{"id":"https://openalex.org/W7220407740","doi":"https://doi.org/10.3389/fphar.2026.1864831","title":"Unsaturated fatty acids as immunometabolic modulators in high-risk pregnancies: mechanisms, clinical evidence, and translational perspectives","display_name":"Unsaturated fatty acids as immunometabolic modulators in high-risk pregnancies: mechanisms, clinical evidence, and translational perspectives","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220407740","doi":"https://doi.org/10.3389/fphar.2026.1864831","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898537","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678167"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1864831","doi":"https://doi.org/10.3389/fphar.2026.1864831","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1864831","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1864831/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1864831/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017733563","display_name":"Edm\u00e1rcio Olinto da Fonseca","orcid":"https://orcid.org/0000-0003-4469-1694","observed_orcids":["https://orcid.org/0000-0003-4469-1694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmarcio Olinto da Fonseca","raw_affiliation_strings":["Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157464862","display_name":"Jocilda Carvalho de Faria","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jocilda Carvalho de Faria","raw_affiliation_strings":["Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157502486","display_name":"Regiane Penaforte Santos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Regiane Penaforte Santos","raw_affiliation_strings":["Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157496595","display_name":"Julia Vieira Carvalho","orcid":"https://orcid.org/0009-0005-3123-2802","observed_orcids":["https://orcid.org/0009-0005-3123-2802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Vieira Carvalho","raw_affiliation_strings":["Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091850821","display_name":"Caroline Maria Oliveira Volpe","orcid":"https://orcid.org/0000-0003-0791-8538","observed_orcids":["https://orcid.org/0000-0003-0791-8538"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Caroline Maria Oliveira Volpe","raw_affiliation_strings":["Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Sa\u00fade Santa Casa BH, Programa de P\u00f3s-gradua\u00e7\u00e3o Stricto sensu em Medicina/Biomedicina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091850821"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51706405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1864831","last_page":"1864831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unsaturated-fatty-acids","display_name":"unsaturated fatty acids","score":0.9639999866485596},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9139999747276306},{"id":"https://openalex.org/keywords/high-risk-pregnancy","display_name":"high-risk pregnancy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9779999852180481},{"id":"https://openalex.org/keywords/placental-inflammation","display_name":"placental inflammation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.7039999961853027},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":1.0},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9100000262260437},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8550000190734863},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.9340000152587891},{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.8339999914169312},{"id":"https://openalex.org/keywords/omega-3-supplementation","display_name":"omega-3 supplementation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/personalized-nutrition","display_name":"personalized nutrition","score":0.8679999709129333},{"id":"https://openalex.org/keywords/maternal-and-perinatal-outcomes","display_name":"maternal and perinatal outcomes","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.7110999822616577},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.6176000237464905},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.4821999967098236},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.47760000824928284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43050000071525574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4065999984741211},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3935000002384186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38260000944137573},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.37459999322891235},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.34700000286102295},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31700000166893005},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.3163999915122986},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2777000069618225},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26989999413490295},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C2777300220","wikidata":"https://www.wikidata.org/wiki/Q378154","display_name":"Essential fatty acid","level":4,"score":0.2531999945640564}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1864831","doi":"https://doi.org/10.3389/fphar.2026.1864831","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1864831","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1864831/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678167","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678167/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678167/pdf/fphar-17-1864831.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42898537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3a4d7310680045ffa272135a4a0b00f6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3a4d7310680045ffa272135a4a0b00f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1864831","doi":"https://doi.org/10.3389/fphar.2026.1864831","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1864831","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1864831/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220407740.pdf","grobid_xml":"https://content.openalex.org/works/W7220407740.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1978128576","https://openalex.org/W1998522372","https://openalex.org/W2000537420","https://openalex.org/W2073049802","https://openalex.org/W2102084287","https://openalex.org/W2288353973","https://openalex.org/W2565763144","https://openalex.org/W2586570290","https://openalex.org/W2587680743","https://openalex.org/W2735527928","https://openalex.org/W2754394790","https://openalex.org/W2765304561","https://openalex.org/W2791386016","https://openalex.org/W2792956190","https://openalex.org/W2795737283","https://openalex.org/W2802901067","https://openalex.org/W2886540520","https://openalex.org/W2889237492","https://openalex.org/W2900846945","https://openalex.org/W2902686549","https://openalex.org/W2903000141","https://openalex.org/W2935104625","https://openalex.org/W2973044691","https://openalex.org/W2988109514","https://openalex.org/W3084138861","https://openalex.org/W3101080846","https://openalex.org/W3101641674","https://openalex.org/W3161556645","https://openalex.org/W3181573421","https://openalex.org/W4206327859","https://openalex.org/W4210796776","https://openalex.org/W4213447498","https://openalex.org/W4214916635","https://openalex.org/W4315491484","https://openalex.org/W4323539253","https://openalex.org/W4378086397","https://openalex.org/W4391574819","https://openalex.org/W4394958894","https://openalex.org/W4396776868","https://openalex.org/W4400767230","https://openalex.org/W4403921523","https://openalex.org/W4404929170","https://openalex.org/W4405559017","https://openalex.org/W4405926193","https://openalex.org/W4407212583","https://openalex.org/W4408107750","https://openalex.org/W4410233113","https://openalex.org/W4411119243","https://openalex.org/W4411213117","https://openalex.org/W4413995448","https://openalex.org/W4414624715","https://openalex.org/W4416094134"],"related_works":["https://openalex.org/W4283031511","https://openalex.org/W3100247122","https://openalex.org/W3090301144","https://openalex.org/W4405703067","https://openalex.org/W210315798","https://openalex.org/W2994847896","https://openalex.org/W2104955599","https://openalex.org/W2626437601","https://openalex.org/W2164950064","https://openalex.org/W2800268259"],"abstract_inverted_index":{"High-risk":[0],"pregnancies":[1],"(HRPs)":[2],"are":[3,32,214,227],"characterized":[4],"by":[5,34],"the":[6,100,123,132,147,154,203,258,273,291],"convergence":[7],"of":[8,70,125,134,156,191,200,293],"metabolic":[9,42],"dysfunction,":[10],"chronic":[11],"low-grade":[12],"inflammation,":[13],"and":[14,21,24,50,59,80,90,97,121,144,174,189,224,242,263,278,284,302,310],"placental":[15,51],"maladaptation,":[16],"leading":[17],"to":[18,246],"increased":[19],"maternal":[20,309],"perinatal":[22],"morbidity":[23],"mortality.":[25],"Emerging":[26],"evidence":[27,137,206,271],"indicates":[28],"that":[29,297],"these":[30,103,247],"conditions":[31],"driven":[33],"a":[35,197],"tightly":[36],"integrated":[37],"immunometabolic":[38,274],"axis,":[39],"in":[40,95,152,182,211,234,313],"which":[41,305],"stress":[43],"activates":[44],"innate":[45],"immune":[46],"pathways,":[47],"amplifying":[48],"systemic":[49],"inflammation.":[52,135],"Unsaturated":[53],"fatty":[54,61,104],"acids":[55,62,105],"(UFAs),":[56],"including":[57,172],"monounsaturated":[58],"polyunsaturated":[60],"(PUFAs),":[63],"have":[64,253],"gained":[65],"attention":[66],"as":[67,76,222,281],"key":[68],"modulators":[69],"this":[71],"axis.":[72],"Omega-3":[73],"PUFAs,":[74],"such":[75,221],"eicosapentaenoic":[77],"acid":[78,82],"(EPA)":[79],"docosahexaenoic":[81],"(DHA),":[83],"influence":[84],"membrane":[85],"composition,":[86],"lipid":[87],"mediator":[88],"synthesis,":[89],"intracellular":[91],"signaling":[92,108],"pathways":[93],"involved":[94],"inflammation":[96],"metabolism.":[98],"At":[99],"cellular":[101],"level,":[102],"attenuate":[106],"pro-inflammatory":[107],"through":[109],"nuclear":[110],"factor":[111],"kappa":[112],"B":[113],"(NF-\u03baB),":[114],"modulate":[115],"inflammasome":[116],"activation,":[117],"improve":[118,308],"mitochondrial":[119],"function,":[120],"promote":[122],"production":[124],"specialized":[126],"pro-resolving":[127],"mediators":[128],"(SPMs),":[129],"thereby":[130],"facilitating":[131],"resolution":[133],"Clinical":[136],"from":[138],"observational":[139],"studies,":[140],"randomized":[141,230],"controlled":[142,231],"trials,":[143],"meta-analyses":[145],"supports":[146],"role":[148,199],"for":[149,169,218,260],"omega-3":[150,201],"supplementation":[151],"reducing":[153],"risk":[155],"preterm":[157,212],"birth,":[158],"particularly":[159],"among":[160],"women":[161],"with":[162],"low":[163],"baseline":[164,185,237,299],"DHA":[165],"status.":[166],"However,":[167],"findings":[168,217],"other":[170,219],"outcomes,":[171,220],"preeclampsia":[173,223],"gestational":[175,225],"diabetes,":[176,226],"remain":[177],"heterogeneous,":[178],"likely":[179,244],"reflecting":[180],"variability":[181],"study":[183,235],"design,":[184,236],"nutritional":[186,238,300],"status,":[187,239],"dosage,":[188,241],"timing":[190],"intervention.":[192],"Although":[193],"several":[194,250],"studies":[195],"support":[196],"beneficial":[198],"supplementation,":[202],"overall":[204],"clinical":[205],"remains":[207],"heterogeneous.":[208],"While":[209],"reductions":[210],"birth":[213],"consistently":[215],"observed,":[216],"inconsistent":[228],"across":[229],"trials.":[232],"Differences":[233],"timing,":[240],"adherence":[243],"contribute":[245],"discrepancies.":[248],"Importantly,":[249],"well-conducted":[251],"trials":[252],"reported":[254],"null":[255],"effects,":[256],"highlighting":[257],"need":[259],"cautious":[261],"interpretation":[262],"more":[264],"targeted":[265],"approaches.":[266],"This":[267],"review":[268],"synthesizes":[269],"current":[270],"on":[272,290],"mechanisms":[275],"underlying":[276],"HRPs":[277],"highlights":[279],"UFAs":[280],"biologically":[282],"plausible":[283],"clinically":[285],"relevant":[286],"modulators.":[287],"It":[288],"focuses":[289],"importance":[292],"precision":[294],"nutrition":[295],"approaches":[296],"incorporate":[298],"assessment":[301],"biomarker-guided":[303],"stratification":[304],"may":[306],"ultimately":[307],"fetal":[311],"outcomes":[312],"high-risk":[314],"populations.":[315]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-06T00:00:00"}
