{"id":"https://openalex.org/W7220375254","doi":"https://doi.org/10.3390/cimb48101027","title":"Dynamics of Endoplasmic Reticulum Stress Responses in Cells with Different Endoplasmic Reticulum Volumes and Senescence States","display_name":"Dynamics of Endoplasmic Reticulum Stress Responses in Cells with Different Endoplasmic Reticulum Volumes and Senescence States","publication_year":2026,"publication_date":"2026-10-04","ids":{"openalex":"https://openalex.org/W7220375254","doi":"https://doi.org/10.3390/cimb48101027","pmid":"https://pubmed.ncbi.nlm.nih.gov/42939565","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13703400"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48101027","doi":"https://doi.org/10.3390/cimb48101027","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48101027","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb48101027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121624101","display_name":"\u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430 \u041c\u0438\u0448\u0438\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksandra V. Mishina","raw_affiliation_strings":["Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018652464","display_name":"\u0410.\u042e. \u041f\u0430\u0441\u044c\u043a\u043e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey. Yu. Pas\u2019ko","raw_affiliation_strings":["Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032098925","display_name":"D V Kolesov","orcid":"https://orcid.org/0000-0003-0270-2893","observed_orcids":["https://orcid.org/0000-0003-0270-2893"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry V. Kolesov","raw_affiliation_strings":["Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026099053","display_name":"\u041b. \u0412. \u041a\u043e\u0432\u0430\u043b\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-0918-7129","observed_orcids":["https://orcid.org/0000-0002-0918-7129"]},"institutions":[{"id":"https://openalex.org/I4210094909","display_name":"Surgut State University","ror":"https://ror.org/01gsr9f55","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210094909"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Lyudmila V. Kovalenko","raw_affiliation_strings":["Medical Institute, Surgut State University, Yugra, 628408 Surgut, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Institute, Surgut State University, Yugra, 628408 Surgut, Russia","institution_ids":["https://openalex.org/I4210094909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048997017","display_name":"Danila M. Zaichenko","orcid":"https://orcid.org/0000-0003-0241-0065","observed_orcids":["https://orcid.org/0000-0003-0241-0065"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Danila M. Zaychenko","raw_affiliation_strings":["Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0241-0065","affiliations":[{"raw_affiliation_string":"Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103074901","display_name":"S. Morozov","orcid":"https://orcid.org/0000-0001-5822-5729","observed_orcids":["https://orcid.org/0000-0001-5822-5729"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey G. Morozov","raw_affiliation_strings":["Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108312614","display_name":"\u0410\u043b\u0435\u043a\u0441\u0435\u0439 \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u0438\u0447 \u041c\u043e\u0441\u043a\u043e\u0432\u0446\u0435\u0432","orcid":"https://orcid.org/0000-0002-5648-824X","observed_orcids":["https://orcid.org/0000-0002-5648-824X"]},"institutions":[{"id":"https://openalex.org/I4210131054","display_name":"Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences","ror":"https://ror.org/03jmc9t23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210131054"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexey A. Moskovtsev","raw_affiliation_strings":["Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","Russian Medical Academy of Postdegree Education, 125993 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Stress Laboratory, FSBI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia","institution_ids":["https://openalex.org/I4210131054"]},{"raw_affiliation_string":"Russian Medical Academy of Postdegree Education, 125993 Moscow, Russia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108312614"],"corresponding_institution_ids":["https://openalex.org/I4210131054"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"10","first_page":"1027","last_page":"1027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9549999833106995},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/xbp1-splicing","display_name":"XBP1 splicing","score":0.921999990940094},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6990000009536743},{"id":"https://openalex.org/keywords/t-lymphoblastoid-cells","display_name":"T-lymphoblastoid cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/actin-cortex","display_name":"actin cortex","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cell-stiffness","display_name":"cell stiffness","score":0.6930000185966492},{"id":"https://openalex.org/keywords/proteotoxic-stress","display_name":"proteotoxic stress","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8966000080108643},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7961999773979187},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.767300009727478},{"id":"https://openalex.org/C2778997996","wikidata":"https://www.wikidata.org/wiki/Q18036598","display_name":"ATF6","level":4,"score":0.4738999903202057},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4713999927043915},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44519999623298645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42410001158714294},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41659998893737793},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37709999084472656},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.3691999912261963},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.26739999651908875},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.2540000081062317}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cimb48101027","doi":"https://doi.org/10.3390/cimb48101027","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48101027","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13703400","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13703400/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13703400/pdf/cimb-48-01027.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Issues Mol Biol","raw_type":"Text"},{"id":"pmid:42939565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42939565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8271b45e3fce4102861aaffae93a1581","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8271b45e3fce4102861aaffae93a1581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 48, Iss 10, p 1027 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cimb48101027","doi":"https://doi.org/10.3390/cimb48101027","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48101027","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220375254.pdf","grobid_xml":"https://content.openalex.org/works/W7220375254.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1530972565","https://openalex.org/W1546139069","https://openalex.org/W1697178647","https://openalex.org/W1970090817","https://openalex.org/W1979164049","https://openalex.org/W1980438612","https://openalex.org/W1986290768","https://openalex.org/W1988251214","https://openalex.org/W1990815825","https://openalex.org/W1993697882","https://openalex.org/W2004314923","https://openalex.org/W2013966205","https://openalex.org/W2018850937","https://openalex.org/W2019312328","https://openalex.org/W2020437934","https://openalex.org/W2027143635","https://openalex.org/W2032410204","https://openalex.org/W2032584297","https://openalex.org/W2035091349","https://openalex.org/W2036355941","https://openalex.org/W2036677133","https://openalex.org/W2047330128","https://openalex.org/W2050994990","https://openalex.org/W2052034388","https://openalex.org/W2069217785","https://openalex.org/W2071767667","https://openalex.org/W2085966620","https://openalex.org/W2087618734","https://openalex.org/W2089198803","https://openalex.org/W2093440304","https://openalex.org/W2103334789","https://openalex.org/W2106305244","https://openalex.org/W2106314483","https://openalex.org/W2112286580","https://openalex.org/W2120736516","https://openalex.org/W2123106337","https://openalex.org/W2127639686","https://openalex.org/W2127906377","https://openalex.org/W2129722310","https://openalex.org/W2130410032","https://openalex.org/W2132056336","https://openalex.org/W2137755719","https://openalex.org/W2139568257","https://openalex.org/W2144065739","https://openalex.org/W2147268730","https://openalex.org/W2147646344","https://openalex.org/W2153074213","https://openalex.org/W2155945227","https://openalex.org/W2159466552","https://openalex.org/W2162695817","https://openalex.org/W2164390141","https://openalex.org/W2164783065","https://openalex.org/W2165362327","https://openalex.org/W2168406910","https://openalex.org/W2171419763","https://openalex.org/W2402997692","https://openalex.org/W2411294323","https://openalex.org/W2416491816","https://openalex.org/W2529411682","https://openalex.org/W2608251316","https://openalex.org/W2911928150","https://openalex.org/W2944727022","https://openalex.org/W2952594353","https://openalex.org/W2979300669","https://openalex.org/W3081483159","https://openalex.org/W3208698634","https://openalex.org/W4232250061","https://openalex.org/W4241385219","https://openalex.org/W4292379725","https://openalex.org/W4299627282","https://openalex.org/W4308329541","https://openalex.org/W4313816775","https://openalex.org/W4385655225","https://openalex.org/W4388500963"],"related_works":["https://openalex.org/W2093398011","https://openalex.org/W2367121235","https://openalex.org/W1967992419","https://openalex.org/W2565502011","https://openalex.org/W2261372947","https://openalex.org/W2132628525","https://openalex.org/W2148632242","https://openalex.org/W2593325467","https://openalex.org/W7170094039","https://openalex.org/W2553091493"],"abstract_inverted_index":{"The":[0],"Unfolded":[1],"Protein":[2],"Response":[3],"(UPR)":[4],"determines":[5],"cell":[6,19,38,213],"fate":[7],"under":[8],"endoplasmic":[9],"reticulum":[10],"(ER)":[11],"stress,":[12],"yet":[13],"its":[14],"temporal":[15,192],"dynamics":[16],"across":[17],"different":[18],"types":[20],"and":[21,36,63,75,128,171,238],"senescence":[22],"states":[23],"re-main":[24],"poorly":[25],"understood.":[26],"In":[27],"this":[28,92,178],"study,":[29],"we":[30,72,103],"investigated":[31],"UPR":[32],"kinetics":[33,83],"in":[34,47,55,88,154,234],"endothelial":[35],"T-lymphoblastoid":[37],"lines":[39],"with":[40,86,98,184,212],"distinct":[41],"ER":[42,52,56,89,107,136],"volumes,":[43],"as":[44,46,140],"well":[45],"senescent":[48,226],"FRSN":[49,96,121],"cells":[50,97,227],"undergoing":[51],"expansion.":[53],"Variations":[54],"volume":[57],"were":[58],"confirmed":[59],"via":[60],"confocal":[61],"microscopy":[62,148],"flow":[64],"cytometry.":[65],"Using":[66],"the":[67,80,155,158,168,191,195,198,204],"'gene":[68],"response":[69,82,109,113,206],"time'":[70],"metric,":[71],"demonstrated":[73],"experimentally":[74],"through":[76],"mathematical":[77],"modeling":[78],"that":[79,105,117,177,189],"BiP":[81],"closely":[84],"correlate":[85],"variations":[87],"volume.":[90],"Applying":[91],"metric":[93],"to":[94,116,134,197,209,241],"presenescent":[95,162],"a":[99,112,125,129,141,151,165,218,230],"significantly":[100],"expanded":[101],"ER,":[102],"found":[104],"their":[106],"stress":[108,137,205,236],"machinery":[110,207],"maintained":[111],"time":[114],"similar":[115],"of":[118,157,161,167,194,220],"exponentially":[119],"growing":[120],"cells,":[122,163],"but":[123],"exhibited":[124],"lower":[126],"amplitude":[127],"prolonged":[130,235],"lag":[131],"phase,":[132],"leading":[133],"chronic":[135],"signaling":[138,237],"such":[139],"protracted":[142],"XBP1(S)":[143],"expression":[144],"profile.":[145],"Scanning":[146],"ion-conductance":[147],"(SICM)":[149],"revealed":[150],"significant":[152],"decrease":[153],"stiffness":[156],"near-surface":[159],"layer":[160],"reflecting":[164],"rarefaction":[166],"actin":[169],"cortex":[170],"possibly":[172],"cytoplasmic":[173],"dilution.":[174],"We":[175],"propose":[176],"structural":[179],"remodeling":[180],"could":[181],"be":[182],"associated":[183],"active":[185],"intracellular":[186],"transport":[187],"impairment":[188],"weakens":[190],"'tethering'":[193],"proteome":[196],"genome":[199],"upon":[200],"cellular":[201],"senescence.":[202],"Consequently,":[203],"fails":[208],"scale":[210],"proportionally":[211],"enlargement":[214],"during":[215],"senescence,":[216],"creating":[217],"state":[219],"'functional":[221],"dilution'.":[222],"This":[223],"prevents":[224],"enlarged":[225],"from":[228],"mounting":[229],"scaled":[231],"response,":[232],"resulting":[233],"increased":[239],"vulnerability":[240],"proteotoxic":[242],"stress.":[243]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-06T00:00:00"}
