{"id":"https://openalex.org/W7220415756","doi":"https://doi.org/10.3389/fphar.2026.1916381","title":"Antidepressant effects of artemisinin and its derivatives: a systematic review and meta-analysis of randomized controlled animal studies","display_name":"Antidepressant effects of artemisinin and its derivatives: a systematic review and meta-analysis of randomized controlled animal studies","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220415756","doi":"https://doi.org/10.3389/fphar.2026.1916381","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898534","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677903"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1916381","doi":"https://doi.org/10.3389/fphar.2026.1916381","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1916381","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1916381/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1916381/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387909","display_name":"Yuan Tian","orcid":"https://orcid.org/0000-0002-6785-0566","observed_orcids":["https://orcid.org/0000-0002-6785-0566","https://orcid.org/0000-0001-6154-0172"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Tian","raw_affiliation_strings":["Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147307709","display_name":"Haiping Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiping Zhang","raw_affiliation_strings":["Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157615555","display_name":"Xu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115695013","display_name":"Luyao Wang","orcid":"https://orcid.org/0009-0008-0952-494X","observed_orcids":["https://orcid.org/0009-0008-0952-494X"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyao Wang","raw_affiliation_strings":["Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Sichuan Provincial Center for Mental Health, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5157615555"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I200296433"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49973333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1916381","last_page":"1916381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin","display_name":"artemisinin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/artemisinin-derivatives","display_name":"artemisinin derivatives","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.9769999980926514},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.6830000281333923},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tail-suspension-test","display_name":"tail suspension test","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sucrose-preference","display_name":"sucrose preference","score":0.9200000166893005},{"id":"https://openalex.org/keywords/open-field-test","display_name":"open field test","score":0.8180000185966492},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.9700000286102295},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.7630000114440918},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6980000138282776},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/publication-bias","display_name":"publication bias","score":0.6629999876022339},{"id":"https://openalex.org/keywords/risk-of-bias","display_name":"risk of bias","score":0.7210000157356262},{"id":"https://openalex.org/keywords/intervention-duration-and-frequency","display_name":"intervention duration and frequency","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7864999771118164},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6459000110626221},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.5800999999046326},{"id":"https://openalex.org/C2780439572","wikidata":"https://www.wikidata.org/wiki/Q919364","display_name":"Publication bias","level":3,"score":0.5615000128746033},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5397999882698059},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.516700029373169},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.49140000343322754},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.4830000102519989},{"id":"https://openalex.org/C28804328","wikidata":"https://www.wikidata.org/wiki/Q7623693","display_name":"Strictly standardized mean difference","level":3,"score":0.46369999647140503},{"id":"https://openalex.org/C2992558993","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Rodent model","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.4221000075340271},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42089998722076416},{"id":"https://openalex.org/C82605166","wikidata":"https://www.wikidata.org/wiki/Q967190","display_name":"Funnel plot","level":4,"score":0.4194999933242798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3734000027179718},{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.36959999799728394},{"id":"https://openalex.org/C520753416","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal testing","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.32670000195503235},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.31459999084472656},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C2778875871","wikidata":"https://www.wikidata.org/wiki/Q4764954","display_name":"Animal models of depression","level":4,"score":0.2754000127315521},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25760000944137573},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C168743327","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Random effects model","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.25}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1916381","doi":"https://doi.org/10.3389/fphar.2026.1916381","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1916381","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1916381/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677903","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677903/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677903/pdf/fphar-17-1916381.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42898534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:40017fc134334f24b6585b0d90d204dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/40017fc134334f24b6585b0d90d204dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1916381","doi":"https://doi.org/10.3389/fphar.2026.1916381","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1916381","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1916381/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220415756.pdf","grobid_xml":"https://content.openalex.org/works/W7220415756.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1709885097","https://openalex.org/W1973914781","https://openalex.org/W1978097115","https://openalex.org/W2014431269","https://openalex.org/W2023282331","https://openalex.org/W2058571677","https://openalex.org/W2064223985","https://openalex.org/W2066703498","https://openalex.org/W2073924899","https://openalex.org/W2090922799","https://openalex.org/W2097740790","https://openalex.org/W2098184601","https://openalex.org/W2125435699","https://openalex.org/W2133856218","https://openalex.org/W2151783694","https://openalex.org/W2152652033","https://openalex.org/W2164759539","https://openalex.org/W2467038324","https://openalex.org/W2531546259","https://openalex.org/W2570555403","https://openalex.org/W2787981664","https://openalex.org/W2810894650","https://openalex.org/W2940919043","https://openalex.org/W2943186854","https://openalex.org/W2943865378","https://openalex.org/W3023958087","https://openalex.org/W3024693406","https://openalex.org/W3043715301","https://openalex.org/W3118615836","https://openalex.org/W3130031892","https://openalex.org/W3148994527","https://openalex.org/W3182221035","https://openalex.org/W4205208574","https://openalex.org/W4213368610","https://openalex.org/W4244358260","https://openalex.org/W4281738515","https://openalex.org/W4294591907","https://openalex.org/W4312210279","https://openalex.org/W4380894238","https://openalex.org/W4386765478","https://openalex.org/W4393219736","https://openalex.org/W4399512836","https://openalex.org/W4403005138","https://openalex.org/W4410464292","https://openalex.org/W4412555854","https://openalex.org/W4413836902","https://openalex.org/W4415302959"],"related_works":["https://openalex.org/W7165742265","https://openalex.org/W7203572059","https://openalex.org/W4402001900","https://openalex.org/W7131251535","https://openalex.org/W4415302959","https://openalex.org/W2912817959","https://openalex.org/W4400930537","https://openalex.org/W4415792712","https://openalex.org/W7117447663","https://openalex.org/W4410797349"],"abstract_inverted_index":{"Introduction:":[0],"Depression":[1],"imposes":[2],"a":[3,14,120,352],"substantial":[4,333],"global":[5],"disease":[6],"burden.":[7],"Current":[8],"pharmacotherapies":[9],"are":[10,387],"often":[11],"limited":[12,307],"by":[13],"delayed":[15],"onset":[16],"of":[17,68,73,96,172,191,198,209,309,317,331,369],"action,":[18],"significant":[19],"adverse":[20],"effects,":[21],"and":[22,31,36,39,76,99,148,159,187,202,231,245,247,255,266,288,335,342,345,383],"high":[23,329],"costs.":[24],"Preclinical":[25],"studies":[26,211],"have":[27,40],"indicated":[28],"that":[29],"artemisinin":[30,69,225,358],"its":[32,391],"derivatives":[33],"possess":[34],"neuroprotective":[35],"anti-inflammatory":[37],"properties":[38],"demonstrated":[41],"antidepressant-like":[42],"effects":[43],"in":[44,70,84,217,228,236,242,251,284,378,393],"rodent":[45,57,71,140],"models.":[46],"However,":[47,366],"no":[48],"meta-analysis":[49],"has":[50],"yet":[51],"been":[52],"performed":[53,165],"on":[54,139],"these":[55],"preclinical":[56,381],"studies.":[58,310],"This":[59,88],"study":[60,89],"aimed":[61],"to":[62,77,111,166,328,375,389],"systematically":[63,90],"evaluate":[64,167,390],"the":[65,82,177,188,196,218,222,229,237,243,252,285,306,312,315,367,379],"antidepressant":[66],"efficacy":[67,392],"models":[72],"depression-like":[74,142,341],"behavior":[75],"identify":[78],"potential":[79],"factors":[80],"influencing":[81],"variability":[83],"treatment":[85],"effects.":[86],"Methods:":[87],"searched":[91],"four":[92],"databases":[93],"(PubMed,":[94],"Web":[95],"Science,":[97],"Embase,":[98],"China":[100],"National":[101],"Knowledge":[102],"Infrastructure),":[103],"including":[104],"randomized":[105],"controlled":[106],"trials":[107,386],"(RCTs)":[108],"published":[109],"up":[110],"May":[112],"2026.":[113],"All":[114],"data":[115],"were":[116,136,164,215],"statistically":[117],"analyzed":[118],"using":[119,154,176,195],"random-effects":[121],"model,":[122],"yielding":[123],"standardized":[124],"mean":[125],"differences":[126],"(SMDs)":[127],"with":[128,221],"their":[129],"95%":[130],"confidence":[131],"intervals":[132],"(CIs).":[133],"Subgroup":[134,257],"analyses":[135,163,258,292],"conducted":[137],"based":[138],"species,":[141,263],"modeling":[143,264],"methods,":[144,265],"intervention":[145,260],"timing,":[146],"duration,":[147,261],"frequency.":[149],"Publication":[150],"bias":[151,173,283,304],"was":[152,174,193,319],"assessed":[153],"Egger's":[155,278],"test,":[156],"funnel":[157],"plots,":[158],"trim-and-fill":[160,291],"analyses.":[161],"Sensitivity":[162,272],"result":[168],"robustness.":[169],"The":[170],"risk":[171,330],"evaluated":[175,194],"Systematic":[178],"Review":[179],"Centre":[180],"for":[181,324,354,364],"Laboratory":[182],"Animal":[183],"Experimentation":[184],"(SYRCLE)":[185],"tool,":[186],"overall":[189],"certainty":[190,316,368],"evidence":[192,318,370],"Grading":[197],"Recommendations":[199],"Assessment,":[200],"Development":[201],"Evaluation":[203],"(GRADE)":[204],"framework.":[205],"Results:":[206],"A":[207],"total":[208],"17":[210],"involving":[212],"402":[213],"rodents":[214],"included":[216,380],"analysis.":[219],"Compared":[220],"control":[223],"group,":[224],"reduced":[226],"immobility":[227],"TST":[230],"FST,":[232],"increased":[233],"sucrose":[234],"preference":[235],"SPT,":[238],"alleviated":[239],"anxiety-like":[240,343],"behaviors":[241,344],"OFT":[244],"EPM,":[246],"improved":[248],"cognitive":[249,347],"performance":[250],"MWM,":[253],"Y-maze,":[254],"NOR.":[256],"identified":[259],"frequency,":[262],"derivative":[267],"type":[268],"as":[269,321,359],"impactful":[270],"moderators.":[271],"tests":[273],"validated":[274],"stable":[275],"outcomes.":[276],"While":[277],"test":[279],"hinted":[280],"at":[281],"publication":[282,303],"OFT,":[286],"TST,":[287],"FST":[289],"datasets,":[290],"imputed":[293],"zero":[294],"missing":[295],"studies,":[296,382],"although":[297],"this":[298],"does":[299],"not":[300],"fully":[301],"exclude":[302],"given":[305],"number":[308],"Under":[311],"GRADE":[313],"framework,":[314],"rated":[320],"very":[322,372],"low":[323,373],"most":[325],"outcomes":[326],"due":[327,374],"bias,":[332],"heterogeneity,":[334],"indirectness.":[336],"Discussion:":[337],"Artemisinin":[338],"can":[339],"ameliorate":[340],"improve":[346],"function.":[348],"These":[349],"findings":[350],"provide":[351],"basis":[353],"further":[355],"investigation":[356],"into":[357],"an":[360],"adjunctive":[361],"therapeutic":[362],"agent":[363],"depression.":[365],"is":[371],"methodological":[376],"limitations":[377],"additional":[384],"clinical":[385],"required":[388],"humans.":[394]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-06T00:00:00"}