{"id":"https://openalex.org/W7220428103","doi":"https://doi.org/10.34133/bmr.0431","title":"Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair","display_name":"Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7220428103","doi":"https://doi.org/10.34133/bmr.0431","pmid":"https://pubmed.ncbi.nlm.nih.gov/42947949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710766"},"language":"en","primary_location":{"id":"doi:10.34133/bmr.0431","doi":"https://doi.org/10.34133/bmr.0431","is_oa":true,"landing_page_url":"https://doi.org/10.34133/bmr.0431","pdf_url":null,"source":{"id":"https://openalex.org/S2737714521","display_name":"Biomaterials Research","issn_l":"1226-4601","issn":["1226-4601","2055-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","kci-registered","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.34133/bmr.0431","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157545096","display_name":"Yuzhe Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhe Wu","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135302087","display_name":"Jingwei Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwei Shi","raw_affiliation_strings":["Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125247135","display_name":"Ruize Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruize Miao","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077649103","display_name":"Linyi Xiang","orcid":"https://orcid.org/0009-0007-7515-7861","observed_orcids":["https://orcid.org/0009-0007-7515-7861"]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linyi Xiang","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125253178","display_name":"Jiacheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiacheng Zhang","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044989875","display_name":"\u8fdf\u7ef4\u610f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyi Chi","raw_affiliation_strings":["The First Clinical Medical College (School of Information and Engineering), \rWenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College (School of Information and Engineering), \rWenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143421387","display_name":"Yuheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuheng Zhang","raw_affiliation_strings":["The Second Clinical Medical College of Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157550065","display_name":"Yibo Geng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibo Geng","raw_affiliation_strings":["Department of Orthopaedics, Tangdu Hospital, \rThe Air Force Medical University, Xi\u2019an 710038, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Tangdu Hospital, \rThe Air Force Medical University, Xi\u2019an 710038, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157492899","display_name":"Xiong Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiong Cai","raw_affiliation_strings":["School of Pharmaceutical Science, \rWenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, \rWenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125142415","display_name":"Yun Shu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Shu","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125169122","display_name":"Jiayi Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayi Zhao","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157650399","display_name":"Junsheng Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junsheng Zhu","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157468329","display_name":"Xiaoqiong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqiong Jiang","raw_affiliation_strings":["Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, \rWenzhou Medical University, Wenzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, \rWenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157583954","display_name":"Haojie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094218","display_name":"Xuan Wu Hospital of the Capital Medical University","ror":"https://ror.org/00k7r7f88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094218"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haojie Zhang","raw_affiliation_strings":["Department of Orthopedics, \rXuanwu Hospital of Capital Medical University, Beijing 100053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, \rXuanwu Hospital of Capital Medical University, Beijing 100053, China","institution_ids":["https://openalex.org/I4210094218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125200543","display_name":"Zhenglin Li","orcid":"https://orcid.org/0000-0002-6583-9013","observed_orcids":["https://orcid.org/0000-0002-6583-9013"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenglin Li","raw_affiliation_strings":["Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","Department of Wound Repair, \rThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, \rWenzhou Medical University, Wenzhou, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0002-6583-9013","affiliations":[{"raw_affiliation_string":"Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Wound Repair, \rThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, \rWenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157424600","display_name":"Xiangyang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyang Wang","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087653537","display_name":"Sunren Sheng","orcid":"https://orcid.org/0000-0001-8277-7590","observed_orcids":["https://orcid.org/0000-0001-8277-7590"]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sunren Sheng","raw_affiliation_strings":["Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157647504","display_name":"Chenchen Zhu","orcid":"https://orcid.org/0000-0001-9953-7366","observed_orcids":["https://orcid.org/0000-0001-9953-7366"]},"institutions":[{"id":"https://openalex.org/I4210150172","display_name":"First Affiliated Hospital of Bengbu Medical College","ror":"https://ror.org/04v043n92","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150172"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenchen Zhu","raw_affiliation_strings":["Department of Ophthalmology, \rThe First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China"],"raw_orcid":"https://orcid.org/0000-0001-9953-7366","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, \rThe First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China","institution_ids":["https://openalex.org/I4210150172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080482277","display_name":"Jianjun Qi","orcid":"https://orcid.org/0000-0002-3594-607X","observed_orcids":["https://orcid.org/0000-0002-3594-607X"]},"institutions":[{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianjun Qi","raw_affiliation_strings":["Department of Laboratory Medicine, \rThe First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, \rThe First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241001, China","institution_ids":["https://openalex.org/I4210167381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122889499","display_name":"Jian Xiao","orcid":"https://orcid.org/0000-0001-7374-6506","observed_orcids":["https://orcid.org/0000-0001-7374-6506"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Xiao","raw_affiliation_strings":["Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Department of Wound Repair, \rThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, \rWenzhou Medical University, Wenzhou, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0001-7374-6506","affiliations":[{"raw_affiliation_string":"Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Department of Wound Repair, \rThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, \rWenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157454109","display_name":"kailiang Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kailiang Zhou","raw_affiliation_strings":["Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","Zhejiang Provincial Key Laboratory of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cixi Biomedical Research Institute, \rWenzhou Medical University, Ningbo 315300, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Department of Orthopaedics, \rThe Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Orthopaedics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5080482277","https://openalex.org/A5122889499","https://openalex.org/A5157454109","https://openalex.org/A5157647504"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982","https://openalex.org/I4210099512","https://openalex.org/I4210150172","https://openalex.org/I4210167381"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7639523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":null,"first_page":"0431","last_page":"0431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.20309999585151672,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-scar","display_name":"glial scar","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.5109999775886536},{"id":"https://openalex.org/keywords/peptide-modification","display_name":"peptide modification","score":0.45899999141693115},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6115999817848206},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6111999750137329},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.482699990272522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4681999981403351},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4449000060558319},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.4219000041484833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40369999408721924},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4016999900341034},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33809998631477356},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3109999895095825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28360000252723694},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2535000145435333},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.34133/bmr.0431","doi":"https://doi.org/10.34133/bmr.0431","is_oa":true,"landing_page_url":"https://doi.org/10.34133/bmr.0431","pdf_url":null,"source":{"id":"https://openalex.org/S2737714521","display_name":"Biomaterials Research","issn_l":"1226-4601","issn":["1226-4601","2055-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","kci-registered","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Research","raw_type":"journal-article"},{"id":"pmid:42947949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42947949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710766","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710766/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomater Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.34133/bmr.0431","doi":"https://doi.org/10.34133/bmr.0431","is_oa":true,"landing_page_url":"https://doi.org/10.34133/bmr.0431","pdf_url":null,"source":{"id":"https://openalex.org/S2737714521","display_name":"Biomaterials Research","issn_l":"1226-4601","issn":["1226-4601","2055-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","kci-registered","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1518912305","https://openalex.org/W1968588589","https://openalex.org/W2016040396","https://openalex.org/W2025675558","https://openalex.org/W2027931245","https://openalex.org/W2065020598","https://openalex.org/W2069412624","https://openalex.org/W2083457479","https://openalex.org/W2103706525","https://openalex.org/W2116287291","https://openalex.org/W2155569675","https://openalex.org/W2299746178","https://openalex.org/W2396039754","https://openalex.org/W2580276486","https://openalex.org/W2613009520","https://openalex.org/W2769599719","https://openalex.org/W2906500081","https://openalex.org/W2916243907","https://openalex.org/W2947359146","https://openalex.org/W2957113653","https://openalex.org/W3003319512","https://openalex.org/W3042183311","https://openalex.org/W3116176019","https://openalex.org/W3134972647","https://openalex.org/W3171124897","https://openalex.org/W3174413142","https://openalex.org/W3190680235","https://openalex.org/W3195576966","https://openalex.org/W4200202286","https://openalex.org/W4212959738","https://openalex.org/W4237441880","https://openalex.org/W4247331516","https://openalex.org/W4281658611","https://openalex.org/W4297371828","https://openalex.org/W4313644005","https://openalex.org/W4380354491","https://openalex.org/W4386023334","https://openalex.org/W4388026512","https://openalex.org/W4402171644","https://openalex.org/W4403403268","https://openalex.org/W4403917912","https://openalex.org/W4409531174","https://openalex.org/W4409619330","https://openalex.org/W4412413348","https://openalex.org/W4416917667","https://openalex.org/W7119188508","https://openalex.org/W7153142282","https://openalex.org/W7160403719"],"related_works":["https://openalex.org/W2782880302","https://openalex.org/W2291952113","https://openalex.org/W7098817907","https://openalex.org/W7143417777","https://openalex.org/W2988758423","https://openalex.org/W4317532918","https://openalex.org/W2173886868","https://openalex.org/W100938503","https://openalex.org/W7145819907","https://openalex.org/W7128973656"],"abstract_inverted_index":{"Spinal":[0],"cord":[1,92,210],"injury":[2,105],"(SCI)":[3],"causes":[4],"irreversible":[5],"neural":[6],"damage":[7],"and":[8,66,99,116,141,178],"functional":[9,118,199],"impairment.":[10],"H-RN":[11,40,63],"is":[12],"a":[13,79],"short":[14,46],"peptide":[15,39,47,62,194],"originating":[16],"from":[17],"the":[18,33,38,51,58,61,68,90,96,104,128,164,192,198],"kringle":[19],"1":[20,174],"domain":[21],"of":[22,37,54,60,131,201],"hepatocyte":[23],"growth":[24,171],"factor.":[25],"Despite":[26],"its":[27],"efficacy":[28],"in":[29,41,64,133,150],"inhibiting":[30],"inflammatory":[31],"responses,":[32],"precise":[34],"neuroprotective":[35],"mechanisms":[36,130],"SCI":[42,65,97],"remain":[43],"unclear.":[44],"The":[45],"CAQK":[48],"can":[49],"target":[50,95],"lesion":[52],"epicenter":[53],"SCI.":[55,121,153],"To":[56],"explore":[57,127],"role":[59],"address":[67],"numerous":[69],"challenges":[70],"faced":[71],"by":[72,158],"conventional":[73],"drug":[74,101],"therapies,":[75],"this":[76],"study":[77],"developed":[78],"synthetic":[80,193],"peptide,":[81],"CAQK-H-RN.":[82],"Our":[83],"results":[84],"revealed":[85,136],"that":[86,137],"CAQK-H-RN":[87,132,138,155,195],"could":[88],"cross":[89],"blood-spinal":[91],"barrier,":[93],"precisely":[94],"region,":[98],"increase":[100],"accumulation":[102],"at":[103],"site,":[106],"thereby":[107,182],"reducing":[108],"glial":[109],"scar":[110],"formation,":[111],"decreasing":[112],"motor":[113],"neuron":[114],"death,":[115],"enhancing":[117],"recovery":[119],"after":[120,152],"RNA":[122],"sequencing":[123],"was":[124],"performed":[125],"to":[126,197,208],"molecular":[129],"SCI,":[134,202],"which":[135,203],"inhibited":[139],"pyroptosis":[140],"ameliorated":[142],"lysosomal":[143],"membrane":[144],"permeabilization":[145],"(LMP)-induced":[146],"autophagic":[147],"flux":[148],"disorders":[149],"neurons":[151],"Additionally,":[154],"alleviated":[156],"LMP":[157],"suppressing":[159],"acid":[160],"sphingomyelinase":[161],"activity":[162],"through":[163],"p38":[165],"mitogen-activated":[166],"protein":[167,173],"kinase/Ets-like":[168],"protein-1":[169],"(Elk-1)/early":[170],"response":[172],"(Egr-1)":[175],"signaling":[176],"cascade":[177],"subsequently":[179],"enhanced":[180],"autophagy,":[181],"mitigating":[183],"neuronal":[184],"death.":[185],"This":[186],"intravenous":[187],"therapeutic":[188],"system":[189],"centered":[190],"on":[191],"contributes":[196],"restoration":[200],"may":[204],"be":[205],"clinically":[206],"applicable":[207],"spinal":[209],"repair.":[211]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}
