{"id":"https://openalex.org/W72200925","doi":null,"title":"Quantitation of gold labelling and antigens in immunolabelled ultrathin sections.","display_name":"Quantitation of gold labelling and antigens in immunolabelled ultrathin sections.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W72200925","mag":"72200925","pmid":"https://pubmed.ncbi.nlm.nih.gov/8157482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1259922"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:340287","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1166832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1166832","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087192429","display_name":"John Milton Lucocq","orcid":"https://orcid.org/0000-0002-5191-0093","observed_orcids":["https://orcid.org/0000-0002-5191-0093"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"J Lucocq","raw_affiliation_strings":["Institute of Anatomy, University of Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087192429"],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":null,"apc_paid":null,"fwci":0.6005,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.60710259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"184 ( Pt 1)","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11830","display_name":"Point processes and geometric inequalities","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoelectron-microscopy","display_name":"immunoelectron microscopy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/colloidal-gold-labeling","display_name":"colloidal gold labeling","score":0.9169999957084656},{"id":"https://openalex.org/keywords/antigen-quantitation","display_name":"antigen quantitation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ultrathin-sections","display_name":"ultrathin sections","score":0.8679999709129333},{"id":"https://openalex.org/keywords/stereology","display_name":"stereology","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2780523633","wikidata":"https://www.wikidata.org/wiki/Q380709","display_name":"Labelling","level":2,"score":0.9022715091705322},{"id":"https://openalex.org/C2993140218","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Immunoelectron microscopy","level":3,"score":0.8630697727203369},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.7353140115737915},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6868278980255127},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.6388865113258362},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.5114532709121704},{"id":"https://openalex.org/C30030713","wikidata":"https://www.wikidata.org/wiki/Q17029513","display_name":"Immunogold labelling","level":3,"score":0.5111244320869446},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.5034970641136169},{"id":"https://openalex.org/C2780659158","wikidata":"https://www.wikidata.org/wiki/Q2466273","display_name":"Immunochemistry","level":3,"score":0.48833224177360535},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.4860570728778839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4625394344329834},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.45217660069465637},{"id":"https://openalex.org/C197445215","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Colloidal particle","level":3,"score":0.43104875087738037},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3953133523464203},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37872540950775146},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3491503596305847},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3267097473144531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29785335063934326},{"id":"https://openalex.org/C59789625","wikidata":"https://www.wikidata.org/wiki/Q181780","display_name":"Colloid","level":2,"score":0.2803875207901001},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24514222145080566},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1908455193042755},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15034687519073486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14591673016548157},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.11825203895568848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10366696119308472},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09919425845146179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005629","descriptor_name":"Frozen Sections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008867","descriptor_name":"Microtomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:europepmc.org:340287","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1166832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:8157482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8157482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of anatomy","raw_type":"Journal Article"},{"id":"mag:72200925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8157482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:340287","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1166832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W265817920","https://openalex.org/W1911836937","https://openalex.org/W1955955709","https://openalex.org/W1964610374","https://openalex.org/W1980290584","https://openalex.org/W1985850221","https://openalex.org/W1986343952","https://openalex.org/W1986393847","https://openalex.org/W1996809299","https://openalex.org/W1999074083","https://openalex.org/W2003689719","https://openalex.org/W2009752320","https://openalex.org/W2010395737","https://openalex.org/W2011666432","https://openalex.org/W2013980139","https://openalex.org/W2020433826","https://openalex.org/W2027043097","https://openalex.org/W2035171821","https://openalex.org/W2044175751","https://openalex.org/W2048792813","https://openalex.org/W2057836786","https://openalex.org/W2068405408","https://openalex.org/W2068521752","https://openalex.org/W2081548123","https://openalex.org/W2082832783","https://openalex.org/W2100329022","https://openalex.org/W2105382539","https://openalex.org/W2106875648","https://openalex.org/W2107196928","https://openalex.org/W2109740923","https://openalex.org/W2118986914","https://openalex.org/W2126961090","https://openalex.org/W2150405813","https://openalex.org/W2157018895","https://openalex.org/W2157725069","https://openalex.org/W2272417159","https://openalex.org/W2314826172","https://openalex.org/W2317667639","https://openalex.org/W2396940619","https://openalex.org/W2410046213","https://openalex.org/W2415454228","https://openalex.org/W2434497782","https://openalex.org/W2435554920","https://openalex.org/W2440837265","https://openalex.org/W4243878555"],"related_works":["https://openalex.org/W2082193096","https://openalex.org/W1988518225","https://openalex.org/W2151272666","https://openalex.org/W2268386531","https://openalex.org/W1600946659","https://openalex.org/W2133067557","https://openalex.org/W2073237840","https://openalex.org/W995740589","https://openalex.org/W1573509991","https://openalex.org/W160805523"],"abstract_inverted_index":{"Immunocytochemistry":[0],"employs":[1],"immunological":[2],"techniques":[3],"to":[4,17,53,63,72,97,112],"localise":[5],"molecular":[6],"components":[7],"in":[8,48,60,136,178],"biological":[9],"material.":[10],"The":[11,100],"most":[12],"commonly":[13],"used":[14,105,177],"approach":[15],"is":[16,38,71,87],"label":[18],"protein":[19],"antigens":[20,59,135],"with":[21,28,82],"antibodies":[22,84],"whose":[23,85],"location":[24,86],"can":[25],"be":[26,113],"revealed":[27,88],"a":[29,180],"microscopic":[30],"marker.":[31],"At":[32],"the":[33,36,45,58,61,67,128,145,168],"ultrastructural":[34],"level":[35],"technique":[37],"known":[39],"as":[40,94],"immunoelectron":[41,49],"microscopy.":[42],"One":[43],"of":[44,56,69,131,134,147,164,167],"major":[46],"challenges":[47],"microscopy":[50],"has":[51,183],"been":[52,184],"find":[54],"ways":[55],"exposing":[57],"specimen":[62],"labelling":[64,133,150,160],"reagents.":[65],"Currently":[66],"method":[68],"choice":[70],"make":[73],"ultrathin":[74,140],"50-100":[75],"nm":[76],"sections.":[77,141],"These":[78],"are":[79,104,171],"then":[80,153],"incubated":[81],"specific":[83],"using":[89],"second":[90],"step":[91],"reagents":[92],"such":[93],"protein-A":[95],"complexed":[96],"colloidal":[98,101],"gold.":[99],"gold":[102,132,149,159],"particles":[103],"because":[106],"they":[107],"have":[108],"sufficient":[109],"electron":[110],"density":[111],"distinguished":[114],"easily":[115],"from":[116],"contrasted":[117],"cellular":[118,137],"structures":[119,138],"and":[120,152],"subsequently":[121],"counted.":[122],"This":[123],"review":[124],"focuses":[125,154],"exclusively":[126],"on":[127,139,155,175],"quantitative":[129],"aspects":[130],"It":[142],"first":[143],"addresses":[144],"problem":[146],"quantifying":[148],"itself":[151],"methods":[156],"which":[157],"use":[158],"for":[161],"absolute":[162],"quantitation":[163],"antigens.":[165],"Many":[166],"approaches":[169],"that":[170,182],"described":[172],"rely":[173],"heavily":[174],"principles":[176],"stereology,":[179],"science":[181],"revolutionised":[185],"recently":[186],"by":[187],"key":[188],"breakthroughs":[189],"(Gundersen":[190],"et":[191],"al.":[192],"1988":[193],"a,":[194],"b;":[195],"Cruz-Orive":[196],"&":[197],"Weibel,":[198],"1990;":[199],"Mayhew,":[200],"1992).":[201]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
