{"id":"https://openalex.org/W7220413052","doi":"https://doi.org/10.1016/j.isci.2026.117390","title":"Lipid-based mRNA chimeric antigen receptor T cells for enhanced in vitro antitumor activity","display_name":"Lipid-based mRNA chimeric antigen receptor T cells for enhanced in vitro antitumor activity","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7220413052","doi":"https://doi.org/10.1016/j.isci.2026.117390","pmid":"https://pubmed.ncbi.nlm.nih.gov/42891071","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13673102"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2026.117390","doi":"https://doi.org/10.1016/j.isci.2026.117390","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117390","pdf_url":"https://www.cell.com/iscience/pdf/S2589-0042(26)02768-9.pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cell.com/iscience/pdf/S2589-0042(26)02768-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100624430","display_name":"Haixia Gao","orcid":"https://orcid.org/0000-0003-0024-2969","observed_orcids":["https://orcid.org/0000-0003-0024-2969","https://orcid.org/0009-0003-4796-347X"]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixia Gao","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0003-4796-347X","affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157648638","display_name":"Yuan Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Fang","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157626472","display_name":"Zhidan Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhidan Tian","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157568626","display_name":"Chuanxin Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chuanxin Guo","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157439985","display_name":"Pei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei Wang","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157656119","display_name":"Tao Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Liu","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157369960","display_name":"Yan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Sun","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091672492","display_name":"Pingjing Zhang","orcid":"https://orcid.org/0009-0000-6292-2949","observed_orcids":["https://orcid.org/0009-0000-6292-2949","https://orcid.org/0000-0002-6129-4685"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pingjing Zhang","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157435638","display_name":"Qijun Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qijun Qian","raw_affiliation_strings":["Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cell Therapy Group Co., Ltd., Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Mengchao Cancer Hospital and School of Medicine, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091672492","https://openalex.org/A5157435638"],"corresponding_institution_ids":["https://openalex.org/I113940042"],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":{"value":3240,"currency":"USD","value_usd":3240},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6172174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"10","first_page":"117390","last_page":"117390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mrna-delivery","display_name":"mRNA delivery","score":0.6069999933242798},{"id":"https://openalex.org/keywords/ionizable-lipids","display_name":"ionizable lipids","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.7670000195503235},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.7310000061988831},{"id":"https://openalex.org/keywords/car-t-cell-engineering","display_name":"CAR-T cell engineering","score":0.75},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.6800000071525574},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.732699990272522},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6902999877929688},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6335999965667725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4876999855041504},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46219998598098755},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.45739999413490295},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42149999737739563},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3483000099658966},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.3409999907016754},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3086000084877014},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C3019217517","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor associated antigen","level":4,"score":0.2971000075340271},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2833000123500824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2797999978065491},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.2718999981880188},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.2590999901294708}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.isci.2026.117390","doi":"https://doi.org/10.1016/j.isci.2026.117390","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117390","pdf_url":"https://www.cell.com/iscience/pdf/S2589-0042(26)02768-9.pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13673102","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13673102/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13673102/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:42891071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42891071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:921c0ea7446a4f18b7d0ccf332048ea7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/921c0ea7446a4f18b7d0ccf332048ea7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 29, Iss 10, Pp 117390- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2026.117390","doi":"https://doi.org/10.1016/j.isci.2026.117390","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117390","pdf_url":"https://www.cell.com/iscience/pdf/S2589-0042(26)02768-9.pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6427813561","display_name":null,"funder_award_id":"23J21900500","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320325553","display_name":"Shanghai University","ror":"https://ror.org/006teas31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220413052.pdf","grobid_xml":"https://content.openalex.org/works/W7220413052.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1972297696","https://openalex.org/W2008028087","https://openalex.org/W2025980739","https://openalex.org/W2033256828","https://openalex.org/W2041663579","https://openalex.org/W2072696333","https://openalex.org/W2089150369","https://openalex.org/W2133298966","https://openalex.org/W2149516210","https://openalex.org/W2168753477","https://openalex.org/W2190427975","https://openalex.org/W2519394980","https://openalex.org/W2554094503","https://openalex.org/W2584193505","https://openalex.org/W2589945527","https://openalex.org/W2748490245","https://openalex.org/W2749329560","https://openalex.org/W2752990404","https://openalex.org/W2771932281","https://openalex.org/W2782708334","https://openalex.org/W2792523566","https://openalex.org/W2792588868","https://openalex.org/W2800488651","https://openalex.org/W2800948756","https://openalex.org/W2891862408","https://openalex.org/W2896863488","https://openalex.org/W2899694188","https://openalex.org/W2905039524","https://openalex.org/W2922481031","https://openalex.org/W2945773776","https://openalex.org/W2945798418","https://openalex.org/W2999972782","https://openalex.org/W3215276910","https://openalex.org/W4214740620","https://openalex.org/W4313379423","https://openalex.org/W4387747059","https://openalex.org/W4392472976","https://openalex.org/W4393182254","https://openalex.org/W4399245607","https://openalex.org/W4405698384","https://openalex.org/W4406132484","https://openalex.org/W4406445815","https://openalex.org/W4407161097","https://openalex.org/W4407413460","https://openalex.org/W4409273214","https://openalex.org/W4410866161","https://openalex.org/W4411454711","https://openalex.org/W4411900529","https://openalex.org/W4413007178","https://openalex.org/W4415308662"],"related_works":["https://openalex.org/W2999972782","https://openalex.org/W4405040045","https://openalex.org/W7161134808","https://openalex.org/W3207676521","https://openalex.org/W7135260915","https://openalex.org/W4409632020","https://openalex.org/W4387747059","https://openalex.org/W4393096594","https://openalex.org/W7161987675","https://openalex.org/W4405040820"],"abstract_inverted_index":{"Chimeric":[0],"antigen":[1],"receptor":[2,125],"(CAR)":[3],"T":[4,49,119,146],"cell":[5,15,147],"therapy":[6],"provides":[7],"substantial":[8],"clinical":[9],"benefits":[10],"in":[11,102],"hematologic":[12],"malignancies.":[13],"However,":[14],"engineering":[16],"using":[17],"conventional":[18],"viral":[19],"vectors":[20],"is":[21,76],"costly,":[22],"labor":[23],"intensive,":[24],"and":[25,57,64,94,105,127],"prone":[26],"to":[27],"safety":[28,108],"risks,":[29],"while":[30],"electroporation-induced":[31],"cellular":[32],"damage":[33],"limits":[34],"manufacturing":[35],"scalability.":[36],"This":[37],"study":[38],"reports":[39],"a":[40,106,140],"safe,":[41],"high-efficiency,":[42],"nonviral":[43],"platform":[44],"for":[45,143],"generating":[46],"mRNA-engineered":[47],"CAR":[48,151],"cells.":[50,97,133],"Herein,":[51],"eight":[52],"ionizable":[53],"lipids":[54],"are":[55],"synthesized":[56],"formulated":[58],"into":[59,88],"lipid":[60,68,137],"nanoparticles.":[61],"Systematic":[62],"screening":[63],"structural":[65],"optimization":[66],"identified":[67],"6":[69,138],"as":[70,139],"the":[71],"lead":[72],"candidate.":[73],"Transfection":[74],"efficiency":[75],"validated":[77],"by":[78,122],"delivering":[79],"enhanced":[80],"green":[81],"fluorescent":[82],"protein":[83],"(":[84],"eGFP":[85],")":[86],"mRNA":[87,115],"DC2.4,":[89],"peripheral":[90],"blood":[91],"mononuclear,":[92],"dendritic,":[93],"natural":[95],"killer":[96],"Murine":[98],"models":[99],"confirm":[100],"robust":[101],"vivo":[103],"expression":[104,126,152],"favorable":[107],"profile.":[109],"Lipid":[110],"6-mediated":[111],"delivery":[112],"of":[113],"MUC1":[114,117],"generates":[116],"-CAR":[118],"cells":[120],"characterized":[121],"high":[123],"surface":[124],"potent":[128],"cytotoxicity":[129],"against":[130],"MUC1-positive":[131],"tumor":[132],"These":[134],"findings":[135],"establish":[136],"feasible":[141],"strategy":[142],"primary":[144],"human":[145],"engineering,":[148],"facilitating":[149],"functional":[150],"with":[153],"minimal":[154],"toxicity.":[155]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}
