcids":["https://orcid.org/0009-0008-7741-2712"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Beren Aylan","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017391390","display_name":"Laure Botella","orcid":"https://orcid.org/0000-0003-2776-4118","observed_orcids":["https://orcid.org/0000-0003-2776-4118"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laure Botella","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068915334","display_name":"Pierre Santucci","orcid":"https://orcid.org/0000-0002-6291-3425","observed_orcids":["https://orcid.org/0000-0002-6291-3425"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pierre Santucci","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082224541","display_name":"Antony Fearns","orcid":"https://orcid.org/0000-0001-9937-8545","observed_orcids":["https://orcid.org/0000-0001-9937-8545"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antony Fearns","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157588819","display_name":"Di Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Di Chen","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088821701","display_name":"Angela Rodgers","orcid":"https://orcid.org/0000-0002-2981-6455","observed_orcids":["https://orcid.org/0000-0002-2981-6455"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angela Rodgers","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003223948","display_name":"Teresa Cortes","orcid":"https://orcid.org/0000-0002-5746-3300","observed_orcids":["https://orcid.org/0000-0002-5746-3300"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210148788","display_name":"Instituto de Biomedicina de Valencia","ror":"https://ror.org/05pq8vh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210148788"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Cortes","raw_affiliation_strings":["Instituto de Biomedicina de Valencia, CSIC, 46010 Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biomedicina de Valencia, CSIC, 46010 Valencia, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210148788"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068817299","display_name":"Maximiliano Gabriel Gutierrez","orcid":"https://orcid.org/0000-0003-3199-0337","observed_orcids":["https://orcid.org/0000-0003-3199-0337"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Maximiliano G. Gutierrez","raw_affiliation_strings":["Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: max.g@crick.ac.uk"],"raw_orcid":"https://orcid.org/0000-0003-3199-0337","affiliations":[{"raw_affiliation_string":"Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: max.g@crick.ac.uk","institution_ids":["https://openalex.org/I2801081054"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068817299"],"corresponding_institution_ids":["https://openalex.org/I2801081054"],"apc_list":{"value":4824,"currency":"USD","value_usd":4824},"apc_paid":{"value":4824,"currency":"USD","value_usd":4824},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74954097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"101617","last_page":"101617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-heterogeneity","display_name":"gene expression heterogeneity","score":0.7200000286102295},{"id":"https://openalex.org/keywords/esx-1-secretion-system","display_name":"ESX-1 secretion system","score":0.9449999928474426},{"id":"https://openalex.org/keywords/promoter-activity","display_name":"promoter activity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7110000252723694},{"id":"https://openalex.org/keywords/phthiocerol-dimycocerosate","display_name":"phthiocerol dimycocerosate","score":0.9449999928474426},{"id":"https://openalex.org/keywords/atg14","display_name":"ATG14","score":0.9829999804496765},{"id":"https://openalex.org/keywords/espa","display_name":"EspA","score":0.8830000162124634},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.906000018119812},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.5699999928474426},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7670999765396118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7102000117301941},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.677299976348877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.645799994468689},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5695000290870667},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.48820000886917114},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.47929999232292175},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45910000801086426},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4269999861717224},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3799999952316284},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35760000348091125},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32659998536109924},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31790000200271606},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2791999876499176},{"id":"https://openalex.org/C20032557","wikidata":"https://www.wikidata.org/wiki/Q286721","display_name":"Serial analysis of gene expression","level":5,"score":0.26899999380111694}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.crmeth.2026.101617","doi":"https://doi.org/10.1016/j.crmeth.2026.101617","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101617","pdf_url":null,"source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},{"id":"pmid:42833215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42833215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports methods","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05844502v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05844502","pdf_url":null,"source":{"id":"https://openalex.org/S4406922393","display_name":"HAL AMU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports Methods, In press, &#x27E8;10.1016/j.crmeth.2026.101617&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.crmeth.2026.101617","doi":"https://doi.org/10.1016/j.crmeth.2026.101617","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101617","pdf_url":null,"source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1540505601","https://openalex.org/W1553697637","https://openalex.org/W1964886582","https://openalex.org/W1969919262","https://openalex.org/W1983301189","https://openalex.org/W1983828601","https://openalex.org/W1996159097","https://openalex.org/W2003304244","https://openalex.org/W2006128966","https://openalex.org/W2007097682","https://openalex.org/W2036635548","https://openalex.org/W2047330514","https://openalex.org/W2048991954","https://openalex.org/W2056191414","https://openalex.org/W2058036222","https://openalex.org/W2074511955","https://openalex.org/W2079630207","https://openalex.org/W2090197974","https://openalex.org/W2095444661","https://openalex.org/W2096781326","https://openalex.org/W2104847655","https://openalex.org/W2106942635","https://openalex.org/W2110447184","https://openalex.org/W2141681443","https://openalex.org/W2143061508","https://openalex.org/W2155347381","https://openalex.org/W2155448089","https://openalex.org/W2165418498","https://openalex.org/W2167279371","https://openalex.org/W2172080878","https://openalex.org/W2580358075","https://openalex.org/W2592510217","https://openalex.org/W2615762114","https://openalex.org/W2617852583","https://openalex.org/W2737860676","https://openalex.org/W2781779907","https://openalex.org/W2789367247","https://openalex.org/W2802701711","https://openalex.org/W2888406753","https://openalex.org/W2912531000","https://openalex.org/W2952692603","https://openalex.org/W2968768238","https://openalex.org/W2977665321","https://openalex.org/W3092588458","https://openalex.org/W3165713878","https://openalex.org/W3185416158","https://openalex.org/W4220856547","https://openalex.org/W4220923838","https://openalex.org/W4226020988","https://openalex.org/W4281992815","https://openalex.org/W4309512955","https://openalex.org/W4360610698","https://openalex.org/W4408875308","https://openalex.org/W4411782216","https://openalex.org/W4414655744","https://openalex.org/W7161632130"],"related_works":["https://openalex.org/W7202257511","https://openalex.org/W4413630436","https://openalex.org/W2499853419","https://openalex.org/W7018722130","https://openalex.org/W2060359620","https://openalex.org/W2615762114","https://openalex.org/W2007752039","https://openalex.org/W1982086226","https://openalex.org/W2141920762","https://openalex.org/W2091195827"],"abstract_inverted_index":{"Visualizing":[0],"when":[1],"and":[2,52,74,88,150],"where":[3],"Mycobacterium":[4],"tuberculosis":[5,18],"(Mtb)":[6],"genes":[7],"are":[8],"expressed":[9],"in":[10,28,68,93,124,132,143,148,151],"the":[11,59,76,89,103],"host":[12],"cell":[13],"is":[14],"crucial":[15],"to":[16],"understand":[17],"heterogeneity.":[19],"However,":[20],"imaging":[21,44],"approaches":[22],"for":[23],"studying":[24],"spatiotemporal":[25],"gene":[26,47,145],"expression":[27,48,146],"Mtb":[29,37,46,60,69,144],"remain":[30],"limited.":[31],"Here,":[32],"we":[33,64,126],"developed":[34],"a":[35,118,133],"dual-fluorophore":[36],"reporter":[38],"system":[39],"that":[40,83],"enables":[41],"high-content,":[42],"live-cell":[43],"of":[45,58,91,98,106],"with":[49,102],"high":[50],"spatial":[51],"temporal":[53,119],"resolution.":[54],"By":[55],"monitoring":[56],"components":[57],"ESX-1":[61,99,129],"secretion":[62],"system,":[63],"observed":[65],"substantial":[66],"heterogeneity":[67,142],"promoter":[70,96,110,130],"activity":[71,97,111,131],"both":[72],"within":[73],"between":[75],"infected":[77],"human":[78],"macrophages.":[79],"We":[80],"further":[81],"found":[82],"phthiocerol":[84],"dimycocerosates":[85],"(PDIM)":[86],"deficiency":[87],"loss":[90],"ATG14":[92],"macrophages":[94],"altered":[95],"components.":[100],"Consistent":[101],"dynamic":[104],"nature":[105],"this":[107],"heterogeneity,":[108],"espA":[109],"changed":[112],"over":[113],"time":[114],"following":[115],"phagocytosis,":[116],"highlighting":[117],"regulation.":[120],"Extending":[121],"these":[122],"observations":[123],"vivo,":[125],"confirmed":[127],"heterogeneous":[128],"C3HeB/FeJ":[134],"mouse":[135],"model.":[136],"Together,":[137],"our":[138],"findings":[139],"reveal":[140],"underappreciated":[141],"dynamics":[147],"vitro":[149],"vivo.":[152]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-06T00:00:00"}
