{"id":"https://openalex.org/W7220439803","doi":"https://doi.org/10.22034/lssj.2024.121","title":"Investigating the Effect of Polymorphisms in Regulating the Expression of Genes Involved in Ovarian Cancer","display_name":"Investigating the Effect of Polymorphisms in Regulating the Expression of Genes Involved in Ovarian Cancer","publication_year":2024,"publication_date":"2024-12-16","ids":{"openalex":"https://openalex.org/W7220439803","doi":"https://doi.org/10.22034/lssj.2024.121"},"language":"en","primary_location":{"id":"pmh:oai:journals.fmsbi.com:article/121","doi":"https://doi.org/10.22034/lssj.2024.121","is_oa":true,"landing_page_url":"https://journals.fmsbi.com/LSSJ/article/view/121","pdf_url":"https://journals.fmsbi.com/LSSJ/article/download/121/143","source":{"id":"https://openalex.org/S7407077655","display_name":"Life Sciences Student Journal","issn_l":"2980-9592","issn":["2980-9592"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2980-9592","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.fmsbi.com/LSSJ/article/download/121/143","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013885342","display_name":"Katayoun Aliyari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aliyari, Katayoun","raw_affiliation_strings":["Dr.aliyaripathobiolab, Borujerd, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr.aliyaripathobiolab, Borujerd, Iran","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047079486","display_name":"Roohollah Zarei Koosha","orcid":"https://orcid.org/0000-0001-5632-3640","observed_orcids":["https://orcid.org/0000-0001-5632-3640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zarei Koosha, Roohollah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083850762","display_name":"Abdolamir Ghadaksaz","orcid":"https://orcid.org/0000-0003-4105-4403","observed_orcids":["https://orcid.org/0000-0003-4105-4403"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ghadaksaz, Abdolamir","raw_affiliation_strings":["Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.22750000655651093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9629999995231628},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.9660000205039978},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.6819999814033508},{"id":"https://openalex.org/keywords/noncoding-regions","display_name":"non-coding regions","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.7630000114440918},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"transcriptional activity","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7516999840736389},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7034000158309937},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6632999777793884},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6360999941825867},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6207000017166138},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5625},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5392000079154968},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.4494999945163727},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44699999690055847},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.4424999952316284},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.38519999384880066},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.38269999623298645},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37139999866485596},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.36880001425743103},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3481000065803528},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.298799991607666},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2935999929904938},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2784999907016754},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C190789776","wikidata":"https://www.wikidata.org/wiki/Q767511","display_name":"Genetic marker","level":3,"score":0.25429999828338623},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:journals.fmsbi.com:article/121","doi":"https://doi.org/10.22034/lssj.2024.121","is_oa":true,"landing_page_url":"https://journals.fmsbi.com/LSSJ/article/view/121","pdf_url":"https://journals.fmsbi.com/LSSJ/article/download/121/143","source":{"id":"https://openalex.org/S7407077655","display_name":"Life Sciences Student Journal","issn_l":"2980-9592","issn":["2980-9592"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2980-9592","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:journals.fmsbi.com:article/121","doi":"https://doi.org/10.22034/lssj.2024.121","is_oa":true,"landing_page_url":"https://journals.fmsbi.com/LSSJ/article/view/121","pdf_url":"https://journals.fmsbi.com/LSSJ/article/download/121/143","source":{"id":"https://openalex.org/S7407077655","display_name":"Life Sciences Student Journal","issn_l":"2980-9592","issn":["2980-9592"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2980-9592","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220439803.pdf","grobid_xml":"https://content.openalex.org/works/W7220439803.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1985288035","https://openalex.org/W2025460005","https://openalex.org/W2041387751","https://openalex.org/W2070953479","https://openalex.org/W2109010345","https://openalex.org/W2131050852","https://openalex.org/W2136345087","https://openalex.org/W2625756837","https://openalex.org/W2903802004","https://openalex.org/W3011245402","https://openalex.org/W3047408082","https://openalex.org/W3127001337","https://openalex.org/W4206294567","https://openalex.org/W4220894799","https://openalex.org/W4297493643","https://openalex.org/W4389177303","https://openalex.org/W4402169861"],"related_works":["https://openalex.org/W4411989323","https://openalex.org/W4403289916","https://openalex.org/W2031341812","https://openalex.org/W3010527002","https://openalex.org/W2279684844","https://openalex.org/W4318826770","https://openalex.org/W2403467722","https://openalex.org/W4396713483","https://openalex.org/W7221786353","https://openalex.org/W4406042845"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1,58,188,199],"is":[2,65],"one":[3],"of":[4,28,69,76,104,118,157,186,195],"the":[5,26,66,74,102,139,154,193,203],"most":[6],"deadly":[7],"gynecological":[8],"malignancies":[9],"due":[10],"to":[11,80,160,210],"late-stage":[12],"diagnosis":[13],"and":[14,20,53,60,91,113,129,201],"complex":[15],"genetic":[16,29,196,212],"interactions.":[17],"Although":[18],"BRCA1":[19],"TP53":[21,140],"gene":[22,32,51,121,180],"mutations":[23],"are":[24,34],"common,":[25],"effects":[27,117],"polymorphisms":[30,47],"on":[31,120],"expression":[33,122],"not":[35],"fully":[36],"understood.":[37],"Genetic":[38],"variations":[39,72,100,137,174],"in":[40,84,138,143,147,153,164,175,198],"regulatory":[41,99],"regions,":[42],"known":[43],"as":[44,88],"single":[45],"nucleotide":[46],"(SNPs),":[48],"can":[49],"affect":[50,73,101,179],"transcription":[52],"posttranscriptional":[54],"processes,":[55],"thereby":[56,167],"influencing":[57],"susceptibility":[59],"progression.":[61],"The":[62,115,132],"current":[63],"shortfall":[64],"insufficient":[67],"knowledge":[68],"how":[70,98],"these":[71],"activation":[75],"crucial":[77],"genes":[78,105],"related":[79],"ovarian":[81,108,187],"cancer,":[82,109],"particularly":[83],"noncoding":[85],"regions":[86,93],"such":[87],"promoters,":[89],"enhancers,":[90],"untranslated":[92],"(UTRs).":[94],"This":[95,190],"research":[96],"explored":[97],"activities":[103],"associated":[106],"with":[107],"including":[110],"TP53,":[111],"BRCA1,":[112],"PTEN.":[114],"functional":[116],"SNPs":[119],"were":[123],"evaluated":[124],"using":[125],"QTL":[126],"analysis,":[127],"ChIP,":[128],"reporter":[130],"assays.":[131],"findings":[133],"illustrated":[134],"that":[135,173],"certain":[136],"promoter":[141],"resulted":[142],"a":[144,151,161,183],"30%":[145],"decrease":[146],"transcriptional":[148],"activity,":[149,181],"whereas":[150],"mutation":[152],"3'":[155],"UTR":[156],"PTEN":[158],"led":[159],"40%":[162],"increase":[163],"mRNA":[165],"stability,":[166],"boosting":[168],"expression.":[169],"These":[170],"results":[171],"indicate":[172],"control":[176],"areas":[177],"significantly":[178],"providing":[182],"new":[184],"understanding":[185],"susceptibility.":[189],"study":[191],"emphasizes":[192],"significance":[194],"differences":[197],"development":[200],"paves":[202],"way":[204],"for":[205],"personalized":[206],"treatment":[207],"approaches":[208],"tailored":[209],"individual":[211],"profiles.":[213]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-06T00:00:00"}