{"id":"https://openalex.org/W7220423575","doi":"https://doi.org/10.3390/ani16193109","title":"Canine Hemangiosarcoma Cell Lines In Vitro Platform Captures Morphological, Functional, and Molecular Diversity","display_name":"Canine Hemangiosarcoma Cell Lines In Vitro Platform Captures Morphological, Functional, and Molecular Diversity","publication_year":2026,"publication_date":"2026-10-03","ids":{"openalex":"https://openalex.org/W7220423575","doi":"https://doi.org/10.3390/ani16193109","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883078","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13663357"},"language":"en","primary_location":{"id":"doi:10.3390/ani16193109","doi":"https://doi.org/10.3390/ani16193109","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16193109","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ani16193109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145763823","display_name":"Lucia di Caporiacco","orcid":"https://orcid.org/0009-0000-3901-7799","observed_orcids":["https://orcid.org/0009-0000-3901-7799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucia di Caporiacco","raw_affiliation_strings":["IRET Foundation ETS, Ozzano Emilia, 40064 Bologna, Italy"],"raw_orcid":"https://orcid.org/0009-0000-3901-7799","affiliations":[{"raw_affiliation_string":"IRET Foundation ETS, Ozzano Emilia, 40064 Bologna, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089598242","display_name":"Francesca Merighi","orcid":"https://orcid.org/0009-0008-8447-4006","observed_orcids":["https://orcid.org/0009-0008-8447-4006"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Merighi","raw_affiliation_strings":["Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058327038","display_name":"Luciana Giardino","orcid":"https://orcid.org/0000-0003-3107-3264","observed_orcids":["https://orcid.org/0000-0003-3107-3264"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luciana Giardino","raw_affiliation_strings":["Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy","Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082978515","display_name":"Laura Marconato","orcid":"https://orcid.org/0000-0002-7843-615X","observed_orcids":["https://orcid.org/0000-0002-7843-615X"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Marconato","raw_affiliation_strings":["Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7843-615X","affiliations":[{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025944779","display_name":"Vito Antonio Baldassarro","orcid":"https://orcid.org/0000-0003-1020-4261","observed_orcids":["https://orcid.org/0000-0003-1020-4261"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vito Antonio Baldassarro","raw_affiliation_strings":["Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy","Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1020-4261","affiliations":[{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023384307","display_name":"Laura Calz\u00e0","orcid":"https://orcid.org/0000-0002-4426-8477","observed_orcids":["https://orcid.org/0000-0002-4426-8477"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Calz\u00e0","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy","Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4426-8477","affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034694644","display_name":"Corinne Quadalti","orcid":"https://orcid.org/0000-0002-0302-3027","observed_orcids":["https://orcid.org/0000-0002-0302-3027"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Corinne Quadalti","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy","Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0302-3027","affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, 40064 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034694644"],"corresponding_institution_ids":["https://openalex.org/I9360294"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2896},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2896},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78092284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"19","first_page":"3109","last_page":"3109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.1225999966263771,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-hemangiosarcoma","display_name":"canine hemangiosarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/angiosarcoma","display_name":"angiosarcoma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/splenic-hemangiosarcoma","display_name":"splenic hemangiosarcoma","score":0.8949999809265137},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cell-line-panel","display_name":"cell line panel","score":0.734000027179718},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/vegf-signaling","display_name":"VEGF signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/age-rage-signaling-pathway","display_name":"AGE-RAGE signaling pathway","score":0.8180000185966492},{"id":"https://openalex.org/keywords/s1p-signaling","display_name":"S1P signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/stat-signaling","display_name":"STAT signaling","score":0.9779999852180481},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mir-126-5p","display_name":"miR-126-5p","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mir-452-5p","display_name":"miR-452-5p","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mir-214-3p","display_name":"miR-214-3p","score":0.984000027179718},{"id":"https://openalex.org/keywords/mir-10b","display_name":"miR-10b","score":0.9139999747276306},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.8899999856948853},{"id":"https://openalex.org/keywords/comparative-oncology","display_name":"comparative oncology","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2781082889","wikidata":"https://www.wikidata.org/wiki/Q539728","display_name":"Hemangiosarcoma","level":3,"score":0.8555999994277954},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.637499988079071},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5940999984741211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5464000105857849},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5406000018119812},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.51910001039505},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4763999879360199},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.41839998960494995},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4165000021457672},{"id":"https://openalex.org/C2779217266","wikidata":"https://www.wikidata.org/wiki/Q2619091","display_name":"Angiosarcoma","level":2,"score":0.39559999108314514},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3944000005722046},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3490000069141388},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.31209999322891235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3084999918937683},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29600000381469727},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2791999876499176},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.2736000120639801},{"id":"https://openalex.org/C74092355","wikidata":"https://www.wikidata.org/wiki/Q1056943","display_name":"Molecular pathology","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.258899986743927}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/ani16193109","doi":"https://doi.org/10.3390/ani16193109","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16193109","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13663357","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663357/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663357/pdf/animals-16-03109.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals (Basel)","raw_type":"Text"},{"id":"pmid:42883078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals : an open access journal from MDPI","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/1088012","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11585/1088012","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c46936305b354a3d8e4917ee608ea041","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c46936305b354a3d8e4917ee608ea041","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Animals, Vol 16, Iss 19, p 3109 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ani16193109","doi":"https://doi.org/10.3390/ani16193109","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16193109","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220423575.pdf","grobid_xml":"https://content.openalex.org/works/W7220423575.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1890000736","https://openalex.org/W1967708939","https://openalex.org/W1979537907","https://openalex.org/W1986042610","https://openalex.org/W1992754156","https://openalex.org/W2000206516","https://openalex.org/W2001330091","https://openalex.org/W2029855461","https://openalex.org/W2070852614","https://openalex.org/W2072841483","https://openalex.org/W2094484532","https://openalex.org/W2114785296","https://openalex.org/W2116672406","https://openalex.org/W2119732961","https://openalex.org/W2129994868","https://openalex.org/W2144047630","https://openalex.org/W2167279371","https://openalex.org/W2341192513","https://openalex.org/W2557339669","https://openalex.org/W2749998272","https://openalex.org/W2774984051","https://openalex.org/W2806597619","https://openalex.org/W2860771507","https://openalex.org/W2901218215","https://openalex.org/W2978797341","https://openalex.org/W2981953687","https://openalex.org/W2995216880","https://openalex.org/W3014009429","https://openalex.org/W3042689819","https://openalex.org/W3045497015","https://openalex.org/W3133715754","https://openalex.org/W3137773611","https://openalex.org/W3177188481","https://openalex.org/W3177212070","https://openalex.org/W3186276856","https://openalex.org/W3199656929","https://openalex.org/W4286697775","https://openalex.org/W4312140586","https://openalex.org/W4313584331","https://openalex.org/W4320920242","https://openalex.org/W4361286589","https://openalex.org/W4385346921","https://openalex.org/W4387118569","https://openalex.org/W4389438299","https://openalex.org/W4389951386","https://openalex.org/W4390127952","https://openalex.org/W4394747404","https://openalex.org/W4397021733","https://openalex.org/W4397022548","https://openalex.org/W4402986822","https://openalex.org/W4404191168","https://openalex.org/W4406882695","https://openalex.org/W4407749007","https://openalex.org/W4410345865","https://openalex.org/W4410374117","https://openalex.org/W4411915786","https://openalex.org/W4416225195","https://openalex.org/W4416575047"],"related_works":["https://openalex.org/W2114785296","https://openalex.org/W2008449196","https://openalex.org/W4397022548","https://openalex.org/W7204443551","https://openalex.org/W2116672406","https://openalex.org/W2146488945","https://openalex.org/W2094484532","https://openalex.org/W7170133164","https://openalex.org/W2241682441","https://openalex.org/W3014009429"],"abstract_inverted_index":{"Both":[0],"canine":[1,43],"hemangiosarcoma":[2,46,158,181],"and":[3,12,52,66,71,98,101,123,139,151,166,191],"human":[4],"angiosarcoma":[5],"are":[6],"aggressive":[7],"malignancies":[8],"characterized":[9,75],"by":[10],"clinical":[11],"molecular":[13],"heterogeneity.":[14],"Current":[15],"in":[16,35,59,109],"vitro":[17,36],"models":[18],"rely":[19],"on":[20],"individual":[21],"cell":[22,47,106],"lines,":[23,171],"failing":[24],"to":[25,95],"capture":[26],"this":[27,76],"biological":[28],"complexity.":[29],"We":[30],"established":[31],"a":[32,39,85,102,145,184],"standardized":[33,186],"2D":[34],"platform":[37,178],"comprising":[38],"panel":[40],"of":[41,90,148],"three":[42],"primary":[44,120],"splenic":[45],"lines":[48,83,117],"(EMN009,":[49],"EMN011,":[50],"EMN017)":[51],"one":[53],"patient-matched":[54],"brain":[55],"metastasis":[56],"(EMN010)":[57],"evaluated":[58],"parallel.":[60],"Using":[61],"gold-standard":[62],"assays-morphometrics,":[63],"growth,":[64],"migration":[65],"tube-formation":[67],"assays-alongside":[68],"disease-relevant":[69],"transcriptomic":[70],"microRNA":[72],"profiling,":[73],"we":[74],"multi-line":[77],"system":[78],"under":[79],"harmonized":[80],"conditions.":[81],"Neoplastic":[82],"shared":[84],"robust":[86],"core":[87],"angiogenic":[88,125],"signature":[89],"42":[91],"overexpressed":[92],"genes":[93],"linked":[94],"VEGF,":[96],"AGE-RAGE,":[97],"S1P":[99],"signaling,":[100],"47-gene":[103],"cancer":[104],"stem":[105],"engine":[107],"enriched":[108],"the":[110,116,132],"Hippo/YAP1":[111],"pathway.":[112],"Transcriptomic":[113],"clustering":[114],"divided":[115],"into":[118],"slower-growing":[119],"tumors":[121],"(EMN009/EMN011)":[122],"highly":[124],"phenotypes":[126],"(EMN017/EMN010).":[127],"Isogenic":[128],"comparison":[129],"revealed":[130],"that":[131],"metastatic":[133],"EMN010":[134],"uniquely":[135],"upregulates":[136],"STAT":[137],"signaling":[138],"peptidyl-tyrosine":[140],"phosphorylation.":[141],"MicroRNA":[142],"profiling":[143],"demonstrated":[144],"global":[146],"downregulation":[147],"tumor-suppressors":[149],"miR-126-5p":[150],"miR-452-5p,":[152],"unleashing":[153],"VEGFA-driven":[154],"angiogenesis,":[155],"while":[156],"visceral":[157],"biomarker":[159],"miR-214-3p":[160],"was":[161],"significantly":[162],"upregulated.":[163],"Conversely,":[164],"miR-10b":[165],"miR-133-3p":[167],"expression":[168],"varied":[169],"across":[170],"reflecting":[172],"ongoing":[173],"clonal":[174],"evolution.":[175],"This":[176],"integrated":[177],"successfully":[179],"recapitulates":[180],"heterogeneity,":[182],"providing":[183],"reliable,":[185],"framework":[187],"for":[188],"comparative":[189],"oncology":[190],"targeted":[192],"pathophysiological":[193],"studies.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}