{"id":"https://openalex.org/W7220439802","doi":"https://doi.org/10.1136/bcr-2026-274113","title":"Reduced venesection requirement as a clue to occult colorectal cancer in hereditary haemochromatosis","display_name":"Reduced venesection requirement as a clue to occult colorectal cancer in hereditary haemochromatosis","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220439802","doi":"https://doi.org/10.1136/bcr-2026-274113","pmid":"https://pubmed.ncbi.nlm.nih.gov/42833850"},"language":"en","primary_location":{"id":"doi:10.1136/bcr-2026-274113","doi":"https://doi.org/10.1136/bcr-2026-274113","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bcr-2026-274113","pdf_url":null,"source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7220439802"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093351213","display_name":"Roisin Burrows-O\u2019Donoghue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801249017","display_name":"Frimley Park Hospital","ror":"https://ror.org/03c75ky76","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801249017","https://openalex.org/I2802828768"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roisin Burrows-O\u2019Donoghue","raw_affiliation_strings":["Frimley Park Hospital NHS Foundation Trust, Frimley, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frimley Park Hospital NHS Foundation Trust, Frimley, UK","institution_ids":["https://openalex.org/I2801249017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157545916","display_name":"Yee Tin Lit","orcid":"https://orcid.org/0009-0009-2442-3706","observed_orcids":["https://orcid.org/0009-0009-2442-3706"]},"institutions":[{"id":"https://openalex.org/I2801249017","display_name":"Frimley Park Hospital","ror":"https://ror.org/03c75ky76","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801249017","https://openalex.org/I2802828768"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yee Tin Lit","raw_affiliation_strings":["Frimley Park Hospital NHS Foundation Trust, Frimley, UK"],"raw_orcid":"https://orcid.org/0009-0009-2442-3706","affiliations":[{"raw_affiliation_string":"Frimley Park Hospital NHS Foundation Trust, Frimley, UK","institution_ids":["https://openalex.org/I2801249017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042913275","display_name":"Lucy Gorard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801249017","display_name":"Frimley Park Hospital","ror":"https://ror.org/03c75ky76","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801249017","https://openalex.org/I2802828768"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Lucy Gorard","raw_affiliation_strings":["Frimley Park Hospital NHS Foundation Trust, Frimley, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frimley Park Hospital NHS Foundation Trust, Frimley, UK","institution_ids":["https://openalex.org/I2801249017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038009766","display_name":"Kuldeep S. Cheent","orcid":"https://orcid.org/0009-0004-2206-5507","observed_orcids":["https://orcid.org/0009-0004-2206-5507"]},"institutions":[{"id":"https://openalex.org/I2801249017","display_name":"Frimley Park Hospital","ror":"https://ror.org/03c75ky76","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801249017","https://openalex.org/I2802828768"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kuldeep Cheent","raw_affiliation_strings":["Frimley Park Hospital NHS Foundation Trust, Frimley, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frimley Park Hospital NHS Foundation Trust, Frimley, UK","institution_ids":["https://openalex.org/I2801249017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042913275"],"corresponding_institution_ids":["https://openalex.org/I2801249017"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"10","first_page":"e274113","last_page":"e274113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-hemochromatosis","display_name":"hereditary hemochromatosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/occult-blood-loss","display_name":"occult blood loss","score":0.6420000195503235},{"id":"https://openalex.org/keywords/phlebotomy","display_name":"phlebotomy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.5950000286102295},{"id":"https://openalex.org/keywords/caecal-adenocarcinoma","display_name":"caecal adenocarcinoma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fecal-immunochemical-test","display_name":"fecal immunochemical test","score":0.8880000114440918},{"id":"https://openalex.org/keywords/iron-absorption","display_name":"iron absorption","score":0.6740000247955322},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8949999809265137},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.6528000235557556},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6502000093460083},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.6420000195503235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.617900013923645},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6033999919891357},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.5983999967575073},{"id":"https://openalex.org/C542804219","wikidata":"https://www.wikidata.org/wiki/Q5526839","display_name":"Gastrointestinal cancer","level":4,"score":0.47130000591278076},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4537000060081482},{"id":"https://openalex.org/C2777357209","wikidata":"https://www.wikidata.org/wiki/Q3595842","display_name":"Phlebotomy","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C2775895862","wikidata":"https://www.wikidata.org/wiki/Q356405","display_name":"Bloodletting","level":3,"score":0.42149999737739563},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.40939998626708984},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.3700999915599823},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.3634999990463257},{"id":"https://openalex.org/C3018783601","wikidata":"https://www.wikidata.org/wiki/Q3144934","display_name":"Hereditary hemochromatosis","level":3,"score":0.36070001125335693},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.34299999475479126},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C2779158730","wikidata":"https://www.wikidata.org/wiki/Q2488276","display_name":"Fecal occult blood","level":5,"score":0.2863999903202057},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2533999979496002},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009780","descriptor_name":"Occult Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018962","descriptor_name":"Phlebotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1136/bcr-2026-274113","doi":"https://doi.org/10.1136/bcr-2026-274113","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bcr-2026-274113","pdf_url":null,"source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},{"id":"pmid:42833850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42833850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ case reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W4282003446","https://openalex.org/W4394879925","https://openalex.org/W4411468408","https://openalex.org/W4415189797"],"related_works":["https://openalex.org/W2028065555","https://openalex.org/W1974736288","https://openalex.org/W4210257467","https://openalex.org/W2072188038","https://openalex.org/W2032809660","https://openalex.org/W1009840878","https://openalex.org/W2273960009","https://openalex.org/W2412585122","https://openalex.org/W3026477975","https://openalex.org/W4210490206"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"(CRC)":[2],"is":[3],"a":[4,13,18],"leading":[5],"cause":[6],"of":[7,15,46,94,113,122],"cancer-related":[8],"mortality":[9],"worldwide.":[10],"We":[11],"report":[12],"case":[14,97],"CRC":[16],"in":[17,20,76,103,106],"man":[19],"his":[21,51],"late":[22],"70s":[23],"with":[24],"hereditary":[25],"haemochromatosis":[26],"(HH)":[27],"who":[28],"historically":[29],"required":[30],"venesection":[31,55,104],"two":[32],"to":[33,38],"three":[34],"times":[35],"per":[36],"year":[37],"maintain":[39],"target":[40],"ferritin":[41,59],"levels.":[42],"Despite":[43],"the":[44,77,84,88],"absence":[45],"gastrointestinal":[47,115],"symptoms":[48],"or":[49],"anaemia,":[50],"requirement":[52],"for":[53],"maintenance":[54],"unexpectedly":[56],"ceased":[57],"and":[58,118],"levels":[60],"remained":[61],"low":[62],"without":[63],"treatment.":[64],"Two":[65],"faecal":[66],"immunochemical":[67],"tests":[68],"were":[69],"negative.":[70],"Colonoscopy":[71],"subsequently":[72],"revealed":[73],"an":[74,100,110],"adenocarcinoma":[75],"caecum.":[78],"Chronic":[79],"occult":[80,114],"blood":[81,116],"loss":[82,117],"from":[83],"tumour":[85],"likely":[86],"counterbalanced":[87],"increased":[89],"intestinal":[90],"iron":[91],"absorption":[92],"characteristic":[93],"HH.":[95],"This":[96],"highlights":[98],"that":[99],"unexplained":[101],"reduction":[102],"requirements":[105],"HH":[107],"may":[108],"represent":[109],"early":[111],"marker":[112],"should":[119],"prompt":[120],"consideration":[121],"further":[123],"investigation.":[124]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-06T00:00:00"}