{"id":"https://openalex.org/W7220396708","doi":"https://doi.org/10.3389/fnagi.2026.1874472","title":"Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study\u2013health disparities cohort","display_name":"Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study\u2013health disparities cohort","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220396708","doi":"https://doi.org/10.3389/fnagi.2026.1874472","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677870"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2026.1874472","doi":"https://doi.org/10.3389/fnagi.2026.1874472","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1874472","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1874472/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1874472/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115822389","display_name":"Kimberly Espejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Espejo","raw_affiliation_strings":["Department of Neurosciences, Alzheimer\u2019s Disease Cooperative Study (ADCS), University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Alzheimer\u2019s Disease Cooperative Study (ADCS), University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157571345","display_name":"Ryan Rulkens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Rulkens","raw_affiliation_strings":["Department of Biological Sciences, University of California San Diego","Hal\u0131c\u0131o\u011flu Data Science Institute, University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Hal\u0131c\u0131o\u011flu Data Science Institute, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060160779","display_name":"Cellas A. Hayes","orcid":"https://orcid.org/0000-0002-6259-9456","observed_orcids":["https://orcid.org/0000-0002-6259-9456"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cellas A. Hayes","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, University of Kentucky","Sanders-Brown Center on Aging, College of Medicine, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Sanders-Brown Center on Aging, College of Medicine, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039953892","display_name":"Joey Annette Contreras","orcid":"https://orcid.org/0000-0002-1778-3641","observed_orcids":["https://orcid.org/0000-0002-1778-3641"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joey A. Contreras","raw_affiliation_strings":["Department of Neurosciences, Alzheimer\u2019s Disease Cooperative Study (ADCS), University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Alzheimer\u2019s Disease Cooperative Study (ADCS), University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039953892","https://openalex.org/A5060160779"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I36258959"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7612821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"1874472","last_page":"1874472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tau-pet","display_name":"tau PET","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.640999972820282},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.7739999890327454},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7760000228881836},{"id":"https://openalex.org/keywords/racial-and-ethnic-diversity","display_name":"racial and ethnic diversity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7383000254631042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7009999752044678},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6521000266075134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5601999759674072},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5339999794960022},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.5331000089645386},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.49390000104904175},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.4796000123023987},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.47940000891685486},{"id":"https://openalex.org/C199374082","wikidata":"https://www.wikidata.org/wiki/Q907080","display_name":"Standardized uptake value","level":3,"score":0.47839999198913574},{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.45840001106262207},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.43389999866485596},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3896999955177307},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38449999690055847},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.3763999938964844},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3580000102519989},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.34450000524520874},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.3287000060081482},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32600000500679016},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.3086000084877014},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3084999918937683},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2865999937057495},{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.2786000072956085},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25949999690055847},{"id":"https://openalex.org/C2776191500","wikidata":"https://www.wikidata.org/wiki/Q2123166","display_name":"Leukoaraiosis","level":4,"score":0.2563000023365021},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnagi.2026.1874472","doi":"https://doi.org/10.3389/fnagi.2026.1874472","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1874472","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1874472/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677870","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677870/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677870/pdf/fnagi-18-1874472.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging Neurosci","raw_type":"Text"},{"id":"pmid:42898366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b6dc71979f7143bf97190ea3fe6f05a7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b6dc71979f7143bf97190ea3fe6f05a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 18 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2026.1874472","doi":"https://doi.org/10.3389/fnagi.2026.1874472","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1874472","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1874472/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4203589831","display_name":"Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans","funder_award_id":"R01AG054073","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8240482529","display_name":"Laboratory of Neuro Imaging Resource (LONIR)","funder_award_id":"P41EB015922","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000866003","display_name":"Health and Aging Brain among Latino Elders (HABLE-AT(N)) Study","funder_award_id":"R01AG058533","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000912972","display_name":"The Health & Aging Brain Study - Health Disparities (HABS-HD)","funder_award_id":"U19AG078109","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220396708.pdf","grobid_xml":"https://content.openalex.org/works/W7220396708.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1974300727","https://openalex.org/W1988761237","https://openalex.org/W1993571512","https://openalex.org/W2006035554","https://openalex.org/W2006958560","https://openalex.org/W2009869050","https://openalex.org/W2037426713","https://openalex.org/W2055077265","https://openalex.org/W2096849439","https://openalex.org/W2099511111","https://openalex.org/W2102848905","https://openalex.org/W2128228199","https://openalex.org/W2162069510","https://openalex.org/W2266863819","https://openalex.org/W2520511459","https://openalex.org/W2560584411","https://openalex.org/W2605454964","https://openalex.org/W2743925765","https://openalex.org/W2759050422","https://openalex.org/W2767301142","https://openalex.org/W2771985790","https://openalex.org/W2798054687","https://openalex.org/W2894357926","https://openalex.org/W2895292592","https://openalex.org/W2911147760","https://openalex.org/W2955006628","https://openalex.org/W3001764054","https://openalex.org/W3035949142","https://openalex.org/W3046275966","https://openalex.org/W3091074342","https://openalex.org/W3160870314","https://openalex.org/W3173173220","https://openalex.org/W4224995914","https://openalex.org/W4241074797","https://openalex.org/W4310037521","https://openalex.org/W4366351919","https://openalex.org/W4376872811","https://openalex.org/W4392544951","https://openalex.org/W4400089962","https://openalex.org/W4404914264","https://openalex.org/W4406155660","https://openalex.org/W4406845258","https://openalex.org/W4410792907","https://openalex.org/W4412882152","https://openalex.org/W4412997769","https://openalex.org/W4413111294","https://openalex.org/W4414069899","https://openalex.org/W4414500667","https://openalex.org/W4414700610","https://openalex.org/W7133849522","https://openalex.org/W7155059170","https://openalex.org/W7160349244"],"related_works":["https://openalex.org/W7214610891","https://openalex.org/W3198521395","https://openalex.org/W4391291126","https://openalex.org/W4380793554","https://openalex.org/W7116942240","https://openalex.org/W2981206461","https://openalex.org/W3217561425","https://openalex.org/W4236452609","https://openalex.org/W4406409551","https://openalex.org/W2761051660"],"abstract_inverted_index":{"Background":[0],"Cardiovascular":[1],"risk":[2,47,91,189,214,246,287,309],"is":[3],"increasingly":[4],"recognized":[5],"as":[6,163,312],"relevant":[7,156],"to":[8,18,86],"cognitive":[9,55,297],"aging":[10],"and":[11,26,35,54,65,99,126,141,159,196,207,225,239,247,249,258,265,271,295,318],"dementia-related":[12],"brain":[13,319],"changes,":[14],"yet":[15],"its":[16],"relationship":[17],"multimodal":[19],"neuroimaging":[20,52,157],"biomarkers":[21,53],"of":[22,183,315],"amyloid,":[23],"tau,":[24],"neurodegeneration,":[25,236],"vascular":[27,237,250],"injury":[28,251],"(AT(N)-V)":[29],"remains":[30],"incompletely":[31],"understood":[32],"in":[33,255],"racially":[34],"ethnically":[36],"diverse":[37,281],"cohorts.":[38],"We":[39],"examined":[40],"whether":[41],"ten-year":[42,187,212,244,285,307],"atherosclerotic":[43],"cardiovascular":[44,73,317],"disease":[45,74],"(ASCVD)":[46],"was":[48,92,190,215,288],"associated":[49,191,217,289],"with":[50,165,192,218,263,290],"AT(N)-V":[51,292],"domain":[56,133],"scores.":[57],"Methods":[58],"This":[59],"cross-sectional":[60,303],"study":[61],"included":[62,104,135],"1,626":[63],"Health":[64],"Aging":[66],"Brain":[67],"Study\u2013Health":[68],"Disparities":[69],"(HABS-HD)":[70],"participants":[71],"without":[72],"or":[75,328],"dementia":[76],"who":[77],"had":[78],"amyloid":[79,107,179,195,234,264],"positron":[80],"emission":[81],"tomography":[82],"(PET)":[83],"imaging":[84,160],"linked":[85],"visit":[87],"1.":[88],"Ten-year":[89],"ASCVD":[90,188,213,245,286,308],"estimated":[93],"using":[94,176],"the":[95],"Pooled":[96],"Cohort":[97],"Equations":[98],"modeled":[100],"continuously.":[101],"Neuroimaging":[102],"outcomes":[103,134],"global":[105,178,194],"florbetaben":[106],"PET":[108,120,180,199,268],"standardized":[109],"uptake":[110],"value":[111],"ratio":[112],"(SUVR),":[113],"medial":[114],"temporal":[115,329],"lobe":[116],"(MTL)":[117],"PI-2620":[118],"tau":[119,198,267],"SUVR,":[121,200],"cortical":[122,202],"thickness,":[123,203],"hippocampal":[124,205],"volume,":[125,206],"white":[127],"matter":[128],"hyperintensity":[129],"(WMH)":[130],"volume.":[131,210],"Cognitive":[132],"memory,":[136,220],"executive":[137,221],"function,":[138,222],"processing":[139,223],"speed,":[140,224],"language.":[142],"Multivariable":[143],"linear":[144],"regression":[145],"models":[146],"accounted":[147],"for":[148,168,230],"apolipoprotein":[149],"E":[150],"(":[151],"APOE":[152,231],")":[153],"\u03b54":[154,232],"status,":[155,233],"biomarkers,":[158],"scanner/protocol":[161],"covariates":[162],"appropriate,":[164],"Holm":[166],"adjustment":[167],"multiple":[169,300],"comparisons.":[170],"Amyloid-status-stratified":[171],"analyses":[172],"were":[173,253,269],"also":[174,216],"conducted":[175],"a":[177,313],"SUVR":[181],"threshold":[182],"1.08.":[184],"Results":[185],"Increasing":[186,211],"increasing":[193,284],"MTL":[197,266],"smaller":[201,204],"increased":[208],"WMH":[209],"lower":[219],"language":[226],"scores":[227],"after":[228],"accounting":[229],"burden,":[235,321],"injury,":[238],"scanner":[240],"covariates.":[241],"Associations":[242],"between":[243],"structural":[248],"markers":[252],"observed":[254],"both":[256],"amyloid-positive":[257],"amyloid-negative":[259,276],"participants,":[260],"whereas":[261],"associations":[262],"modest":[270],"statistically":[272],"significant":[273],"only":[274],"among":[275],"participants.":[277],"Conclusion":[278],"In":[279],"this":[280],"HABS-HD":[282],"sample,":[283],"greater":[291],"biomarker":[293],"burden":[294],"poorer":[296],"performance":[298],"across":[299],"domains.":[301],"These":[302],"findings":[304],"suggest":[305],"that":[306],"may":[310],"serve":[311],"marker":[314],"co-occurring":[316],"health":[320],"but":[322],"they":[323],"do":[324],"not":[325],"establish":[326],"causality":[327],"direction.":[330]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}