{"id":"https://openalex.org/W7220409506","doi":"https://doi.org/10.3389/fpsyt.2026.1977499","title":"Depression and musculoskeletal diseases: a framework of systemic mechanisms","display_name":"Depression and musculoskeletal diseases: a framework of systemic mechanisms","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220409506","doi":"https://doi.org/10.3389/fpsyt.2026.1977499","pmid":"https://pubmed.ncbi.nlm.nih.gov/42899055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678528"},"language":"en","primary_location":{"id":"doi:10.3389/fpsyt.2026.1977499","doi":"https://doi.org/10.3389/fpsyt.2026.1977499","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2026.1977499","pdf_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1977499/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1977499/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157574606","display_name":"Xiaoyun Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyun Yang","raw_affiliation_strings":["Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100309765","display_name":"Yang Zhao","orcid":"https://orcid.org/0009-0004-5344-2360","observed_orcids":["https://orcid.org/0009-0004-5344-2360"]},"institutions":[{"id":"https://openalex.org/I4210096047","display_name":"Yantai Automobile Engineering Professional College","ror":"https://ror.org/00sh5y950","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhao","raw_affiliation_strings":["Department of General Education, Yantai Automobile Engineering Professional College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Education, Yantai Automobile Engineering Professional College","institution_ids":["https://openalex.org/I4210096047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110375646","display_name":"Wang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096047","display_name":"Yantai Automobile Engineering Professional College","ror":"https://ror.org/00sh5y950","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Gao","raw_affiliation_strings":["Department of General Education, Yantai Automobile Engineering Professional College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Education, Yantai Automobile Engineering Professional College","institution_ids":["https://openalex.org/I4210096047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112639460","display_name":"Jinkun Liu","orcid":"https://orcid.org/0000-0001-6652-1229","observed_orcids":["https://orcid.org/0000-0001-6652-1229"]},"institutions":[{"id":"https://openalex.org/I4210096047","display_name":"Yantai Automobile Engineering Professional College","ror":"https://ror.org/00sh5y950","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinkun Liu","raw_affiliation_strings":["Department of Transportation Engineering, Yantai Automobile Engineering Professional College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transportation Engineering, Yantai Automobile Engineering Professional College","institution_ids":["https://openalex.org/I4210096047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157488104","display_name":"Tao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096047","display_name":"Yantai Automobile Engineering Professional College","ror":"https://ror.org/00sh5y950","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["School of Marxism, Yantai Automobile Engineering Professional College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Marxism, Yantai Automobile Engineering Professional College","institution_ids":["https://openalex.org/I4210096047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432452","display_name":"Jingyu Wang","orcid":"https://orcid.org/0000-0001-7017-1938","observed_orcids":["https://orcid.org/0000-0001-7017-1938","https://orcid.org/0009-0004-2206-1266","https://orcid.org/0009-0007-1154-0300"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jingyu Wang","raw_affiliation_strings":["Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129308683","display_name":"\u738b\u98de\u96ea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Feixue Wang","raw_affiliation_strings":["Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Shandong Medical and Pharmaceutical University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100432452","https://openalex.org/A5129308683"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1977499","last_page":"1977499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.18690000474452972,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/musculoskeletal-disorders","display_name":"musculoskeletal disorders","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bidirectional-interaction","display_name":"bidirectional interaction","score":0.6320000290870667},{"id":"https://openalex.org/keywords/neuroendocrine-dysfunction","display_name":"neuroendocrine dysfunction","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.9300000071525574},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.5249999761581421},{"id":"https://openalex.org/keywords/psychosocial-interventions","display_name":"psychosocial interventions","score":0.8259999752044678},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.652999997138977},{"id":"https://openalex.org/keywords/dietary-change","display_name":"dietary change","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.6678000092506409},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6664000153541565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5332000255584717},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.476500004529953},{"id":"https://openalex.org/C2993471631","wikidata":"https://www.wikidata.org/wiki/Q4116663","display_name":"Musculoskeletal pain","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.3521000146865845},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3384000062942505},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33820000290870667},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.31119999289512634},{"id":"https://openalex.org/C2777414892","wikidata":"https://www.wikidata.org/wiki/Q4116663","display_name":"Musculoskeletal disorder","level":4,"score":0.2980000078678131},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C137886200","wikidata":"https://www.wikidata.org/wiki/Q2725568","display_name":"Biopsychosocial model","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25049999356269836}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fpsyt.2026.1977499","doi":"https://doi.org/10.3389/fpsyt.2026.1977499","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2026.1977499","pdf_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1977499/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},{"id":"pmid:42899055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42899055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678528","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678528/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Psychiatry","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10e1f8eed80e4174a92599f4a907f4be","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/10e1f8eed80e4174a92599f4a907f4be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Psychiatry, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fpsyt.2026.1977499","doi":"https://doi.org/10.3389/fpsyt.2026.1977499","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2026.1977499","pdf_url":"https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1977499/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220409506.pdf","grobid_xml":"https://content.openalex.org/works/W7220409506.grobid-xml"},"referenced_works_count":164,"referenced_works":["https://openalex.org/W86293904","https://openalex.org/W1479925286","https://openalex.org/W1490701657","https://openalex.org/W1493844743","https://openalex.org/W1639854378","https://openalex.org/W1756714365","https://openalex.org/W1966380557","https://openalex.org/W1966652886","https://openalex.org/W1977568667","https://openalex.org/W1982063012","https://openalex.org/W1986031269","https://openalex.org/W1990079987","https://openalex.org/W1993704673","https://openalex.org/W2001395916","https://openalex.org/W2011118191","https://openalex.org/W2011766130","https://openalex.org/W2013876494","https://openalex.org/W2016616411","https://openalex.org/W2018495408","https://openalex.org/W2023730787","https://openalex.org/W2027186997","https://openalex.org/W2032891517","https://openalex.org/W2034478656","https://openalex.org/W2037044418","https://openalex.org/W2044212277","https://openalex.org/W2049578370","https://openalex.org/W2050104200","https://openalex.org/W2052121420","https://openalex.org/W2057328368","https://openalex.org/W2064262366","https://openalex.org/W2065827234","https://openalex.org/W2073052871","https://openalex.org/W2087613249","https://openalex.org/W2088025468","https://openalex.org/W2093196756","https://openalex.org/W2127986065","https://openalex.org/W2132933661","https://openalex.org/W2135261840","https://openalex.org/W2138153565","https://openalex.org/W2149936178","https://openalex.org/W2151025663","https://openalex.org/W2153152770","https://openalex.org/W2153314004","https://openalex.org/W2158982739","https://openalex.org/W2164906297","https://openalex.org/W2168408572","https://openalex.org/W2168681940","https://openalex.org/W2169353681","https://openalex.org/W2170447689","https://openalex.org/W2171628509","https://openalex.org/W2179719109","https://openalex.org/W2236655565","https://openalex.org/W2292679276","https://openalex.org/W2360744652","https://openalex.org/W2424482192","https://openalex.org/W2460515486","https://openalex.org/W2582903515","https://openalex.org/W2606912748","https://openalex.org/W2607282171","https://openalex.org/W2616091527","https://openalex.org/W2727190324","https://openalex.org/W2730451865","https://openalex.org/W2735579573","https://openalex.org/W2738600621","https://openalex.org/W2755440592","https://openalex.org/W2765739547","https://openalex.org/W2768885511","https://openalex.org/W2779742302","https://openalex.org/W2792072360","https://openalex.org/W2802701292","https://openalex.org/W2805664065","https://openalex.org/W2808860595","https://openalex.org/W2810284427","https://openalex.org/W2936631711","https://openalex.org/W2937718630","https://openalex.org/W2937767484","https://openalex.org/W2971369923","https://openalex.org/W2976137416","https://openalex.org/W2992978377","https://openalex.org/W2999910954","https://openalex.org/W3000036091","https://openalex.org/W3003910680","https://openalex.org/W3012374822","https://openalex.org/W3016197306","https://openalex.org/W3016738360","https://openalex.org/W3023781031","https://openalex.org/W3027015665","https://openalex.org/W3030421574","https://openalex.org/W3035259691","https://openalex.org/W3036152249","https://openalex.org/W3044656313","https://openalex.org/W3122300958","https://openalex.org/W3155629299","https://openalex.org/W3164270472","https://openalex.org/W3179483599","https://openalex.org/W4200004795","https://openalex.org/W4200317974","https://openalex.org/W4205549221","https://openalex.org/W4206768471","https://openalex.org/W4207018518","https://openalex.org/W4220653098","https://openalex.org/W4220981505","https://openalex.org/W4221025948","https://openalex.org/W4224213947","https://openalex.org/W4245884070","https://openalex.org/W4283012122","https://openalex.org/W4290634622","https://openalex.org/W4308154019","https://openalex.org/W4313361124","https://openalex.org/W4313379931","https://openalex.org/W4313650082","https://openalex.org/W4318911843","https://openalex.org/W4323047939","https://openalex.org/W4365479014","https://openalex.org/W4377047450","https://openalex.org/W4379619604","https://openalex.org/W4381949224","https://openalex.org/W4382646041","https://openalex.org/W4387222831","https://openalex.org/W4387675632","https://openalex.org/W4388301133","https://openalex.org/W4391654900","https://openalex.org/W4391991431","https://openalex.org/W4393038229","https://openalex.org/W4396661153","https://openalex.org/W4398155691","https://openalex.org/W4399989509","https://openalex.org/W4400132029","https://openalex.org/W4401228814","https://openalex.org/W4401810448","https://openalex.org/W4402508053","https://openalex.org/W4403584506","https://openalex.org/W4404091272","https://openalex.org/W4405668666","https://openalex.org/W4405894408","https://openalex.org/W4408304747","https://openalex.org/W4408957520","https://openalex.org/W4409246638","https://openalex.org/W4409881563","https://openalex.org/W4411434236","https://openalex.org/W4411476801","https://openalex.org/W4412602464","https://openalex.org/W4412863079","https://openalex.org/W4413185022","https://openalex.org/W4414345253","https://openalex.org/W4414674403","https://openalex.org/W4415234686","https://openalex.org/W4415559920","https://openalex.org/W4415655434","https://openalex.org/W7125392336","https://openalex.org/W7133539014","https://openalex.org/W7138966819","https://openalex.org/W7150085655","https://openalex.org/W7154890356","https://openalex.org/W7160123830","https://openalex.org/W7160600697","https://openalex.org/W7163140309","https://openalex.org/W7163923889","https://openalex.org/W7164208499","https://openalex.org/W7165058641","https://openalex.org/W7165160312","https://openalex.org/W7167886036","https://openalex.org/W7168163661","https://openalex.org/W7169510838"],"related_works":["https://openalex.org/W4402620088","https://openalex.org/W7125392336","https://openalex.org/W2081767395","https://openalex.org/W4408922027","https://openalex.org/W7160307397","https://openalex.org/W2732566345","https://openalex.org/W7214663597","https://openalex.org/W7062604463","https://openalex.org/W2079451064","https://openalex.org/W2993013987"],"abstract_inverted_index":{"Musculoskeletal":[0],"disorders":[1,110],"(MSDs)":[2],"encompass":[3],"a":[4,24],"broad":[5],"spectrum":[6],"of":[7,58,95,153],"conditions":[8],"affecting":[9],"bones,":[10],"joints,":[11],"and":[12,18,21,41,49,82,97,140],"muscles,":[13],"characterized":[14],"by":[15,112],"significant":[16],"pain":[17],"functional":[19],"impairment,":[20],"have":[22],"become":[23],"major":[25],"global":[26],"health":[27],"burden.":[28],"In":[29],"recent":[30],"years,":[31],"accumulating":[32],"evidence":[33],"has":[34],"revealed":[35],"complex":[36,125],"bidirectional":[37],"interactions":[38,100],"between":[39],"depression":[40,48,88],"musculoskeletal":[42,109],"health.":[43],"This":[44],"review":[45],"focuses":[46],"on":[47],"delineates":[50],"how":[51],"it":[52],"may":[53],"influence":[54],"the":[55,79,150],"pathological":[56],"progression":[57],"MSDs":[59,96],"through":[60],"multiple":[61,102],"pathways,":[62],"including":[63],"neuroendocrine":[64],"dysregulation,":[65],"aberrant":[66],"inflammatory":[67],"responses,":[68],"epigenetic":[69],"modifications,":[70],"dysregulated":[71],"extracellular":[72],"vesicle-mediated":[73],"communication,":[74],"abnormal":[75],"neural":[76],"activity":[77],"along":[78],"brain-joint":[80],"axis,":[81],"gut":[83],"microbiota":[84],"ecological":[85],"imbalance.":[86],"Collectively,":[87],"is":[89],"associated":[90],"with":[91,127],"an":[92],"increased":[93],"risk":[94],"engages":[98],"intricate":[99],"across":[101],"biological":[103],"systems.":[104],"Our":[105],"study":[106],"underscores":[107],"that":[108],"are":[111],"no":[113],"means":[114],"confined":[115],"to":[116],"isolated":[117],"joints":[118],"or":[119],"local":[120],"tissues,":[121],"but":[122],"rather":[123],"represent":[124],"diseases":[126],"prominent":[128],"systemic":[129],"features.":[130],"Integrated":[131],"management":[132],"strategies":[133],"combining":[134],"psychosocial":[135],"interventions,":[136],"appropriate":[137],"physical":[138],"exercise,":[139],"dietary":[141],"modification":[142],"hold":[143],"promise":[144],"as":[145],"potential":[146],"multitargeted":[147],"approaches":[148],"for":[149],"comprehensive":[151],"treatment":[152],"MSDs.":[154]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-06T00:00:00"}