{"id":"https://openalex.org/W7220385998","doi":"https://doi.org/10.64898/2026.09.28.754926","title":"Restoration of (nor)adrenergic-like Ca\u00b2\u207a signalling counteracts age-related motor decline","display_name":"Restoration of (nor)adrenergic-like Ca\u00b2\u207a signalling counteracts age-related motor decline","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220385998","doi":"https://doi.org/10.64898/2026.09.28.754926"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.754926","doi":"https://doi.org/10.64898/2026.09.28.754926","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754926","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.09.28.754926.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.09.28.754926.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047621645","display_name":"Anemari Horvat","orcid":"https://orcid.org/0000-0003-1990-5160","observed_orcids":["https://orcid.org/0000-0003-1990-5160"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]},{"id":"https://openalex.org/I4210147019","display_name":"Celica (Slovenia)","ror":"https://ror.org/047h1e475","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210147019"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Anemari Horvat","raw_affiliation_strings":["Laboratory of Cell Engineering, Celica Biomedical, Slovenia","Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia"],"raw_orcid":"https://orcid.org/0000-0003-1990-5160","affiliations":[{"raw_affiliation_string":"Laboratory of Cell Engineering, Celica Biomedical, Slovenia","institution_ids":["https://openalex.org/I4210147019"]},{"raw_affiliation_string":"Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076930400","display_name":"Ur\u0161ka \u010cerne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Ur\u0161ka \u010cerne","raw_affiliation_strings":["Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059567975","display_name":"Anne-Kristin Dahse","orcid":"https://orcid.org/0000-0003-1487-0296","observed_orcids":["https://orcid.org/0000-0003-1487-0296"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne-Kristin Dahse","raw_affiliation_strings":["Division of General Biochemistry, Rudolf Sch\u00f6nheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Biochemistry, Rudolf Sch\u00f6nheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118752061","display_name":"Lara-Sophie Brodmerkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lara-Sophie Brodmerkel","raw_affiliation_strings":["Division of General Biochemistry, Rudolf Sch\u00f6nheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Biochemistry, Rudolf Sch\u00f6nheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130339923","display_name":"Alja\u017e Bratani\u010d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Alja\u017e Bratani\u010d","raw_affiliation_strings":["Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040093734","display_name":"Madlen Matz\u2010Soja","orcid":"https://orcid.org/0000-0002-5929-3704","observed_orcids":["https://orcid.org/0000-0002-5929-3704"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Madlen Matz-Soja","raw_affiliation_strings":["Research Laboratory for Clinical and Experimental Hepatology, Central Research Building, Leipzig University, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory for Clinical and Experimental Hepatology, Central Research Building, Leipzig University, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015127544","display_name":"Stefanie Schirmeier","orcid":"https://orcid.org/0000-0001-8431-9593","observed_orcids":["https://orcid.org/0000-0001-8431-9593"]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Schirmeier","raw_affiliation_strings":["Faculty of Biology, Technische Universit\u00e4t Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Technische Universit\u00e4t Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025932270","display_name":"Robert Zorec","orcid":"https://orcid.org/0000-0002-7478-3875","observed_orcids":["https://orcid.org/0000-0002-7478-3875"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]},{"id":"https://openalex.org/I4210147019","display_name":"Celica (Slovenia)","ror":"https://ror.org/047h1e475","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210147019"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Robert Zorec","raw_affiliation_strings":["Laboratory of Cell Engineering, Celica Biomedical, Slovenia","Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Engineering, Celica Biomedical, Slovenia","institution_ids":["https://openalex.org/I4210147019"]},{"raw_affiliation_string":"Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025937863","display_name":"Nicole Scholz","orcid":"https://orcid.org/0000-0001-8087-8451","observed_orcids":["https://orcid.org/0000-0001-8087-8451"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Scholz","raw_affiliation_strings":["Division of General Biochemistry, Rudolf Sch\u00f6nheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8087-8451","affiliations":[{"raw_affiliation_string":"Division of General Biochemistry, Rudolf Sch\u00f6nheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055433973","display_name":"Nina Vardjan","orcid":"https://orcid.org/0000-0001-8174-1668","observed_orcids":["https://orcid.org/0000-0001-8174-1668"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]},{"id":"https://openalex.org/I4210147019","display_name":"Celica (Slovenia)","ror":"https://ror.org/047h1e475","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210147019"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Nina Vardjan","raw_affiliation_strings":["Laboratory of Cell Engineering, Celica Biomedical, Slovenia","Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia"],"raw_orcid":"https://orcid.org/0000-0001-8174-1668","affiliations":[{"raw_affiliation_string":"Laboratory of Cell Engineering, Celica Biomedical, Slovenia","institution_ids":["https://openalex.org/I4210147019"]},{"raw_affiliation_string":"Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055433973"],"corresponding_institution_ids":["https://openalex.org/I153976015","https://openalex.org/I4210147019"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.39329999685287476,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8999999761581421},{"id":"https://openalex.org/keywords/age-related-motor-decline","display_name":"age-related motor decline","score":0.8360000252723694},{"id":"https://openalex.org/keywords/noradrenergic-signaling","display_name":"noradrenergic signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/octopamine","display_name":"octopamine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cerebral-metabolism","display_name":"brain metabolism","score":0.753000020980835},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lactate-transport","display_name":"lactate transport","score":0.6629999876022339},{"id":"https://openalex.org/keywords/monocarboxylate-transporters","display_name":"monocarboxylate transporters","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.5059999823570251},{"id":"https://openalex.org/keywords/locomotion","display_name":"locomotion","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-metabolism","display_name":"oxidative metabolism","score":0.6790000200271606},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5770000219345093},{"id":"https://openalex.org/C2780696224","wikidata":"https://www.wikidata.org/wiki/Q424979","display_name":"Octopamine (neurotransmitter)","level":4,"score":0.5475000143051147},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49470001459121704},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4941999912261963},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.47530001401901245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45570001006126404},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.45089998841285706},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42649999260902405},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.4131999909877777},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.40779998898506165},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.39590001106262207},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39160001277923584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37700000405311584},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3711000084877014},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3652999997138977},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.36239999532699585},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.33309999108314514},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30809998512268066},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.2802000045776367},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.25859999656677246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.28.754926","doi":"https://doi.org/10.64898/2026.09.28.754926","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754926","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.09.28.754926.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.754926","doi":"https://doi.org/10.64898/2026.09.28.754926","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754926","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.09.28.754926.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2312702310","display_name":null,"funder_award_id":"FOR 2149","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4994359279","display_name":"SFB 1423: Strukturelle Dynamik der GPCRAktivierung und Signaltransduktion","funder_award_id":"421152132","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5164672607","display_name":null,"funder_award_id":"SCHO1791/1-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7235324716","display_name":"Funktionelle Analyse der Adh\u00e4sionsGPCRKlasse in Drosophila","funder_award_id":"265903901","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G800619057","display_name":null,"funder_award_id":"FOR2149/P01","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220385998.pdf","grobid_xml":"https://content.openalex.org/works/W7220385998.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W593333272","https://openalex.org/W1921252690","https://openalex.org/W1966496672","https://openalex.org/W1967441301","https://openalex.org/W1971748110","https://openalex.org/W2001725826","https://openalex.org/W2009185900","https://openalex.org/W2012592260","https://openalex.org/W2031155126","https://openalex.org/W2032860166","https://openalex.org/W2039528431","https://openalex.org/W2040002798","https://openalex.org/W2042535445","https://openalex.org/W2055755990","https://openalex.org/W2062298528","https://openalex.org/W2064235709","https://openalex.org/W2064759622","https://openalex.org/W2067871811","https://openalex.org/W2071719711","https://openalex.org/W2072773125","https://openalex.org/W2079574859","https://openalex.org/W2082815622","https://openalex.org/W2089689599","https://openalex.org/W2091491744","https://openalex.org/W2092098765","https://openalex.org/W2092635505","https://openalex.org/W2096064113","https://openalex.org/W2102548112","https://openalex.org/W2112994046","https://openalex.org/W2137249515","https://openalex.org/W2151326362","https://openalex.org/W2161999580","https://openalex.org/W2169067272","https://openalex.org/W2202641067","https://openalex.org/W2224116510","https://openalex.org/W2348381464","https://openalex.org/W2536080392","https://openalex.org/W2609511098","https://openalex.org/W2610960352","https://openalex.org/W2736580434","https://openalex.org/W2739598026","https://openalex.org/W2739924689","https://openalex.org/W2740236599","https://openalex.org/W2749644761","https://openalex.org/W2760001608","https://openalex.org/W2778312964","https://openalex.org/W2806146174","https://openalex.org/W2885430510","https://openalex.org/W2906611257","https://openalex.org/W2914883871","https://openalex.org/W2917226079","https://openalex.org/W2950849463","https://openalex.org/W2997978325","https://openalex.org/W3014634065","https://openalex.org/W3014747171","https://openalex.org/W3020660075","https://openalex.org/W3087822810","https://openalex.org/W3094518567","https://openalex.org/W3116541429","https://openalex.org/W3118601380","https://openalex.org/W3131288202","https://openalex.org/W3171367875","https://openalex.org/W3190684006","https://openalex.org/W3201680702","https://openalex.org/W3210471463","https://openalex.org/W4200336781","https://openalex.org/W4214861448","https://openalex.org/W4221075913","https://openalex.org/W4292487796","https://openalex.org/W4304692485","https://openalex.org/W4318915363","https://openalex.org/W4322489173","https://openalex.org/W4366747949","https://openalex.org/W4367557440","https://openalex.org/W4381855986","https://openalex.org/W4393858355","https://openalex.org/W4402816236","https://openalex.org/W4403110514","https://openalex.org/W4406334848","https://openalex.org/W4415692901","https://openalex.org/W7148308506"],"related_works":["https://openalex.org/W7007847107","https://openalex.org/W3127764966","https://openalex.org/W2054760839","https://openalex.org/W13965795","https://openalex.org/W2016260603","https://openalex.org/W609346837","https://openalex.org/W170266416","https://openalex.org/W2008913285","https://openalex.org/W2507896428","https://openalex.org/W4387576208"],"abstract_inverted_index":{"Abstract":[0],"Aging":[1,47],"disrupts":[2],"neural":[3,100],"function,":[4],"but":[5],"whether":[6],"impaired":[7],"noradrenergic":[8],"control":[9],"of":[10,34,45,113,151],"brain":[11,152],"metabolism":[12,153],"contributes":[13],"to":[14,79],"functional":[15],"decline":[16],"remains":[17],"unclear.":[18],"Using":[19],"genetically":[20],"encoded":[21],"fluorescent":[22],"sensors":[23],"we":[24],"measured":[25],"metabolic":[26,95],"and":[27,32,54,66,72,99,135,154],"signaling":[28],"responses":[29,96],"in":[30,64,69,97,126],"neurons":[31,129],"glia":[33],"living":[35],"Drosophila":[36],"brains":[37],"following":[38],"stimulation":[39],"with":[40,75,110],"octopamine,":[41],"the":[42],"invertebrate":[43],"analogue":[44],"noradrenaline.":[46],"was":[48,108],"accompanied":[49],"by":[50],"neurodegeneration,":[51],"reduced":[52],"locomotion":[53],"enhanced":[55],"oxidative":[56],"whole-brain":[57],"metabolism.":[58],"Octopamine":[59],"increased":[60],"D-glucose":[61],"uptake":[62],"selectively":[63],"astrocytes":[65,71,98],"elevated":[67],"L-lactate":[68,81,89],"both":[70],"neurons,":[73],"consistent":[74],"astrocytic":[76,88],"glycolysis":[77],"coupled":[78],"neuronal":[80],"uptake;":[82],"monocarboxylate":[83],"transporter":[84],"inhibition":[85],"caused":[86],"selective":[87],"accumulation.":[90],"In":[91],"aged":[92],"animals":[93],"octopamine-evoked":[94],"Ca\u00b2\u207a":[101,133,145],"transients":[102],"were":[103],"markedly":[104],"reduced.":[105],"This":[106],"impairment":[107],"associated":[109],"lower":[111],"expression":[112],"adrenoceptor-like":[114],"tyramine":[115],"1":[116,119,123,143],"receptor":[117],"(Tyr":[118],"R).":[120],"Selective":[121],"Tyr":[122,142],"R":[124],"overexpression":[125],"(nor)adrenergic-like":[127],"Tdc2":[128],"prolonged":[130],"lifespan,":[131],"restored":[132],"signalling":[134,146],"improved":[136],"locomotor":[137],"performance.":[138],"These":[139],"findings":[140],"identify":[141],"R-dependent":[144],"as":[147],"an":[148],"age-sensitive":[149],"regulator":[150],"motor":[155],"function.":[156]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-06T00:00:00"}
