{"id":"https://openalex.org/W7220439592","doi":"https://doi.org/10.1186/s13765-026-01124-y","title":"Combination of doxorubicin and myo-inositol induces apoptosis in MCF7 cells associated with altered total p38 MAPK levels","display_name":"Combination of doxorubicin and myo-inositol induces apoptosis in MCF7 cells associated with altered total p38 MAPK levels","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220439592","doi":"https://doi.org/10.1186/s13765-026-01124-y"},"language":"en","primary_location":{"id":"doi:10.1186/s13765-026-01124-y","doi":"https://doi.org/10.1186/s13765-026-01124-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13765-026-01124-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13765-026-01124-y.pdf","source":{"id":"https://openalex.org/S2764370109","display_name":"Applied Biological Chemistry","issn_l":"0368-2897","issn":["0368-2897","2468-0834","2468-0842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13765-026-01124-y.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005153784","display_name":"Berna \u00d6zdem","orcid":"https://orcid.org/0000-0002-4481-2866","observed_orcids":["https://orcid.org/0000-0002-4481-2866"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berna \u00d6zdem","raw_affiliation_strings":["Health Science Institute, Department of Medical Biology, Inonu University, Malatya, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science Institute, Department of Medical Biology, Inonu University, Malatya, T\u00fcrkiye","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157655573","display_name":"Tugce Kaymaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281109512","display_name":"Nev\u015fehir Hac\u0131 Bekta\u015f Veli University","ror":"https://ror.org/019jds967","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281109512"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Tugce Kaymaz","raw_affiliation_strings":["Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Nevsehir Haci Bektas Veli University, Nevsehir, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Nevsehir Haci Bektas Veli University, Nevsehir, T\u00fcrkiye","institution_ids":["https://openalex.org/I1281109512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035872285","display_name":"I\u015f\u0131l Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0002-3027-6054","observed_orcids":["https://orcid.org/0000-0002-3027-6054"]},"institutions":[{"id":"https://openalex.org/I8666313","display_name":"Beykent University","ror":"https://ror.org/03dcvf827","country_code":"TR","type":"education","lineage":["https://openalex.org/I8666313"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"I\u015f\u0131l Y\u0131ld\u0131r\u0131m","raw_affiliation_strings":["Vocational School, Pharmacy Services Program, Istanbul Beykent University, Biochemistry area, Istanbul, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-3027-6054","affiliations":[{"raw_affiliation_string":"Vocational School, Pharmacy Services Program, Istanbul Beykent University, Biochemistry area, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I8666313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006515267","display_name":"Cemil Demir","orcid":"https://orcid.org/0000-0002-6365-0196","observed_orcids":["https://orcid.org/0000-0002-6365-0196"]},"institutions":[{"id":"https://openalex.org/I217764696","display_name":"Mardin Artuklu University","ror":"https://ror.org/0396cd675","country_code":"TR","type":"education","lineage":["https://openalex.org/I217764696"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cemil Demir","raw_affiliation_strings":["Health Services Vocational School, Department of Medical Services and Techniques, Mardin Artuklu University, Mardin, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Services Vocational School, Department of Medical Services and Techniques, Mardin Artuklu University, Mardin, T\u00fcrkiye","institution_ids":["https://openalex.org/I217764696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035872285","https://openalex.org/A5157655573"],"corresponding_institution_ids":["https://openalex.org/I1281109512","https://openalex.org/I8666313"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.4169999957084656,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.4169999957084656,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.09059999883174896,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":1.0},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.906000018119812},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6669999957084656},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9190000295639038},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.609000027179718},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8294000029563904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8165000081062317},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7646999955177307},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6664000153541565},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6510999798774719},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.600600004196167},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5494999885559082},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47620001435279846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43720000982284546},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42340001463890076},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.39480000734329224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38659998774528503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3862000107765198},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.38580000400543213},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3720000088214874},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2815000116825104},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s13765-026-01124-y","doi":"https://doi.org/10.1186/s13765-026-01124-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13765-026-01124-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13765-026-01124-y.pdf","source":{"id":"https://openalex.org/S2764370109","display_name":"Applied Biological Chemistry","issn_l":"0368-2897","issn":["0368-2897","2468-0834","2468-0842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:648a9218d41347fba6c0db8e78741776","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/648a9218d41347fba6c0db8e78741776","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Biological Chemistry, Vol 69, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13765-026-01124-y","doi":"https://doi.org/10.1186/s13765-026-01124-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13765-026-01124-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13765-026-01124-y.pdf","source":{"id":"https://openalex.org/S2764370109","display_name":"Applied Biological Chemistry","issn_l":"0368-2897","issn":["0368-2897","2468-0834","2468-0842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220439592.pdf","grobid_xml":"https://content.openalex.org/works/W7220439592.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1982021988","https://openalex.org/W2239528726","https://openalex.org/W2473764235","https://openalex.org/W2558318064","https://openalex.org/W2593436234","https://openalex.org/W3094515853","https://openalex.org/W3122470240","https://openalex.org/W3136070778","https://openalex.org/W3151551947","https://openalex.org/W3160714455","https://openalex.org/W3178247243","https://openalex.org/W3188214163","https://openalex.org/W3203286644","https://openalex.org/W3203293506","https://openalex.org/W3211640072","https://openalex.org/W4211069155","https://openalex.org/W4221039523","https://openalex.org/W4283578162","https://openalex.org/W4304099273","https://openalex.org/W4308834893","https://openalex.org/W4308866990","https://openalex.org/W4365448039","https://openalex.org/W4366091290","https://openalex.org/W4366828179","https://openalex.org/W4387298501","https://openalex.org/W4391535825","https://openalex.org/W4393143013","https://openalex.org/W4399423778","https://openalex.org/W4399737484","https://openalex.org/W4400744652","https://openalex.org/W4402498858","https://openalex.org/W4405874692","https://openalex.org/W4408066215","https://openalex.org/W4409621989","https://openalex.org/W4410267986","https://openalex.org/W4411791890","https://openalex.org/W4413447357","https://openalex.org/W4414416296","https://openalex.org/W7163441361"],"related_works":["https://openalex.org/W2115532546","https://openalex.org/W6924989983","https://openalex.org/W3137314715","https://openalex.org/W2364061739","https://openalex.org/W4388227492","https://openalex.org/W2987324413","https://openalex.org/W2425544421","https://openalex.org/W2092453845","https://openalex.org/W3186629832","https://openalex.org/W2001932120"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"compounds":[2],"are":[3],"attracting":[4],"increasing":[5],"attention":[6],"in":[7,36,79,134,165,207],"cancer":[8,56],"treatment":[9,128,154],"due":[10],"to":[11,14,121,171],"their":[12],"ability":[13],"regulate":[15],"key":[16],"pathways":[17],"associated":[18],"with":[19,51,140,217],"cell":[20,132,158,205],"proliferation,":[21],"apoptosis,":[22,99],"and":[23,59,76,103,115,137,174,185,201],"chemotherapy":[24],"resistance.":[25],"Myo-inositol,":[26],"a":[27,135,179,221],"naturally":[28],"occurring":[29],"carbocyclic":[30],"sugar,":[31],"has":[32],"demonstrated":[33],"its":[34],"potential":[35,123],"hormone-sensitive":[37],"cancers,":[38],"including":[39],"breast":[40,55],"cancer.":[41],"This":[42],"study":[43],"investigates":[44],"the":[45,60,64,95,166,197],"synergistic":[46],"effect":[47,142],"of":[48,63,199,213],"combining":[49],"doxorubicin":[50,172,202],"myo-inositol":[52,72,175,200],"on":[53,143],"MCF7":[54,80,131,208],"cells":[57],"(ER+),":[58],"possible":[61],"involvement":[62],"p38":[65,87,100,215],"MAPK":[66,88,101],"signaling":[67],"pathway.":[68],"We":[69],"hypothesized":[70],"that":[71,196],"enhances":[73,203],"doxorubicin-induced":[74],"cytotoxicity":[75],"promotes":[77],"apoptosis":[78],"cells,":[81,148,209],"potentially":[82,210],"by":[83,107],"modulating":[84],"stress-responsive":[85],"Total":[86,214],"levels.":[89],"Cell":[90],"viability":[91],"was":[92],"assessed":[93,106],"using":[94],"MTS":[96],"assay,":[97],"while":[98],"levels,":[102],"ROS":[104],"were":[105,119,163],"flow":[108],"cytometry.":[109],"ADME":[110],"predictions,":[111],"KEGG":[112],"pathway":[113],"analysis,":[114],"subcellular":[116],"compartment":[117],"analysis":[118],"performed":[120],"explore":[122],"mechanistic":[124,222],"links.":[125],"The":[126,152],"combination":[127,167,198],"significantly":[129],"reduced":[130],"proliferation":[133],"dose-":[136],"time-dependent":[138],"manner,":[139],"minimal":[141],"normal":[144],"MCF":[145],"10":[146],"A":[147],"suggesting":[149],"selective":[150],"cytotoxicity.":[151],"combined":[153],"induced":[155],"25.12%":[156],"apoptotic":[157,204],"death.":[159],"Interestingly,":[160],"Phospho-p38-MAPK":[161],"levels":[162],"lower":[164],"group":[168],"(58.82%)":[169],"compared":[170],"(90.17%)":[173],"(72.51%)":[176],"alone,":[177],"indicating":[178],"1.53-fold":[180],"(":[181,187],"p":[182,188],"<":[183,189],"0.01)":[184],"1.23-fold":[186],"0.05)":[190],"reduction,":[191],"respectively.":[192],"These":[193],"findings":[194],"suggest":[195],"death":[206],"through":[211],"modulation":[212],"MAPK,":[216],"computational":[218],"analyses":[219],"supporting":[220],"basis.":[223]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-06T00:00:00"}
