{"id":"https://openalex.org/W7220368954","doi":"https://doi.org/10.3389/fimmu.2026.1905624","title":"AKNA serves as a prognostic biomarker and restrains endometrial cancer progression via STING activation and macrophage reprogramming","display_name":"AKNA serves as a prognostic biomarker and restrains endometrial cancer progression via STING activation and macrophage reprogramming","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7220368954","doi":"https://doi.org/10.3389/fimmu.2026.1905624","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677899"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1905624","doi":"https://doi.org/10.3389/fimmu.2026.1905624","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1905624","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1905624/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1905624/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055348444","display_name":"Yuan Tu","orcid":"https://orcid.org/0000-0002-9800-4637","observed_orcids":["https://orcid.org/0000-0002-9800-4637"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Tu","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013753729","display_name":"Lingya Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210112295","display_name":"Qianjiang Central Hospital","ror":"https://ror.org/0238gcb09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112295"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingya Xu","raw_affiliation_strings":["Department of Gynecology, Chongqing University Qianjiang Hospital (Qianjiang Central Hospital of Chongqing)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Chongqing University Qianjiang Hospital (Qianjiang Central Hospital of Chongqing)","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210112295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157546457","display_name":"Chengfan Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengfan Tian","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133120955","display_name":"\u6c85\u7075 \u77f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanling Shi","raw_affiliation_strings":["International Medical College, Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Medical College, Chongqing Medical University","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157564230","display_name":"Jiaxin Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxin Yu","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050619283","display_name":"Chunxia Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159428","display_name":"Children's Hospital of Chongqing Medical University","ror":"https://ror.org/05pz4ws32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunxia Gong","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Women and Children\u2019s Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Women and Children\u2019s Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210159428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157554322","display_name":"Tianyu Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Peng","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150610785","display_name":"Hangkun Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HangKun Yu","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030956269","display_name":"Rui Yuan","orcid":"https://orcid.org/0000-0003-1203-1958","observed_orcids":["https://orcid.org/0000-0003-1203-1958"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui Yuan","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157405305","display_name":"Peng Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Jiang","raw_affiliation_strings":["Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University","institution_ids":["https://openalex.org/I4210129459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030956269","https://openalex.org/A5157405305"],"corresponding_institution_ids":["https://openalex.org/I4210129459"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76951517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1905624","last_page":"1905624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.7139999866485596},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.8510000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9520000219345093},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cancer-recurrence-prediction","display_name":"tumor recurrence prediction","score":0.5690000057220459},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5040000081062317},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/prognostic-nomogram","display_name":"prognostic nomogram","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.7261999845504761},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6773999929428101},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6717000007629395},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.5422999858856201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49070000648498535},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.48019999265670776},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4122999906539917},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37070000171661377},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3659999966621399},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.3474000096321106},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.3357999920845032},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.31619998812675476},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.3041999936103821},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.29409998655319214},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.27390000224113464},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.262800008058548},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2506999969482422}],"mesh":[{"descriptor_ui":"D000099196","descriptor_name":"cGAS-STING Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1905624","doi":"https://doi.org/10.3389/fimmu.2026.1905624","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1905624","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1905624/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:42898530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677899","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677899/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:060f7307002949a8822584dace14aed7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/060f7307002949a8822584dace14aed7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1905624","doi":"https://doi.org/10.3389/fimmu.2026.1905624","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1905624","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1905624/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3431869594","display_name":null,"funder_award_id":"2024M753872","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G504305494","display_name":null,"funder_award_id":"CSTB2024NSCQ","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"},{"id":"https://openalex.org/G7759569173","display_name":null,"funder_award_id":"CSTB2024NSCQ-MSX1240","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220368954.pdf","grobid_xml":"https://content.openalex.org/works/W7220368954.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1624592617","https://openalex.org/W1990000646","https://openalex.org/W2078247731","https://openalex.org/W2108068107","https://openalex.org/W2130430382","https://openalex.org/W2135660738","https://openalex.org/W2154171253","https://openalex.org/W2736730167","https://openalex.org/W2783667606","https://openalex.org/W2809000676","https://openalex.org/W2904601225","https://openalex.org/W2916431834","https://openalex.org/W2937441321","https://openalex.org/W2965100833","https://openalex.org/W3024191006","https://openalex.org/W3025315697","https://openalex.org/W3042355687","https://openalex.org/W3151167688","https://openalex.org/W3205986048","https://openalex.org/W3213298674","https://openalex.org/W4205929518","https://openalex.org/W4221042330","https://openalex.org/W4223523934","https://openalex.org/W4226396199","https://openalex.org/W4297464616","https://openalex.org/W4303045074","https://openalex.org/W4308834893","https://openalex.org/W4310117115","https://openalex.org/W4313455187","https://openalex.org/W4321373309","https://openalex.org/W4321790613","https://openalex.org/W4386438154","https://openalex.org/W4393935425","https://openalex.org/W4394617791","https://openalex.org/W4394961120","https://openalex.org/W4396577885","https://openalex.org/W4399913467","https://openalex.org/W4400358660","https://openalex.org/W4406629014","https://openalex.org/W4406906143","https://openalex.org/W4408182419","https://openalex.org/W4408245877","https://openalex.org/W4409185733","https://openalex.org/W4409573822","https://openalex.org/W4409818259","https://openalex.org/W4411254832","https://openalex.org/W4412140299","https://openalex.org/W4412174549","https://openalex.org/W4413682483","https://openalex.org/W4414120775","https://openalex.org/W4416043446","https://openalex.org/W4417017326","https://openalex.org/W4417327144","https://openalex.org/W7126025590","https://openalex.org/W7136406980"],"related_works":["https://openalex.org/W1541609617","https://openalex.org/W1978071683","https://openalex.org/W3213298674","https://openalex.org/W4406906143","https://openalex.org/W4390639811","https://openalex.org/W2078247731","https://openalex.org/W2949669071","https://openalex.org/W2987257951","https://openalex.org/W4412015993","https://openalex.org/W3209732115"],"abstract_inverted_index":{"Background:":[0],"AKNA,":[1],"an":[2],"AT-hook":[3],"transcription":[4],"factor,":[5],"plays":[6],"a":[7,251,265],"critical":[8],"role":[9],"in":[10,20,113,121,219,227],"cancer":[11,22],"development.":[12],"However,":[13],"its":[14],"prognostic":[15,100,253],"value":[16],"and":[17,31,50,70,80,110,137,143,154,162,167,194,203,223,230,243,255,260],"biological":[18],"function":[19],"endometrial":[21],"(EC)":[23],"remain":[24],"unclear.":[25],"Methods:":[26],"experimental":[27],"models.":[28],"Immunohistochemistry,":[29],"RT-qPCR":[30],"Western":[32],"blotting":[33],"were":[34,54,84],"used":[35],"for":[36,258,269],"expression":[37,104],"validation.":[38],"Functional":[39],"assays,":[40],"including":[41],"lentiviral-mediated":[42],"AKNA":[43,61,103,117,146,174,187,212,234,248],"knockdown/overexpression,":[44],"CCK-8,":[45],"scratch-wound,":[46],"Transwell,":[47],"flow":[48],"cytometry,":[49],"colony":[51],"formation":[52],"assays":[53,83],"conducted":[55],"to":[56,86,165,190],"assess":[57],"the":[58,88,191],"effects":[59],"of":[60,91,93,135,272],"modulation":[62],"on":[63],"proliferation,":[64,151],"migration,":[65,152],"invasion,":[66,153],"epithelial-mesenchymal":[67,155],"transition,":[68,156],"chemosensitivity":[69],"macrophage":[71,160,246],"polarization.":[72,247],"Mechanistically,":[73,186],"chromatin":[74],"immunoprecipitation":[75],"(ChIP)":[76],"sequencing":[77],"(ChIP-seq),":[78],"ChIP-qPCR,":[79],"dual-luciferase":[81],"reporter":[82],"employed":[85],"define":[87],"transcriptional":[89],"regulation":[90],"stimulator":[92],"interferon":[94,204],"genes":[95],"(STING)":[96],"by":[97,179,239],"AKNA.":[98],"A":[99],"nomogram":[101,210],"integrating":[102],"with":[105,125,131,213],"clinicopathological":[106,214],"features":[107,215],"was":[108,118,129],"developed":[109],"externally":[111],"validated":[112],"independent":[114],"cohorts.":[115,232],"Results:":[116],"significantly":[119],"downregulated":[120],"EC":[122,149,221,237],"tissues":[123],"compared":[124],"normal":[126],"endometrium,":[127],"which":[128],"associated":[130],"advanced":[132],"International":[133],"Federation":[134],"Gynecology":[136],"Obstetrics":[138],"stage,":[139],"aggressive":[140],"histological":[141],"subtypes,":[142],"poor":[144],"prognosis.":[145],"knockdown":[147],"promoted":[148],"cell":[150],"while":[157],"enhancing":[158],"M2":[159,245],"polarization":[161],"reducing":[163],"sensitivity":[164],"paclitaxel":[166],"potentially":[168],"compromising":[169],"anti-tumor":[170],"innate":[171,261],"immunity.":[172],"Conversely,":[173],"overexpression":[175],"or":[176],"STING":[177,192,242],"activation":[178],"cyclic":[180],"GMP-AMP":[181],"reversed":[182],"these":[183],"malignant":[184],"phenotypes.":[185],"directly":[188],"bound":[189],"promoter":[193],"transcriptionally":[195,240],"activated":[196],"STING,":[197],"thereby":[198],"inducing":[199],"TANK-binding":[200],"kinase":[201],"1":[202],"regulatory":[205],"factor":[206],"3":[207],"phosphorylation.":[208],"The":[209],"combining":[211],"demonstrated":[216],"high":[217],"accuracy":[218],"predicting":[220],"recurrence":[222],"outperformed":[224],"single-variable":[225],"models":[226],"both":[228],"training":[229],"validation":[231],"Conclusions:":[233],"deficiency":[235],"promotes":[236],"progression":[238],"suppressing":[241],"driving":[244],"serves":[249],"as":[250],"robust":[252],"biomarker":[254],"predictive":[256],"indicator":[257],"chemotherapy":[259],"immune":[262],"modulation,":[263],"offering":[264],"promising":[266],"therapeutic":[267],"target":[268],"precision":[270],"treatment":[271],"EC.":[273]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-06T00:00:00"}