{"id":"https://openalex.org/W7220428713","doi":"https://doi.org/10.3390/molecules31193531","title":"A Dual-Functional Magnetic Nanoparticle for Rapid Extraction and Targeted Tumor Delivery of Tiancimycin","display_name":"A Dual-Functional Magnetic Nanoparticle for Rapid Extraction and Targeted Tumor Delivery of Tiancimycin","publication_year":2026,"publication_date":"2026-10-03","ids":{"openalex":"https://openalex.org/W7220428713","doi":"https://doi.org/10.3390/molecules31193531","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13666505"},"language":"en","primary_location":{"id":"doi:10.3390/molecules31193531","doi":"https://doi.org/10.3390/molecules31193531","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31193531","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/molecules31193531","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157654482","display_name":"Chengyu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengyu Zhang","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025793387","display_name":"Peng Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhong","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157515717","display_name":"Daxin Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daxin Zhao","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112107455","display_name":"Yun Lv","orcid":"https://orcid.org/0009-0007-2072-9228","observed_orcids":["https://orcid.org/0009-0007-2072-9228","https://orcid.org/0009-0000-3693-7530"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Lv","raw_affiliation_strings":["National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100594223","display_name":"Ximeng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ximeng Zhang","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120961421","display_name":"Chunyan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyan Chen","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070184745","display_name":"Huijuan Yu","orcid":"https://orcid.org/0000-0003-3222-7608","observed_orcids":["https://orcid.org/0000-0003-3222-7608"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijuan Yu","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":"https://orcid.org/0000-0003-3222-7608","affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103147751","display_name":"Xin Chai","orcid":"https://orcid.org/0000-0002-2662-4140","observed_orcids":["https://orcid.org/0000-0002-2662-4140"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chai","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059512146","display_name":"\u5f20\u4e91\u838e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunsha Zhang","raw_affiliation_strings":["School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628339","display_name":"Jiaxing Zhang","orcid":"https://orcid.org/0000-0003-4104-6657","observed_orcids":["https://orcid.org/0000-0003-4104-6657","https://orcid.org/0009-0003-7061-2133"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxing Zhang","raw_affiliation_strings":["Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"],"raw_orcid":"https://orcid.org/0000-0003-4104-6657","affiliations":[{"raw_affiliation_string":"Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157566900","display_name":"Yuefei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuefei Wang","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060769915","display_name":"Xiaohui Yan","orcid":"https://orcid.org/0000-0001-7295-8902","observed_orcids":["https://orcid.org/0000-0001-7295-8902"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohui Yan","raw_affiliation_strings":["Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"],"raw_orcid":"https://orcid.org/0000-0001-7295-8902","affiliations":[{"raw_affiliation_string":"Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China","institution_ids":[]},{"raw_affiliation_string":"National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China","institution_ids":["https://openalex.org/I12411659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060769915","https://openalex.org/A5157566900"],"corresponding_institution_ids":["https://openalex.org/I12411659"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58024217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"19","first_page":"3531","last_page":"3531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"magnetic nanoparticles","score":0.8889999985694885},{"id":"https://openalex.org/keywords/natural-product-extraction","display_name":"natural product extraction","score":0.5690000057220459},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.8759999871253967},{"id":"https://openalex.org/keywords/folate-receptor-targeting","display_name":"folate receptor targeting","score":0.9070000052452087},{"id":"https://openalex.org/keywords/targeted-tumor-delivery","display_name":"targeted tumor delivery","score":0.7070000171661377},{"id":"https://openalex.org/keywords/drug-loading","display_name":"drug loading","score":0.5120000243186951},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.734000027179718},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pi-pi-stacking","display_name":"\u03c0-\u03c0 stacking","score":0.6370000243186951},{"id":"https://openalex.org/keywords/reusable-adsorbent","display_name":"recyclable adsorbent","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6574000120162964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6309999823570251},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.6297000050544739},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5270000100135803},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.47209998965263367},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.46799999475479126},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4634999930858612},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.4546999931335449},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.4526999890804291},{"id":"https://openalex.org/C33347731","wikidata":"https://www.wikidata.org/wiki/Q285210","display_name":"Stacking","level":2,"score":0.4253000020980835},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.4156000018119812},{"id":"https://openalex.org/C2779833257","wikidata":"https://www.wikidata.org/wiki/Q2663154","display_name":"Magnetic separation","level":2,"score":0.38940000534057617},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.38850000500679016},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.328000009059906},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.26190000772476196}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053281","descriptor_name":"Enediynes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053281","descriptor_name":"Enediynes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D053281","descriptor_name":"Enediynes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053281","descriptor_name":"Enediynes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058185","descriptor_name":"Magnetite Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules31193531","doi":"https://doi.org/10.3390/molecules31193531","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31193531","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13666505","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13666505/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13666505/pdf/molecules-31-03531.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:42883295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:67205b0ae5954766b7e7be319e960c55","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/67205b0ae5954766b7e7be319e960c55","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 31, Iss 19, p 3531 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules31193531","doi":"https://doi.org/10.3390/molecules31193531","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31193531","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322701","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220428713.pdf","grobid_xml":"https://content.openalex.org/works/W7220428713.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W2046437917","https://openalex.org/W2089837236","https://openalex.org/W2166984808","https://openalex.org/W2561858807","https://openalex.org/W2785861421","https://openalex.org/W2808969991","https://openalex.org/W2889713599","https://openalex.org/W2971930919","https://openalex.org/W3000930224","https://openalex.org/W3176247014","https://openalex.org/W3185902737","https://openalex.org/W3207641289","https://openalex.org/W4377089205","https://openalex.org/W4390571419","https://openalex.org/W4392783859","https://openalex.org/W4394875127","https://openalex.org/W4396642929","https://openalex.org/W4399300327","https://openalex.org/W4399730328","https://openalex.org/W4399756205","https://openalex.org/W4402363102","https://openalex.org/W4403233863","https://openalex.org/W4406882800","https://openalex.org/W4408107995","https://openalex.org/W4409904516","https://openalex.org/W4409953095","https://openalex.org/W4410199871","https://openalex.org/W4410553567","https://openalex.org/W4410711658","https://openalex.org/W4411867602","https://openalex.org/W4412427789","https://openalex.org/W4412507982","https://openalex.org/W4412989103","https://openalex.org/W4415304086","https://openalex.org/W4415881632","https://openalex.org/W4416416820","https://openalex.org/W7118194896","https://openalex.org/W7123359872","https://openalex.org/W7124247668","https://openalex.org/W7125510457","https://openalex.org/W7125594171","https://openalex.org/W7125686926","https://openalex.org/W7129059927","https://openalex.org/W7134979442","https://openalex.org/W7139968899"],"related_works":["https://openalex.org/W2771954391","https://openalex.org/W4220908900","https://openalex.org/W2064834559","https://openalex.org/W2760601535","https://openalex.org/W4368353334","https://openalex.org/W3155005792","https://openalex.org/W2069968818","https://openalex.org/W2331176948","https://openalex.org/W4377089205","https://openalex.org/W2885905172"],"abstract_inverted_index":{"Anthraquinone-fused":[0],"enediynes":[1],"(AFEs)":[2],"are":[3,212],"a":[4,70,144],"class":[5,28],"of":[6,29,45,64,126,161,229],"microbial":[7],"natural":[8,91],"products":[9],"with":[10],"remarkable":[11],"cytotoxicity":[12],"and":[13,37,53,58,72,79,89,101,104,118,163,169,173,209,227],"exhibit":[14],"promising":[15],"application":[16,221,234],"prospects":[17,222],"in":[18,47,94,151,200,223],"tumor":[19,155],"therapy.":[20],"Taking":[21],"tiancimycins":[22],"(TNMs)":[23],"as":[24,143,238],"an":[25],"example,":[26],"this":[27,65,98,217],"compounds":[30],"holds":[31,219],"great":[32,220],"potential":[33],"against":[34],"triple-negative":[35],"breast":[36],"liver":[38],"cancers.":[39],"However,":[40],"the":[41,61,83,95,111,123,134,137,187,196,201,224],"low":[42],"production":[43],"titers":[44],"AFEs":[46,88],"actinobacterial":[48],"hosts":[49],"make":[50],"their":[51,90],"enrichment":[52,78],"separation":[54,226],"processes":[55],"both":[56],"cumbersome":[57],"costly.":[59],"Therefore,":[60],"main":[62],"objective":[63],"study":[66,99],"was":[67,141],"to":[68],"develop":[69],"rapid":[71,225],"reusable":[73],"magnetic":[74,107],"platform":[75],"for":[76,148,166],"TNM":[77,167,170],"recovery.":[80],"Inspired":[81],"by":[82],"pi-pi":[84],"stacking":[85],"interactions":[86],"between":[87],"binding":[92],"proteins":[93],"producing":[96],"strains,":[97],"designed":[100],"prepared":[102],"alizarin-":[103],"folic":[105,138],"acid-co-modified":[106],"nanoparticles":[108,115,150],"(PNMP-AZ-FA).":[109],"On":[110,133],"one":[112],"hand,":[113,136],"these":[114],"can":[116],"directly":[117],"specifically":[119],"adsorb":[120],"TNMs":[121],"from":[122],"crude":[124],"extract":[125],"Streptomyces":[127],"sp.":[128],"CB03234-S,":[129],"enabling":[130],"efficient":[131],"separation.":[132],"other":[135],"acid":[139],"modification":[140],"explored":[142],"proof-of-concept":[145],"delivery":[146],"element":[147],"drug-loaded":[149],"folate":[152],"receptor":[153],"(FR)-expressing":[154],"models.":[156],"PNMP-AZ-FA":[157],"showed":[158],"loading":[159],"capacities":[160],"87.8":[162],"106.7":[164],"mg/g":[165],"A":[168],"D,":[171],"respectively,":[172],"retained":[174],"high":[175],"adsorption":[176],"performance":[177],"during":[178],"20":[179],"repeated":[180],"cycles.":[181],"Animal":[182],"experiment":[183],"results":[184],"demonstrated":[185],"that":[186],"TNM-loaded":[188],"nanoparticle":[189,218],"(PNMP-AZ-FA@TNM":[190],"A)":[191],"improved":[192],"antitumor":[193],"activity":[194],"under":[195],"tested":[197],"conditions,":[198],"especially":[199],"FR-high":[202],"KB":[203],"model;":[204],"however,":[205],"receptor-dependent":[206],"uptake,":[207],"biodistribution,":[208],"pharmacokinetic":[210],"validation":[211],"still":[213],"required.":[214],"In":[215],"summary,":[216],"acquisition":[228],"AFEs,":[230],"while":[231],"its":[232],"tumor-delivery":[233],"should":[235],"be":[236],"regarded":[237],"preliminary":[239],"evidence.":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}