{"id":"https://openalex.org/W7220397359","doi":"https://doi.org/10.1016/j.rpth.2026.105474","title":"PB2735 Direct Oral Anticoagulants versus Vitamin K Antagonists for the Treatment of Venous Thromboembolism in Sickle Cell Disease: A Bayesian Meta-Analysis","display_name":"PB2735 Direct Oral Anticoagulants versus Vitamin K Antagonists for the Treatment of Venous Thromboembolism in Sickle Cell Disease: A Bayesian Meta-Analysis","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7220397359","doi":"https://doi.org/10.1016/j.rpth.2026.105474"},"language":"en","primary_location":{"id":"doi:10.1016/j.rpth.2026.105474","doi":"https://doi.org/10.1016/j.rpth.2026.105474","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.105474","pdf_url":"https://www.rpthjournal.org/article/S2475-0379(26)02132-1/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.rpthjournal.org/article/S2475-0379(26)02132-1/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004445767","display_name":"Sylvain Le Jeune","orcid":"https://orcid.org/0000-0002-2897-8102","observed_orcids":["https://orcid.org/0000-0002-2897-8102"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Le Jeune","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023227285","display_name":"Isabelle Mah\u00e9","orcid":"https://orcid.org/0000-0003-1760-7880","observed_orcids":["https://orcid.org/0000-0003-1760-7880"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Mah\u00e9","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010485705","display_name":"Antonio Morabito","orcid":"https://orcid.org/0009-0003-6441-056X","observed_orcids":["https://orcid.org/0009-0003-6441-056X"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antonio Morabito","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151499051","display_name":"J\u00e9r\u00e9my Datchanamourty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00e9my Datchanamourty","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084879219","display_name":"Florent Happe","orcid":"https://orcid.org/0000-0002-7233-681X","observed_orcids":["https://orcid.org/0000-0002-7233-681X"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florent Happe","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057281870","display_name":"E. Versini","orcid":"https://orcid.org/0000-0003-4857-2975","observed_orcids":["https://orcid.org/0000-0003-4857-2975"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edouard Versini","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017595664","display_name":"C. Affo","orcid":"https://orcid.org/0009-0004-3852-7382","observed_orcids":["https://orcid.org/0009-0004-3852-7382"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Louis Affo","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108118812","display_name":"Corinne Fr\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Frere","raw_affiliation_strings":["Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210097159"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210097159"],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"105474","last_page":"105474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/anticoagulation-efficacy","display_name":"anticoagulant efficacy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/anticoagulation-safety","display_name":"anticoagulant safety","score":0.9890000224113464},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8324999809265137},{"id":"https://openalex.org/C2991741193","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thromboembolism","level":3,"score":0.6826000213623047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6018000245094299},{"id":"https://openalex.org/C2993590494","wikidata":"https://www.wikidata.org/wiki/Q182338","display_name":"Vitamin k","level":2,"score":0.5293999910354614},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45410001277923584},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.3734000027179718},{"id":"https://openalex.org/C2776704044","wikidata":"https://www.wikidata.org/wiki/Q2852541","display_name":"Vitamin K antagonist","level":4,"score":0.35600000619888306},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33169999718666077},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31850001215934753},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C3017811039","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Major bleeding","level":3,"score":0.2554999887943268}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.rpth.2026.105474","doi":"https://doi.org/10.1016/j.rpth.2026.105474","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.105474","pdf_url":"https://www.rpthjournal.org/article/S2475-0379(26)02132-1/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.rpth.2026.105474","doi":"https://doi.org/10.1016/j.rpth.2026.105474","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.105474","pdf_url":"https://www.rpthjournal.org/article/S2475-0379(26)02132-1/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220397359.pdf","grobid_xml":"https://content.openalex.org/works/W7220397359.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7221797050","https://openalex.org/W7220372730","https://openalex.org/W2871725650","https://openalex.org/W7220406578","https://openalex.org/W7220416321","https://openalex.org/W4225263854","https://openalex.org/W4225121615","https://openalex.org/W3025103909","https://openalex.org/W4220667953","https://openalex.org/W4252244726"],"abstract_inverted_index":{"Direct":[0],"Oral":[1],"Anticoagulants":[2],"(DOACs)":[3],"are":[4],"increasingly":[5],"used":[6],"as":[7],"alternatives":[8],"to":[9,41],"Vitamin":[10],"K":[11],"Antagonists":[12],"(VKAs)":[13],"for":[14],"the":[15],"treatment":[16],"of":[17],"venous":[18],"thromboembolism":[19],"(VTE)":[20],"in":[21,36,58],"patients":[22],"with":[23],"sickle":[24],"cell":[25],"disease":[26],"(SCD).":[27],"However,":[28],"comparative":[29],"evidence":[30],"on":[31],"their":[32],"efficacy":[33],"and":[34,55],"safety":[35],"this":[37],"population":[38],"remains":[39],"limited":[40],"small":[42,52],"observational":[43],"studies.":[44,60],"Previous":[45],"frequentist":[46],"meta-analyses":[47],"may":[48],"lack":[49],"robustness":[50],"given":[51],"sample":[53],"sizes":[54],"zero-event":[56],"data":[57],"some":[59]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}