{"id":"https://openalex.org/W7220395015","doi":"https://doi.org/10.3389/fimmu.2026.1854761","title":"Platform-based manufacturing of tumor-infiltrating lymphocytes derived from different solid tumor types","display_name":"Platform-based manufacturing of tumor-infiltrating lymphocytes derived from different solid tumor types","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220395015","doi":"https://doi.org/10.3389/fimmu.2026.1854761","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677931"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1854761","doi":"https://doi.org/10.3389/fimmu.2026.1854761","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1854761","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1854761/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1854761/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136401916","display_name":"Justin Lievense","orcid":"https://orcid.org/0009-0003-1492-1732","observed_orcids":["https://orcid.org/0009-0003-1492-1732"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Justin Lievense","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063303676","display_name":"Liselotte Tas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Liselotte Tas","raw_affiliation_strings":["Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109437516","display_name":"Maaike van Zon","orcid":"https://orcid.org/0009-0008-8810-0191","observed_orcids":["https://orcid.org/0009-0008-8810-0191"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maaike van Zon","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157645648","display_name":"Kari-Anne Legu\u00e9-van Duinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kari-Anne Legu\u00e9-van Duinen","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053097772","display_name":"Rosa A. van Amerongen","orcid":"https://orcid.org/0000-0002-5560-0957","observed_orcids":["https://orcid.org/0000-0002-5560-0957"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rosa van Amerongen","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008247992","display_name":"Sander Kouwen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sander Kouwen","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111130704","display_name":"Rosalie van Riessen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rosalie van Riessen","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157423073","display_name":"Femke Sluiter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Femke Sluiter","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157378053","display_name":"Jeltsje Hagg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeltsje Hagg","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079990737","display_name":"Madelon Badoux","orcid":"https://orcid.org/0009-0003-2946-5952","observed_orcids":["https://orcid.org/0009-0003-2946-5952"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Madelon Badoux","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157603961","display_name":"Iris Manders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Iris Manders","raw_affiliation_strings":["Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121333396","display_name":"E. Vedder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eva Vedder","raw_affiliation_strings":["Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010298788","display_name":"Erica Sellink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erica Sellink","raw_affiliation_strings":["Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014721757","display_name":"Tom T. P. Seijkens","orcid":"https://orcid.org/0009-0008-5223-9538","observed_orcids":["https://orcid.org/0009-0008-5223-9538","https://orcid.org/0000-0001-6370-1267"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tom Seijkens","raw_affiliation_strings":["Division of Medical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007742002","display_name":"K. Hartemink","orcid":"https://orcid.org/0000-0001-8951-6430","observed_orcids":["https://orcid.org/0000-0001-8951-6430"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Koen Hartemink","raw_affiliation_strings":["Department of Pulmonary Disease, Leiden University Medical Center","Department of Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Disease, Leiden University Medical Center","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071409135","display_name":"Marcus J. Rijken","orcid":"https://orcid.org/0000-0003-0914-5508","observed_orcids":["https://orcid.org/0000-0003-0914-5508"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcus Rijken","raw_affiliation_strings":["Department of Gynaecologic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","Julius Centre for Health Science and Primary Care, University Medical Center Utrecht"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecologic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Julius Centre for Health Science and Primary Care, University Medical Center Utrecht","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024428654","display_name":"Oscar Roberto Brouwer","orcid":"https://orcid.org/0000-0001-6244-0456","observed_orcids":["https://orcid.org/0000-0001-6244-0456"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Oscar Brouwer","raw_affiliation_strings":["Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008917524","display_name":"Suzanne M. Castenmiller","orcid":"https://orcid.org/0000-0001-9751-980X","observed_orcids":["https://orcid.org/0000-0001-9751-980X"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Suzanne Castenmiller","raw_affiliation_strings":["Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation","Landsteiner Laboratory, Amsterdam Medical Center","Oncode Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Landsteiner Laboratory, Amsterdam Medical Center","institution_ids":["https://openalex.org/I4210151833"]},{"raw_affiliation_string":"Oncode Institute","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110460747","display_name":"Marten Hansen","orcid":"https://orcid.org/0000-0003-1379-2759","observed_orcids":["https://orcid.org/0000-0003-1379-2759"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marten Hansen","raw_affiliation_strings":["Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","Landsteiner Laboratory, Amsterdam Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Laboratory for Cell Therapy, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Landsteiner Laboratory, Amsterdam Medical Center","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087282255","display_name":"Monika C. Wolkers","orcid":"https://orcid.org/0000-0003-3242-1363","observed_orcids":["https://orcid.org/0000-0003-3242-1363"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monika Wolkers","raw_affiliation_strings":["Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation","Landsteiner Laboratory, Amsterdam Medical Center","Oncode Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research T-cell differentiation lab, Sanquin Blood Supply Foundation","institution_ids":["https://openalex.org/I3020210244"]},{"raw_affiliation_string":"Landsteiner Laboratory, Amsterdam Medical Center","institution_ids":["https://openalex.org/I4210151833"]},{"raw_affiliation_string":"Oncode Institute","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017136846","display_name":"John B.A.G. Haanen","orcid":"https://orcid.org/0000-0001-5884-7704","observed_orcids":["https://orcid.org/0000-0001-5884-7704"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["CH","NL"],"is_corresponding":false,"raw_author_name":"John Haanen","raw_affiliation_strings":["Department of Medical Oncology, Leiden University Medical Center","Division of Medical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","The Melanoma Clinic, Centre Hospitalier Universitaire Vaudois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Leiden University Medical Center","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Division of Medical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"The Melanoma Clinic, Centre Hospitalier Universitaire Vaudois","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos Beijnen","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Utrecht University","Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Utrecht University","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042101087","display_name":"Cynthia M. Nijenhuis","orcid":"https://orcid.org/0009-0005-2707-1380","observed_orcids":["https://orcid.org/0009-0005-2707-1380"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cynthia Nijenhuis","raw_affiliation_strings":["BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTherapeutics Unit, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080035300","display_name":"Inge Jedema","orcid":"https://orcid.org/0000-0001-9042-6459","observed_orcids":["https://orcid.org/0000-0001-9042-6459"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Inge Jedema","raw_affiliation_strings":["Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085958205","display_name":"Bastiaan Nuijen","orcid":"https://orcid.org/0000-0002-8652-3560","observed_orcids":["https://orcid.org/0000-0002-8652-3560"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Bastiaan Nuijen","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5080035300","https://openalex.org/A5085958205"],"corresponding_institution_ids":["https://openalex.org/I2898336195"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7204536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1854761","last_page":"1854761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/penile-cancer","display_name":"penile cancer","score":1.0},{"id":"https://openalex.org/keywords/process-development","display_name":"process development","score":0.6399999856948853},{"id":"https://openalex.org/keywords/quality-standards","display_name":"quality standards","score":0.5559999942779541},{"id":"https://openalex.org/keywords/ifn-gamma-secretion","display_name":"IFN-gamma secretion","score":0.6669999957084656},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.6480000019073486},{"id":"https://openalex.org/keywords/manufacturing-scalability","display_name":"industrial scalability","score":0.4009999930858612},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.625}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6216999888420105},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.5996999740600586},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.59579998254776},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.582099974155426},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5569000244140625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.529699981212616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5273000001907349},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.492000013589859},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4722000062465668},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4341000020503998},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3666999936103821},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.365200012922287},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.35499998927116394},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.32829999923706055},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3174000084400177},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.3111000061035156},{"id":"https://openalex.org/C3019255331","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive immunotherapy","level":4,"score":0.29670000076293945},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2872999906539917},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2623000144958496},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2026.1854761","doi":"https://doi.org/10.3389/fimmu.2026.1854761","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1854761","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1854761/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677931","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677931/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677931/pdf/fimmu-17-1854761.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42898410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6110553bda4a42aba068a09bb340bb53","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6110553bda4a42aba068a09bb340bb53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/492648","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/492648","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1854761","doi":"https://doi.org/10.3389/fimmu.2026.1854761","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1854761","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1854761/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220395015.pdf","grobid_xml":"https://content.openalex.org/works/W7220395015.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W47217405","https://openalex.org/W1977191992","https://openalex.org/W1986215428","https://openalex.org/W1990331651","https://openalex.org/W2030682069","https://openalex.org/W2034745242","https://openalex.org/W2085890670","https://openalex.org/W2087025867","https://openalex.org/W2096951064","https://openalex.org/W2113149311","https://openalex.org/W2113847305","https://openalex.org/W2127756533","https://openalex.org/W2132923173","https://openalex.org/W2145353379","https://openalex.org/W2155959680","https://openalex.org/W2170403104","https://openalex.org/W2302719382","https://openalex.org/W2309691699","https://openalex.org/W2329702540","https://openalex.org/W2333997296","https://openalex.org/W2397198511","https://openalex.org/W2548653188","https://openalex.org/W2570323108","https://openalex.org/W2587415553","https://openalex.org/W2604931745","https://openalex.org/W2606495925","https://openalex.org/W2740820462","https://openalex.org/W2768599330","https://openalex.org/W2772231333","https://openalex.org/W2777093732","https://openalex.org/W2803451300","https://openalex.org/W2806704237","https://openalex.org/W2902509781","https://openalex.org/W2911882091","https://openalex.org/W3014430241","https://openalex.org/W3035143809","https://openalex.org/W3087656967","https://openalex.org/W3131066429","https://openalex.org/W3140279834","https://openalex.org/W3162968491","https://openalex.org/W3176786809","https://openalex.org/W3193095160","https://openalex.org/W3193325476","https://openalex.org/W3217772429","https://openalex.org/W4205306227","https://openalex.org/W4206041598","https://openalex.org/W4210440082","https://openalex.org/W4220687116","https://openalex.org/W4283311629","https://openalex.org/W4285728803","https://openalex.org/W4307431326","https://openalex.org/W4309039962","https://openalex.org/W4311584464","https://openalex.org/W4319240035","https://openalex.org/W4320517213","https://openalex.org/W4377564583","https://openalex.org/W4385751939","https://openalex.org/W4387440965","https://openalex.org/W4391467446","https://openalex.org/W4396578915","https://openalex.org/W4400928344","https://openalex.org/W4402516419","https://openalex.org/W4403380540","https://openalex.org/W4405195601","https://openalex.org/W4408387151","https://openalex.org/W4411112502","https://openalex.org/W4412059446","https://openalex.org/W4412537955","https://openalex.org/W4412631680","https://openalex.org/W4416568902"],"related_works":["https://openalex.org/W3048831913","https://openalex.org/W4415871414","https://openalex.org/W2282942463","https://openalex.org/W2902509781","https://openalex.org/W4417240756","https://openalex.org/W2329702540","https://openalex.org/W4409448970","https://openalex.org/W2895610076","https://openalex.org/W4412922549","https://openalex.org/W2055820960"],"abstract_inverted_index":{"Background":[0],"In":[1,245],"adoptive":[2],"cell":[3,119],"therapy":[4,47,328],"with":[5,40,277,313],"tumor-infiltrating":[6],"lymphocytes":[7],"(TILs),":[8],"TILs":[9,85,97,112],"are":[10],"isolated":[11],"and":[12,29,54,78,124,202,215,218,241,263,292,335,338],"expanded":[13],"ex":[14],"vivo":[15],"from":[16,98,113,288,306],"an":[17],"autologous":[18,153],"tumor":[19,101,154,183,233,290,309,342],"lesion.":[20],"TIL":[21,27,46,327],"therapy,":[22],"comprising":[23],"preparative":[24],"lymphodepleting":[25],"chemotherapy,":[26],"infusion,":[28],"post-infusion":[30],"supportive":[31],"interleukin-2":[32],"(IL-2)":[33],"administration,":[34],"has":[35],"demonstrated":[36],"efficacy":[37],"in":[38,44,67,251,314,326],"patients":[39],"metastatic":[41,83],"melanoma.":[42],"Interest":[43],"extending":[45],"to":[48,63,104,148,158,174,274,331],"other":[49,340],"solid":[50,100,308,341],"tumors":[51],"is":[52],"growing,":[53],"a":[55,75,90,219,278],"tumor-agnostic":[56,91],"manufacturing":[57,76],"platform":[58,92,302,322],"would":[59],"allow":[60],"first-in-human":[61],"trials":[62,330],"be":[64,87,275,324],"launched":[65],"rapidly":[66],"these":[68],"indications.":[69],"Objective":[70],"This":[71,321],"study":[72],"investigated":[73],"whether":[74],"process":[77,133],"control":[79],"strategy":[80],"developed":[81],"for":[82,93,318],"melanoma-derived":[84],"could":[86],"adapted":[88],"into":[89],"the":[94,160,194,232,268],"generation":[95],"of":[96,110,163,189,210,221,253,270],"different":[99],"types,":[102,234],"referred":[103],"as":[105],"NTU101.":[106],"Methods":[107],"The":[108,300],"feasibility":[109],"generating":[111],"endometrial":[114],"carcinoma":[115],"(ENDC,":[116],"n=9),":[117,123],"non-small":[118],"lung":[120],"cancer":[121,126],"(NSCLC,":[122],"penile":[125],"(PENC,":[127],"n=10)":[128],"lesions":[129],"was":[130,146,156,249,285],"assessed":[131],"during":[132],"development":[134],"(PD)":[135],"runs":[136],"using":[137],"predefined":[138,195],"quality":[139,170,196,297],"criteria.":[140,298],"Throughout":[141],"PD":[142,167,190,235],"runs,":[143],"flow":[144],"cytometry":[145],"used":[147,157],"characterize":[149],"cells.":[150],"When":[151],"available,":[152],"digest":[155],"assess":[159],"tumor-reactive":[161,247,316],"potential":[162,248,317],"TILs.":[164],"Based":[165],"on":[166],"experience,":[168],"adjusted":[169],"criteria":[171],"were":[172],"applied":[173,325],"manufacture":[175],"one":[176],"full-scale":[177],"GMP":[178,283],"NTU101-drug":[179],"product":[180],"(DP)":[181],"per":[182],"type.":[184],"Results":[185],"Overall,":[186],"89%":[187],"(n=25/28)":[188],"NTU101-DPs":[191,236,255,305],"manufactured":[192,287],"met":[193,295],"criteria,":[197],"containing":[198],"at":[199],"least":[200],"0.5\u00d710^9":[201],"90%":[203],"viable":[204],"CD45+CD3+":[205],"cells,":[206],"less":[207],"than":[208,223],"1.0%":[209],"cellular":[211],"impurities":[212],"(viable":[213],"CD45-":[214],"CD19+":[216],"cells),":[217],"potency":[220],"more":[222,279],"1.0\u00d710^3":[224],"pg/mL":[225],"IFN-\u03b3":[226],"secretion":[227],"upon":[228],"CD3/CD28-polymer":[229],"stimulation.":[230],"Across":[231],"had":[237],"comparable":[238,304],"T-cell":[239],"subset":[240],"differentiation":[242],"state":[243],"compositions.":[244],"vitro":[246,315],"detected":[250],"82%":[252],"tested":[254],"(ENDC:":[256],"71%,":[257],"n=5/7;":[258],"NSCLC:":[259],"80%,":[260],"n=":[261],"4/5;":[262],"PENC:":[264],"100%,":[265],"n=5/5),":[266],"although":[267],"level":[269],"reactivity":[271],"will":[272],"need":[273],"confirmed":[276],"in-depth":[280],"assay.":[281],"One":[282],"NTU101-DP":[284],"then":[286],"each":[289],"type,":[291],"all":[293],"three":[294,307],"NTU101\u2019s":[296],"Conclusion":[299],"NTU101":[301],"produced":[303],"types":[310],"beyond":[311],"melanoma,":[312],"some":[319],"batches.":[320],"can":[323],"clinical":[329],"generate":[332],"ENDC-,":[333],"NSCLC-,":[334],"PENC-derived":[336],"TILs,":[337],"possibly":[339],"types.":[343]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-06T00:00:00"}