{"id":"https://openalex.org/W7220378283","doi":"https://doi.org/10.1016/j.rpth.2026.106330","title":"PB3711 Rheopheresis increases thrombolytic potential through the generation of fibrinolytic neutrophil-derived extracellular vesicles","display_name":"PB3711 Rheopheresis increases thrombolytic potential through the generation of fibrinolytic neutrophil-derived extracellular vesicles","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7220378283","doi":"https://doi.org/10.1016/j.rpth.2026.106330"},"language":"en","primary_location":{"id":"doi:10.1016/j.rpth.2026.106330","doi":"https://doi.org/10.1016/j.rpth.2026.106330","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.106330","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.rpth.2026.106330","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5157365463","display_name":"Analucia Conca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Analucia Conca","raw_affiliation_strings":["C2vn, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019968265","display_name":"Akhil Antony Konkoth","orcid":"https://orcid.org/0000-0002-3692-6556","observed_orcids":["https://orcid.org/0000-0002-3692-6556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akhil Konkoth","raw_affiliation_strings":["C2vn, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038638853","display_name":"Evelyne Abdili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Evelyne Abdili","raw_affiliation_strings":["H\u00f4pital de la Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058429227","display_name":"Justine Solignac","orcid":"https://orcid.org/0000-0002-3621-3329","observed_orcids":["https://orcid.org/0000-0002-3621-3329"]},"institutions":[{"id":"https://openalex.org/I4210095915","display_name":"H\u00f4pital de la Conception","ror":"https://ror.org/00s7v8q53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210095915"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Justine Solignac","raw_affiliation_strings":["H\u00f4pital de La Conception, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital de La Conception, Marseille, France","institution_ids":["https://openalex.org/I4210095915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157483815","display_name":"Arnaud Laurent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Laurent","raw_affiliation_strings":["H\u00f4pital de la Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006955960","display_name":"Sylvie Cointe","orcid":"https://orcid.org/0000-0001-6539-7879","observed_orcids":["https://orcid.org/0000-0001-6539-7879"]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie COINTE","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital de la Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital de la Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066431987","display_name":"Sandra E. Ghayad","orcid":"https://orcid.org/0000-0001-5009-1594","observed_orcids":["https://orcid.org/0000-0001-5009-1594"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Ghayad","raw_affiliation_strings":["C2vn, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108877515","display_name":"Corinne Chareyre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corinne Chareyre","raw_affiliation_strings":["C2vn, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108313758","display_name":"Amandine Bonifay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amandine Bonifay","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital de la Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital de la Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046524333","display_name":"Stephane Burtey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095915","display_name":"H\u00f4pital de la Conception","ror":"https://ror.org/00s7v8q53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210095915"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Burtey Stephane","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital de La Conception, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital de La Conception, Marseille, France","institution_ids":["https://openalex.org/I4210095915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074375778","display_name":"Philippe Brunet","orcid":"https://orcid.org/0000-0002-1396-5296","observed_orcids":["https://orcid.org/0000-0002-1396-5296"]},"institutions":[{"id":"https://openalex.org/I4210095915","display_name":"H\u00f4pital de la Conception","ror":"https://ror.org/00s7v8q53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210095915"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Brunet","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital de La Conception, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital de La Conception, Marseille, France","institution_ids":["https://openalex.org/I4210095915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018259733","display_name":"Fran\u00e7oise Dignat\u2010George","orcid":"https://orcid.org/0000-0001-7006-4462","observed_orcids":["https://orcid.org/0000-0001-7006-4462"]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Dignat-George","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital de la Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital de la Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018471206","display_name":"Thomas Robert","orcid":"https://orcid.org/0000-0002-7580-0913","observed_orcids":["https://orcid.org/0000-0002-7580-0913"]},"institutions":[{"id":"https://openalex.org/I4210116727","display_name":"H\u00f4pital Saint Joseph","ror":"https://ror.org/0219xsk19","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Robert","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital Saint-Joseph, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital Saint-Joseph, Marseille, France","institution_ids":["https://openalex.org/I4210116727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046792925","display_name":"Romaric Lacroix","orcid":"https://orcid.org/0000-0002-5756-470X","observed_orcids":["https://orcid.org/0000-0002-5756-470X"]},"institutions":[{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romaric Lacroix","raw_affiliation_strings":["C2vn, Marseille, France","H\u00f4pital de la Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C2vn, Marseille, France","institution_ids":[]},{"raw_affiliation_string":"H\u00f4pital de la Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"106330","last_page":"106330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheopheresis","display_name":"rheopheresis","score":1.0},{"id":"https://openalex.org/keywords/extracorporeal-apheresis","display_name":"extracorporeal apheresis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/critical-limb-ischemia","display_name":"critical limb ischemia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.9110000133514404},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6349999904632568},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.4526999890804291},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43939998745918274},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3458000123500824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33889999985694885},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26649999618530273},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.25769999623298645},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.24009999632835388}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.rpth.2026.106330","doi":"https://doi.org/10.1016/j.rpth.2026.106330","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.106330","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.rpth.2026.106330","doi":"https://doi.org/10.1016/j.rpth.2026.106330","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.106330","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220455951","https://openalex.org/W7220385046","https://openalex.org/W7220363505","https://openalex.org/W7220456629","https://openalex.org/W7220458007","https://openalex.org/W7220450709","https://openalex.org/W7220401646","https://openalex.org/W4388597279","https://openalex.org/W7220383730","https://openalex.org/W2321179029"],"abstract_inverted_index":{"Critical":[0],"limb":[1],"ischemia":[2],"in":[3],"hemodialysis":[4],"patients":[5],"is":[6],"characterized":[7],"by":[8,15],"microvascular":[9],"dysfunction":[10],"that":[11,68,73],"can":[12],"be":[13],"improved":[14],"rheopheresis,":[16],"an":[17],"extracorporeal":[18],"apheresis":[19,55],"technique":[20],"based":[21],"on":[22],"double":[23],"blood":[24],"filtration.":[25],"Although":[26],"rheopheresis":[27,74],"has":[28],"been":[29],"shown":[30],"to":[31],"enhance":[32],"tissue":[33],"perfusion,":[34],"partly":[35],"through":[36],"the":[37,45,62],"removal":[38],"of":[39,64],"high\u2013molecular-weight":[40],"proteins":[41],"and":[42,61,78,82],"anti-inflammatory":[43],"effects,":[44],"mechanisms":[46],"underpinning":[47],"its":[48],"therapeutic":[49],"benefit":[50],"remain":[51],"poorly":[52],"understood.":[53],"Because":[54],"membranes":[56],"may":[57],"trigger":[58],"cellular":[59],"activation":[60],"release":[63],"extracellular":[65],"vesicles":[66],"(EVs)":[67],"modulate":[69],"hemostasis,":[70],"we":[71],"hypothesized":[72],"promotes":[75],"EV":[76],"generation":[77],"alters":[79],"their":[80],"procoagulant":[81],"fibrinolytic":[83],"activities.":[84]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}