{"id":"https://openalex.org/W7220439209","doi":"https://doi.org/10.1080/15569527.2026.2740523","title":"Subclinical intestinal inflammation in psoriasis: a cross-sectional comparative study using fecal calprotectin","display_name":"Subclinical intestinal inflammation in psoriasis: a cross-sectional comparative study using fecal calprotectin","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220439209","doi":"https://doi.org/10.1080/15569527.2026.2740523","pmid":"https://pubmed.ncbi.nlm.nih.gov/42832771"},"language":"en","primary_location":{"id":"doi:10.1080/15569527.2026.2740523","doi":"https://doi.org/10.1080/15569527.2026.2740523","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15569527.2026.2740523","pdf_url":null,"source":{"id":"https://openalex.org/S52317855","display_name":"Cutaneous and Ocular Toxicology","issn_l":"1556-9527","issn":["1556-9527","1556-9535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutaneous and Ocular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088099484","display_name":"M\u00fccahit Marsak","orcid":"https://orcid.org/0000-0002-9905-3158","observed_orcids":["https://orcid.org/0000-0002-9905-3158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mucahit Marsak","raw_affiliation_strings":["Department of Dermatology, Private Universal Eye Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-9905-3158","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Private Universal Eye Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017696318","display_name":"Serpil \u015eener","orcid":"https://orcid.org/0000-0002-7012-2666","observed_orcids":["https://orcid.org/0000-0002-7012-2666"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serpil Sener","raw_affiliation_strings":["Faculty of Medicine, Department of Dermatology, Inonu University"],"raw_orcid":"https://orcid.org/0000-0002-7012-2666","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Dermatology, Inonu University","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054548989","display_name":"Mehmet Enes G\u00fcner","orcid":"https://orcid.org/0000-0001-5424-4674","observed_orcids":["https://orcid.org/0000-0001-5424-4674"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet Enes G\u00fcner","raw_affiliation_strings":["Faculty of Medicine, Department of Dermatology, Inonu University"],"raw_orcid":"https://orcid.org/0000-0001-5424-4674","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Dermatology, Inonu University","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085729840","display_name":"Dursun T\u00fcrkmen","orcid":"https://orcid.org/0000-0001-9076-4669","observed_orcids":["https://orcid.org/0000-0001-9076-4669"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dursun Turkmen","raw_affiliation_strings":["Faculty of Medicine, Department of Dermatology, Inonu University"],"raw_orcid":"https://orcid.org/0000-0001-9076-4669","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Dermatology, Inonu University","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025644401","display_name":"Nihal Altun\u0131\u015f\u0131k","orcid":"https://orcid.org/0000-0001-6844-1097","observed_orcids":["https://orcid.org/0000-0001-6844-1097"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nihal Altunisik","raw_affiliation_strings":["Faculty of Medicine, Department of Dermatology, Inonu University"],"raw_orcid":"https://orcid.org/0000-0001-6844-1097","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Dermatology, Inonu University","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028171777","display_name":"Zekiye Kanat","orcid":"https://orcid.org/0000-0003-0263-4587","observed_orcids":["https://orcid.org/0000-0003-0263-4587"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zekiye Kanat","raw_affiliation_strings":["Faculty of Medicine, Department of Dermatology, Inonu University"],"raw_orcid":"https://orcid.org/0000-0003-0263-4587","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Dermatology, Inonu University","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009597826","display_name":"Y\u00fccel Duman","orcid":"https://orcid.org/0000-0002-9090-2096","observed_orcids":["https://orcid.org/0000-0002-9090-2096"]},"institutions":[{"id":"https://openalex.org/I121596126","display_name":"Aksaray University","ror":"https://ror.org/026db3d50","country_code":"TR","type":"education","lineage":["https://openalex.org/I121596126"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Y\u00fccel Duman","raw_affiliation_strings":["Faculty of Medicine, Department of Medical Microbiology, Aksaray University"],"raw_orcid":"https://orcid.org/0000-0002-9090-2096","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Medical Microbiology, Aksaray University","institution_ids":["https://openalex.org/I121596126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054548989"],"corresponding_institution_ids":["https://openalex.org/I20126385"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.39480000734329224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fecal-calprotectin","display_name":"fecal calprotectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.7850000262260437},{"id":"https://openalex.org/keywords/gut-skin-axis","display_name":"gut-skin axis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/psoriasis-severity","display_name":"psoriasis severity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/gastrointestinal-symptom-rating-scale","display_name":"Gastrointestinal Symptom Rating Scale","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.8460999727249146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7264000177383423},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.623199999332428},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6161999702453613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5740000009536743},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5482000112533569},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3440999984741211},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.2815999984741211},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C2910850605","wikidata":"https://www.wikidata.org/wiki/Q210352","display_name":"Mucosal inflammation","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/15569527.2026.2740523","doi":"https://doi.org/10.1080/15569527.2026.2740523","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15569527.2026.2740523","pdf_url":null,"source":{"id":"https://openalex.org/S52317855","display_name":"Cutaneous and Ocular Toxicology","issn_l":"1556-9527","issn":["1556-9527","1556-9535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutaneous and Ocular Toxicology","raw_type":"journal-article"},{"id":"pmid:42832771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42832771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutaneous and ocular toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2587719747","https://openalex.org/W2914205992","https://openalex.org/W2970968550","https://openalex.org/W3124488291","https://openalex.org/W3158985708","https://openalex.org/W4295681688","https://openalex.org/W4309787413","https://openalex.org/W4386027089","https://openalex.org/W4387563339","https://openalex.org/W4390742670","https://openalex.org/W4394688188","https://openalex.org/W4399331317","https://openalex.org/W4399576367","https://openalex.org/W4402173452","https://openalex.org/W4408508471","https://openalex.org/W4409218422","https://openalex.org/W4414474982","https://openalex.org/W4416978248"],"related_works":["https://openalex.org/W7214618556","https://openalex.org/W2900204117","https://openalex.org/W7119244119","https://openalex.org/W2914205992","https://openalex.org/W2789987809","https://openalex.org/W4405595962","https://openalex.org/W4402173452","https://openalex.org/W3137078475","https://openalex.org/W4312140935","https://openalex.org/W4388867892"],"abstract_inverted_index":{"Background":[0],"Psoriasis":[1,87],"has":[2],"been":[3],"linked":[4],"to":[5],"inflammatory":[6],"bowel":[7],"disease":[8,210],"and":[9,30,38,65,82,89,94,122,149,160,184,206,226],"the":[10,76,86,137,163],"gut\u2013skin":[11],"axis,":[12],"but":[13],"whether":[14],"cutaneous":[15,204],"psoriasis":[16,37,55,83,147,205,224],"is":[17],"associated":[18,189],"with":[19,36,40,128,190,201],"subclinical":[20],"intestinal":[21],"inflammation":[22],"remains":[23],"uncertain.Objectives":[24],"To":[25],"evaluate":[26],"fecal":[27],"calprotectin":[28],"(FC)":[29],"gastrointestinal":[31,73,209],"symptom":[32],"burden":[33],"in":[34,108,116,126,146,153],"adults":[35,200],"controls,":[39,127],"exploratory":[41],"comparison":[42],"by":[43,71,75,85],"systemic":[44,58,63,111,120],"treatment":[45],"status.Methods":[46],"This":[47],"cross-sectional":[48],"comparative":[49],"study":[50],"included":[51],"72":[52],"adults:":[53],"22":[54],"patients":[56,109,148,225],"receiving":[57,62,110,119],"therapy,":[59,64,112,121],"25":[60,66],"not":[61,118,179,187],"controls.":[67,227],"FC":[68,102,141,166,185],"was":[69,142,168,186,221],"measured":[70],"ELISA,":[72],"symptoms":[74],"Gastrointestinal":[77],"Symptom":[78],"Rating":[79],"Scale":[80],"(GSRS),":[81],"severity":[84],"Area":[88],"Severity":[90],"Index":[91],"(PASI).":[92],"Age-":[93],"sex-adjusted":[95],"analyses":[96],"used":[97],"log-transformed":[98],"FC.Results":[99],"Median":[100],"(IQR)":[101],"levels":[103],"were":[104],"60.0":[105],"(30.0\u2013263.1)":[106],"\u00b5g/g":[107,115,125,145,152],"48.4":[113],"(30.0\u2013188.0)":[114],"those":[117],"57.6":[123,150],"(30.0\u2013157.7)":[124,151],"no":[129,214],"significant":[130,216],"three-group":[131],"difference":[132,220],"(p":[133,155],"=":[134,156,174],"0.554).":[135],"In":[136,194],"pooled":[138],"comparison,":[139],"median":[140],"53.1":[143],"(30.0\u2013197.3)":[144],"controls":[154],"0.503).":[157],"After":[158],"age":[159],"sex":[161],"adjustment,":[162],"geometric":[164],"mean":[165],"ratio":[167],"1.30":[169],"(95%":[170],"CI":[171],"0.74\u20132.28;":[172],"p":[173],"0.356).":[175],"GSRS":[176],"scores":[177],"did":[178],"differ":[180],"significantly":[181,188],"between":[182,223],"groups,":[183],"PASI":[191],"or":[192,211,218],"GSRS.Conclusions":[193],"this":[195],"small,":[196],"selected":[197],"cohort":[198],"of":[199],"predominantly":[202],"mild":[203],"without":[207],"known":[208],"psoriatic":[212],"arthritis,":[213],"statistically":[215],"FC-":[217],"GSRS-based":[219],"detected":[222],"Larger":[228],"prospective":[229],"studies":[230],"are":[231],"needed.":[232]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}