{"id":"https://openalex.org/W7220022547","doi":"https://doi.org/10.7417/ct.2026.2157","title":"Frequency and Risk Factors of Cancer Therapy-Related Cardiac Dysfunction in Patients Receiving Chemotherapy: A Prospective Cohort Study at a Tertiary Centre.","display_name":"Frequency and Risk Factors of Cancer Therapy-Related Cardiac Dysfunction in Patients Receiving Chemotherapy: A Prospective Cohort Study at a Tertiary Centre.","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7220022547","doi":"https://doi.org/10.7417/ct.2026.2157","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922226"},"language":"en","primary_location":{"id":"pmh:oai::article/1756","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1756","pdf_url":"https://themultiphysicsjournal.com/index.php/ijm/article/download/1756/1109","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://themultiphysicsjournal.com/index.php/ijm/article/download/1756/1109","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159406449","display_name":"Ly Van Chieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801941164","display_name":"Cho Ray Hospital","ror":"https://ror.org/00n8yb347","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I2801941164"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Van Chieu Ly","raw_affiliation_strings":["Cardiovascular Centre, Cho Ray Hospital, Ho Chi Minh City 700000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Centre, Cho Ray Hospital, Ho Chi Minh City 700000, Vietnam","institution_ids":["https://openalex.org/I2801941164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159398000","display_name":"Tran Huu Chinh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801941164","display_name":"Cho Ray Hospital","ror":"https://ror.org/00n8yb347","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I2801941164"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Huu Chinh Tran","raw_affiliation_strings":["Cardiovascular Centre, Cho Ray Hospital, Ho Chi Minh City 700000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Centre, Cho Ray Hospital, Ho Chi Minh City 700000, Vietnam","institution_ids":["https://openalex.org/I2801941164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159409430","display_name":"Nguyen Tri Thuc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152602","display_name":"Ministry of Health","ror":"https://ror.org/055546q82","country_code":"VN","type":"government","lineage":["https://openalex.org/I4210152602"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Tri Thuc Nguyen","raw_affiliation_strings":["Ministry of Health, Ha Noi 10000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Health, Ha Noi 10000, Vietnam","institution_ids":["https://openalex.org/I4210152602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129668110","display_name":"Hoang Sy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802508454","display_name":"University of Medicine and Pharmacy at Ho Chi Minh City","ror":"https://ror.org/025kb2624","country_code":"VN","type":"education","lineage":["https://openalex.org/I2802508454"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Van Sy Hoang","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam","institution_ids":["https://openalex.org/I2802508454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7635049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"177","issue":"6","first_page":"1503","last_page":"1510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10270","display_name":"Blockchain Technology Applications and Security","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1710","display_name":"Information Systems"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10270","display_name":"Blockchain Technology Applications and Security","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1710","display_name":"Information Systems"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10603","display_name":"Smart Grid Energy Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13975","display_name":"Energy, Economy, and Technology Trends","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decentralized-energy-markets","display_name":"decentralized energy markets","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blockchain","display_name":"blockchain","score":0.9869999885559082},{"id":"https://openalex.org/keywords/smart-contracts","display_name":"smart contracts","score":0.949999988079071},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.9350000023841858},{"id":"https://openalex.org/keywords/internet-of-things","display_name":"Internet of Things","score":0.925000011920929},{"id":"https://openalex.org/keywords/behavioral-economics","display_name":"behavioral economics","score":0.9710000157356262},{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"reinforcement learning","score":0.8980000019073486},{"id":"https://openalex.org/keywords/load-forecasting","display_name":"load forecasting","score":0.7609999775886536},{"id":"https://openalex.org/keywords/energy-optimization","display_name":"energy optimization","score":0.9419999718666077},{"id":"https://openalex.org/keywords/renewable-energy-incentives","display_name":"renewable energy incentives","score":0.7549999952316284},{"id":"https://openalex.org/keywords/energy-transactions","display_name":"energy transactions","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C188573790","wikidata":"https://www.wikidata.org/wiki/Q12705","display_name":"Renewable energy","level":2,"score":0.6367999911308289},{"id":"https://openalex.org/C134560507","wikidata":"https://www.wikidata.org/wiki/Q753291","display_name":"Environmental economics","level":1,"score":0.6262000203132629},{"id":"https://openalex.org/C29122968","wikidata":"https://www.wikidata.org/wiki/Q1414816","display_name":"Incentive","level":2,"score":0.5769000053405762},{"id":"https://openalex.org/C2780233690","wikidata":"https://www.wikidata.org/wiki/Q535347","display_name":"Transparency (behavior)","level":2,"score":0.5745999813079834},{"id":"https://openalex.org/C2779438525","wikidata":"https://www.wikidata.org/wiki/Q5255048","display_name":"Demand response","level":3,"score":0.5292999744415283},{"id":"https://openalex.org/C75949130","wikidata":"https://www.wikidata.org/wiki/Q848010","display_name":"Database transaction","level":2,"score":0.4650000035762787},{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.4113999903202057},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.40529999136924744},{"id":"https://openalex.org/C2780165032","wikidata":"https://www.wikidata.org/wiki/Q16869822","display_name":"Energy consumption","level":2,"score":0.398499995470047},{"id":"https://openalex.org/C39996523","wikidata":"https://www.wikidata.org/wiki/Q7313092","display_name":"Renewable energy credit","level":5,"score":0.39309999346733093},{"id":"https://openalex.org/C10558101","wikidata":"https://www.wikidata.org/wiki/Q689855","display_name":"Smart grid","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C58941895","wikidata":"https://www.wikidata.org/wiki/Q295865","display_name":"Ecosystem services","level":3,"score":0.3573000133037567},{"id":"https://openalex.org/C109574028","wikidata":"https://www.wikidata.org/wiki/Q647525","display_name":"Behavioral economics","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C143517461","wikidata":"https://www.wikidata.org/wiki/Q1138571","display_name":"Renewable resource","level":3,"score":0.3472999930381775},{"id":"https://openalex.org/C7817414","wikidata":"https://www.wikidata.org/wiki/Q1779504","display_name":"Energy management","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C2779370713","wikidata":"https://www.wikidata.org/wiki/Q357554","display_name":"Load management","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C520343842","wikidata":"https://www.wikidata.org/wiki/Q3353193","display_name":"Energy engineering","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C98965940","wikidata":"https://www.wikidata.org/wiki/Q877496","display_name":"Transaction cost","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C40700","wikidata":"https://www.wikidata.org/wiki/Q1411783","display_name":"Industrial organization","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C2777172336","wikidata":"https://www.wikidata.org/wiki/Q2700433","display_name":"Energy security","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C2742236","wikidata":"https://www.wikidata.org/wiki/Q924713","display_name":"Efficient energy use","level":2,"score":0.2994999885559082},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28769999742507935},{"id":"https://openalex.org/C30772137","wikidata":"https://www.wikidata.org/wiki/Q5164762","display_name":"Consumption (sociology)","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C520301825","wikidata":"https://www.wikidata.org/wiki/Q380170","display_name":"Energy conservation","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C552854447","wikidata":"https://www.wikidata.org/wiki/Q131201","display_name":"Sustainable development","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C2780609101","wikidata":"https://www.wikidata.org/wiki/Q17156588","display_name":"Resource management (computing)","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C544738498","wikidata":"https://www.wikidata.org/wiki/Q861135","display_name":"Distributed generation","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C4216890","wikidata":"https://www.wikidata.org/wiki/Q815823","display_name":"Business model","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.26010000705718994},{"id":"https://openalex.org/C78639753","wikidata":"https://www.wikidata.org/wiki/Q3318160","display_name":"Behavioral modeling","level":2,"score":0.2549999952316284}],"mesh":[{"descriptor_ui":"D000094582","descriptor_name":"Global Longitudinal Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020107","descriptor_name":"Troponin T","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D062606","descriptor_name":"Tertiary Care Centers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmh:oai::article/1756","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1756","pdf_url":"https://themultiphysicsjournal.com/index.php/ijm/article/download/1756/1109","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:42922226","doi":"https://doi.org/10.7417/ct.2026.2157","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Clinica terapeutica","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai::article/1756","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1756","pdf_url":"https://themultiphysicsjournal.com/index.php/ijm/article/download/1756/1109","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7220022547.pdf","grobid_xml":"https://content.openalex.org/works/W7220022547.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223573933","https://openalex.org/W4402097838","https://openalex.org/W4403544230","https://openalex.org/W2950811601","https://openalex.org/W3107641774","https://openalex.org/W4415118880","https://openalex.org/W7126159635","https://openalex.org/W4395680542","https://openalex.org/W4415209492","https://openalex.org/W7221816290"],"abstract_inverted_index":{"Background:":[0],"Cancer":[1],"therapy-related":[2],"cardiac":[3,274],"dysfunction":[4],"(CTRCD)":[5],"is":[6,20],"an":[7],"increasingly":[8],"recognised":[9],"consequence":[10],"of":[11,48,76,253],"contemporary":[12],"oncological":[13],"treatment.":[14],"Left":[15],"ventricular":[16],"ejection":[17],"fraction":[18],"(LVEF)":[19],"insensitive":[21],"to":[22,55,234,272],"subclinical":[23],"myocardial":[24],"injury,":[25],"and":[26,45,54,61,91,104,161,175,186,211],"locally":[27,256],"validated":[28,257],"thresholds":[29],"for":[30,66],"global":[31],"longitudinal":[32],"strain":[33],"(GLS)":[34],"are":[35],"lacking":[36],"in":[37,50,151,191,231],"Vietnamese":[38],"patients.":[39,254],"Objectives:":[40],"To":[41],"determine":[42],"the":[43,127,235],"frequency":[44],"risk":[46,135,232],"factors":[47],"CTRCD":[49,110,149,171,250],"patients":[51,78,153],"receiving":[52],"chemotherapy,":[53],"validate":[56],"a":[57,62,72,180,194,228,268],"localised":[58],"GLS":[59,167,188,258],"threshold":[60,259],"biomarker-based":[63],"surveillance":[64],"strategy":[65],"early":[67],"detection.":[68],"Methods:":[69],"We":[70],"conducted":[71],"prospective":[73],"cohort":[74],"study":[75],"235":[77],"at":[79,89],"Cho":[80],"Ray":[81],"Hospital":[82],"(September":[83],"2023-December":[84],"2025).":[85],"Patients":[86],"were":[87,132,218],"assessed":[88,120],"baseline":[90],"every":[92],"three":[93],"months":[94],"with":[95,138,158,172,189,220,227,261],"two-dimensional":[96],"speckle-tracking":[97],"echocardiography":[98],"(GLS),":[99],"high-sensitivity":[100],"troponin":[101],"T":[102],"(hs-TnT)":[103],"N-terminal":[105],"pro-B-type":[106],"natriuretic":[107],"peptide":[108],"(NT-proBNP).":[109],"was":[111,119,129,156,224],"defined":[112],"by":[113,144],"international":[114],"consensus":[115],"criteria.":[116],"Diagnostic":[117],"accuracy":[118],"using":[121],"receiver":[122],"operating":[123],"characteristic":[124],"analysis;":[125],"as":[126,134],"outcome":[128],"common,":[130],"associations":[131],"quantified":[133],"ratios":[136],"(RR)":[137],"95%":[139,200,208,215,240],"confidence":[140],"intervals":[141],"(CI)":[142],"estimated":[143],"modified":[145],"Poisson":[146],"regression.":[147],"Results:":[148],"occurred":[150],"82":[152],"(34.9%).":[154],"Incidence":[155],"highest":[157],"anthracyclines":[159],"(41.2%)":[160],"HER2-targeted":[162],"therapy":[163],"(37.2%).":[164],"A":[165,255],"relative":[166],"reduction":[168],"\u226512.1%":[169],"predicted":[170],"73%":[173],"sensitivity":[174],"83%":[176],"specificity.":[177],"hs-TnT":[178,190,262],"achieved":[179],"100%":[181,195,246],"negative":[182],"predictive":[183],"value":[184],"(NPV),":[185],"combining":[187],"parallel":[192],"retained":[193],"NPV.":[196],"Hypertension":[197],"(RR":[198,206,213,238],"2.50,":[199],"CI":[201,209,216,241],"1.78-3.50),":[202],"coronary":[203],"artery":[204],"disease":[205],"2.47,":[207],"1.82-3.35)":[210],"dyslipidaemia":[212],"2.10,":[214],"1.49-2.97)":[217],"associated":[219],"CTRCD.":[221],"HFA-ICOS":[222],"stratification":[223],"strongly":[225],"predictive,":[226],"stepwise":[229],"increase":[230],"up":[233],"very-high-risk":[236],"category":[237],"18.6,":[239],"7.94-43.6":[242],"versus":[243],"low":[244],"risk;":[245],"event":[247],"rate).":[248],"Conclusions:":[249],"affected":[251],"one-third":[252],"combined":[260],"enables":[263],"early,":[264],"resource-efficient":[265],"detection,":[266],"supporting":[267],"shift":[269],"from":[270],"reactive":[271],"proactive":[273],"surveillance.":[275]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-05T00:00:00"}