{"id":"https://openalex.org/W7220394361","doi":"https://doi.org/10.3389/fcimb.2026.1929024","title":"Reframing clathrin-mediated viral entry: evidence standards, context dependence and host-directed vulnerabilities","display_name":"Reframing clathrin-mediated viral entry: evidence standards, context dependence and host-directed vulnerabilities","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220394361","doi":"https://doi.org/10.3389/fcimb.2026.1929024","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678436"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1929024","doi":"https://doi.org/10.3389/fcimb.2026.1929024","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1929024","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1929024/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1929024/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157654016","display_name":"Qinying Wang","orcid":"https://orcid.org/0009-0005-0404-4531","observed_orcids":["https://orcid.org/0009-0005-0404-4531"]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]},{"id":"https://openalex.org/I4210155511","display_name":"First Affiliated Hospital of Henan University","ror":"https://ror.org/0536rsk67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155511"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinying Wang","raw_affiliation_strings":["Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","Department of The First Clinical Medical College, Henan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210144860","https://openalex.org/I4210155511"]},{"raw_affiliation_string":"Department of The First Clinical Medical College, Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152760126","display_name":"Liran Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liran Xu","raw_affiliation_strings":["Department of The First Clinical Medical College, Henan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of The First Clinical Medical College, Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128348592","display_name":"Yangang Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangang Sun","raw_affiliation_strings":["School of Medicine, Henan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157457253","display_name":"Yuting Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]},{"id":"https://openalex.org/I4210155511","display_name":"First Affiliated Hospital of Henan University","ror":"https://ror.org/0536rsk67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155511"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Xia","raw_affiliation_strings":["Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","Department of The First Clinical Medical College, Henan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210144860","https://openalex.org/I4210155511"]},{"raw_affiliation_string":"Department of The First Clinical Medical College, Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101393913","display_name":"Jingyu Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210144860","display_name":"First Affiliated Hospital of Henan University of Traditional Chinese Medicine","ror":"https://ror.org/059c9vn90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144860"]},{"id":"https://openalex.org/I4210155511","display_name":"First Affiliated Hospital of Henan University","ror":"https://ror.org/0536rsk67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155511"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingyu Yue","raw_affiliation_strings":["Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210144860","https://openalex.org/I4210155511"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101393913"],"corresponding_institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210144860","https://openalex.org/I4210155511"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45803698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1929024","last_page":"1929024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.9909999966621399},{"id":"https://openalex.org/keywords/host-targeted-antiviral-therapy","display_name":"host-directed antiviral therapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/standards-of-evidence","display_name":"evidence standards","score":0.5080000162124634},{"id":"https://openalex.org/keywords/context-dependence","display_name":"context sensitivity","score":0.5460000038146973},{"id":"https://openalex.org/keywords/endosomal-trafficking","display_name":"endosomal trafficking","score":0.609000027179718},{"id":"https://openalex.org/keywords/tpc2","display_name":"TPC2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/npc1","display_name":"NPC1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pikfyve","display_name":"PIKfyve","score":0.953000009059906},{"id":"https://openalex.org/keywords/actin-dynamics","display_name":"actin dynamics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/membrane-lipids","display_name":"membrane lipids","score":0.5889999866485596},{"id":"https://openalex.org/keywords/evidence-framework","display_name":"evidence framework","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6191999912261963},{"id":"https://openalex.org/C187029079","wikidata":"https://www.wikidata.org/wiki/Q958679","display_name":"Cognitive reframing","level":2,"score":0.605400025844574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5613999962806702},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5590000152587891},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5239999890327454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5152999758720398},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.436599999666214},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.38929998874664307},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36090001463890076},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C199776023","wikidata":"https://www.wikidata.org/wiki/Q202875","display_name":"Negotiation","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.3244999945163727},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32030001282691956},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.30399999022483826},{"id":"https://openalex.org/C117943116","wikidata":"https://www.wikidata.org/wiki/Q1135604","display_name":"Receptor-mediated endocytosis","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.28459998965263367},{"id":"https://openalex.org/C2776261394","wikidata":"https://www.wikidata.org/wiki/Q315562","display_name":"Impossibility","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.2646999955177307},{"id":"https://openalex.org/C55004796","wikidata":"https://www.wikidata.org/wiki/Q1163938","display_name":"Barriers to entry","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.2526000142097473},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.25099998712539673},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.2502000033855438}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2026.1929024","doi":"https://doi.org/10.3389/fcimb.2026.1929024","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1929024","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1929024/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678436","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678436/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678436/pdf/fcimb-16-1929024.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:42898937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:065c54fe5b0041179c4d30e42b644e3b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/065c54fe5b0041179c4d30e42b644e3b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1929024","doi":"https://doi.org/10.3389/fcimb.2026.1929024","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1929024","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1929024/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318564","display_name":"Health Commission of Henan Province","ror":"https://ror.org/04nne1357"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220394361.pdf","grobid_xml":"https://content.openalex.org/works/W7220394361.grobid-xml"},"referenced_works_count":203,"referenced_works":["https://openalex.org/W1486052360","https://openalex.org/W1486444904","https://openalex.org/W1550693054","https://openalex.org/W1594078235","https://openalex.org/W1773066715","https://openalex.org/W1852549140","https://openalex.org/W1857453373","https://openalex.org/W1946944190","https://openalex.org/W1955709303","https://openalex.org/W1961999388","https://openalex.org/W1963967499","https://openalex.org/W1965156920","https://openalex.org/W1967814129","https://openalex.org/W1968517266","https://openalex.org/W1970437313","https://openalex.org/W1971060242","https://openalex.org/W1972623359","https://openalex.org/W1975282084","https://openalex.org/W1976528399","https://openalex.org/W1977898869","https://openalex.org/W1979711577","https://openalex.org/W1980843025","https://openalex.org/W1981431290","https://openalex.org/W1982076909","https://openalex.org/W1982116050","https://openalex.org/W1985118265","https://openalex.org/W1987835269","https://openalex.org/W1990039165","https://openalex.org/W1991635060","https://openalex.org/W1991893658","https://openalex.org/W1993355802","https://openalex.org/W2002516761","https://openalex.org/W2004544233","https://openalex.org/W2004942398","https://openalex.org/W2007322316","https://openalex.org/W2010651460","https://openalex.org/W2011564077","https://openalex.org/W2011625746","https://openalex.org/W2013274873","https://openalex.org/W2013346825","https://openalex.org/W2013595896","https://openalex.org/W2015636028","https://openalex.org/W2016747731","https://openalex.org/W2016967864","https://openalex.org/W2020072455","https://openalex.org/W2023863818","https://openalex.org/W2025022118","https://openalex.org/W2025494340","https://openalex.org/W2026918043","https://openalex.org/W2027292195","https://openalex.org/W2029496354","https://openalex.org/W2029873308","https://openalex.org/W2032444338","https://openalex.org/W2032554631","https://openalex.org/W2035039373","https://openalex.org/W2035655655","https://openalex.org/W2036258571","https://openalex.org/W2039794487","https://openalex.org/W2040010587","https://openalex.org/W2040207361","https://openalex.org/W2041093934","https://openalex.org/W2041780927","https://openalex.org/W2041848251","https://openalex.org/W2043620814","https://openalex.org/W2048195672","https://openalex.org/W2049485366","https://openalex.org/W2051758487","https://openalex.org/W2053616965","https://openalex.org/W2062627843","https://openalex.org/W2062741582","https://openalex.org/W2063414626","https://openalex.org/W2066383202","https://openalex.org/W2067521963","https://openalex.org/W2069813642","https://openalex.org/W2073527665","https://openalex.org/W2079099220","https://openalex.org/W2082426787","https://openalex.org/W2082471681","https://openalex.org/W2084604716","https://openalex.org/W2085852911","https://openalex.org/W2089974427","https://openalex.org/W2093374651","https://openalex.org/W2094562050","https://openalex.org/W2094882170","https://openalex.org/W2096154351","https://openalex.org/W2096630683","https://openalex.org/W2097494814","https://openalex.org/W2097721584","https://openalex.org/W2099051954","https://openalex.org/W2100153882","https://openalex.org/W2101189847","https://openalex.org/W2105671322","https://openalex.org/W2109512206","https://openalex.org/W2109909805","https://openalex.org/W2110951885","https://openalex.org/W2112032807","https://openalex.org/W2113446109","https://openalex.org/W2114628856","https://openalex.org/W2114792084","https://openalex.org/W2115994196","https://openalex.org/W2116071714","https://openalex.org/W2116156311","https://openalex.org/W2116301223","https://openalex.org/W2116885823","https://openalex.org/W2119680107","https://openalex.org/W2124780069","https://openalex.org/W2125545448","https://openalex.org/W2126126419","https://openalex.org/W2128073840","https://openalex.org/W2130921226","https://openalex.org/W2132823166","https://openalex.org/W2139556812","https://openalex.org/W2141808811","https://openalex.org/W2145068137","https://openalex.org/W2150892563","https://openalex.org/W2152238363","https://openalex.org/W2152298725","https://openalex.org/W2152505144","https://openalex.org/W2152562775","https://openalex.org/W2154104502","https://openalex.org/W2154156417","https://openalex.org/W2154904804","https://openalex.org/W2155259994","https://openalex.org/W2156228214","https://openalex.org/W2156312157","https://openalex.org/W2157643349","https://openalex.org/W2162326083","https://openalex.org/W2166730447","https://openalex.org/W2167386045","https://openalex.org/W2167806590","https://openalex.org/W2168301431","https://openalex.org/W2169552340","https://openalex.org/W2252568502","https://openalex.org/W2268121442","https://openalex.org/W2284046515","https://openalex.org/W2296911202","https://openalex.org/W2469988178","https://openalex.org/W2479797542","https://openalex.org/W2525315911","https://openalex.org/W2569913531","https://openalex.org/W2603402600","https://openalex.org/W2604418563","https://openalex.org/W2606181774","https://openalex.org/W2606690329","https://openalex.org/W2614446987","https://openalex.org/W2737714891","https://openalex.org/W2739035379","https://openalex.org/W2775762540","https://openalex.org/W2783694527","https://openalex.org/W2792939613","https://openalex.org/W2793567263","https://openalex.org/W2800413193","https://openalex.org/W2803841447","https://openalex.org/W2809147071","https://openalex.org/W2810037075","https://openalex.org/W2886865129","https://openalex.org/W2904226822","https://openalex.org/W2909924790","https://openalex.org/W2912018574","https://openalex.org/W2946841087","https://openalex.org/W2947175610","https://openalex.org/W2970477119","https://openalex.org/W2998130894","https://openalex.org/W2999351204","https://openalex.org/W3004919484","https://openalex.org/W3008589136","https://openalex.org/W3009912996","https://openalex.org/W3010619947","https://openalex.org/W3021474835","https://openalex.org/W3034046141","https://openalex.org/W3037733345","https://openalex.org/W3044236042","https://openalex.org/W3044927477","https://openalex.org/W3047775844","https://openalex.org/W3088505298","https://openalex.org/W3121790907","https://openalex.org/W3122083218","https://openalex.org/W3134319203","https://openalex.org/W3135875197","https://openalex.org/W3153071425","https://openalex.org/W3173514762","https://openalex.org/W3198561245","https://openalex.org/W4200364487","https://openalex.org/W4200505340","https://openalex.org/W4205646435","https://openalex.org/W4225133075","https://openalex.org/W4320485522","https://openalex.org/W4366824443","https://openalex.org/W4367607500","https://openalex.org/W4383481937","https://openalex.org/W4390615092","https://openalex.org/W4396872319","https://openalex.org/W4399437609","https://openalex.org/W4399532940","https://openalex.org/W4399829910","https://openalex.org/W4401618190","https://openalex.org/W4403010185","https://openalex.org/W4404623096","https://openalex.org/W4405636656","https://openalex.org/W4409817434","https://openalex.org/W4411624823","https://openalex.org/W4415146861","https://openalex.org/W7167636930"],"related_works":["https://openalex.org/W7222856380","https://openalex.org/W3161049983","https://openalex.org/W2030068918","https://openalex.org/W3211193095","https://openalex.org/W1980337527","https://openalex.org/W3000314724","https://openalex.org/W2614446987","https://openalex.org/W2889955198","https://openalex.org/W2012620164","https://openalex.org/W1547192620"],"abstract_inverted_index":{"Viral":[0,78],"entry":[1,102,140],"is":[2,103,162],"the":[3],"first":[4],"obligatory":[5],"step":[6],"of":[7,67,80,109,126,234],"productive":[8,127],"infection":[9],"and":[10,27,43,86,97,136,178,190,210,225],"a":[11,65,74,143,182],"rational":[12],"point":[13],"for":[14],"host-directed":[15,199],"antiviral":[16],"intervention.":[17],"This":[18],"structured":[19],"narrative":[20],"review":[21,165],"synthesizes":[22],"evidence":[23,125,161,184],"from":[24,198],"database":[25],"searches":[26],"citation":[28],"tracking":[29],"performed":[30],"up":[31],"to":[32,46],"18":[33],"June":[34],"2026.":[35],"Clathrin-mediated":[36],"endocytosis":[37],"(CME)":[38],"can":[39],"internalize":[40],"virus-receptor":[41],"complexes":[42],"deliver":[44],"them":[45],"endosomal":[47],"compartments":[48],"that":[49,186],"support":[50],"penetration,":[51],"fusion,":[52],"capsid":[53],"remodeling,":[54],"uncoating":[55],"or":[56,111,118,134],"genome":[57],"release.":[58],"However,":[59],"CME":[60,81,113,236],"should":[61],"be":[62],"interpreted":[63],"as":[64,73,151,217,231],"series":[66],"experimentally":[68],"separable":[69],"checkpoints":[70],"rather":[71,153,229],"than":[72,154,230],"single":[75],"pathway":[76],"label.":[77],"use":[79],"varies":[82],"with":[83,123,181],"strain,":[84],"receptor":[85,167],"cofactor":[87],"availability,":[88],"host-cell":[89],"type,":[90],"membrane":[91,172,202],"composition,":[92],"protease":[93],"environment,":[94],"inoculum":[95],"size":[96],"synchronization":[98],"conditions.":[99],"Strict":[100],"CME-dependent":[101,191],"assigned":[104],"only":[105],"when":[106,157],"direct":[107,159],"perturbation":[108],"core":[110],"proximal":[112],"machinery,":[114],"supported":[115],"by":[116],"rescue":[117],"an":[119,137],"orthogonal":[120],"approach,":[121],"converges":[122],"stage-resolved":[124],"virion":[128],"progression":[129],"through":[130],"clathrin/AP-2-positive":[131],"coated":[132],"pits":[133],"vesicles":[135],"early":[138],"functional":[139],"readout":[141],"in":[142,226],"defined":[144],"virus-receptor-cell":[145],"context.":[146],"Pharmacological":[147],"findings":[148],"are":[149,215],"treated":[150],"supportive":[152],"universally":[155],"mandatory":[156],"stronger":[158],"mechanistic":[160,196],"available.":[163],"The":[164],"integrates":[166],"organization,":[168],"cargo-specific":[169],"adaptor":[170],"recruitment,":[171],"lipids,":[173],"particle":[174],"geometry,":[175],"actin":[176],"dynamics":[177],"virus-induced":[179],"remodeling":[180],"transparent":[183],"framework":[185],"distinguishes":[187],"CME-associated,":[188],"CME-involved":[189],"entry.":[192],"It":[193],"further":[194],"separates":[195],"probes":[197],"strategies":[200],"targeting":[201],"sphingolipids,":[203],"TPC2-dependent":[204],"endolysosomal":[205],"trafficking,":[206],"NPC1/cholesterol":[207],"homeostasis,":[208],"PIKfyve":[209],"kinase-regulated":[211],"trafficking.":[212],"Translational":[213],"priorities":[214],"framed":[216],"context-dependent":[218],"opportunities":[219],"requiring":[220],"target":[221],"engagement,":[222],"disease-relevant":[223],"models":[224],"vivo":[227],"validation":[228],"validated":[232],"consequences":[233],"global":[235],"blockade.":[237]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-06T00:00:00"}